Diane Mathis

Author PubWeight™ 281.70‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Projection of an immunological self shadow within the thymus by the aire protein. Science 2002 12.15
2 Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009 9.71
3 FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006 9.24
4 Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010 8.90
5 The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med 2008 6.07
6 Gut immune maturation depends on colonization with a host-specific microbiota. Cell 2012 5.91
7 Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 2002 5.82
8 Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 2007 5.67
9 Arthritis critically dependent on innate immune system players. Immunity 2002 5.31
10 Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med 2002 5.09
11 Stability of the regulatory T cell lineage in vivo. Science 2010 4.89
12 The cellular mechanism of Aire control of T cell tolerance. Immunity 2005 4.74
13 PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 2012 4.31
14 Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 2009 4.07
15 CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med 2004 3.57
16 Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A 2011 3.55
17 Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol 2007 3.47
18 Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity 2008 3.25
19 How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol 2002 3.20
20 Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med 2005 3.14
21 A special population of regulatory T cells potentiates muscle repair. Cell 2013 3.09
22 A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity 2005 3.07
23 Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 2002 2.98
24 Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med 2003 2.94
25 Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J Exp Med 2004 2.92
26 Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity 2011 2.87
27 Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 2007 2.84
28 Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A 2006 2.83
29 Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 2014 2.77
30 Aire's partners in the molecular control of immunological tolerance. Cell 2010 2.68
31 Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells. Nat Immunol 2004 2.68
32 Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med 2005 2.61
33 Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science 2006 2.38
34 Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc Natl Acad Sci U S A 2010 2.30
35 How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity 2009 2.15
36 TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J Exp Med 2007 2.15
37 Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol 2013 2.13
38 Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 2006 2.12
39 Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nat Immunol 2012 2.11
40 Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis. Proc Natl Acad Sci U S A 2010 2.09
41 Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med 2005 2.08
42 Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 2005 2.06
43 Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity. Proc Natl Acad Sci U S A 2004 1.96
44 Arthritogenic monoclonal antibodies from K/BxN mice. J Exp Med 2002 1.94
45 Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. J Clin Invest 2010 1.93
46 Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy. Am J Pathol 2008 1.93
47 A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nat Immunol 2012 1.93
48 The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci U S A 2008 1.85
49 Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci U S A 2007 1.84
50 Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A 2008 1.83
51 Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity. J Clin Invest 2003 1.80
52 Identification of transcriptional regulators in the mouse immune system. Nat Immunol 2013 1.79
53 Defective central tolerance induction in NOD mice: genomics and genetics. Immunity 2005 1.74
54 The K/BxN arthritis model. Curr Protoc Immunol 2008 1.74
55 Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity. J Exp Med 2009 1.71
56 Regulatory T cells in nonlymphoid tissues. Nat Immunol 2013 1.69
57 Danger-free autoimmune disease in Aire-deficient mice. Proc Natl Acad Sci U S A 2007 1.67
58 The molecular program induced in T cells undergoing homeostatic proliferation. Proc Natl Acad Sci U S A 2004 1.66
59 The transcriptional landscape of αβ T cell differentiation. Nat Immunol 2013 1.61
60 Commercially available outbred mice for genome-wide association studies. PLoS Genet 2010 1.58
61 Mast cells in autoimmune disease. Nature 2002 1.58
62 How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci U S A 2005 1.55
63 Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Sci Transl Med 2013 1.55
64 Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. J Exp Med 2013 1.53
65 Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis. Arthritis Rheum 2007 1.52
66 Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A 2007 1.51
67 Imaging inflammation of the pancreatic islets in type 1 diabetes. Proc Natl Acad Sci U S A 2004 1.51
68 Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A 2011 1.50
69 An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity 2012 1.50
70 Gene expression microarrays: glimpses of the immunological genome. Nat Immunol 2006 1.48
71 Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med 2007 1.44
72 Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci U S A 2008 1.41
73 Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders. Arthritis Rheum 2003 1.41
74 Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. J Exp Med 2010 1.41
