PubRank

Dana J Philpott

Author PubWeight™ 154.90‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003 10.79
2 Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 2003 7.49
3 Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 2004 7.22
4 Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2009 5.83
5 Nod-like proteins in immunity, inflammation and disease. Nat Immunol 2006 5.25
6 Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 2003 3.83
7 Bacterial infection causes stress-induced memory dysfunction in mice. Gut 2010 3.06
8 Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut 2011 2.91
9 NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. EMBO Rep 2008 2.83
10 Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe 2012 2.70
11 Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep 2004 2.64
12 Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev 2005 2.50
13 Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat Med 2011 2.48
14 A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. Proc Natl Acad Sci U S A 2007 2.46
15 Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe 2009 2.21
16 Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity 2007 2.15
17 Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut. Nature 2011 2.04
18 Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J 2002 1.94
19 Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol 2005 1.90
20 Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells. Cell Microbiol 2009 1.87
21 Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol 2012 1.86
22 Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol 2003 1.79
23 Nod2-dependent Th2 polarization of antigen-specific immunity. J Immunol 2008 1.78
24 NLRC5 limits the activation of inflammatory pathways. J Immunol 2010 1.73
25 The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner. Immunity 2013 1.71
26 pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem 2009 1.68
27 An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix. J Cell Sci 2009 1.62
28 Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures. EMBO J 2013 1.61
29 Intracellular vs extracellular recognition of pathogens--common concepts in mammals and flies. Trends Microbiol 2002 1.59
30 NACHT-LRR proteins (NLRs) in bacterial infection and immunity. Trends Microbiol 2005 1.42
31 The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. Cell Microbiol 2007 1.41
32 Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin. EMBO Rep 2005 1.41
33 The microbial and danger signals that activate Nod-like receptors. Cytokine 2008 1.38
34 NOD1 activators link innate immunity to insulin resistance. Diabetes 2011 1.38
35 Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm (Vienna) 2011 1.35
36 Aspergillus fumigatus induces innate immune responses in alveolar macrophages through the MAPK pathway independently of TLR2 and TLR4. J Immunol 2006 1.29
37 Nod1 participates in the innate immune response to Pseudomonas aeruginosa. J Biol Chem 2005 1.29
38 The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists. J Biol Chem 2005 1.28
39 Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis. Proc Natl Acad Sci U S A 2008 1.24
40 Innate immune sensing of microbes by Nod proteins. Ann N Y Acad Sci 2006 1.24
41 Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway. Eur J Immunol 2007 1.24
42 Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. Infect Immun 2010 1.20
43 Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages. Infect Immun 2006 1.19
44 What is new with Nods? Curr Opin Immunol 2010 1.18
45 Mini-review: the role of peptidoglycan recognition in innate immunity. Eur J Immunol 2004 1.18
46 Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands. Eur J Immunol 2011 1.14
47 Muramylpeptide shedding modulates cell sensing of Shigella flexneri. Cell Microbiol 2007 1.13
48 Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology 2012 1.12
49 Innate immune recognition at the epithelial barrier drives adaptive immunity: APCs take the back seat. Trends Immunol 2007 1.12
50 Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis. Immunol Rev 2011 1.11
51 Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation. J Allergy Clin Immunol 2010 1.10
52 Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis. Gut Microbes 2013 1.10
53 Mammalian NLR proteins; discriminating foe from friend. Immunol Cell Biol 2007 1.08
54 Role of Nod1 in mucosal dendritic cells during Salmonella pathogenicity island 1-independent Salmonella enterica serovar Typhimurium infection. Infect Immun 2009 1.06
