Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells.

PubWeight™: 1.23‹?› | Rank: Top 10%

🔗 View Article (PMC 3085397)

Published in Immunity on March 31, 2011

Authors

Hozefa S Bandukwala1, Yongqing Wu, Markus Feuerer, Yongheng Chen, Bianca Barboza, Srimoyee Ghosh, James C Stroud, Christophe Benoist, Diane Mathis, Anjana Rao, Lin Chen

Author Affiliations

1: Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital, Boston, MA 02115, USA.

Articles citing this

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell (2012) 2.79

The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells. Immunity (2015) 1.94

An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity (2012) 1.50

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A (2012) 1.39

Comparative Genomics Reveals Key Gain-of-Function Events in Foxp3 during Regulatory T Cell Evolution. Front Immunol (2012) 1.26

Location, location, location: it's all in the timing for replication origins. Genes Dev (2013) 1.23

Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell Rep (2012) 1.14

DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation. Cell Rep (2012) 1.12

Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2012) 1.11

NFATc1/αA: The other Face of NFAT Factors in Lymphocytes. Cell Commun Signal (2012) 0.98

PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation. J Biol Chem (2014) 0.86

DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Res (2015) 0.84

Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-κB. PLoS One (2012) 0.84

The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding. PLoS Genet (2015) 0.81

Different molecular complexes that mediate transcriptional induction and repression by FoxP3. Nat Immunol (2017) 0.80

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3. Sci Rep (2015) 0.80

Searching for the Achilles Heel of FOXP3. Front Oncol (2013) 0.79

A Potential Structural Switch for Regulating DNA-Binding by TEAD Transcription Factors. J Mol Biol (2016) 0.78

Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells. Exp Mol Pathol (2012) 0.78

Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program. Sci Rep (2016) 0.77

Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site. Nucleic Acids Res (2015) 0.77

C/EBPβ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling. Mol Cell Biol (2015) 0.76

Conserved forkhead dimerization motif controls DNA replication timing and spatial organization of chromosomes in S. cerevisiae. Proc Natl Acad Sci U S A (2017) 0.75

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites. Proc Natl Acad Sci U S A (2016) 0.75

Three-Dimensional Domain Swapping Changes the Folding Mechanism of the Forkhead Domain of FoxP1. Biophys J (2016) 0.75

Deletion of Fanca or Fancd2 dysregulates Treg in mice. Blood (2014) 0.75

Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes, VLDLR and CNTNAP2 in the Zebra Finch Song System. Front Mol Neurosci (2017) 0.75

Articles cited by this

Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57

Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity (2005) 23.00

A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet (2001) 15.27

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet (2001) 14.15

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet (2001) 10.92

Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity (2009) 9.28

FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature (2007) 7.04

FOXP3: of mice and men. Annu Rev Immunol (2006) 6.89

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol (2007) 6.80

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature (2007) 6.58

Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature (2007) 5.81

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature (2007) 5.14

Control of regulatory T cell lineage commitment and maintenance. Immunity (2009) 4.63

T helper cell subsets in insulin-dependent diabetes. Science (1995) 3.92

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature (1998) 3.71

Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet (2002) 3.61

Structural biology of the tumor suppressor p53. Annu Rev Biochem (2008) 3.36

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A (2007) 3.32

Structural basis of DNA recognition by p53 tetramers. Mol Cell (2006) 3.29

The evolution of Fox genes and their role in development and disease. Nat Rev Genet (2009) 3.13

Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol (2010) 2.80

Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest (2006) 2.58

Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor. J Immunol (2006) 2.44

How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity (2009) 2.15

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14

Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity (2009) 2.05

Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2009) 2.02

Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. J Biol Chem (2003) 1.77

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol (2007) 1.67

The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66

Structure of the forkhead domain of FOXP2 bound to DNA. Structure (2006) 1.61

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J Exp Med (2009) 1.57

IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol Res (2007) 1.51

Runx proteins regulate Foxp3 expression. J Exp Med (2009) 1.45

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci U S A (2006) 1.41

Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. Structure (2010) 1.39

FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int Immunol (2007) 1.39

Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element. Nat Struct Biol (2003) 1.37

IPEX as a result of mutations in FOXP3. Clin Dev Immunol (2007) 1.30

FOXP3 actively represses transcription by recruiting the HAT/HDAC complex. Cell Cycle (2007) 1.22

Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX). J Med Genet (2001) 1.10

An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. Nat Struct Biol (2003) 1.04

Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3. PLoS One (2009) 0.99

Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element. Structure (2008) 0.93

Structure of NFAT bound to DNA as a monomer. J Mol Biol (2003) 0.87

Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction. J Autoimmun (2007) 0.86

Regulatory T cells: key players in tolerance and autoimmunity. Endocrinol Metab Clin North Am (2009) 0.86

Articles by these authors

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97

Mapping and sequencing of structural variation from eight human genomes. Nature (2008) 30.28

Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78

Regulation of the germinal center response by microRNA-155. Science (2007) 12.25

Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science (2007) 10.60

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell (2006) 10.19

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59

Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39

FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev (2005) 8.95

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature (2010) 8.87

Orai1 is an essential pore subunit of the CRAC channel. Nature (2006) 8.60

The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23

The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One (2010) 8.10

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41

Aberrant T cell differentiation in the absence of Dicer. J Exp Med (2005) 6.58

Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol (2006) 6.10

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med (2008) 6.07

Gut immune maturation depends on colonization with a host-specific microbiota. Cell (2012) 5.91

The genome of a songbird. Nature (2010) 5.90

Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science (2002) 5.82

Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74

Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity (2007) 5.67

Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31

Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11

Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med (2002) 5.09

Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med (2004) 5.08

MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94

Stability of the regulatory T cell lineage in vivo. Science (2010) 4.89

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol (2006) 4.81

The cellular mechanism of Aire control of T cell tolerance. Immunity (2005) 4.74

Genome architectures revealed by tethered chromosome conformation capture and population-based modeling. Nat Biotechnol (2011) 4.56

Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity (2010) 4.52

DNA binding site sequence directs glucocorticoid receptor structure and activity. Science (2009) 4.48

Aire. Annu Rev Immunol (2009) 4.43

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol (2002) 4.38

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature (2012) 4.31

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution. Nat Neurosci (2007) 4.28

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol (2004) 4.21

Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 4.14

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 4.07

Transcriptional mechanisms underlying lymphocyte tolerance. Cell (2002) 4.04

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol (2008) 3.98

An epigenetic view of helper T cell differentiation. Nat Immunol (2003) 3.87

Biochemical and functional characterization of Orai proteins. J Biol Chem (2007) 3.87

Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83

A burst of segmental duplications in the genome of the African great ape ancestor. Nature (2009) 3.63

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature (2006) 3.61

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med (2004) 3.57

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A (2011) 3.55

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (2009) 3.47

Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol (2007) 3.47

Evolutionary toggling of the MAPT 17q21.31 inversion region. Nat Genet (2008) 3.42

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25

How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol (2002) 3.20

Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol (2006) 3.19

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol (2013) 3.18

Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Science (2008) 3.17

Single-vector inducible lentiviral RNAi system for oncology target validation. Cell Cycle (2009) 3.14

Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med (2005) 3.14

A special population of regulatory T cells potentiates muscle repair. Cell (2013) 3.09

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A (2011) 3.07

A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity (2005) 3.07

The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol (2002) 3.05