Published in Nat Rev Genet on July 18, 2012
PRecisiOn MEdicine to Target Frailty of Endocrine-metabolic Origin (PROMETEO) | NCT04856683
WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta. N Engl J Med (2013) 2.91
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits. Nature (2013) 2.55
HDAC5 controls MEF2C-driven sclerostin expression in osteocytes. J Bone Miner Res (2015) 1.60
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature (2015) 1.53
Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. J Clin Invest (2014) 1.53
Genetic profiling and individualized assessment of fracture risk. Nat Rev Endocrinol (2013) 1.47
The relevance of mouse models for investigating age-related bone loss in humans. J Gerontol A Biol Sci Med Sci (2013) 1.23
On genome-wide association studies and their meta-analyses: lessons learned from osteoporosis studies. J Clin Endocrinol Metab (2013) 1.18
A trans-ethnic genome-wide association study identifies gender-specific loci influencing pediatric aBMD and BMC at the distal radius. Hum Mol Genet (2015) 0.96
Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics. Mol Endocrinol (2014) 0.94
MicroRNAs regulate bone metabolism. J Bone Miner Metab (2013) 0.91
Genome-wide Association Studies for Osteoporosis: A 2013 Update. J Bone Metab (2014) 0.90
Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus. Bone (2014) 0.88
Integrating Epigenomic Elements and GWASs Identifies BDNF Gene Affecting Bone Mineral Density and Osteoporotic Fracture Risk. Sci Rep (2016) 0.88
Diametrical diseases reflect evolutionary-genetic tradeoffs: Evidence from psychiatry, neurology, rheumatology, oncology and immunology. Evol Med Public Health (2015) 0.85
Genetic control of estrogen-regulated transcriptional and cellular responses in mouse uterus. FASEB J (2013) 0.85
Meta-analysis of genome-wide studies identifies MEF2C SNPs associated with bone mineral density at forearm. J Med Genet (2013) 0.83
Polymorphisms in genes in the RANKL/RANK/OPG pathway are associated with bone mineral density at different skeletal sites in post-menopausal women. Osteoporos Int (2014) 0.83
A genomics-based systems approach towards drug repositioning for rheumatoid arthritis. BMC Genomics (2016) 0.82
The genetics of bone mass and susceptibility to bone diseases. Nat Rev Rheumatol (2016) 0.82
SIBLING family genes and bone mineral density: association and allele-specific expression in humans. Bone (2014) 0.81
A method for analyzing multiple continuous phenotypes in rare variant association studies allowing for flexible correlations in variant effects. Eur J Hum Genet (2016) 0.81
Height and bone mineral density are associated with naevus count supporting the importance of growth in melanoma susceptibility. PLoS One (2015) 0.81
Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review. J Diabetes Metab Disord (2014) 0.81
On individual genome-wide association studies and their meta-analysis. Hum Genet (2013) 0.81
Association between estrogen receptor α gene (ESR1) PvuII (C/T) and XbaI (A/G) polymorphisms and hip fracture risk: evidence from a meta-analysis. PLoS One (2013) 0.80
Attenuated monocyte apoptosis, a new mechanism for osteoporosis suggested by a transcriptome-wide expression study of monocytes. PLoS One (2015) 0.79
Large-scale analysis reveals a functional single-nucleotide polymorphism in the 5'-flanking region of PRDM16 gene associated with lean body mass. Aging Cell (2014) 0.79
Clinical impact of recent genetic discoveries in osteoporosis. Appl Clin Genet (2013) 0.79
Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density. Oncotarget (2016) 0.79
The role of genetics in estrogen responses: a critical piece of an intricate puzzle. FASEB J (2014) 0.78
Reply to Rational drug repositioning by medical genetics. Nat Biotechnol (2013) 0.78
Developmental origins of genotype-phenotype correlations in chronic diseases of old age. Aging Dis (2012) 0.78
Genetic analysis identifies DDR2 as a novel gene affecting bone mineral density and osteoporotic fractures in Chinese population. PLoS One (2015) 0.77
Understanding the links among neuromedin U gene, beta2-adrenoceptor gene and bone health: an observational study in European children. PLoS One (2013) 0.77
Integrative analysis of GWASs, human protein interaction, and gene expression identified gene modules associated with BMDs. J Clin Endocrinol Metab (2014) 0.77
Genome-wide Survey of Runs of Homozygosity Identifies Recessive Loci for Bone Mineral Density in Caucasian and Chinese Populations. J Bone Miner Res (2015) 0.77
MicroRNA variants as genetic determinants of bone mass. Bone (2015) 0.77
Association analyses of FGFR2 gene polymorphisms with femoral neck bone mineral density in Chinese Han population. Mol Genet Genomics (2014) 0.77
Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche. J Clin Endocrinol Metab (2015) 0.76
DenguePredict: An Integrated Drug Repositioning Approach towards Drug Discovery for Dengue. AMIA Annu Symp Proc (2015) 0.76
Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway. Endocrinology (2015) 0.76