55 The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides. Cell Microbiol 2009 1.05
56 Identification of the critical residues involved in peptidoglycan detection by Nod1. J Biol Chem 2005 1.05
57 Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc Natl Acad Sci U S A 2011 1.05
58 A new role for intestinal alkaline phosphatase in gut barrier maintenance. Gastroenterology 2008 1.01
59 Nod-like receptors in the control of intestinal inflammation. Curr Opin Immunol 2012 1.00
60 NOD2 activation induces muscle cell-autonomous innate immune responses and insulin resistance. Endocrinology 2010 1.00
61 The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella-containing vacuole. Biol Open 2012 0.95
62 NOD2: a potential target for regulating liver injury. Lab Invest 2008 0.95
63 Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome. J Immunol 2012 0.95
64 Innate immune defense through RNA interference. Sci STKE 2006 0.94
65 Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection. PLoS One 2012 0.94
66 NLRX1 does not inhibit MAVS-dependent antiviral signalling. Innate Immun 2012 0.94
67 NF-kappaB activation during acute Helicobacter pylori infection in mice. Infect Immun 2007 0.92
68 Innate immune recognition of microbes through Nod1 and Nod2: implications for disease. Microbes Infect 2004 0.92
69 Neutrophil migration during liver injury is under nucleotide-binding oligomerization domain 1 control. Gastroenterology 2009 0.92
70 A commensal Helicobacter sp. of the rodent intestinal flora activates TLR2 and NOD1 responses in epithelial cells. PLoS One 2009 0.91
71 Nods and 'intracellular' innate immunity. C R Biol 2004 0.91
72 Intracellular bacteriolysis triggers a massive apoptotic cell death in Shigella-infected epithelial cells. Microbes Infect 2008 0.89
73 Nod-like receptors in intestinal homeostasis, inflammation, and cancer. J Leukoc Biol 2011 0.89
74 Nod proteins link bacterial sensing and autophagy. Autophagy 2010 0.88
75 Sensing microbes by diverse hosts. Workshop on pattern recognition proteins and receptors. EMBO Rep 2003 0.87
76 Nutrient sensing and metabolic stress pathways in innate immunity. Cell Microbiol 2013 0.87
77 Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection. J Immunol 2013 0.87
78 Disruption of Nod-like receptors alters inflammatory response to infection but does not confer protection in experimental cerebral malaria. Am J Trop Med Hyg 2009 0.85
79 Bacterial autophagy: the trigger, the target and the timing. Autophagy 2012 0.85
80 Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis. Cell Host Microbe 2013 0.84
81 Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3. J Biol Chem 2012 0.84
82 Crohn's disease-associated Nod2 mutants reduce IL10 transcription. Nat Immunol 2009 0.84
83 Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients. PLoS Pathog 2013 0.83
84 Gut microbes extend reach to systemic innate immunity. Nat Med 2010 0.82
85 Adenoviral vectors stimulate innate immune responses in macrophages through cross-talk with epithelial cells. Immunol Lett 2010 0.82
86 An epithelial armamentarium to sense the microbiota. Semin Immunol 2013 0.80
87 Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to Salmonella enterica serovar Typhimurium infection in vivo. Infect Immun 2012 0.80
88 A TNF-α-CCL20-CCR6 axis regulates Nod1-induced B cell responses. J Immunol 2014 0.79
89 'Nodophagy': New crossroads in Crohn disease pathogenesis. Gut Microbes 2010 0.79
90 PGRP-LB minds the fort. Immunity 2006 0.79
91 T cell intrinsic NOD2 is dispensable for CD8 T cell immunity. PLoS One 2013 0.78
92 Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis. PLoS One 2013 0.77
93 Examining host-microbial interactions through the lens of NOD: From plants to mammals. Semin Immunol 2012 0.77
94 Enterohaemorrhagic, but not enteropathogenic, Escherichia coli infection of epithelial cells disrupts signalling responses to tumour necrosis factor-alpha. Microbiology 2011 0.76
95 Constitutive induction of intestinal Tc17 cells in the absence of hematopoietic cell-specific MHC class II expression. Eur J Immunol 2013 0.76
96 Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway. Inflamm Bowel Dis 2015 0.76
97 Corrigendum: Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin. Nat Med 2016 0.75
98 Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae. J Acquir Immune Defic Syndr 2014 0.75
99 Innate immunity: the connection with inflammation and disease. Semin Immunol 2009 0.75
100 NLRs: Nucleotide-Binding Domain and Leucine-Rich-Repeat-Containing Proteins. Ecosal Plus 2009 0.75