PubRank

Rudolph E Tanzi

Author PubWeight™ 258.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med 2008 19.71
2 Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet 2007 14.05
3 Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 2007 12.13
4 Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 2011 10.07
5 Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 2008 6.71
6 Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med 2012 6.27
7 Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A 2003 5.44
8 The genetics of Alzheimer disease: back to the future. Neuron 2010 4.91
9 Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet 2008 4.66
10 Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci 2008 4.64
11 Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med 2005 4.34
12 Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet 2012 4.27
13 Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron 2007 3.98
14 Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 2003 3.58
15 Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 2013 3.43
16 Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am J Pathol 2004 3.24
17 Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum Mol Genet 2003 3.00
18 Alzheimer's disease: the cholesterol connection. Nat Neurosci 2003 2.99
19 The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS One 2010 2.78
20 Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science 2011 2.66
21 The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol 2008 2.54
22 Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell 2010 2.46
23 The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci 2007 2.42
24 Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron 2008 2.30
25 The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology 2006 2.26
26 Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron 2010 2.20
27 Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology 2012 2.08
28 The genetic epidemiology of neurodegenerative disease. J Clin Invest 2005 2.08
29 An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem 2002 2.00
30 Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J Biol Chem 2002 1.99
31 Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet 2003 1.91
32 The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg 2011 1.88
33 Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci 2006 1.83
34 Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol 2012 1.76
35 Genome-wide association studies in Alzheimer's disease. Hum Mol Genet 2009 1.70
36 The synaptic Abeta hypothesis of Alzheimer disease. Nat Neurosci 2005 1.68
37 The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β. Neurobiol Aging 2010 1.62
38 Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. Arch Neurol 2008 1.60
39 Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci 2010 1.58
40 Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics 2008 1.58
41 PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis 2010 1.57
42 The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol 2009 1.56
43 The current status of Alzheimer's disease genetics: what do we tell the patients? Pharmacol Res 2004 1.53
44 BACE is degraded via the lysosomal pathway. J Biol Chem 2005 1.53
45 Alzheimer's disease: one disorder, too many genes? Hum Mol Genet 2004 1.48
46 Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet 2009 1.46
47 Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science 2013 1.45
48 Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci 2008 1.44
49 Alzheimer's disease and post-operative cognitive dysfunction. Exp Gerontol 2006 1.41
50 The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem 2008 1.31
51 No association between CALHM1 and Alzheimer's disease risk. Cell 2008 1.30
52 Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann N Y Acad Sci 2004 1.28
53 The genetics of Alzheimer's disease. Prog Mol Biol Transl Sci 2012 1.28
54 Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP). J Biol Chem 2003 1.26
55 Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem 2006 1.26
56 ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function. Neuron 2013 1.25
57 Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics 2008 1.23
58 Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome. PLoS One 2010 1.23
59 An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener 2007 1.22
60 Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. J Biol Chem 2007 1.22
61 Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. J Biol Inorg Chem 2004 1.21
62 The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. J Alzheimers Dis 2010 1.19
63 The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Arch Gen Psychiatry 2011 1.16
64 Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Hum Mol Genet 2007 1.16
65 Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease. Alzheimer Dis Assoc Disord 2010 1.14
66 Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem 2010 1.14
67 Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection. Proc Natl Acad Sci U S A 2003 1.13
68 GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. Arch Neurol 2009 1.13
69 Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease. Am J Epidemiol 2008 1.13
70 Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium. Eur J Hum Genet 2009 1.12
71 Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1. J Biol Chem 2003 1.12
72 TREM2 and neurodegenerative disease. N Engl J Med 2013 1.12
73 RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing. J Biol Chem 2005 1.11
74 HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem 2007 1.09
75 Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation 2010 1.08
76 GENETICS. The Human Variome Project. Science 2008 1.07