The case for genome-wide association studies of bone acquisition in paediatric and adolescent populations. Bonekey Rep (2016) 0.76
Endochondral ossification pathway genes and postmenopausal osteoporosis: Association and specific allele related serum bone sialoprotein levels in Han Chinese. Sci Rep (2015) 0.75
Phenotype-Genotype Association Analysis of ACTH-Secreting Pituitary Adenoma and Its Molecular Link to Patient Osteoporosis. Int J Mol Sci (2016) 0.75
HLA alleles association with changes in bone mineral density in HIV-1-infected adults changing treatment to tenofovir-emtricitabine or abacavir-lamivudine. PLoS One (2014) 0.75
Rapid phenotyping of knockout mice to identify genetic determinants of bone strength. J Endocrinol (2016) 0.75
High osteoporosis risk among East Africans linked to lactase persistence genotype. Bonekey Rep (2016) 0.75
A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population. Front Endocrinol (Lausanne) (2016) 0.75
Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association Studies. PLoS One (2016) 0.75
Genetic factors influencing the risk of multiple myeloma bone disease. Leukemia (2015) 0.75
Genetic Contribution of Femoral Neck Bone Geometry to the Risk of Developing Osteoporosis: A Family-Based Study. PLoS One (2016) 0.75
Association of the I264T variant in the sulfide quinone reductase-like (SQRDL) gene with osteoporosis in Korean postmenopausal women. PLoS One (2015) 0.75
Serum 25-hydroxyvitamin D and bone turnover markers in Palestinian postmenopausal osteoporosis and normal women. Arch Osteoporos (2017) 0.75
Genetic control of ductal morphology, estrogen-induced ductal growth, and gene expression in female mouse mammary gland. Endocrinology (2014) 0.75
The influence of genetic variability and proinflammatory status on the development of bone disease in patients with Gaucher disease. PLoS One (2015) 0.75
Value of rare low bone mass diseases for osteoporosis genetics. Bonekey Rep (2016) 0.75
Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass in Young and Healthy Mice. Sci Rep (2017) 0.75
Using GWAS to identify novel therapeutic targets for osteoporosis. Transl Res (2016) 0.75
Bone Density and Timing of Puberty in a Longitudinal Study of Girls. J Pediatr Adolesc Gynecol (2014) 0.75
How frequent is osteogenesis imperfecta in patients with idiopathic osteoporosis?: Case reports. Medicine (Baltimore) (2017) 0.75
Epigenome-wide association of DNA methylation in whole blood with bone mineral density. J Bone Miner Res (2017) 0.75
A common polymorphism rs1800247 in osteocalcin gene was associated with serum osteocalcin levels, bone mineral density, and fracture: the Shanghai Changfeng Study. Osteoporos Int (2015) 0.75
Strong familial association of bone mineral density between parents and offspring: KNHANES 2008-2011. Osteoporos Int (2016) 0.75
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nat Genet (2017) 0.75
Genetic Dissection of Trabecular Bone Structure with Mouse Inter-subspecific Consomic Strains. G3 (Bethesda) (2017) 0.75
A Statistical Approach to Fine Mapping for the Identification of Potential Causal Variants Related to Bone Mineral Density. J Bone Miner Res (2017) 0.75
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA (2002) 80.37
Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med (2001) 16.81
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell (1997) 15.96
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell (2002) 15.20
Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res (2007) 14.84
Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med (2009) 13.57
Heritability in the genomics era--concepts and misconceptions. Nat Rev Genet (2008) 13.42
Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ (1996) 11.60
Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group. N Engl J Med (1995) 10.99
Genetic heterogeneity in human disease. Cell (2010) 10.67
FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int (2008) 8.75
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet (2008) 7.05
Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med (1999) 6.94
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66
Human metabolic individuality in biomedical and pharmaceutical research. Nature (2011) 6.56
Multiple genetic loci for bone mineral density and fractures. N Engl J Med (2008) 6.35
Matrix-embedded cells control osteoclast formation. Nat Med (2011) 5.77
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum Mol Genet (2001) 5.72
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
New sequence variants associated with bone mineral density. Nat Genet (2008) 3.43
Osteoprotegerin deficiency and juvenile Paget's disease. N Engl J Med (2002) 3.34
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nat Genet (1997) 3.20
Genetic control of bone formation. Annu Rev Cell Dev Biol (2009) 3.06
The empirical power of rare variant association methods: results from sanger sequencing in 1,998 individuals. PLoS Genet (2012) 2.86
Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am J Hum Genet (2003) 2.86
Dimorphic effects of Notch signaling in bone homeostasis. Nat Med (2008) 2.82
Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev (2007) 2.82
