Published in Nature on June 25, 2008
Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer (2009) 4.66
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol (2015) 1.61
DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning. Genome Biol (2017) 1.37
Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol (2012) 1.37
Atypical E2F repressors and activators coordinate placental development. Dev Cell (2012) 1.33
Network calisthenics: control of E2F dynamics in cell cycle entry. Cell Cycle (2011) 1.25
E2f3a and E2f3b contribute to the control of cell proliferation and mouse development. Mol Cell Biol (2008) 1.13
Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. Cancer Res (2011) 1.12
Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer. Genome Res (2013) 1.11
E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation. Genes Dev (2009) 1.07
Cell-context specific role of the E2F/Rb pathway in development and disease. Glia (2010) 1.04
Cell proliferation in the absence of E2F1-3. Dev Biol (2010) 0.98
E2f1-3 are critical for myeloid development. J Biol Chem (2010) 0.97
The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. EMBO J (2011) 0.95
E2F3 plays an essential role in cardiac development and function. Cell Cycle (2008) 0.94
Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3. Proc Natl Acad Sci U S A (2013) 0.93
HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors. Oncogene (2013) 0.92
E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3. Cell Death Differ (2013) 0.92
Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn (2012) 0.91
The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells. Mol Cell Biol (2009) 0.88
Second generation tyrosine kinase inhibitors prevent disease progression in high-risk (high CIP2A) chronic myeloid leukaemia patients. Leukemia (2015) 0.87
Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation. Oncogene (2012) 0.86
Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival. PLoS Genet (2010) 0.85
Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D. Genes Dev (2016) 0.83
Tension and robustness in multitasking cellular networks. PLoS Comput Biol (2012) 0.82
E2F4 cooperates with pRB in the development of extra-embryonic tissues. Dev Biol (2009) 0.82
Tissue-specific targeting of cell fate regulatory genes by E2f factors. Cell Death Differ (2015) 0.82
Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality. Cell Cycle (2010) 0.81
In Silico Prediction for Regulation of Transcription Factors onTheir Shared Target Genes Indicates Relevant Clinical Implications in a Breast Cancer Population. Cancer Inform (2012) 0.80
Cooperative activation of tissue-specific genes by pRB and E2F1. Cancer Res (2013) 0.80
Protection of CpG islands against de novo DNA methylation during oogenesis is associated with the recognition site of E2f1 and E2f2. Epigenetics Chromatin (2014) 0.80
Functional and association analysis of frizzled 1 (FZD1) promoter haplotypes with femoral neck geometry. Bone (2010) 0.79
ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells. BMC Cell Biol (2013) 0.78
Flipping the switch from g1 to s phase with e3 ubiquitin ligases. Genes Cancer (2012) 0.78
Cellular transformation of mouse embryo fibroblasts in the absence of activator E2Fs. J Virol (2015) 0.78
Ablation of the transcription factors E2F1-2 limits neuroinflammation and associated neurological deficits after contusive spinal cord injury. Cell Cycle (2015) 0.77
CDK4, pRB and E2F1: connected to insulin. Cell Div (2010) 0.77
The heart: mostly postmitotic or mostly premitotic? Myocyte cell cycle, senescence, and quiescence. Can J Cardiol (2014) 0.77
Transcriptional control of stem cell fate by E2Fs and pocket proteins. Front Genet (2015) 0.77
E2f4 and E2f5 are essential for the development of the male reproductive system. Cell Cycle (2016) 0.76
EBV Nuclear Antigen 3C Mediates Regulation of E2F6 to Inhibit E2F1 Transcription and Promote Cell Proliferation. PLoS Pathog (2016) 0.75
Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. J Clin Invest (2017) 0.75
The role of E2F1 in the development of hypertrophic cardiomyopathy. Int J Clin Exp Pathol (2011) 0.75
Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model. Cell Cycle (2016) 0.75
LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression. PLoS One (2014) 0.75
Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer. Oncogene (2016) 0.75
Evidence for a strong correlation between transcription factor protein disorder and organismic complexity. Genome Biol Evol (2017) 0.75
Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol (2002) 7.64
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell (1992) 6.32
E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell (1996) 5.26
Tumor induction and tissue atrophy in mice lacking E2F-1. Cell (1996) 4.80
The E2F1-3 transcription factors are essential for cellular proliferation. Nature (2001) 4.37
Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr Mol Med (2006) 3.86
The E2F family: specific functions and overlapping interests. EMBO J (2004) 3.33
E2f3 is critical for normal cellular proliferation. Genes Dev (2000) 3.26
Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell (2008) 2.61
Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. EMBO J (2002) 2.49
E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell (2000) 2.48
Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol Cell Biol (2000) 2.24
Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity (2001) 2.09
DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc Natl Acad Sci U S A (1994) 2.08
E2F-associated chromatin modifiers and cell cycle control. Curr Opin Cell Biol (2007) 2.04
E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol Cell Biol (2001) 1.91
dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. Mol Cell (2001) 1.79
Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor. Mol Cell Biol (2003) 1.76
Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice. Mol Cell Biol (2003) 1.56
dE2F2, a novel E2F-family transcription factor in Drosophila melanogaster. Biochem Biophys Res Commun (1998) 1.54
Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo. Mol Cell Biol (2002) 1.44
A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Genes Dev (2004) 1.42
Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol (2007) 1.37
Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis. Proc Natl Acad Sci U S A (2007) 1.19
Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues. Mol Cell Biol (2007) 1.07
Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer (2009) 4.66
Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21
Extra-embryonic function of Rb is essential for embryonic development and viability. Nature (2003) 3.92
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev (2003) 3.58
Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res (2008) 3.41
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest (2006) 3.27
Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell (2008) 2.61
Parenchymal volume preservation and ischemia during partial nephrectomy: functional and volumetric analysis. Urology (2013) 2.59
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature (2004) 2.49
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature (2009) 2.22
Genomic alterations in tumor stroma. Cancer Res (2009) 2.18
Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood (2009) 2.17
The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood (2008) 2.05
Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem (2003) 2.04
Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem (2005) 1.95
Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet (2004) 1.94
Rb is critical in a mammalian tissue stem cell population. Genes Dev (2007) 1.92
Exploring functional relationships between components of the gene expression machinery. Nat Struct Mol Biol (2005) 1.87
Lifestyle associated risk factors in adolescents. Indian J Pediatr (2006) 1.79
Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. Cancer Res (2008) 1.78
In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised mice. Cancer Biol Ther (2003) 1.77
Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A (2003) 1.74
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling. Nat Cell Biol (2010) 1.74
Evidence for a stepwise program of extrathymic T cell development within the human tonsil. J Clin Invest (2012) 1.72
E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7. Oncogene (2005) 1.69
Healthcare resource utilization and epidemiology of pediatric burn-associated hospitalizations, United States, 2000. J Burn Care Res (2007) 1.69
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem (2008) 1.67
Aberrant regulation of survivin by the RB/E2F family of proteins. J Biol Chem (2004) 1.58
LQAS: User Beware. Int J Epidemiol (2010) 1.56
Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol (2009) 1.56
E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop. Mol Cell Biol (2007) 1.55
Division and apoptosis of E2f-deficient retinal progenitors. Nature (2009) 1.55
Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma. Leuk Res (2011) 1.53
Reconstruction of cellular biological structures from optical microscopy data. IEEE Trans Vis Comput Graph (2008) 1.52
Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin. EMBO J (2006) 1.52
NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med (2012) 1.52
Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc Natl Acad Sci U S A (2002) 1.51
Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. Cell Growth Differ (2002) 1.51
Coexistence of chronic calcific pancreatitis and celiac disease. Indian J Gastroenterol (2007) 1.45
Essential role for survivin in early brain development. J Neurosci (2005) 1.44
Myocardial transcriptional profiles in a murine model of sepsis: evidence for the importance of age. Pediatr Crit Care Med (2008) 1.43
Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation. J Biol Chem (2006) 1.43
Poliovirus cre(2C)-dependent synthesis of VPgpUpU is required for positive- but not negative-strand RNA synthesis. J Virol (2003) 1.43
Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice. J Immunol (2008) 1.42
A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone. Cancer Res (2005) 1.40
An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. Cancer Res (2010) 1.39
E2F8 is essential for polyploidization in mammalian cells. Nat Cell Biol (2012) 1.39
Tensor classification of N-point correlation function features for histology tissue segmentation. Med Image Anal (2008) 1.38
Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol (2012) 1.37
Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol (2007) 1.37
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer. Mol Cancer Ther (2009) 1.36
Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1). Circ Res (2003) 1.35
Copper-induced vascular endothelial growth factor expression and wound healing. Am J Physiol Heart Circ Physiol (2002) 1.33
Atypical E2F repressors and activators coordinate placental development. Dev Cell (2012) 1.33
e-Science, caGrid, and Translational Biomedical Research. Computer (Long Beach Calif) (2008) 1.32
Principles and safety measures of electrosurgery in laparoscopy. JSLS (2012) 1.31
Human bone marrow stromal cells enhance breast cancer cell growth rates in a cell line-dependent manner when evaluated in 3D tumor environments. Cancer Lett (2007) 1.31
CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet (2007) 1.28
Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis. PLoS One (2009) 1.26
E2F7 represses a network of oscillating cell cycle genes to control S-phase progression. Nucleic Acids Res (2011) 1.26
S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways. Cancer Res (2011) 1.25