Published in Nature on October 01, 2008
Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature (2010) 22.04
Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol (2009) 19.99
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell (2009) 10.50
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev (2010) 7.14
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev (2008) 7.07
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
The Amphimedon queenslandica genome and the evolution of animal complexity. Nature (2010) 5.11
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell (2009) 4.39
Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA. PLoS Biol (2009) 4.32
Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell (2010) 4.20
The dynamic genome of Hydra. Nature (2010) 4.00
MicroRNAs can generate thresholds in target gene expression. Nat Genet (2011) 3.90
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A comprehensive survey of 3' animal miRNA modification events and a possible role for 3' adenylation in modulating miRNA targeting effectiveness. Genome Res (2010) 2.87
A broadly conserved pathway generates 3'UTR-directed primary piRNAs. Curr Biol (2009) 2.69
Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Res (2009) 2.68
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Structure of yeast Argonaute with guide RNA. Nature (2012) 2.38
Ancient animal microRNAs and the evolution of tissue identity. Nature (2010) 2.35
microRNAs reveal the interrelationships of hagfish, lampreys, and gnathostomes and the nature of the ancestral vertebrate. Proc Natl Acad Sci U S A (2010) 2.25
Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi. Mol Cell (2010) 2.23
MicroRNA gene evolution in Arabidopsis lyrata and Arabidopsis thaliana. Plant Cell (2010) 2.22
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Genomic insights into the marine sponge microbiome. Nat Rev Microbiol (2012) 1.83
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet (2009) 1.83
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The interplay between transcription factors and microRNAs in genome-scale regulatory networks. Bioessays (2009) 1.72
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A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. EMBO J (2011) 1.58
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Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles. Genome Res (2011) 1.57
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Impact of microRNA regulation on variation in human gene expression. Genome Res (2012) 1.49
Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production. Mol Genet Genomics (2010) 1.48
miRNA Repertoires of Demosponges Stylissa carteri and Xestospongia testudinaria. PLoS One (2016) 1.38
Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi. Genes Dev (2010) 1.35
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MicroRNA-mediated control in the skin. Cell Death Differ (2009) 1.30
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Evidence for the biogenesis of more than 1,000 novel human microRNAs. Genome Biol (2014) 1.23
A Kaposi's sarcoma-associated herpesvirus-encoded ortholog of microRNA miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2Rγnull mice. J Virol (2011) 1.22
The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans. Nucleic Acids Res (2010) 1.22
Genome-wide identification of Schistosoma japonicum microRNAs using a deep-sequencing approach. PLoS One (2009) 1.20
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Repertoire of bovine miRNA and miRNA-like small regulatory RNAs expressed upon viral infection. PLoS One (2009) 1.19
Distinct functions for the Drosophila piRNA pathway in genome maintenance and telomere protection. PLoS Genet (2010) 1.19
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shutdown is a component of the Drosophila piRNA biogenesis machinery. RNA (2012) 1.10
Population dynamics of PIWI-interacting RNAs (piRNAs) and their targets in Drosophila. Genome Res (2009) 1.10
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A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). BMC Genomics (2011) 1.09
Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis. RNA (2010) 1.08
Retrotransposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germline. Genome Res (2014) 1.07
Discovery and characterization of medaka miRNA genes by next generation sequencing platform. BMC Genomics (2010) 1.07
The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer. Genome Res (2011) 1.07
AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline. Dev Cell (2012) 1.06
The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in Caenorhabditis elegans. Genetics (2010) 1.06
Characterization of bovine miRNAs by sequencing and bioinformatics analysis. BMC Mol Biol (2009) 1.05
Integrating the roles of long and small non-coding RNA in brain function and disease. Mol Psychiatry (2014) 1.04
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Clusters of microRNAs emerge by new hairpins in existing transcripts. Nucleic Acids Res (2013) 1.00
Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation. Development (2013) 0.99
PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proc Natl Acad Sci U S A (2013) 0.98
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Untangling the web: the diverse functions of the PIWI/piRNA pathway. Mol Reprod Dev (2013) 0.98
Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics (2012) 0.97
Evolution of the let-7 microRNA family. RNA Biol (2012) 0.97
The miR-10 microRNA precursor family. RNA Biol (2011) 0.97
The initial uridine of primary piRNAs does not create the tenth adenine that Is the hallmark of secondary piRNAs. Mol Cell (2014) 0.96
A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements. BMC Genomics (2014) 0.96
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Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
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Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell (2006) 15.12
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CDD: a conserved domain database for interactive domain family analysis. Nucleic Acids Res (2006) 11.41
A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila. Science (2007) 10.73
Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization. Science (2007) 9.79
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36
Developmentally regulated piRNA clusters implicate MILI in transposon control. Science (2007) 7.68
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell (2006) 7.14
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature (2008) 6.69
The Trichoplax genome and the nature of placozoans. Nature (2008) 5.56
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol (2007) 5.35
A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95
miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii. Nature (2007) 4.72
Retracted DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol (2007) 4.45
Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies. Curr Biol (2008) 4.07
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RNA-guided DNA deletion in Tetrahymena: an RNAi-based mechanism for programmed genome rearrangements. Annu Rev Genet (2005) 2.04
Genesis and expansion of metazoan transcription factor gene classes. Mol Biol Evol (2008) 2.01
Dinucleoside pyrophosphate are substrates for T4-induced RNA ligase. Proc Natl Acad Sci U S A (1977) 1.94
Drosha in primary microRNA processing. Cold Spring Harb Symp Quant Biol (2006) 1.58
Deep conservation of microRNA-target relationships and 3'UTR motifs in vertebrates, flies, and nematodes. Cold Spring Harb Symp Quant Biol (2006) 1.55
Wnt and TGF-beta expression in the sponge Amphimedon queenslandica and the origin of metazoan embryonic patterning. PLoS One (2007) 1.54
Testing the new animal phylogeny: a phylum level molecular analysis of the animal kingdom. Mol Phylogenet Evol (2008) 1.36
Inactivation of parathyroid hormone mRNA by treatment with periodate and aniline. Nature (1976) 1.23
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Prediction of mammalian microRNA targets. Cell (2003) 53.70
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95
MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell (2007) 38.42
Most mammalian mRNAs are conserved targets of microRNAs. Genome Res (2008) 37.16
The impact of microRNAs on protein output. Nature (2008) 32.39
MicroRNAs modulate hematopoietic lineage differentiation. Science (2003) 30.05
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature (2010) 22.04
The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science (2005) 20.51
A uniform system for microRNA annotation. RNA (2003) 20.28
Community structure and metabolism through reconstruction of microbial genomes from the environment. Nature (2004) 20.20
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Prediction of plant microRNA targets. Cell (2002) 19.20
MicroRNA-directed cleavage of HOXB8 mRNA. Science (2004) 18.33
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Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell (2006) 15.12
The Sorghum bicolor genome and the diversification of grasses. Nature (2009) 14.62
MicroRNAS and their regulatory roles in plants. Annu Rev Plant Biol (2006) 14.44
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA (2005) 14.14
Computational identification of plant microRNAs and their targets, including a stress-induced miRNA. Mol Cell (2004) 12.97
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science (2007) 12.42
A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana. Genes Dev (2006) 11.71
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
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MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16
The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science (2007) 11.15
The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins. Science (2002) 11.11
Genome-scale approaches to resolving incongruence in molecular phylogenies. Nature (2003) 10.73
Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell (2009) 10.50
The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism. Science (2004) 9.97
A biochemical framework for RNA silencing in plants. Genes Dev (2003) 9.95
Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization. Science (2007) 9.79
Intronic microRNA precursors that bypass Drosha processing. Nature (2007) 9.65
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell (2005) 9.35
Assemblathon 1: a competitive assessment of de novo short read assembly methods. Genome Res (2011) 8.38
The amphioxus genome and the evolution of the chordate karyotype. Nature (2008) 8.03
Rapid whole-genome mutational profiling using next-generation sequencing technologies. Genome Res (2008) 8.01
Characterization of the piRNA complex from rat testes. Science (2006) 7.86
Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs. Mol Cell (2004) 7.68
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Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev (2008) 7.07
Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. Science (2006) 6.74
The Phaeodactylum genome reveals the evolutionary history of diatom genomes. Nature (2008) 6.70
The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. Genes Dev (2004) 6.69
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The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell (2005) 5.90
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A two-hit trigger for siRNA biogenesis in plants. Cell (2006) 5.60
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol (2011) 5.57
The Trichoplax genome and the nature of placozoans. Nature (2008) 5.56
Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina). Nat Biotechnol (2008) 5.38
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
The Amphimedon queenslandica genome and the evolution of animal complexity. Nature (2010) 5.11
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs. Nature (2008) 5.05
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The genome of the Western clawed frog Xenopus tropicalis. Science (2010) 4.70
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. Mol Cell (2008) 4.48
Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell (2010) 4.20
The high-quality draft genome of peach (Prunus persica) identifies unique patterns of genetic diversity, domestication and genome evolution. Nat Genet (2013) 4.20
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A (2007) 4.15
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The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78
Genomic analysis of organismal complexity in the multicellular green alga Volvox carteri. Science (2010) 3.70
MicroRNA regulation of NAC-domain targets is required for proper formation and separation of adjacent embryonic, vegetative, and floral organs. Curr Biol (2004) 3.63
MicroRNA-directed regulation of Arabidopsis AUXIN RESPONSE FACTOR17 is essential for proper development and modulates expression of early auxin response genes. Plant Cell (2005) 3.62
Common functions for diverse small RNAs of land plants. Plant Cell (2007) 3.30
The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res (2008) 3.04
TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway. Nat Struct Mol Biol (2008) 2.98
AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1. Mol Cell (2006) 2.94
The genome of Naegleria gruberi illuminates early eukaryotic versatility. Cell (2010) 2.93
A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands. Genes Dev (2008) 2.45
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Expanded identification and characterization of mammalian circular RNAs. Genome Biol (2014) 2.39
Structure of yeast Argonaute with guide RNA. Nature (2012) 2.38
Compact and ordered collapse of randomly generated RNA sequences. Nat Struct Mol Biol (2005) 2.36
Sponge paleogenomics reveals an ancient role for carbonic anhydrase in skeletogenesis. Science (2007) 2.33
The DNA sequence and biology of human chromosome 19. Nature (2004) 2.29
Promoter elements associated with RNA Pol II stalling in the Drosophila embryo. Proc Natl Acad Sci U S A (2008) 2.25
Early evolution of animal cell signaling and adhesion genes. Proc Natl Acad Sci U S A (2006) 2.20
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Evidence for a microRNA expansion in the bilaterian ancestor. Dev Genes Evol (2006) 2.11