PubRank

Neil Osheroff

Author PubWeight™ 83.92‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med 2005 3.06
2 The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res 2008 2.64
3 DNA topoisomerase II, genotoxicity, and cancer. Mutat Res 2007 1.95
4 Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks. J Biol Chem 2005 1.68
5 A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature 2010 1.59
6 Topoisomerase II and the etiology of chromosomal translocations. DNA Repair (Amst) 2006 1.41
7 A two-drug model for etoposide action against human topoisomerase IIalpha. J Biol Chem 2002 1.38
8 Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes. Curr Top Med Chem 2003 1.36
9 Mechanism of quinolone action and resistance. Biochemistry 2014 1.34
10 Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. PLoS One 2010 1.29
11 From music to macromolecules: using rich media/podcast lecture recordings to enhance the preclinical educational experience. Med Teach 2008 1.22
12 Metnase promotes restart and repair of stalled and collapsed replication forks. Nucleic Acids Res 2010 1.21
13 1,4-Benzoquinone is a topoisomerase II poison. Biochemistry 2004 1.21
14 Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage. Nucleic Acids Res 2008 1.17
15 (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases. Chem Res Toxicol 2008 1.15
16 Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res 2002 1.15
17 The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs. Biochemistry 2006 1.12
18 Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry 2006 1.11
19 Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis. Blood 2008 1.11
20 Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry 2008 1.11
21 Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry 2007 1.10
22 Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Biochemistry 2007 1.10
23 Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification. Nucleic Acids Res 2011 1.10
24 Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat Struct Mol Biol 2012 1.09
25 Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain. Biochemistry 2008 1.09
26 Topoisomerase II and leukemia. Ann N Y Acad Sci 2014 1.04
27 Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation. PLoS Genet 2013 1.04
28 Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance. Nucleic Acids Res 2013 1.04
29 DNA Topology and Topoisomerases: Teaching a "Knotty" Subject. Biochem Mol Biol Educ 2008 1.04
30 Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry 2011 1.03
31 Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing. Oncogene 2003 1.03
32 Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison. Chem Res Toxicol 2005 1.02
33 Oxidative metabolites of curcumin poison human type II topoisomerases. Biochemistry 2012 1.02
34 Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme. Biochemistry 2005 1.02
35 N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison. Biochemistry 2004 1.01
36 Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance. Biochemistry 2011 1.01
37 DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proc Natl Acad Sci U S A 2012 0.99
38 Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition. Mol Biol Cell 2008 0.99
39 Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity. Biochemistry 2008 0.99
40 Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. Chem Res Toxicol 2008 0.99
41 Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. Biochemistry 2007 0.98
42 The use of divalent metal ions by type II topoisomerases. Metallomics 2010 0.98
43 Biological characterization of MLN944: a potent DNA binding agent. Mol Cancer Ther 2004 0.97
44 Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry 2004 0.97
45 Site-specific DNA cleavage by Chlorella virus topoisomerase II. Biochemistry 2002 0.97
46 Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry 2005 0.96
47 Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions. ACS Chem Biol 2013 0.96
48 Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal. Nucleic Acids Res 2007 0.95
49 The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I. Nucleic Acids Res 2010 0.94
50 Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood 2009 0.92
51 Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks. Nucleic Acids Res 2003 0.92
52 Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions. Biochemistry 2012 0.90
53 Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem Res Toxicol 2007 0.89
54 The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells. Biochemistry 2008 0.88
55 Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites. Chem Biol Interact 2005 0.88
56 Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage. Biochemistry 2003 0.88
57 MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site. Oncogene 2002 0.87
58 Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes. Biochemistry 2005 0.86
59 Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks. Radiat Res 2003 0.86
60 Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes. Biochemistry 2006 0.86
61 Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. Biochemistry 2009 0.86
62 Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV. Nucleic Acids Res 2011 0.86
63 Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV. Biochemistry 2014 0.85
64 Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons. Biochemistry 2009 0.85
65 Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα. Chem Res Toxicol 2014 0.84
66 Etoposide quinone is a redox-dependent topoisomerase II poison. Biochemistry 2011 0.84
67 Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. Blood 2008 0.84
68 Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry 2009 0.83
69 Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα. J Biol Chem 2013 0.83
70 First ruthenium organometallic complex of antibacterial agent ofloxacin. Crystal structure and interactions with DNA. Inorg Chem 2010 0.82
71 DNA ligation catalyzed by human topoisomerase II alpha. Biochemistry 2004 0.81
72 Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism. Biochemistry 2014 0.81
73 Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism. J Biol Chem 2002 0.81
74 Etoposide quinone is a covalent poison of human topoisomerase IIβ. Biochemistry 2014 0.80
75 Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases. Chem Res Toxicol 2013 0.80
76 Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides. Nucleic Acids Res 2006 0.80
77 Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex. Biochemistry 2011 0.78
78 Topoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy. PLoS One 2010 0.78
79 Topoisomerase IB-DNA interactions: X marks the spot. Structure 2010 0.76
80 Cleavage of plasmid DNA by eukaryotic topoisomerase II. Methods Mol Biol 2009 0.75
81 Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions. Biochemistry 2015 0.75
82 DNA methylation impacts the cleavage activity of Chlorella virus topoisomerase II. Biochemistry 2005 0.75