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80
Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. FASEB J (2010) 2.74
TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J Exp Med (1998) 2.68
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun (1998) 2.66
Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial. Ann Intern Med (2007) 2.64
Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am J Hum Genet (2010) 2.57
Transethnic meta-analysis of genomewide association studies. Genet Epidemiol (2011) 2.53
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA (2008) 2.52
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
A twin approach to unraveling epigenetics. Trends Genet (2011) 2.38
R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell (2008) 2.37
Genetic factors in determining bone mass. J Clin Invest (1973) 2.35
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet (2011) 2.34
B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood (2007) 2.16
Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am J Hum Genet (2009) 2.14
Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development (2006) 2.06
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nat Genet (2007) 2.04
The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res (1996) 1.99
Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Hum Mol Genet (2009) 1.99
Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. Am J Hum Genet (2004) 1.97
Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration. J Bone Miner Res (2010) 1.90
Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet (1996) 1.89
Genetic liability to fractures in the elderly. Arch Intern Med (2005) 1.88
The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. J Endocrinol (2011) 1.85
Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass. J Bone Miner Res (2007) 1.82
Genetics of osteoporosis. Endocr Rev (2010) 1.81
Control of the SOST bone enhancer by PTH using MEF2 transcription factors. J Bone Miner Res (2007) 1.74
Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab (2010) 1.62
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett (2008) 1.60
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone. Nat Genet (2010) 1.58
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet (2012) 1.55
Signaling networks in RUNX2-dependent bone development. J Cell Biochem (2011) 1.53
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genet (2012) 1.49
Wnt signaling in bone metabolism. J Bone Miner Metab (2009) 1.48
Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol (2004) 1.45
Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet (2010) 1.41
Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am J Hum Genet (2008) 1.41
Haploinsufficiency of parathyroid hormone-related peptide (PTHrP) results in abnormal postnatal bone development. Dev Biol (1996) 1.31
Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women. J Clin Endocrinol Metab (2010) 1.30
Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet (2005) 1.30
The potential of genes and other markers to inform about risk. Cancer Epidemiol Biomarkers Prev (2010) 1.29
Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD. J Bone Miner Res (2004) 1.24
Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effects. J Bone Miner Res (2006) 1.08
Diagnosis of osteoporosis. Osteoporos Int (1997) 1.06
Update in new anabolic therapies for osteoporosis. J Clin Endocrinol Metab (2010) 1.03
The genetics of proximal femur geometry, distribution of bone mass and bone mineral density. Osteoporos Int (1996) 1.02
Sclerostin: a novel target for intervention in the treatment of osteoporosis. Discov Med (2011) 1.01
Assessment of fracture risk by bone density measurements. Semin Nucl Med (1997) 0.97
Clinical review 2: Genetic determinants of bone density and fracture risk--state of the art and future directions. J Clin Endocrinol Metab (2010) 0.96
Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci. Bone (2009) 0.90
Genome-wide linkage screen of bone mineral density (BMD) in European pedigrees ascertained through a male relative with low BMD values: evidence for quantitative trait loci on 17q21-23, 11q12-13, 13q12-14, and 22q11. J Clin Endocrinol Metab (2008) 0.89
An efficient paradigm for genetic epidemiology cohort creation. PLoS One (2010) 0.82
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med (2004) 6.55
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
Heritability of adult body height: a comparative study of twin cohorts in eight countries. Twin Res (2003) 6.43
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
A genome-wide perspective of genetic variation in human metabolism. Nat Genet (2009) 5.00
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat Genet (2007) 4.61
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med (2008) 3.68
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet (2007) 3.47
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet (2006) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. Proc Natl Acad Sci U S A (2007) 3.10