75 Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proc Natl Acad Sci U S A 2011 1.38
76 The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease. Adv Immunol 2004 1.38
77 The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription. Proc Natl Acad Sci U S A 2008 1.33
78 Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1. Arthritis Rheum 2010 1.31
79 Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc Natl Acad Sci U S A 2007 1.31
80 A plaidoyer for 'systems immunology'. Immunol Rev 2006 1.30
81 The K/BxN mouse model of inflammatory arthritis: theory and practice. Methods Mol Med 2007 1.30
82 T-cell compartments of prediabetic NOD mice. Diabetes 2003 1.27
83 Altered natural killer cells in type 1 diabetic patients. Diabetes 2007 1.26
84 A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis. Proc Natl Acad Sci U S A 2009 1.26
85 The immune system's involvement in obesity-driven type 2 diabetes. Semin Immunol 2013 1.25
86 Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism. Semin Immunol 2011 1.23
87 Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model. Arthritis Rheum 2010 1.23
88 Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity 2011 1.23
89 Lack of Foxp3 function and expression in the thymic epithelium. J Exp Med 2007 1.22
90 IL-17-producing T cells can augment autoantibody-induced arthritis. Proc Natl Acad Sci U S A 2009 1.22
91 Transcriptomes of the B and T lineages compared by multiplatform microarray profiling. J Immunol 2011 1.22
92 A shared gene-expression signature in innate-like lymphocytes. Immunol Rev 2006 1.19
93 Treg cells, life history, and diversity. Cold Spring Harb Perspect Biol 2012 1.19
94 Interleukin-4 can be a key positive regulator of inflammatory arthritis. Arthritis Rheum 2005 1.18
95 Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview. Diabetes 2004 1.17
96 Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci U S A 2010 1.17
97 Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected. J Immunol 2007 1.15
98 Soluble factors secreted by T cells promote β-cell proliferation. Diabetes 2013 1.14
99 Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes. J Clin Invest 2005 1.14
100 Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. J Clin Invest 2005 1.13
101 Transcriptional impact of Aire varies with cell type. Proc Natl Acad Sci U S A 2008 1.12
102 Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. Proc Natl Acad Sci U S A 2014 1.11
103 Modeling CTLA4-linked autoimmunity with RNA interference in mice. Proc Natl Acad Sci U S A 2006 1.08
104 Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation. Proc Natl Acad Sci U S A 2007 1.06
105 Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen. Proc Natl Acad Sci U S A 2006 1.05
106 A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice. Proc Natl Acad Sci U S A 2011 1.03
107 Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J Immunol 2003 1.02
108 AIRE and APECED: molecular insights into an autoimmune disease. Immunol Rev 2005 1.02
109 Interindividual variation in human T regulatory cells. Proc Natl Acad Sci U S A 2014 1.01
110 Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells. Proc Natl Acad Sci U S A 2012 1.01
111 Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1). Diabetes 2008 1.01
112 Thymic negative selection is functional in NOD mice. J Exp Med 2012 1.00
113 Treg cells: guardians for life. Nat Immunol 2007 1.00
114 B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients. Proc Natl Acad Sci U S A 2008 0.98
115 The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 2009 0.98
116 Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc Natl Acad Sci U S A 2012 0.96
117 Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice. J Proteome Res 2010 0.96
118 A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus. PLoS Biol 2010 0.95
119 The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice. Proc Natl Acad Sci U S A 2007 0.94
120 Fluorescent exendin-4 derivatives for pancreatic β-cell analysis. Bioconjug Chem 2013 0.93
121 Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis Rheum 2009 0.92
122 Consortium biology in immunology: the perspective from the Immunological Genome Project. Nat Rev Immunol 2012 0.92
123 Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice. Proc Natl Acad Sci U S A 2005 0.91
124 Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. Proc Natl Acad Sci U S A 2006 0.90
125 A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice. Proc Natl Acad Sci U S A 2010 0.90
126 Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice. Arthritis Rheum 2011 0.90
127 Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model. Arthritis Rheum 2007 0.89
128 An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription. Proc Natl Acad Sci U S A 2014 0.88
129 Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Arthritis Rheum 2004 0.86
130 Differential splicing across immune system lineages. Proc Natl Acad Sci U S A 2013 0.85
131 Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. Proc Natl Acad Sci U S A 2013 0.84
132 Good riddance: Thymocyte clonal deletion prevents autoimmunity. Curr Opin Immunol 2004 0.84
133 Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cells. Diabetes 2004 0.81
134 Differential response of regulatory and conventional CD4⁺ lymphocytes to CD3 engagement: clues to a possible mechanism of anti-CD3 action? J Immunol 2013 0.80
135 A broad analysis of IL1 polymorphism and rheumatoid arthritis. Arthritis Rheum 2008 0.79
136 Green T(R) cells. Immunity 2005 0.78
137 The neuropeptide neuromedin U promotes autoantibody-mediated arthritis. Arthritis Res Ther 2012 0.75
138 Regulatory T-cell differentiation: Committed to control: a precocious choice? Immunol Cell Biol 2007 0.75