Published in J Biol Chem on February 14, 2009
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer (2009) 2.18
NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med (2011) 1.15
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2012) 1.11
Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. J Exp Med (2014) 1.08
Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer. Gastroenterology (2011) 1.04
NFAT gene family in inflammation and cancer. Curr Mol Med (2013) 1.02
Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc Natl Acad Sci U S A (2011) 0.99
NFATc1/αA: The other Face of NFAT Factors in Lymphocytes. Cell Commun Signal (2012) 0.98
Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity. Mol Cell Biol (2011) 0.95
NFAT as cancer target: mission possible? Biochim Biophys Acta (2014) 0.91
The small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activation. J Immunol (2012) 0.90
Primers on molecular pathways--the NFAT transcription pathway in pancreatic cancer. Pancreatology (2010) 0.90
DNA binding sites target nuclear NFATc1 to heterochromatin regions in adult skeletal muscle fibers. Histochem Cell Biol (2010) 0.86
Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB. Nucleic Acids Res (2013) 0.85
Small ubiquitin-like modifier (SUMO) conjugation impedes transcriptional silencing by the polycomb group repressor Sex Comb on Midleg. J Biol Chem (2011) 0.83
Two heterozygous mutations in NFATC1 in a patient with Tricuspid Atresia. PLoS One (2012) 0.81
The 'N-factors' in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancer. Oncogenesis (2012) 0.80
Alternative splicing of transcription factors' genes: beyond the increase of proteome diversity. Comp Funct Genomics (2009) 0.80
Cell cycle and apoptosis regulation by NFAT transcription factors: new roles for an old player. Cell Death Dis (2016) 0.79
Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17. Cell Death Differ (2014) 0.78
C/EBPβ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling. Mol Cell Biol (2015) 0.76
Regulatory T-Cell-Mediated Suppression of Conventional T-Cells and Dendritic Cells by Different cAMP Intracellular Pathways. Front Immunol (2016) 0.76
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells. Nat Commun (2016) 0.75
Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. J Biol Chem (2016) 0.75
The Local Edge Machine: inference of dynamic models of gene regulation. Genome Biol (2016) 0.75
Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes. J Immunol (2017) 0.75
The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6. EMBO J (2016) 0.75
Translating the histone code. Science (2001) 56.77
Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity (2006) 10.53
SUMO: a history of modification. Mol Cell (2005) 10.40
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res (1995) 7.95
NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol (2005) 6.25
PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev (2001) 5.79
Profile of histone lysine methylation across transcribed mammalian chromatin. Mol Cell Biol (2006) 5.01
SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? Genes Dev (2004) 4.80
Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation. Science (2002) 4.57
Something about SUMO inhibits transcription. Curr Opin Genet Dev (2005) 4.05
Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells. Immunity (1999) 3.69
The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SUMO-1 modification. J Biol Chem (2001) 3.64
Modification with SUMO. A role in transcriptional regulation. EMBO Rep (2003) 3.25
SUMO promotes HDAC-mediated transcriptional repression. Mol Cell (2004) 2.97
Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med (2007) 2.88
NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity (2001) 2.38
Cellular proteins localized at and interacting within ND10/PML nuclear bodies/PODs suggest functions of a nuclear depot. Oncogene (2001) 2.33
Replication and transcription: shaping the landscape of the genome. Nat Rev Genet (2005) 2.30
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity (1998) 2.06
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity (1998) 2.00
Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis. Immunity (2002) 1.94
A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol Cell Biol (2000) 1.90
The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation. Biochim Biophys Acta (1995) 1.67
Identification of a nuclear domain with deacetylase activity. Proc Natl Acad Sci U S A (2000) 1.64
The role of NF-AT transcription factors in T cell activation and differentiation. Biochim Biophys Acta (2000) 1.54
Signals from CD28 induce stable epigenetic modification of the IL-2 promoter. J Immunol (2005) 1.52
Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells. Blood (2007) 1.43
Nuclear bodies and compartments: functional roles and cellular signalling in health and disease. Cell Signal (2004) 1.41
The PML nuclear bodies: actors or extras? Curr Opin Genet Dev (1999) 1.40
Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. J Biol Chem (2004) 1.31
PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase. J Cell Sci (2006) 1.30
Nuclear organisation and gene expression. Curr Opin Cell Biol (2002) 1.19
NFATc1 autoregulation: a crucial step for cell-fate determination. Trends Immunol (2006) 1.15
A role for Cajal bodies in assembly of the nuclear transcription machinery. FEBS Lett (2001) 1.14
Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells. Proc Natl Acad Sci U S A (2007) 1.12
Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes. J Immunol (1999) 1.08
A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti-IgM-induced cell death. Eur J Immunol (1999) 1.00
SUMOylation interferes with CCAAT/enhancer-binding protein beta-mediated c-myc repression, but not IL-4 activation in T cells. J Immunol (2006) 0.95
C/EBPbeta enhances IL-4 but impairs IL-2 and IFN-gamma induction in T cells. Eur J Immunol (2000) 0.92
Set of optimized luciferase reporter gene plasmids compatible with widely used CAT vectors. Biotechniques (1997) 0.92
Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol (2007) 7.86
Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med (2002) 4.37
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med (2005) 3.70
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity (2010) 3.64
