Anti-lung cancer effects of novel ginsenoside 25-OCH(3)-PPD.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 2748063)

Published in Lung Cancer on January 07, 2009

Authors

Wei Wang1, Elizabeth R Rayburn, Jie Hang, Yuqing Zhao, Hui Wang, Ruiwen Zhang

Author Affiliations

1: Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Articles citing this

Chemical Diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng. J Ginseng Res (2012) 1.91

Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action. Front Pharmacol (2012) 1.35

Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2. PLoS One (2012) 1.09

Preclinical evaluation of anticancer efficacy and pharmacological properties of FBA-TPQ, a novel synthetic makaluvamine analog. Mar Drugs (2012) 0.91

Oral nano-delivery of anticancer ginsenoside 25-OCH3-PPD, a natural inhibitor of the MDM2 oncogene: Nanoparticle preparation, characterization, in vitro and in vivo anti-prostate cancer activity, and mechanisms of action. Oncotarget (2015) 0.88

JKA97, a novel benzylidene analog of harmine, exerts anti-cancer effects by inducing G1 arrest, apoptosis, and p53-independent up-regulation of p21. PLoS One (2012) 0.85

RYBP predicts survival of patients with non-small cell lung cancer and regulates tumor cell growth and the response to chemotherapy. Cancer Lett (2015) 0.82

Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells. BMC Complement Altern Med (2013) 0.77

Pharmacokinetics of panaxatrol disuccinate sodium, a novel anti-cancer drug from Panax notoginseng, in healthy volunteers and patients with advanced solid tumors. Acta Pharmacol Sin (2010) 0.76

Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites. Evid Based Complement Alternat Med (2016) 0.75

In vitro metabolism of 20(R)-25-methoxyl-dammarane-3, 12, 20-triol from Panax notoginseng in human, monkey, dog, rat, and mouse liver microsomes. PLoS One (2014) 0.75

Articles cited by this

Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol (1999) 6.30

Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res (2001) 2.80

In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol (2006) 2.33

Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy. Proc Natl Acad Sci U S A (2003) 1.87

MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy. Curr Cancer Drug Targets (2005) 1.83

Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene (2005) 1.51

Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-backbone antisense oligonucleotides: in vitro and in vivo activities and mechanisms. Prostate (2003) 1.22

20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action. Br J Cancer (2008) 1.21

Isolation, structural determination, and evaluation of the biological activity of 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol [20(S)-25-OCH3-PPD], a novel natural product from Panax notoginseng. Med Chem (2007) 1.16

Panax ginseng: a role in cancer therapy? Integr Cancer Ther (2003) 1.09

Molecular pathogenesis of lung cancer. J Thorac Cardiovasc Surg (1999) 1.09

Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and its correlation with lymph node metastases. Lung Cancer (2007) 1.01

Recent advances in validating MDM2 as a cancer target. Anticancer Agents Med Chem (2009) 0.94

Articles by these authors

Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21

The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23

Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis (2013) 6.60

Nova regulates brain-specific splicing to shape the synapse. Nat Genet (2005) 6.58

Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell (2009) 5.81

Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biol (2007) 5.53

Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63

Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21

Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41

Human genomic deletions mediated by recombination between Alu elements. Am J Hum Genet (2006) 3.15

Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res (2008) 2.97

Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83

A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli. J Exp Med (2004) 2.81

Heritability of alternative splicing in the human genome. Genome Res (2007) 2.76

Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. Antimicrob Agents Chemother (2012) 2.65

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54

A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45

Cell-specific aptamer probes for membrane protein elucidation in cancer cells. J Proteome Res (2008) 2.44

Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate. J Virol (2002) 2.43

c-Myc is required for maintenance of glioma cancer stem cells. PLoS One (2008) 2.41

In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol (2006) 2.33

Agricultural origins and the isotopic identity of domestication in northern China. Proc Natl Acad Sci U S A (2009) 2.32

Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study. J Antimicrob Chemother (2011) 2.30

Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature (2012) 2.26

The Drosophila melanogaster transcriptome by paired-end RNA sequencing. Genome Res (2010) 2.25

Novel rank-based statistical methods reveal microRNAs with differential expression in multiple cancer types. PLoS One (2009) 2.21

Gaussian Bare-Bones Differential Evolution. IEEE Trans Cybern (2013) 2.08

Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res (2007) 2.07

Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res (2004) 2.07

High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China. Clin Infect Dis (2010) 2.02

Solution state characterization of amyloid beta-derived diffusible ligands. Biochemistry (2006) 1.96

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet (2012) 1.96

COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog (2006) 1.95

Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment. Anesthesiology (2013) 1.93

MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. J Biol Chem (2004) 1.93

Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. Antimicrob Agents Chemother (2008) 1.91

Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat (2009) 1.90

ANOSVA: a statistical method for detecting splice variation from expression data. Bioinformatics (2005) 1.88

Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy. Proc Natl Acad Sci U S A (2003) 1.87

Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis (2008) 1.87

Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J (2005) 1.85

MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy. Curr Cancer Drug Targets (2005) 1.83

A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis. Clin Cancer Res (2011) 1.82

High prevalence of multidrug-resistant nonfermenters in hospital-acquired pneumonia in Asia. Am J Respir Crit Care Med (2011) 1.80

Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A (2007) 1.80

Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol (2012) 1.76

Measuring microRNAs: comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods. BMC Biotechnol (2008) 1.75

CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J Am Soc Nephrol (2003) 1.73

Wnt/beta-catenin signaling pathway as a novel cancer drug target. Curr Cancer Drug Targets (2004) 1.72

A large multicenter correlation study of thyroid nodule cytopathology and histopathology. Thyroid (2010) 1.68

MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells. FEBS J (2012) 1.67

Current evaluation of the millennium phytomedicine- ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr Med Chem (2009) 1.67

Emergence of primate genes by retrotransposon-mediated sequence transduction. Proc Natl Acad Sci U S A (2006) 1.66

Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation. EMBO J (2008) 1.65

Experimental studies on anisotropic thermoelectric properties and structures of n-type Bi2Te2.7Se0.3. Nano Lett (2010) 1.63

Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients. J Hepatol (2010) 1.63

Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements. Hum Genet (2013) 1.63

Clinical impact of methicillin resistance on outcome of patients with Staphylococcus aureus infection: a stratified analysis according to underlying diseases and sites of infection in a large prospective cohort. J Infect (2010) 1.63

Superresolution imaging of targeted proteins in fixed and living cells using photoactivatable organic fluorophores. J Am Chem Soc (2010) 1.61

Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res (2007) 1.60

Evaluation of the coverage and depth of transcriptome by RNA-Seq in chickens. BMC Bioinformatics (2011) 1.60

Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea. Gastroenterology (2005) 1.58

Molecular classification of thyroid nodules using high-dimensionality genomic data. J Clin Endocrinol Metab (2010) 1.57

Population health impact and cost-effectiveness of monitoring inactive chronic hepatitis B and treating eligible patients in Shanghai, China. Hepatology (2014) 1.56

Serology of severe acute respiratory syndrome: implications for surveillance and outcome. J Infect Dis (2004) 1.55

Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots. Eur J Nucl Med Mol Imaging (2008) 1.55

Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China. Nephrol Dial Transplant (2008) 1.55

The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell Cycle (2009) 1.52

The MDM2-p53 pathway revisited. J Biomed Res (2013) 1.52

Backward genotype-trait association (BGTA)-based dissection of complex traits in case-control designs. Hum Hered (2006) 1.52

Restaging of locally advanced rectal cancer with magnetic resonance imaging and endoluminal ultrasound after preoperative chemoradiotherapy: a systemic review and meta-analysis. Dis Colon Rectum (2014) 1.52

Substitutional alloy of Bi and Te at high pressure. Phys Rev Lett (2011) 1.51

Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene (2005) 1.51

Current evaluation of the millennium phytomedicine--ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr Med Chem (2009) 1.50

Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity. Vaccine (2009) 1.49

A systematic review of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity and its Portsmouth modification as predictors of post-operative morbidity and mortality in patients undergoing pancreatic surgery. Am J Surg (2013) 1.49

Rapid change of methicillin-resistant Staphylococcus aureus clones in a Chinese tertiary care hospital over a 15-year period. Antimicrob Agents Chemother (2010) 1.48

AgBase: supporting functional modeling in agricultural organisms. Nucleic Acids Res (2010) 1.48

Geminivirus AL2 and L2 proteins interact with and inactivate SNF1 kinase. Plant Cell (2003) 1.47

Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing. J Med Genet (2013) 1.47

Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res (2008) 1.47

The WRKY6 transcription factor modulates PHOSPHATE1 expression in response to low Pi stress in Arabidopsis. Plant Cell (2009) 1.47

Mobile DNA in Old World monkeys: a glimpse through the rhesus macaque genome. Science (2007) 1.47

Effect of antisense VEGF cDNA transfection on the growth of chronic myeloid leukemia K562 cells in vitro and in nude mice. Leuk Res (2004) 1.45

HSP90-buffered genetic variation is common in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2008) 1.45

Retracted Factors predicting surgical site infection after posterior lumbar surgery: A multicenter retrospective study. Medicine (Baltimore) (2017) 1.44

5'-Transducing SVA retrotransposon groups spread efficiently throughout the human genome. Genome Res (2009) 1.43