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Geographical structure and differential natural selection among North European populations. Genome Res (2009) 3.03
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet (2009) 2.58
Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am J Hum Genet (2010) 2.57
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A (2010) 2.47
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47
The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford Study. Arthritis Rheum (2002) 2.42
A twin approach to unraveling epigenetics. Trends Genet (2011) 2.38
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet (2013) 2.36
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet (2011) 2.34
Activation markers of coagulation and fibrinolysis in twins: heritability of the prethrombotic state. Lancet (2002) 2.26
Human telomere biology: pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol (2006) 2.16
Genetic effects on baseline values of C-reactive protein and serum amyloid a protein: a comparison of monozygotic and dizygotic twins. Clin Chem (2003) 2.15
Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis. Ann Rheum Dis (2010) 2.14
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet (2009) 2.09
A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum (2010) 2.02
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Hum Mol Genet (2009) 1.99
Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum (2007) 1.95
Genetic influences on female infidelity and number of sexual partners in humans: a linkage and association study of the role of the vasopressin receptor gene (AVPR1A). Twin Res (2004) 1.87
Male-pattern baldness susceptibility locus at 20p11. Nat Genet (2008) 1.87
Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet (2009) 1.87
A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood (2009) 1.85
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS Genet (2011) 1.83
Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study. Arthritis Rheum (2002) 1.82
EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet (2009) 1.82
Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genet (2008) 1.80
Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation. J Clin Endocrinol Metab (2005) 1.76
Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo. Cancer Epidemiol Biomarkers Prev (2007) 1.75
The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans. Blood (2007) 1.73
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet (2013) 1.72
Loci at chromosomes 13, 19 and 20 influence age at natural menopause. Nat Genet (2009) 1.72
Genetic influences on exercise participation in 37,051 twin pairs from seven countries. PLoS One (2006) 1.71
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Hum Mol Genet (2009) 1.71
The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance. Ann Rheum Dis (2010) 1.70
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med (2013) 1.70
Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res (2002) 1.69
Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol (2010) 1.67
Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet (2010) 1.67
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Ann Rheum Dis (2012) 1.66
Pain reporting at different body sites is explained by a single underlying genetic factor. Rheumatology (Oxford) (2010) 1.65
Multiple loci are associated with white blood cell phenotypes. PLoS Genet (2011) 1.65
A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins. Am J Hum Genet (2004) 1.63
Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study. Arthritis Rheum (2009) 1.61
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet (2011) 1.60
Human metabolic profiles are stably controlled by genetic and environmental variation. Mol Syst Biol (2011) 1.60
Heritability of responses to painful stimuli in women: a classical twin study. Brain (2007) 1.59
Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences. Circulation (2004) 1.59
cMYB is involved in the regulation of fetal hemoglobin production in adults. Blood (2006) 1.59
Assessment of gene-by-sex interaction effect on bone mineral density. J Bone Miner Res (2012) 1.58
Structural, psychological, and genetic influences on low back and neck pain: a study of adult female twins. Arthritis Rheum (2004) 1.57
Genetic influence on early age-related maculopathy: a twin study. Ophthalmology (2002) 1.57
Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial. Arthritis Rheum (2008) 1.51
Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. Am J Hum Genet (2009) 1.51
A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet (2013) 1.50
Metabolomic study of carotid-femoral pulse-wave velocity in women. J Hypertens (2015) 1.49
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genet (2012) 1.49
Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int J Epidemiol (2013) 1.48
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr (2007) 1.47
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. Epigenetics (2014) 1.47
When is a replication not a replication? Or how to spot a good genetic association study. Arthritis Rheum (2006) 1.47