Published in Proc Natl Acad Sci U S A on September 16, 2003
MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy. Blood (2005) 2.88
RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo. J Biol Chem (2005) 2.38
Identifying gene-disease associations using centrality on a literature mined gene-interaction network. Bioinformatics (2008) 2.32
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell (2012) 1.79
The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression. J Natl Cancer Inst (2013) 1.76
Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation. EMBO J (2008) 1.65
Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy. J Cell Mol Med (2008) 1.32
Targeting the p53-MDM2 interaction to treat cancer. Br J Cancer (2004) 1.25
Regulation of prostate cancer progression by galectin-3. Am J Pathol (2009) 1.21
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In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues. Clin Cancer Res (2009) 1.13
Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer. Mol Cell Biol (2006) 1.12
A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. PLoS One (2009) 1.11
Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells. Cancer Res (2010) 1.10
Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2. PLoS One (2012) 1.09
Phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis. PLoS One (2010) 1.05
Molecular mechanisms involving prostate cancer racial disparity. Am J Transl Res (2009) 1.02
Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest. Mol Cell Biol (2007) 1.01
Antisense-MDM2 sensitizes LNCaP prostate cancer cells to androgen deprivation, radiation, and the combination in vivo. Int J Radiat Oncol Biol Phys (2007) 1.01
Anti-lung cancer effects of novel ginsenoside 25-OCH(3)-PPD. Lung Cancer (2009) 1.00
Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. Gastroenterology (2014) 0.99
Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. Br J Cancer (2004) 0.93
Antioxidant activity of growth hormone-releasing hormone antagonists in LNCaP human prostate cancer line. Proc Natl Acad Sci U S A (2008) 0.91
Antisense MDM2 enhances the response of androgen insensitive human prostate cancer cells to androgen deprivation in vitro and in vivo. Prostate (2008) 0.91
FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer. PLoS One (2012) 0.90
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The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma. Arch Biochem Biophys (2014) 0.89
Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation. Oncotarget (2015) 0.85
Histone deacetylase cytoplasmic trapping by a novel fluorescent HDAC inhibitor. Mol Cancer Ther (2011) 0.85
Antisense MDM2 enhances E2F1-induced apoptosis and the combination sensitizes androgen-sensitive [corrected] and androgen-insensitive [corrected] prostate cancer cells to radiation. Mol Cancer Res (2008) 0.84
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A quantitative LC-MS/MS method for determination of SP-141, a novel pyrido[b]indole anticancer agent, and its application to a mouse PK study. J Chromatogr B Analyt Technol Biomed Life Sci (2014) 0.81
u-PA inhibitor amiloride suppresses peritoneal metastasis in gastric cancer. World J Surg Oncol (2012) 0.80
Pathway detection from protein interaction networks and gene expression data using color-coding methods and A∗ search algorithms. ScientificWorldJournal (2012) 0.80
Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. Mol Cell Proteomics (2009) 0.79
MDM2 and P53 polymorphisms contribute together to the risk and survival of prostate cancer. Oncotarget (2016) 0.79
A novel function of RNAs arising from the long terminal repeat of human endogenous retrovirus 9 in cell cycle arrest. J Virol (2012) 0.79
Mesenchymal stem cells modified to express lentivirus TNF-α Tumstatin(45-132) inhibit the growth of prostate cancer. J Cell Mol Med (2011) 0.79
The Use of Antisense Oligonucleotides in Evaluating Survivin as a Therapeutic Target for Radiation Sensitization in Lung Cancer. Biol Proced Online (2004) 0.78
Molecular basis for prostate cancer racial disparities. Front Biosci (Landmark Ed) (2017) 0.78
Development and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice. Biomed Chromatogr (2014) 0.77
Anoikis triggers Mdm2-dependent p53 degradation. Mol Cell Biochem (2010) 0.77
MDM2 expression and regulation in prostate cancer racial disparity. Int J Clin Exp Pathol (2008) 0.76
A piRNA-like Small RNA Induces Chemoresistance to Cisplatin-Based Therapy by Inhibiting Apoptosis in Lung Squamous Cell Carcinoma. Mol Ther Nucleic Acids (2017) 0.75
MDM2 knockdown mediated by a triazine-modified dendrimer in the treatment of non-small cell lung cancer. Oncotarget (2016) 0.75
Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy. J Biomed Res (2016) 0.75
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Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence. J Natl Cancer Inst (1999) 1.63
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Gene expression changes in response to E2F1 activation. Nucleic Acids Res (2002) 1.44
p53 and bcl-2 immunohistochemistry in pretreatment prostate needle biopsies to predict recurrence of prostate cancer after radical prostatectomy. J Urol (1999) 1.44
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Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-backbone antisense oligonucleotides: in vitro and in vivo activities and mechanisms. Prostate (2003) 1.22
