Published in Mol Cell Biol on June 01, 1993
Developmental regulation of human gamma-globin genes in transgenic mice. Mol Cell Biol (1993) 1.81
RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol Cell Biol (1994) 1.66
Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities. Blood (2011) 1.36
Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching. EMBO J (1999) 1.36
Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein. EMBO J (1995) 1.30
Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4. Mol Cell Biol (2000) 1.24
Developmental- and differentiation-specific patterns of human gamma- and beta-globin promoter DNA methylation. Blood (2007) 1.17
Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. Hum Genet (2010) 1.00
Established epigenetic modifications determine the expression of developmentally regulated globin genes in somatic cell hybrids. Mol Cell Biol (1995) 0.89
Specific repression of beta-globin promoter activity by nuclear ferritin. Proc Natl Acad Sci U S A (2001) 0.87
Characterization of the deoxycytidine kinase promoter in human lymphoblast cell lines. J Clin Invest (1995) 0.86
Intronic and flanking sequences are required to silence enhancement of an embryonic beta-type globin gene. Mol Cell Biol (1996) 0.85
Developmentally regulated extended domains of DNA hypomethylation encompass highly transcribed genes of the human beta-globin locus. Exp Hematol (2009) 0.83
The p16-specific reactivation and inhibition of cell migration through demethylation of CpG islands by engineered transcription factors. Hum Gene Ther (2012) 0.82
Evidence for a bigenic chromatin subdomain in regulation of the fetal-to-adult hemoglobin switch. Mol Cell Biol (2008) 0.78
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol (1982) 116.75
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acids Res (1981) 35.39
Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc Natl Acad Sci U S A (1984) 17.51
Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell (1987) 15.79
Affinity purification of sequence-specific DNA binding proteins. Proc Natl Acad Sci U S A (1986) 14.92
A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome. Cell (1984) 9.15
DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues. Cell (1980) 8.41
The "beta-like-globin" gene domain in human erythroid cells. Proc Natl Acad Sci U S A (1985) 8.35
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell (1992) 8.10
Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J (1985) 5.84
Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell (1989) 5.12
CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. Genes Dev (1989) 5.00
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell (1991) 4.90
Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter. Nature (1986) 4.77
Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints. J Mol Biol (1988) 4.75
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Nature (1990) 4.53
Developmental regulation of beta-globin gene switching. Cell (1988) 4.11
Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells. Genes Dev (1990) 4.07
Human gamma- to beta-globin gene switching in transgenic mice. Genes Dev (1990) 4.04
Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter. Genes Dev (1988) 4.02
Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor. Nature (1989) 3.76
Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein. EMBO J (1992) 3.43
5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. N Engl J Med (1982) 3.29
An embryonic pattern of expression of a human fetal globin gene in transgenic mice. Nature (1986) 3.07
Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated. Genes Dev (1988) 3.05
Importance of globin gene order for correct developmental expression. Genes Dev (1991) 2.85
Specific expression of a foreign beta-globin gene in erythroid cells of transgenic mice. Nature (1985) 2.79
Cytosine methylation does not affect binding of transcription factor Sp1. Proc Natl Acad Sci U S A (1988) 2.56
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest (1984) 2.43
Short and long range activation by the SV40 enhancer. Nucleic Acids Res (1984) 2.35
Human gamma-globin genes silenced independently of other genes in the beta-globin locus. Nature (1991) 2.23
5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. Proc Natl Acad Sci U S A (1982) 2.19
Fetal haemoglobin production and the sickle gene in the oases of Eastern Saudi Arabia. Br J Haematol (1978) 1.98
The beta-globin stage selector element factor is erythroid-specific promoter/enhancer binding protein NF-E4. Genes Dev (1989) 1.90
Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts. Proc Natl Acad Sci U S A (1983) 1.68
A novel type of secondary modification of two CCGG residues in the human gamma delta beta-globin gene locus. Nucleic Acids Res (1980) 1.67
Nuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin. Mol Cell Biol (1988) 1.63
Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex. Proc Natl Acad Sci U S A (1983) 1.60
Site specific demethylation in the promoter of human gamma-globin gene does not alleviate methylation mediated suppression. EMBO J (1987) 1.56
Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells. Mol Cell Biol (1987) 1.35
Therapeutic approaches to hemoglobin switching in treatment of hemoglobinopathies. Annu Rev Med (1992) 1.24
Interaction of Sp1 with the human gamma globin promoter: binding and transactivation of normal and mutant promoters. Blood (1991) 1.19
The developmental switch in embryonic rho-globin expression is correlated with erythroid lineage-specific differences in transcription factor levels. Development (1992) 1.19
Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells. Blood (1990) 1.18
The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein. Nucleic Acids Res (1989) 1.15
Increased Sp1 binding mediates erythroid-specific overexpression of a mutated (HPFH) gamma-globulin promoter. Nucleic Acids Res (1989) 1.06
DNA methylation: a secondary event in globin gene switching? Genes Dev (1988) 1.04
A naturally occurring gamma globin gene mutation enhances SP1 binding activity. Mol Cell Biol (1990) 1.02
Developmental biology of human hemoglobins. Prog Hematol (1977) 1.01
Mutations in two regions upstream of the A gamma globin gene canonical promoter affect gene expression. Nucleic Acids Res (1989) 0.94
The T----C substitution at -198 of the A gamma-globin gene associated with the British form of HPFH generates overlapping recognition sites for two DNA-binding proteins. Nucleic Acids Res (1990) 0.88
An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin. J Biol Chem (1992) 0.80
Expression of human globin genes in transgenic mice carrying the beta-globin gene cluster with a mutation causing G gamma beta + hereditary persistence of fetal hemoglobin. Ann N Y Acad Sci (1990) 0.77
A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection. Cell (1989) 7.64
Transport of cationic amino acids by the mouse ecotropic retrovirus receptor. Nature (1991) 5.40
Retroviral entry mediated by receptor priming and low pH triggering of an envelope glycoprotein. Cell (2000) 4.88
Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem (1992) 4.88
Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. N Engl J Med (1994) 4.86
Biochemical evidence that patched is the Hedgehog receptor. Nature (1996) 4.53
An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation. Mol Cell Biol (1988) 4.08
Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells. Genes Dev (1990) 4.07
A family of long reiterated DNA sequences, one copy of which is next to the human beta globin gene. Nucleic Acids Res (1980) 3.91
Locus control regions of mammalian beta-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights. Gene (1997) 3.77
Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc Natl Acad Sci U S A (1986) 3.71
Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res (1998) 3.36
Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. Nat Genet (2000) 3.33
5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. N Engl J Med (1982) 3.29
The functional human dihydrofolate reductase gene. J Biol Chem (1984) 3.28
Characterization of a human colon/lung carcinoma oncogene. Nature (1983) 3.26
Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution. Science (1997) 3.13
The HL-60 transforming sequence: a ras oncogene coexisting with altered myc genes in hematopoietic tumors. Cell (1983) 3.00
RNA processing errors in patients with beta-thalassemia. