Published in Cancer Cell Int on November 03, 2008
Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov (2009) 3.50
Global Decrease of Histone H3K27 Acetylation in ZEB1-Induced Epithelial to Mesenchymal Transition in Lung Cancer Cells. Cancers (Basel) (2013) 1.65
Overexpression of MEOX2 and TWIST1 is associated with H3K27me3 levels and determines lung cancer chemoresistance and prognosis. PLoS One (2014) 1.41
Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis. Oncogene (2013) 1.25
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem (2013) 1.23
G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes. Proc Natl Acad Sci U S A (2012) 1.17
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer (2012) 1.15
Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. Mol Cancer (2015) 1.08
Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS Med Chem Lett (2014) 1.05
Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy. J Cell Mol Med (2009) 1.03
Targets in epigenetics: inhibiting the methyl writers of the histone code. Curr Chem Genomics (2011) 1.03
EZH2, an epigenetic driver of prostate cancer. Protein Cell (2013) 1.02
Epigenetic regulation of miR-212 expression in lung cancer. PLoS One (2011) 1.01
Selective inhibitors of protein methyltransferases. J Med Chem (2014) 1.01
Epigenetics of estrogen receptor signaling: role in hormonal cancer progression and therapy. Cancers (Basel) (2011) 1.00
Chemical probes of histone lysine methyltransferases. ACS Chem Biol (2014) 0.95
EZH2 promotes malignant behaviors via cell cycle dysregulation and its mRNA level associates with prognosis of patient with non-small cell lung cancer. PLoS One (2012) 0.94
The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis. Mol Cancer (2014) 0.93
The role of epigenetics in resistance to Cisplatin chemotherapy in lung cancer. Cancers (Basel) (2011) 0.86
TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells. Prostate (2013) 0.84
Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma. Mol Cancer (2014) 0.83
Improved therapeutic effect against leukemia by a combination of the histone methyltransferase inhibitor chaetocin and the histone deacetylase inhibitor trichostatin A. J Korean Med Sci (2013) 0.81
Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2. ACS Med Chem Lett (2014) 0.80
Viral epigenetics. Methods Mol Biol (2015) 0.78
The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia. PLoS One (2015) 0.78
Inhibition of EZH2 expression is associated with the proliferation, apoptosis, and migration of SW620 colorectal cancer cells in vitro. Exp Biol Med (Maywood) (2014) 0.77
Targeting EZH2 for cancer therapy: progress and perspective. Curr Protein Pept Sci (2015) 0.77
Inhibitors of Protein Methyltransferases and Demethylases. Chem Rev (2017) 0.76
Inhibition of EZH2 expression is associated with the proliferation, apoptosis and migration of SW620 colorectal cancer cells in vitro. Exp Biol Med (Maywood) (2015) 0.76
Chromatin Memory in the Development of Human Cancers. Gene Technol (2014) 0.75
Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. J Med Chem (2017) 0.75
Emerging role of linker histone variant H1x as a biomarker with prognostic value in astrocytic gliomas. A multivariate analysis including trimethylation of H3K9 and H4K20. PLoS One (2015) 0.75
EZH2-mediated repression of GSK-3β and TP53 promotes Wnt/β-catenin signaling-dependent cell expansion in cervical carcinoma. Oncotarget (2016) 0.75
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
Chromatin modifications and their function. Cell (2007) 55.98
Cancer genes and the pathways they control. Nat Med (2004) 24.22
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature (2001) 19.67
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature (2001) 19.54
The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature (2002) 18.30
Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature (2000) 18.26
Creation of human tumour cells with defined genetic elements. Nature (1999) 16.47
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A (2003) 13.68
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science (2001) 13.55
The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol (2005) 12.70
Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer (2006) 11.48
Epigenetics in human disease and prospects for epigenetic therapy. Nature (2004) 11.46
Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer (2006) 11.22
Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J (2003) 9.55
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev (2004) 7.89
Histone methylation in transcriptional control. Curr Opin Genet Dev (2002) 7.21
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J Biol Chem (2001) 7.21
Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov (2006) 6.39
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature (2002) 6.09
Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet (2002) 5.86
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol (2002) 5.67
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol (2004) 4.72
The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Biol (2005) 4.52
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol (2005) 4.24
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene (2002) 2.97
Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim Biophys Acta (2002) 2.96
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (2003) 2.91
Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. Cell (2003) 2.86
Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PLoS One (2008) 2.52
The epigenetic magic of histone lysine methylation. FEBS J (2006) 2.52
Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Nat Cell Biol (2006) 1.97
Activated p53 suppresses the histone methyltransferase EZH2 gene. Oncogene (2004) 1.94
Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression. Mol Cell Biol (2000) 1.93
DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras. Oncogene (2003) 1.39
Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1. Biochem Biophys Res Commun (2003) 1.29
Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters. Cancer Res (2005) 1.23
Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A. Oncogene (2004) 1.16
The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3. Cancer Res (2007) 1.06
Histone modifications in corepressor functions. Curr Top Dev Biol (2004) 0.83
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science (2004) 61.56
Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med (2008) 10.12
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem (2003) 8.34
Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res (2005) 6.93
High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol (2005) 5.04
Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer. J Clin Oncol (2010) 4.19
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res (2005) 4.13
Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays. Clin Cancer Res (2005) 3.79
Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts. J Clin Oncol (2006) 3.53
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res (2004) 3.20
Contributions of high mobility group box protein in experimental and clinical acute lung injury. Am J Respir Crit Care Med (2004) 2.50
Transformation of carbon dioxide. Chem Rev (2007) 2.39
Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol (2002) 2.30
Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study. Pulm Pharmacol Ther (2011) 2.29
HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol (2005) 2.21
Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2010) 2.03
Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit. Crit Care (2010) 1.81
Infusion of the beta-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats. Crit Care Med (2005) 1.73
Serum indicators for the diagnosis of pneumocystis pneumonia. Chest (2007) 1.73
The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury. J Immunol (2009) 1.71
Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol (2007) 1.63
Bronchoscopic microsampling method for measuring drug concentration in epithelial lining fluid. Am J Respir Crit Care Med (2003) 1.62
Tumor necrosis factor-alpha mediates hyperglycemia-augmented gut barrier dysfunction in endotoxemia. Crit Care Med (2009) 1.57
Role of soluble receptor for advanced glycation end products on endotoxin-induced lung injury. Am J Respir Crit Care Med (2008) 1.47
Sputum cathelicidin, urokinase plasminogen activation system components, and cytokines discriminate cystic fibrosis, COPD, and asthma inflammation. Chest (2005) 1.44
Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. J Heart Lung Transplant (2007) 1.44
Contribution of high-mobility group box-1 to the development of ventilator-induced lung injury. Am J Respir Crit Care Med (2006) 1.42
HSV encephalitis with posterior localization. Neurology (2003) 1.42
Role of interleukin-6 in bleomycin-induced lung inflammatory changes in mice. Am J Respir Cell Mol Biol (2007) 1.41
Activation of the FGF2-FGFR1 autocrine pathway: a novel mechanism of acquired resistance to gefitinib in NSCLC. Mol Cancer Res (2013) 1.40
Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling. Cardiovasc Res (2008) 1.35
Attenuation of endotoxin-induced acute lung injury by the Rho-associated kinase inhibitor, Y-27632. Am J Respir Cell Mol Biol (2005) 1.35
Reversal of elastase-induced pulmonary emphysema and promotion of alveolar epithelial cell proliferation by simvastatin in mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.32
Anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis. World J Surg (2006) 1.30
Roles of oxidants and redox signaling in the pathogenesis of acute respiratory distress syndrome. Antioxid Redox Signal (2008) 1.28
Relationship between neutrophil elastase and acute lung injury in humans. Pulm Pharmacol Ther (2004) 1.23
Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-[kappa]B activation. Am J Respir Cell Mol Biol (2003) 1.21
Characteristics of diabetes associated with poor improvements in clinical outcomes after lumbar spine surgery. Spine (Phila Pa 1976) (2013) 1.18
Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. Am J Physiol Lung Cell Mol Physiol (2003) 1.13
Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. J Pharmacol Exp Ther (2004) 1.12
Systemic and local high mobility group box 1 concentrations during severe infection. Crit Care Med (2007) 1.10
Pulmonary levels of high-mobility group box 1 during mechanical ventilation and ventilator-associated pneumonia. Shock (2008) 1.09
Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs. J Immunol (2004) 1.08
MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cells. J Leukoc Biol (2004) 1.07
Radiation injury after hypofractionated stereotactic radiotherapy for peripheral small lung tumors: serial changes on CT. AJR Am J Roentgenol (2004) 1.07
The PCR-invader method (structure-specific 5' nuclease-based method), a sensitive method for detecting EGFR gene mutations in lung cancer specimens; comparison with direct sequencing. Int J Clin Oncol (2011) 1.07
Effect of CD14 blockade on endotoxin-induced acute lung injury in mice. Am J Respir Cell Mol Biol (2003) 1.07
Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis. Respir Res (2009) 1.02
Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma. Mol Med Rep (2013) 1.02
Molecular sub-group-specific immunophenotypic changes are associated with outcome in recurrent posterior fossa ependymoma. Acta Neuropathol (2013) 1.01
DNA methylation profiles at precancerous stages associated with recurrence of lung adenocarcinoma. PLoS One (2013) 1.00
Pharmacology of acute lung injury. Pulm Pharmacol Ther (2002) 1.00
Hyperventilation and finger exercise increase venous-arterial Pco2 and pH differences. Am J Emerg Med (2008) 0.98
Neutrophil elastase and systemic inflammatory response syndrome in the initiation and development of acute lung injury among critically ill patients. Biomed Pharmacother (2007) 0.98
Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis. Respiration (2009) 0.97
Production and activation of matrix metalloproteinase 7 (matrilysin 1) in the lungs of patients with idiopathic pulmonary fibrosis. Arch Pathol Lab Med (2010) 0.96
TLR3-mediated synthesis and release of eotaxin-1/CCL11 from human bronchial smooth muscle cells stimulated with double-stranded RNA. J Immunol (2007) 0.96
Various adhesion molecules impair microvascular leukocyte kinetics in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2005) 0.96
Contribution of p38 MAPK, NF-κB and glucocorticoid signaling pathways to ER stress-induced increase in retinal endothelial permeability. Arch Biochem Biophys (2012) 0.95
Effects of pulmonary exposure to carbon nanotubes on lung and systemic inflammation with coagulatory disturbance induced by lipopolysaccharide in mice. Exp Biol Med (Maywood) (2008) 0.95
Safety and efficacy of oral rehydration therapy until 2 h before surgery: a multicenter randomized controlled trial. J Anesth (2011) 0.94
Articular cartilage repair with autologous bone marrow mesenchymal cells. J Cell Physiol (2010) 0.94
Therapeutic effects of various initial combinations of chemotherapy including clarithromycin against Mycobacterium avium complex pulmonary disease. Chest (2009) 0.94
Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers. Cancer Res (2012) 0.93
Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma. Allergol Int (2008) 0.93
Cyclooxygenase-2/prostaglandin D2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation. J Immunol (2008) 0.93
Asymmetric degeneration of paravertebral muscles in patients with degenerative lumbar scoliosis. Spine (Phila Pa 1976) (2012) 0.93
Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease. Int J Cancer (2014) 0.93
Differences in pulmonary function before vs. 1 year after hypofractionated stereotactic radiotherapy for small peripheral lung tumors. Int J Radiat Oncol Biol Phys (2005) 0.92
Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung. Crit Care Med (2004) 0.92
Role of metallothionein in lung inflammation induced by ozone exposure in mice. Free Radic Biol Med (2008) 0.92
Carbon black nanoparticles enhance bleomycin-induced lung inflammatory and fibrotic changes in mice. Exp Biol Med (Maywood) (2011) 0.91
Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study. Respir Res (2008) 0.91
Serodiagnostic contributions of antibody titers against mycobacterial lipid antigens in Mycobacterium avium complex pulmonary disease. Clin Infect Dis (2009) 0.90
Role of Rho-kinase in reexpansion pulmonary edema in rabbits. Am J Physiol Lung Cell Mol Physiol (2005) 0.90
A combination chemotherapy of carboplatin and irinotecan with granulocyte colony-stimulating factor (G-CSF) support in elderly patients with small cell lung cancer. Lung Cancer (2006) 0.90
Tongue metastasis as an initial presentation of a lung cancer. Intern Med (2004) 0.89
Preparation of liposomes using an improved supercritical reverse phase evaporation method. Langmuir (2006) 0.88
Elevated serum adiponectin level in patients with Mycobacterium avium-intracellulare complex pulmonary disease. Respiration (2009) 0.88
The influence of approach side on facet preservation in microscopic bilateral decompression via a unilateral approach for degenerative lumbar scoliosis. Clinical article. J Neurosurg Spine (2010) 0.88
Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis. Pulm Med (2011) 0.88
Tandem keyhole foraminotomy in the treatment of cervical radiculopathy: retrospective review of 35 cases. J Orthop Surg Res (2014) 0.87
Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response. Respir Res (2009) 0.87
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis. Shock (2010) 0.87
Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing. Lung Cancer (2012) 0.86
Time to change diagnostic criteria of ARDS: towards the disease entity-based subgrouping. Pulm Pharmacol Ther (2005) 0.86
Endothelin-1 level in epithelial lining fluid of patients with acute respiratory distress syndrome. Respirology (2007) 0.85
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome. Respirology (2008) 0.85
Induction of mucin and MUC5AC expression by the protease activity of Aspergillus fumigatus in airway epithelial cells. J Immunol (2011) 0.85
High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol (2008) 0.85
Protective role of vascular endothelial growth factor in endotoxin-induced acute lung injury in mice. Respir Res (2007) 0.85