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Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma. Arch Dermatol Res (2000) 1.15
Differential post-translational modification of the tumour suppressor proteins Rb and p53 modulate the rates of radiation-induced apoptosis in vivo. Oncogene (2001) 1.14
Abnormal expression of MDM2 in prostate carcinoma. Mod Pathol (2001) 1.14
Inactivation of the p53 pathway in prostate cancer: impact on tumor progression. Clin Cancer Res (1999) 1.13
Targeting the Mycobacterium tuberculosis 30/32-kDa mycolyl transferase complex as a therapeutic strategy against tuberculosis: Proof of principle by using antisense technology. Proc Natl Acad Sci U S A (2002) 1.13
Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage. Mol Cell Biol (2002) 1.13
Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms. Clin Cancer Res (2001) 1.12
MDM2 oncogene as a novel target for human cancer therapy. Curr Pharm Des (2000) 1.09
Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration. Proc Natl Acad Sci U S A (1999) 1.09
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Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. Mol Carcinog (2000) 1.04
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Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells. Prostate (2001) 0.98
p53-independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells. Jpn J Cancer Res (2000) 0.97
Radiation-induced apoptosis mediated by retinoblastoma protein. Cancer Res (1998) 0.94
Differential requirements for ras and the retinoblastoma tumor suppressor protein in the androgen dependence of prostatic adenocarcinoma cells. Cell Growth Differ (2000) 0.93
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Potential roles of antisense technology in cancer chemotherapy. Oncogene (2000) 0.90
Alterations in expression of E2F-1 and E2F-responsive genes by RB, p53 and p21(Sdi1/WAF1/Cip1) expression. FEBS Lett (2001) 0.89
The nitroxide tempol induces oxidative stress, p21(WAF1/CIP1), and cell death in HL60 cells. Free Radic Biol Med (2000) 0.89
Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53. Cancer Res (2001) 0.88
MDM2 mRNA expression is a favorable prognostic factor in non-small-cell lung cancer. Int J Cancer (2000) 0.86
Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions. Br J Cancer (2001) 0.86
Antisense anticancer oligonucleotide therapeutics. Curr Cancer Drug Targets (2001) 0.86
Differential expression of cell death regulators in response to thapsigargin and adriamycin in Bcl-2 transfected DU145 prostatic cancer cells. J Pathol (2001) 0.85
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Ablation of p21waf1cip1 expression enhances the capacity of p53-deficient human tumor cells to repair UVB-induced DNA damage. Cancer Res (2001) 0.81
p53 mutations in prostatic intraepithelial neoplasia and concurrent carcinoma: analysis of laser capture microdissected specimens from non-transition and transition zones. Jpn J Cancer Res (2000) 0.79
RB activation and repression of C-MYC transcription precede apoptosis of human prostate epithelial cells. Urology (2001) 0.79
Selective repression of growth-regulating cdk2, cyclin E and E2F1 genes in human cell senescence. Kobe J Med Sci (1994) 0.78
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis (2013) 6.60
Nova regulates brain-specific splicing to shape the synapse. Nat Genet (2005) 6.58
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell (2009) 5.81
Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biol (2007) 5.53
Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63
Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41
Human genomic deletions mediated by recombination between Alu elements. Am J Hum Genet (2006) 3.15
Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res (2008) 2.97
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83
A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli. J Exp Med (2004) 2.81
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Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. Antimicrob Agents Chemother (2012) 2.65
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45
Cell-specific aptamer probes for membrane protein elucidation in cancer cells. J Proteome Res (2008) 2.44
Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate. J Virol (2002) 2.43
c-Myc is required for maintenance of glioma cancer stem cells. PLoS One (2008) 2.41
In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol (2006) 2.33
Agricultural origins and the isotopic identity of domestication in northern China. Proc Natl Acad Sci U S A (2009) 2.32
Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study. J Antimicrob Chemother (2011) 2.30
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature (2012) 2.26
The Drosophila melanogaster transcriptome by paired-end RNA sequencing. Genome Res (2010) 2.25
Novel rank-based statistical methods reveal microRNAs with differential expression in multiple cancer types. PLoS One (2009) 2.21
Gaussian Bare-Bones Differential Evolution. IEEE Trans Cybern (2013) 2.08
Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res (2007) 2.07
Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res (2004) 2.07
High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China. Clin Infect Dis (2010) 2.02
Solution state characterization of amyloid beta-derived diffusible ligands. Biochemistry (2006) 1.96
Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet (2012) 1.96
COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog (2006) 1.95
Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment. Anesthesiology (2013) 1.93
MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. J Biol Chem (2004) 1.93
Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. Antimicrob Agents Chemother (2008) 1.91
Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat (2009) 1.90
ANOSVA: a statistical method for detecting splice variation from expression data. Bioinformatics (2005) 1.88
Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis (2008) 1.87
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J (2005) 1.85
MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy. Curr Cancer Drug Targets (2005) 1.83
High prevalence of multidrug-resistant nonfermenters in hospital-acquired pneumonia in Asia. Am J Respir Crit Care Med (2011) 1.80
Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A (2007) 1.80
Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol (2012) 1.76
Measuring microRNAs: comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods. BMC Biotechnol (2008) 1.75
CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J Am Soc Nephrol (2003) 1.73
Wnt/beta-catenin signaling pathway as a novel cancer drug target. Curr Cancer Drug Targets (2004) 1.72
A large multicenter correlation study of thyroid nodule cytopathology and histopathology. Thyroid (2010) 1.68
MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells. FEBS J (2012) 1.67
Emergence of primate genes by retrotransposon-mediated sequence transduction. Proc Natl Acad Sci U S A (2006) 1.66
Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation. EMBO J (2008) 1.65
Experimental studies on anisotropic thermoelectric properties and structures of n-type Bi2Te2.7Se0.3. Nano Lett (2010) 1.63
Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients. J Hepatol (2010) 1.63
Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements. Hum Genet (2013) 1.63
Superresolution imaging of targeted proteins in fixed and living cells using photoactivatable organic fluorophores. J Am Chem Soc (2010) 1.61
Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res (2007) 1.60
Evaluation of the coverage and depth of transcriptome by RNA-Seq in chickens. BMC Bioinformatics (2011) 1.60
Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea. Gastroenterology (2005) 1.58
Molecular classification of thyroid nodules using high-dimensionality genomic data. J Clin Endocrinol Metab (2010) 1.57
Population health impact and cost-effectiveness of monitoring inactive chronic hepatitis B and treating eligible patients in Shanghai, China. Hepatology (2014) 1.56
Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China. Nephrol Dial Transplant (2008) 1.55
Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots. Eur J Nucl Med Mol Imaging (2008) 1.55
Serology of severe acute respiratory syndrome: implications for surveillance and outcome. J Infect Dis (2004) 1.55
Protein kinase A RIalpha antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation. Clin Cancer Res (2002) 1.55
The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell Cycle (2009) 1.52
Backward genotype-trait association (BGTA)-based dissection of complex traits in case-control designs. Hum Hered (2006) 1.52
The MDM2-p53 pathway revisited. J Biomed Res (2013) 1.52
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Substitutional alloy of Bi and Te at high pressure. Phys Rev Lett (2011) 1.51
Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene (2005) 1.51
Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity. Vaccine (2009) 1.49
Rapid change of methicillin-resistant Staphylococcus aureus clones in a Chinese tertiary care hospital over a 15-year period. Antimicrob Agents Chemother (2010) 1.48
AgBase: supporting functional modeling in agricultural organisms. Nucleic Acids Res (2010) 1.48
Geminivirus AL2 and L2 proteins interact with and inactivate SNF1 kinase. Plant Cell (2003) 1.47
Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing. J Med Genet (2013) 1.47
Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res (2008) 1.47
The WRKY6 transcription factor modulates PHOSPHATE1 expression in response to low Pi stress in Arabidopsis. Plant Cell (2009) 1.47
Nanoarchitectonics: a conceptual paradigm for design and synthesis of dimension-controlled functional nanomaterials. J Nanosci Nanotechnol (2011) 1.47
Mobile DNA in Old World monkeys: a glimpse through the rhesus macaque genome. Science (2007) 1.47
Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics. Oncogene (2004) 1.47
Effect of antisense VEGF cDNA transfection on the growth of chronic myeloid leukemia K562 cells in vitro and in nude mice. Leuk Res (2004) 1.45
HSP90-buffered genetic variation is common in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2008) 1.45
Retracted Factors predicting surgical site infection after posterior lumbar surgery: A multicenter retrospective study. Medicine (Baltimore) (2017) 1.44
5'-Transducing SVA retrotransposon groups spread efficiently throughout the human genome. Genome Res (2009) 1.43
Tenofovir alafenamide vs. tenofovir disoproxil fumarate in single tablet regimens for initial HIV-1 therapy: a randomized phase 2 study. J Acquir Immune Defic Syndr (2014) 1.43