Published in Biochim Biophys Acta on August 21, 2010
PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet (2010) 2.30
Parkin disease: a clinicopathologic entity? JAMA Neurol (2013) 1.68
The genetics of Parkinson's disease: progress and therapeutic implications. Mov Disord (2013) 1.63
Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast. J Biol Chem (2011) 1.38
Protein neddylation: beyond cullin-RING ligases. Nat Rev Mol Cell Biol (2015) 1.33
SOD1 and mitochondria in ALS: a dangerous liaison. J Bioenerg Biomembr (2011) 1.24
Cancer and neurodegeneration: between the devil and the deep blue sea. PLoS Genet (2010) 1.21
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci (2013) 1.19
The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction. Front Physiol (2012) 1.14
Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode. J Biol Chem (2012) 1.06
Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories. Neuropathol Appl Neurobiol (2015) 0.96
Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. J Clin Invest (2015) 0.95
Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. J Biol Chem (2012) 0.95
The dynamics of the mitochondrial organelle as a potential therapeutic target. J Cereb Blood Flow Metab (2012) 0.94
Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol Cell Biol (2013) 0.93
Pathogenesis-targeted, disease-modifying therapies in Parkinson disease. Neurotherapeutics (2014) 0.92
Autophagy during vertebrate development. Cells (2012) 0.92
Mending a broken heart: the role of mitophagy in cardioprotection. Am J Physiol Heart Circ Physiol (2014) 0.91
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies. FASEB J (2013) 0.88
Parkin' control: regulation of PGC-1α through PARIS in Parkinson's disease. Dis Model Mech (2011) 0.86
The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease. Parkinsons Dis (2012) 0.84
Parkin disease and the Lewy body conundrum. Mov Disord (2013) 0.84
Recent advances in Parkinson’s disease genetics. J Neurol (2014) 0.84
Mitochondrial dynamics and cell death in heart failure. Heart Fail Rev (2016) 0.83
Mitophagy and heart failure. J Mol Med (Berl) (2015) 0.82
Deubiquitinating enzymes regulate PARK2-mediated mitophagy. Autophagy (2015) 0.81
Efficient Mitochondrial Genome Editing by CRISPR/Cas9. Biomed Res Int (2015) 0.79
Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration. Int J Cell Biol (2012) 0.79
PINK1 positively regulates IL-1β-mediated signaling through Tollip and IRAK1 modulation. J Neuroinflammation (2012) 0.78
The critical roles of mitophagy in cerebral ischemia. Protein Cell (2016) 0.77
ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad. Front Cell Neurosci (2015) 0.77
Mitochondrial targets for pharmacological intervention in human disease. J Proteome Res (2014) 0.76
Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins. Cells (2012) 0.76
Inhibition of the mitochondrial calcium uniporter (MCU) rescues dopaminergic neurons in pink1(-/-) zebrafish. Eur J Neurosci (2016) 0.76
The pallidopyramidal syndromes: nosology, aetiology and pathogenesis. Curr Opin Neurol (2013) 0.76
Intracellular pH Modulates Autophagy and Mitophagy. J Biol Chem (2016) 0.75
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease. Drug Des Devel Ther (2017) 0.75
Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice. Acta Neuropathol Commun (2017) 0.75
Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy. Protein Cell (2016) 0.75
Nonsyndromic Parkinson disease in a family with autosomal dominant optic atrophy due to OPA1 mutations. Neurol Genet (2017) 0.75
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Alpha-synuclein in Lewy bodies. Nature (1997) 20.83
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81
Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol (2010) 12.26
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature (2006) 11.91
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature (2006) 11.81
Growing roles for the mTOR pathway. Curr Opin Cell Biol (2005) 11.66
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J (2007) 9.65
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science (2004) 8.71
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc Natl Acad Sci U S A (1998) 8.41
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25
Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol (2010) 7.62
Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol (2007) 7.43
The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol (1998) 7.41
Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem (2003) 6.84
The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol (2010) 5.95
Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell (2009) 5.85
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78
Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci (2007) 5.68
Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep (2009) 5.52
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A (2008) 5.43
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem (2006) 5.39
Lithium delays progression of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2008) 5.37
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A (2010) 5.17
Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases. Hum Mol Genet (2009) 5.15
NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14
The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J (2001) 4.99
Cellular differentiation in the kidneys of newborn mice studies with the electron microscope. J Biophys Biochem Cytol (1957) 4.91
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem (2009) 4.90
Autophagy and aging: the importance of maintaining "clean" cells. Autophagy (2005) 4.61
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol (2007) 4.60
The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. Brain (2009) 4.01
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat Genet (2006) 4.01
Autophagy: cellular and molecular mechanisms. J Pathol (2010) 3.96