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest (2005) 2.91
Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med (2007) 2.88
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science (2004) 2.39
Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis. Immunity (2002) 1.94
The regulatory T cell family: distinct subsets and their interrelations. J Immunol (2003) 1.92
Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol Cell Biol (2002) 1.87
Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells. Blood (2009) 1.78
T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. Gastroenterology (2013) 1.77
Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells. Nat Med (2002) 1.75
Term and preterm labor: decreased suppressive activity and changes in composition of the regulatory T-cell pool. Immunol Cell Biol (2012) 1.65
RelB forms transcriptionally inactive complexes with RelA/p65. J Biol Chem (2003) 1.63
Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo. Blood (2006) 1.62
Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. J Exp Med (2002) 1.61
NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation. J Biol Chem (2004) 1.59
NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. J Exp Med (2005) 1.55
Human CD25+ regulatory T cells: two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+ T helper cells. Eur J Immunol (2004) 1.43
Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. Blood (2007) 1.38
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol (2013) 1.37
Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines. J Immunol (2006) 1.29
p38 inhibitors prevent TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci (2006) 1.28
A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. Blood (2005) 1.27
Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice. Blood (2007) 1.23
TGFbeta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo. Int Immunol (2004) 1.22
A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. J Immunol (2007) 1.21
Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells: selective escape of CD44high/CD24low/HER2low breast cancer stem cells. Cancer Res (2009) 1.19
Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cells. J Immunol (2004) 1.19
Experience-driven development: effector/memory-like alphaE+Foxp3+ regulatory T cells originate from both naive T cells and naturally occurring naive-like regulatory T cells. J Immunol (2008) 1.19
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation. Mol Cell Biol (2003) 1.18
MHC class II-expressing hepatocytes function as antigen-presenting cells and activate specific CD4 T lymphocyutes. Hepatology (2003) 1.15
NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med (2011) 1.15
Encoding of motor skill in the corticomuscular system of musicians. Curr Biol (2010) 1.14
Case reports of PML in patients treated for psoriasis. N Engl J Med (2013) 1.13
Inhibition of cAMP degradation improves regulatory T cell-mediated suppression. J Immunol (2009) 1.13
Synthetic antitumor vaccines from tetanus toxoid conjugates of MUC1 glycopeptides with the Thomsen-Friedenreich antigen and a fluorine-substituted analogue. Angew Chem Int Ed Engl (2010) 1.11
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2012) 1.11
Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. J Exp Med (2014) 1.08
The streptococcal exotoxin streptolysin O activates mast cells to produce tumor necrosis factor alpha by p38 mitogen-activated protein kinase- and protein kinase C-dependent pathways. Infect Immun (2003) 1.07
Characteristic gene expression profile of primary human cerebral endothelial cells. FASEB J (2002) 1.07
The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells. Proc Natl Acad Sci U S A (2013) 1.07
Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. J Immunol (2009) 1.06
Subcutaneous interferon-beta injections in patients with multiple sclerosis initiate inflammatory skin reactions by local chemokine induction. J Neuroimmunol (2005) 1.05
NFAT transcription factors in control of peripheral T cell tolerance. Eur J Immunol (2006) 1.05
From interleukin-9 to T helper 9 cells. Ann N Y Acad Sci (2012) 1.05
miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression. PLoS One (2009) 1.04
Murine liver antigen presenting cells control suppressor activity of CD4+CD25+ regulatory T cells. Hepatology (2005) 1.03
Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells. Eur J Immunol (2011) 1.03
CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2. J Clin Invest (2014) 1.02
Synthetic vaccines consisting of tumor-associated MUC1 glycopeptide antigens and a T-cell epitope for the induction of a highly specific humoral immune response. Angew Chem Int Ed Engl (2008) 1.01
Influenza A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia. J Immunol (2003) 1.01
Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown. PLoS One (2010) 1.00
A synthetic vaccine consisting of a tumor-associated sialyl-T(N)-MUC1 tandem-repeat glycopeptide and tetanus toxoid: induction of a strong and highly selective immune response. Angew Chem Int Ed Engl (2009) 1.00
PKB rescues calcineurin/NFAT-induced arrest of Rag expression and pre-T cell differentiation. J Immunol (2006) 1.00
A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation. Clin Immunol (2010) 0.99
Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc Natl Acad Sci U S A (2011) 0.99
Cyclic AMP underpins suppression by regulatory T cells. Eur J Immunol (2012) 0.98
A fully synthetic vaccine consisting of a tumor-associated glycopeptide antigen and a T-cell epitope for the induction of a highly specific humoral immune response. Angew Chem Int Ed Engl (2005) 0.98
NFATc1/αA: The other Face of NFAT Factors in Lymphocytes. Cell Commun Signal (2012) 0.98
Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression. Blood (2007) 0.97
The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma. J Immunol (2012) 0.96
Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk. J Med Genet (2013) 0.96
Protein kinase A regulates GATA-3-dependent activation of IL-5 gene expression in Th2 cells. J Immunol (2003) 0.95
SUMOylation interferes with CCAAT/enhancer-binding protein beta-mediated c-myc repression, but not IL-4 activation in T cells. J Immunol (2006) 0.95
An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development. Nat Immunol (2012) 0.95