77 Isoflurane decreases self-renewal capacity of rat cultured neural stem cells. Anesthesiology 2011 1.06
78 Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples. Am J Hum Genet 2006 1.06
79 RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem 2006 1.05
80 The galvanization of beta-amyloid in Alzheimer's disease. Proc Natl Acad Sci U S A 2002 1.05
81 Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients. J Biol Chem 2005 1.04
82 The zinc dyshomeostasis hypothesis of Alzheimer's disease. PLoS One 2012 1.02
83 Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 2011 1.02
84 Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet 2003 1.01
85 Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. J Biol Chem 2010 1.01
86 Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation. Biochem Soc Trans 2010 1.00
87 Cerebrospinal fluid aβ to tau ratio and postoperative cognitive change. Ann Surg 2013 0.99
88 Exploring candidate gene associations with neuropsychological performance. Am J Med Genet B Neuropsychiatr Genet 2007 0.99
89 Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. Exp Gerontol 2004 0.98
90 Metal exposure and Alzheimer's pathogenesis. J Struct Biol 2006 0.98
91 Association of GSK3B with Alzheimer disease and frontotemporal dementia. Arch Neurol 2008 0.98
92 Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population. J Med Genet 2007 0.98
93 Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry 2014 0.98
94 Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. PLoS One 2011 0.98
95 Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1. J Mol Neurosci 2005 0.97
96 Alzheimer disease: New light on an old CLU. Nat Rev Neurol 2010 0.97
97 The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. J Mol Neurosci 2002 0.97
98 LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP. Curr Alzheimer Res 2005 0.97
99 Effects of ubiquilin 1 on the unfolded protein response. J Mol Neurosci 2008 0.97
100 Spatial memory is intact in aged rats after propofol anesthesia. Anesth Analg 2008 0.95
101 Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab 2010 0.93
102 Alzheimer's disease: The latest suspect. Nature 2008 0.92
103 Is alpha-T catenin (VR22) an Alzheimer's disease risk gene? J Med Genet 2007 0.92
104 Altered hippocampal gene expression 2 days after general anesthesia in rats. Eur J Pharmacol 2006 0.92
105 Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. J Biol Chem 2006 0.91
106 Hypocapnia induces caspase-3 activation and increases Abeta production. Neurodegener Dis 2004 0.91
107 APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. J Neurochem 2005 0.91
108 TREM2 and Risk of Alzheimer's Disease--Friend or Foe? N Engl J Med 2015 0.91
109 iPSCs to the rescue in Alzheimer's research. Cell Stem Cell 2012 0.90
110 Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. Hum Mol Genet 2007 0.89
111 Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Mol Cell Biol 2011 0.89
112 Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation. J Biol Chem 2004 0.88
113 CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid. Neurosci Lett 2009 0.88
114 SUMO1 modulates Aβ generation via BACE1 accumulation. Neurobiol Aging 2012 0.87
115 Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. J Biol Chem 2004 0.87
116 Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons. J Neurosci 2014 0.86
117 Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography. Hum Mol Genet 2013 0.85
118 Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. J Mol Neurosci 2002 0.84
119 Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol 2015 0.84
120 The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data. Neurobiol Aging 2005 0.83
121 Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage. Curr Alzheimer Res 2010 0.83
122 Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Arch Neurol 2012 0.83
123 Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests. Stat Biosci 2009 0.82
124 Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort. Am J Med Genet B Neuropsychiatr Genet 2007 0.82
125 Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS. Neurobiol Dis 2012 0.81
126 On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies. Hum Hered 2012 0.81
127 Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation. Commun Integr Biol 2011 0.80
128 Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease. J Alzheimers Dis 2013 0.80
129 Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1. Cell Signal 2008 0.79
130 Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1. J Neurochem 2002 0.79
131 RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing. Transl Neurodegener 2012 0.79
132 A current view of Alzheimer's disease. F1000 Biol Rep 2009 0.78
133 Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. J Alzheimers Dis 2010 0.78
134 Welcome to the complex disease world. Alpha2-macroglobulin and Alzheimer's disease. Exp Neurol 2003 0.78
135 Novel therapeutics for Alzheimer's disease. Neurotherapeutics 2008 0.77
136 Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing. J Neurochem 2010 0.77
137 Targeting ubiquilin-1 in Alzheimer's disease. Expert Opin Ther Targets 2013 0.77
138 Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells. Biochemistry 2013 0.76
139 Correspondence to Sand et Al. "Critical reappraisal of a catechol-o-methyltransferase transversion variant in schizophrenia". Biol Psychiatry 2010 0.75
140 Correction to Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry 2015 0.75
141 Artefactual effects of lipid-based cell transfection reagents on AbetaPP processing and Abeta production. Amyloid 2006 0.75
142 Corrigendum: Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). Sci Rep 2016 0.75