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol (2007) 3.86
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem (2008) 3.86
ROS, mitochondria and the regulation of autophagy. Trends Cell Biol (2007) 3.73
Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann Neurol (2006) 3.72
Parkinson's disease: from monogenic forms to genetic susceptibility factors. Hum Mol Genet (2009) 3.56
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res (2005) 3.54
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J (2008) 3.51
Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28
Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy (2005) 3.27
Autophagy and human disease. Cell Cycle (2007) 3.22
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell (2009) 3.17
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17
Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem (2004) 3.07
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun (2008) 3.06
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc Natl Acad Sci U S A (2005) 3.00
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem (2010) 2.93
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ (2009) 2.93
Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem (2008) 2.86
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci (2006) 2.85
ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy (2007) 2.67
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet (2009) 2.55
ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease. Neurology (2007) 2.51
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry (2009) 2.38
Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy (2006) 2.37
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat Neurosci (2009) 2.35
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A (2010) 2.34
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One (2008) 2.33
Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem (2006) 2.32
Characterization of PINK1 processing, stability, and subcellular localization. J Neurochem (2008) 2.29
Mechanisms of chaperone-mediated autophagy. Int J Biochem Cell Biol (2004) 2.27
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci (2010) 2.15
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc Natl Acad Sci U S A (2010) 2.10
Selective and non-selective autophagic degradation of mitochondria in yeast. Autophagy (2007) 2.07
Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol (2004) 2.01
Dysfunction of endocytic and autophagic pathways in a lysosomal storage disease. Ann Neurol (2006) 1.92
Mitophagy. Biochim Biophys Acta (2009) 1.92
Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy. Autophagy (2009) 1.90
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS One (2009) 1.88
Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia. Sci Signal (2009) 1.84
Parkin-induced mitophagy in the pathogenesis of Parkinson disease. Autophagy (2009) 1.82
Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines. Exp Neurol (2000) 1.80
Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy (2007) 1.79
Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Brain Pathol (2003) 1.75
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy (2008) 1.74
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochim Biophys Acta (2008) 1.73
The PINK1/Parkin pathway: a mitochondrial quality control system? J Bioenerg Biomembr (2009) 1.72
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. J Neurosci Res (2009) 1.68
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ (2010) 1.63
The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases. Biochim Biophys Acta (2009) 1.56
Autophagy, mitochondria and cell death in lysosomal storage diseases. Autophagy (2007) 1.55
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. J Neurochem (2009) 1.52
Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Hum Mol Genet (2010) 1.52
Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet (2011) 9.10
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol (2008) 6.76
A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet (2005) 5.81
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat Rev Neurosci (2006) 4.87
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol (2007) 4.60
Selection and evaluation of tagging SNPs in the neuronal-sodium-channel gene SCN1A: implications for linkage-disequilibrium gene mapping. Am J Hum Genet (2003) 4.58
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. Brain (2009) 4.01
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40
Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell (2012) 3.39
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med (2003) 3.37
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell (2009) 3.17
A robust model for read count data in exome sequencing experiments and implications for copy number variant calling. Bioinformatics (2012) 3.10
Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Lancet Neurol (2007) 2.88
The role of pathogenic DJ-1 mutations in Parkinson's disease. Ann Neurol (2003) 2.80
Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. Am J Hum Genet (2010) 2.61
A single-nucleotide polymorphism tagging set for human drug metabolism and transport. Nat Genet (2004) 2.44
Parkin disease: a phenotypic study of a large case series. Brain (2003) 2.41
Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Proc Natl Acad Sci U S A (2005) 2.39
Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol (2008) 2.34
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One (2008) 2.33
PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet (2010) 2.30
Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains. Ann Neurol (2012) 2.20
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain (2003) 2.17
Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A. Am J Hum Genet (2007) 2.04
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem (2006) 1.91
Mutations in the autoregulatory domain of β-tubulin 4a cause hereditary dystonia. Ann Neurol (2013) 1.90
Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis. Am J Hum Genet (2012) 1.78
Clinical and genetic characterization of families with triple A (Allgrove) syndrome. Brain (2002) 1.76
The structure of the tau haplotype in controls and in progressive supranuclear palsy. Hum Mol Genet (2004) 1.72
Genome scans and candidate gene approaches in the study of common diseases and variable drug responses. Trends Genet (2003) 1.71
Autosomal recessive, DYT2-like primary torsion dystonia: a new family. Neurology (2003) 1.69
PARK6-linked parkinsonism occurs in several European families. Ann Neurol (2002) 1.68
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet (2012) 1.68
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain (2010) 1.67
Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene. Genome Res (2004) 1.65
A heterozygous effect for PINK1 mutations in Parkinson's disease? Ann Neurol (2006) 1.61
A genetically mediated bias in decision making driven by failure of amygdala control. J Neurosci (2009) 1.59
Corticobasal degeneration syndrome with basal ganglia calcification: Fahr's disease as a corticobasal look-alike? Mov Disord (2002) 1.57
Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study. Ann Neurol (2002) 1.51
In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study. Exp Neurol (2010) 1.47
Parkinson's disease and cancer: two wars, one front. Nat Rev Cancer (2011) 1.45
PRRT2 gene mutations: from paroxysmal dyskinesia to episodic ataxia and hemiplegic migraine. Neurology (2012) 1.44
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. Nat Cell Biol (2009) 1.41
Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nat Genet (2007) 1.38
Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. Neurology (2012) 1.33
Myoclonus-dystonia syndrome: epsilon-sarcoglycan mutations and phenotype. Ann Neurol (2002) 1.33
Progression of nigrostriatal dysfunction in a parkin kindred: an [18F]dopa PET and clinical study. Brain (2002) 1.30
Cancer and neurodegeneration: between the devil and the deep blue sea. PLoS Genet (2010) 1.21
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci (2013) 1.19
Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. PLoS One (2009) 1.19
Molecular pathogenesis of Parkinson's disease. Hum Mol Genet (2005) 1.16
Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism. Brain (2004) 1.16
Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis. Nat Genet (2013) 1.15
Hyposmia and cognitive impairment in Gaucher disease patients and carriers. Mov Disord (2012) 1.15
Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients. Acta Neuropathol (2008) 1.15
Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2. Neuroimage (2010) 1.15
Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease. Mov Disord (2012) 1.14
Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease. Neurobiol Aging (2007) 1.14
PINK1 function in health and disease. EMBO Mol Med (2009) 1.14
Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease. J Cell Sci (2012) 1.11
A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease. Ann Neurol (2004) 1.11
A clinical, genetic and biochemical study of SPG7 mutations in hereditary spastic paraplegia. Brain (2004) 1.11
Molecular basis of Parkinson's disease. Neuroreport (2009) 1.06
UCHL-1 is not a Parkinson's disease susceptibility gene. Ann Neurol (2006) 1.06
Genome-wide association studies: the key to unlocking neurodegeneration? Nat Neurosci (2010) 1.05
Signalling properties of inorganic polyphosphate in the mammalian brain. Nat Commun (2013) 1.05
Genetic and clinical heterogeneity in paroxysmal kinesigenic dyskinesia: evidence for a third EKD gene. Mov Disord (2002) 1.05
Different patterns of electrophysiological deficits in manifesting and non-manifesting carriers of the DYT1 gene mutation. Brain (2003) 1.04
Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption. J Biol Chem (2007) 1.04
Cell death pathways in Parkinson's disease: role of mitochondria. Antioxid Redox Signal (2009) 1.03
The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease. Neurosci Lett (2002) 1.03
Somatic and germline mosaicism in sporadic early-onset Alzheimer's disease. Hum Mol Genet (2004) 1.03
Mouse models for neurological disease. Lancet Neurol (2002) 1.02
Slowly progressive cerebellar ataxia and cervical dystonia: clinical presentation of a new form of spinocerebellar ataxia? Mov Disord (2003) 1.01
Genetic variability at the PARK16 locus. Eur J Hum Genet (2010) 1.01
Failure to replicate previously reported genetic associations with sporadic temporal lobe epilepsy: where to from here? Brain (2005) 1.00
Genetic and functional characterisation of the P/Q calcium channel in episodic ataxia with epilepsy. J Physiol (2010) 0.99
Connexin 32 promoter P2 mutations: a mechanism of peripheral nerve dysfunction. Ann Neurol (2004) 0.99
Large-scale pathways-based association study in amyotrophic lateral sclerosis. Brain (2007) 0.98
The genetics of dystonia: new twists in an old tale. Brain (2013) 0.98
A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy. Epilepsia (2007) 0.98
Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4 ) gene. Hum Mol Genet (2003) 0.97
Study of the genetic variability in a Parkinson's Disease gene: EIF4G1. Neurosci Lett (2012) 0.96
The role of interruptions in polyQ in the pathology of SCA1. PLoS Genet (2013) 0.96
Targeting mitochondrial dysfunction in neurodegenerative disease: Part I. Expert Opin Ther Targets (2010) 0.95
Parkin disease in a Brazilian kindred: Manifesting heterozygotes and clinical follow-up over 10 years. Mov Disord (2005) 0.94
Targeting mitochondrial dysfunction in neurodegenerative disease: Part II. Expert Opin Ther Targets (2010) 0.94
Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage. Biochemistry (2014) 0.94
Partial epilepsy with pericentral spikes: a new familial epilepsy syndrome with evidence for linkage to chromosome 4p15. Ann Neurol (2002) 0.93
Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival. Hum Mol Genet (2003) 0.93