Published in Intensive Care Med on April 15, 2009
An updated meta-analysis to understand the variable efficacy of drotrecogin alfa (activated) in severe sepsis and septic shock. Minerva Anestesiol (2012) 1.44
Year in review in Intensive Care Medicine 2009: I. Pneumonia and infections, sepsis, outcome, acute renal failure and acid base, nutrition and glycaemic control. Intensive Care Med (2010) 0.89
Inhibitors of propagation of coagulation: factors V and X. Br J Clin Pharmacol (2011) 0.76
Managing septic shock. F1000 Med Rep (2010) 0.75
Case report: perioperative use of protein c concentrate for protein C deficiency in THA. Clin Orthop Relat Res (2009) 0.75
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med (2014) 7.07
Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA (2009) 6.55
Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation (2011) 6.47
Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet (2007) 5.23
Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data. Lancet (2011) 4.78
Prevention and treatment of major blood loss. N Engl J Med (2007) 4.72
Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med (2005) 3.97
Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med (2004) 3.89
A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality. Intensive Care Med (2014) 3.56
Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma (2008) 3.40
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med (2014) 3.37
Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). Am J Respir Crit Care Med (2007) 3.34
Early vs late tracheotomy for prevention of pneumonia in mechanically ventilated adult ICU patients: a randomized controlled trial. JAMA (2010) 3.20
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
Challenges in end-of-life care in the ICU. Statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003. Intensive Care Med (2004) 3.16
Usefulness of transcranial echography in patients with decompressive craniectomy: a comparison with computed tomography scan. Crit Care Med (2012) 3.10
Challenges in end-of-life care in the ICU: statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003: executive summary. Crit Care Med (2004) 2.95
Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial. Lancet (2003) 2.86
2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema. Allergy Asthma Clin Immunol (2010) 2.75
In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival. Intensive Care Med (2006) 2.72
The optimal intensity of vitamin K antagonists in patients with mechanical heart valves: a meta-analysis. J Am Coll Cardiol (2003) 2.71
A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med (2013) 2.68
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors. J Clin Oncol (2002) 2.55
Activation of inflammation and coagulation after infusion of C-reactive protein in humans. Circ Res (2005) 2.46
Evaluation of patient skin breakdown and comfort with a new face mask for non-invasive ventilation: a multi-center study. Intensive Care Med (2002) 2.46
Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol (2007) 2.46
Adequacy of antimicrobial treatment and outcome of Staphylococcus aureus bacteremia in 9 Western European countries. Clin Infect Dis (2009) 2.39
The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks. Intensive Care Med (2011) 2.28
Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents alveolar coagulation in patients without lung injury. Anesthesiology (2006) 2.19
ENHANCE: results of a global open-label trial of drotrecogin alfa (activated) in children with severe sepsis. Pediatr Crit Care Med (2006) 2.19
Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk. Blood (2010) 2.14
Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure. Crit Care Med (2005) 2.12
Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis. Crit Care Med (2010) 2.11
Nasal high-flow versus Venturi mask oxygen therapy after extubation. Effects on oxygenation, comfort, and clinical outcome. Am J Respir Crit Care Med (2014) 2.05
Is worsening multiple organ failure the cause of death in patients with severe sepsis? Crit Care Med (2011) 2.04
Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood (2008) 2.03
Euthanasia, therapeutic obstinacy or something else? An Italian case. Intensive Care Med (2005) 2.03
Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo. Diabetes (2006) 1.97
Noninvasive versus invasive ventilation for acute respiratory failure in patients with hematologic malignancies: a 5-year multicenter observational survey. Crit Care Med (2011) 1.96
Association between thrombotic microangiopathy and reduced ADAMTS13 activity in malignant hypertension. Hypertension (2008) 1.95
Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1. Circ Res (2006) 1.95
Management of adult Jehovah's Witness patients with acute bleeding. Am J Med (2009) 1.89
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood (2007) 1.86
Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia. Crit Care Med (2006) 1.82
Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med (2008) 1.82
A meta-analysis of complications and mortality of extracorporeal membrane oxygenation. Crit Care Resusc (2013) 1.77
Supernatant of aged erythrocytes causes lung inflammation and coagulopathy in a "two-hit" in vivo syngeneic transfusion model. Anesthesiology (2010) 1.72
Systemic inflammatory response and progression to severe sepsis in critically ill infected patients. Am J Respir Crit Care Med (2004) 1.72
New fundamentals in hemostasis. Physiol Rev (2013) 1.70
Struggle for implementation of new strategies in intensive care medicine: anticoagulation, insulin, and lower tidal volumes. J Crit Care (2005) 1.66
Noninvasive ventilation after early extubation in patients recovering from hypoxemic acute respiratory failure: a single-centre feasibility study. Intensive Care Med (2012) 1.63
Serum levels of mannose-binding lectin and the risk of future coronary artery disease in apparently healthy men and women. Arterioscler Thromb Vasc Biol (2006) 1.62
Time course of platelet counts in critically ill patients. Crit Care Med (2002) 1.60
Adjunctive corticosteroid therapy in pediatric severe sepsis: observations from the RESOLVE study. Pediatr Crit Care Med (2011) 1.60
Risk factors for acute kidney injury in critically ill patients receiving high intravenous doses of colistin methanesulfonate and/or other nephrotoxic antibiotics: a retrospective cohort study. Crit Care (2013) 1.60
Diagnostic accuracy of passive leg raising for prediction of fluid responsiveness in adults: systematic review and meta-analysis of clinical studies. Intensive Care Med (2010) 1.58
Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats. Crit Care Med (2008) 1.58
Noninvasive positive-pressure ventilation with different interfaces in patients with respiratory failure after abdominal surgery: a matched-control study. Respir Care (2007) 1.57
A multicenter, randomized trial of noninvasive ventilation with helium-oxygen mixture in exacerbations of chronic obstructive lung disease. Crit Care Med (2010) 1.56
Long-term follow-up of a phase 2 study of oral teriflunomide in relapsing multiple sclerosis: safety and efficacy results up to 8.5 years. Mult Scler (2012) 1.55
Activation of coagulation and inhibition of fibrinolysis in the human lung on bronchial instillation of lipoteichoic acid and lipopolysaccharide. Crit Care Med (2009) 1.55
Ventilator-associated pneumonia: current status and future recommendations. J Clin Monit Comput (2010) 1.54
Pulmonary activation of coagulation and inhibition of fibrinolysis after burn injuries and inhalation trauma. J Trauma (2011) 1.54
Drotrecogin alfa (activated) treatment of older patients with severe sepsis. Clin Infect Dis (2003) 1.54
A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality. Intensive Care Med (2015) 1.54
Online vs live methods for teaching difficult airway management to anesthesiology residents. Intensive Care Med (2005) 1.51
Non-invasive ventilation delivered by conventional interfaces and helmet in the emergency department. Eur J Emerg Med (2003) 1.51
Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study. Intensive Care Med (2012) 1.47
Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS Med (2008) 1.46
Levels of vancomycin in the cerebral interstitial fluid after severe head injury. Intensive Care Med (2006) 1.46
Time-course of cytokines during delirium in elderly patients with hip fractures. J Am Geriatr Soc (2008) 1.45
Dobutamine does not influence inflammatory pathways during human endotoxemia. Crit Care Med (2006) 1.44
Suspected acute pulmonary embolism: evaluation with multi-detector row CT versus digital subtraction pulmonary arteriography. Radiology (2004) 1.44
Cytokines and acute phase response in delirium. J Psychosom Res (2007) 1.42
In-hospital cardiac arrest: survival depends mainly on the effectiveness of the emergency response. Resuscitation (2004) 1.41
Perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and non-cardiac surgery: a consensus document from Italian cardiological, surgical and anaesthesiological societies. EuroIntervention (2014) 1.41
Endogenous tissue-type plasminogen activator impairs host defense during severe experimental Gram-negative sepsis (melioidosis)*. Crit Care Med (2012) 1.41
Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study. Antimicrob Agents Chemother (2009) 1.40
Biomarker response to drotrecogin alfa (activated) in children with severe sepsis: results from the RESOLVE clinical trial*. Pediatr Crit Care Med (2012) 1.40
Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia. J Immunol (2002) 1.39
Noninvasive ventilation options in pediatric myasthenia gravis. Paediatr Anaesth (2005) 1.39
Immunonutrients in critically ill patients: an analysis of the most recent literature. Minerva Anestesiol (2015) 1.39
Geriatric conditions in acutely hospitalized older patients: prevalence and one-year survival and functional decline. PLoS One (2011) 1.39
Early diagnosis of candidemia in intensive care unit patients with sepsis: a prospective comparison of (1→3)-β-D-glucan assay, Candida score, and colonization index. Crit Care (2011) 1.38
Use of activated protein C in liver transplantation patients with septic shock. Liver Transpl (2008) 1.38
Factors that predict outcome of intensive care treatment in very elderly patients: a review. Crit Care (2005) 1.37
Tissue factor and coronary artery disease. Cardiovasc Res (2002) 1.37
Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated). Clin Infect Dis (2003) 1.33
Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans. Am J Respir Crit Care Med (2005) 1.33
Bioavailability of subcutaneous low-molecular-weight heparin to patients on vasopressors. Lancet (2002) 1.32
Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage. Crit Care (2006) 1.32
A pilot trial of serial 18F-fluorodeoxyglucose positron emission tomography in patients with medically inoperable stage I non-small-cell lung cancer treated with hypofractionated stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys (2009) 1.29
The epidemiology of acute respiratory failure in critically ill patients(*). Chest (2002) 1.29
High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria. Crit Care (2014) 1.25