Published in Nat Biotechnol on April 01, 2009
Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet (2010) 10.71
Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29
Bioinformatic Identification of Novel Methyltransferases. Epigenomics (2009) 1.01
Epigenetic mechanisms involved in developmental nutritional programming. World J Diabetes (2011) 0.95
Linking epidemiology to epigenomics--where are we today? Cancer Prev Res (Phila) (2010) 0.80
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell (2008) 32.65
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature (2008) 26.78
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
Multiplex amplification of large sets of human exons. Nat Methods (2007) 15.11
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Padlock probes: circularizing oligonucleotides for localized DNA detection. Science (1994) 6.17
A human B cell methylome at 100-base pair resolution. Proc Natl Acad Sci U S A (2009) 4.72
The DNA methylation paradox. Trends Genet (1999) 4.40
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell (2010) 16.12
Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet (2006) 13.63
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87
Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62
Pan-cancer patterns of somatic copy number alteration. Nat Genet (2013) 7.73
Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res (2005) 6.49
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet (2011) 5.70
Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res (2011) 4.84
Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn (2006) 4.68
Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proc Natl Acad Sci U S A (2004) 4.39
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol (2002) 3.79
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol (2002) 3.61
The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS One (2009) 3.41
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One (2007) 3.30
Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Res (2004) 3.23
Interplay between the cancer genome and epigenome. Cell (2013) 3.05
Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine. Cancer Res (2002) 3.02
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun (2013) 2.94
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet (2009) 2.85
Preferential response of cancer cells to zebularine. Cancer Cell (2004) 2.39
Cigarette smoking and colorectal cancer risk by molecularly defined subtypes. J Natl Cancer Inst (2010) 2.38
Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Res (2013) 2.19
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev (2008) 2.12
Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res (Phila) (2008) 2.04
DNA methylation as a biomarker for cardiovascular disease risk. PLoS One (2010) 2.04
Bis-SNP: combined DNA methylation and SNP calling for Bisulfite-seq data. Genome Biol (2012) 2.02
Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer. Cancer Res (2006) 1.99
Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog (2010) 1.94
A comparison of cluster analysis methods using DNA methylation data. Bioinformatics (2004) 1.94
Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level. Nucleic Acids Res (2005) 1.94
Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. PLoS One (2009) 1.90
DNA hypomethylation and ovarian cancer biology. Cancer Res (2004) 1.75
Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice. Cancer Res (2002) 1.73
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73
Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients. Clin Cancer Res (2004) 1.69
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol (2004) 1.68
The landscape of microsatellite instability in colorectal and endometrial cancer genomes. Cell (2013) 1.68
DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines. PLoS One (2010) 1.65
Sensitive detection of DNA methylation. Ann N Y Acad Sci (2003) 1.65
Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene (2002) 1.59
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology (2007) 1.56
Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS One (2007) 1.55
Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res (2006) 1.52
Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells (2010) 1.50
Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Res (2010) 1.47
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet (2012) 1.47
Discovery of multi-dimensional modules by integrative analysis of cancer genomic data. Nucleic Acids Res (2012) 1.46
MethyLight. Methods Mol Biol (2009) 1.45
Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine. Oncotarget (2013) 1.44
DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Res (2008) 1.42
An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma. J Natl Cancer Inst (2013) 1.42
Distinct methylation profiles of glioma subtypes. Int J Cancer (2003) 1.38
Hierarchical clustering of lung cancer cell lines using DNA methylation markers. Cancer Epidemiol Biomarkers Prev (2002) 1.38
Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Res (2008) 1.36
Sex differential in methylation patterns of selected genes in Singapore Chinese. Hum Genet (2005) 1.35
DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis. Lab Invest (2007) 1.34
Cell division is required for de novo methylation of CpG islands in bladder cancer cells. Cancer Res (2002) 1.32
Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation (2002) 1.32
Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma. Am J Surg Pathol (2006) 1.29
Characterizing DNA methylation alterations from The Cancer Genome Atlas. J Clin Invest (2014) 1.27
Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. Mol Cancer (2008) 1.24
Combined bisulfite restriction analysis (COBRA). Methods Mol Biol (2002) 1.20
Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels. Hum Genet (2002) 1.19
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol Cell Biol (2002) 1.18
Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. Eur J Cancer (2005) 1.18
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells. Nucleic Acids Res (2004) 1.17
Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer. PLoS One (2012) 1.14
Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. Mol Cancer (2007) 1.14
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. Int J Cancer (2009) 1.14
cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue. PLoS One (2012) 1.14