Published in Exp Hematol on May 19, 2009
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Oral decitabine reactivates expression of the methylated gamma-globin gene in Papio anubis. Am J Hematol (2007) 0.99
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5-Azacytidine increases fetal hemoglobin production in a patient with sickle cell disease. Prog Clin Biol Res (1983) 0.90
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Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation. Cell (2005) 6.17
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet (2004) 4.45
Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing. Proc Natl Acad Sci U S A (2010) 3.28
Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. J Exp Med (2012) 2.85
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The human beta-globin locus control region can silence as well as activate gene expression. Mol Cell Biol (2005) 2.19
Uncovering growth-suppressive MicroRNAs in lung cancer. Clin Cancer Res (2009) 2.19
Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood (2010) 2.16
Transferrin therapy ameliorates disease in beta-thalassemic mice. Nat Med (2010) 2.04
Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells. DNA Repair (Amst) (2006) 2.03
Type 3 deiodinase is critical for the maturation and function of the thyroid axis. J Clin Invest (2006) 1.95
Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin. Blood (2007) 1.92
Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells. Stem Cells (2006) 1.92
Preventing gene silencing with human replicators. Nat Biotechnol (2006) 1.84
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res (2009) 1.80
Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position. Mol Cell Biol (2002) 1.78
Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells. Blood (2007) 1.76
Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development. Exp Hematol (2005) 1.65
Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas. Proc Natl Acad Sci U S A (2007) 1.61
Large-scale production of embryonic red blood cells from human embryonic stem cells. Exp Hematol (2006) 1.61
Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells. Proc Natl Acad Sci U S A (2002) 1.61
Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J Cell Biol (2008) 1.52
ADAMTS13 is expressed in hepatic stellate cells. Lab Invest (2005) 1.49
Gene length and proximity to neighbors affect genome-wide expression levels. Genome Res (2003) 1.47
Predictable dynamic program of timing of DNA replication in human cells. Genome Res (2009) 1.47
Methylation protects cytidines from AID-mediated deamination. Mol Immunol (2005) 1.46
The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts. Endocrinology (2002) 1.45
A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger. Exp Hematol (2008) 1.42
Mammalian linker-histone subtypes differentially affect gene expression in vivo. Proc Natl Acad Sci U S A (2003) 1.37
Production of embryonic and fetal-like red blood cells from human induced pluripotent stem cells. PLoS One (2011) 1.19
Role for MKL1 in megakaryocytic maturation. Blood (2009) 1.19
Developmental- and differentiation-specific patterns of human gamma- and beta-globin promoter DNA methylation. Blood (2007) 1.17
DNA methylation supports intrinsic epigenetic memory in mammalian cells. PLoS Genet (2006) 1.17
Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy? J Biol Chem (2005) 1.16
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. Proc Natl Acad Sci U S A (2002) 1.16
Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge. J Immunol (2012) 1.16
Zinc-finger nuclease-mediated correction of α-thalassemia in iPS cells. Blood (2012) 1.15
Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex. Blood (2006) 1.15
An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers. Blood (2007) 1.14
Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol (2011) 1.13
High-resolution mapping of h1 linker histone variants in embryonic stem cells. PLoS Genet (2013) 1.11
Decreased replication origin activity in temporal transition regions. J Cell Biol (2009) 1.09
Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Cancer Res (2013) 1.06
Transcriptional interference among the murine beta-like globin genes. Blood (2006) 1.06
Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation. J Biol Chem (2005) 1.04
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway. Blood (2011) 1.03
Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism. Blood (2013) 1.00
Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation. Am J Physiol Endocrinol Metab (2006) 0.99
Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes. Blood (2005) 0.99
Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions. FASEB J (2010) 0.98
High-efficiency siRNA-based gene knockdown in human embryonic stem cells. RNA (2010) 0.98
Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression. J Mol Biol (2006) 0.97
Genetic deletion of mouse platelet glycoprotein Ibbeta produces a Bernard-Soulier phenotype with increased alpha-granule size. Blood (2004) 0.97
Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed. Mol Cancer Ther (2010) 0.96
GenPlay, a multipurpose genome analyzer and browser. Bioinformatics (2011) 0.95
Erythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family. Mol Cell Biol (2005) 0.95
Nanomolecular targeting of dendritic cells for ovarian cancer therapy. Future Oncol (2009) 0.94
Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis. Cancer Biol Ther (2011) 0.94
Exogenous iron increases hemoglobin in beta-thalassemic mice. Exp Hematol (2008) 0.94
Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator. PLoS One (2009) 0.92
Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema. Front Physiol (2013) 0.90
Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression. Blood (2009) 0.89
Vinblastine rapidly induces NOXA and acutely sensitizes primary chronic lymphocytic leukemia cells to ABT-737. Mol Cancer Ther (2013) 0.89
CpG hypomethylation in a large domain encompassing the embryonic beta-like globin genes in primitive erythrocytes. Mol Cell Biol (2007) 0.88
Novel, high-yield red blood cell production methods from CD34-positive cells derived from human embryonic stem, yolk sac, fetal liver, cord blood, and peripheral blood. Stem Cells Transl Med (2012) 0.87
Ikaros increases normal apoptosis in adult erythroid cells. Am J Hematol (2006) 0.87
Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1. J Biol Chem (2004) 0.87
Chromatin insulation by a transcriptional activator. Proc Natl Acad Sci U S A (2003) 0.87
Quantification of magnetic nanoparticles with low frequency magnetic fields: compensating for relaxation effects. Nanotechnology (2013) 0.86
Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region. Proc Natl Acad Sci U S A (2003) 0.86
Transgenic mice and hemoglobinopathies. Methods Mol Med (2003) 0.86
Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo. Blood Cells Mol Dis (2011) 0.85
Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions. Mol Endocrinol (2014) 0.84
Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy. Integr Biol (Camb) (2013) 0.84
Local tumour hyperthermia as immunotherapy for metastatic cancer. Int J Hyperthermia (2014) 0.83
Complex developmental patterns of histone modifications associated with the human beta-globin switch in primary cells. Exp Hematol (2009) 0.83
Exposure to Cigarette Smoke Disrupts CCL20-Mediated Antimicrobial Activity in Respiratory Epithelial Cells. Open Immunol J (2009) 0.82
Differentiation of human embryonic stem cells into mesenchymal stem cells by the "raclure" method. Methods Mol Biol (2011) 0.82
Engineering a blood-retinal barrier with human embryonic stem cell-derived retinal pigment epithelium: transcriptome and functional analysis. Stem Cells Transl Med (2013) 0.81
Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells. Blood (2012) 0.80
An embryonic stage-specific enhancer within the murine β-globin locus mediates domain-wide histone hyperacetylation. Blood (2011) 0.80
Generation of transgenic mice expressing human hemoglobin E. Blood Cells Mol Dis (2004) 0.79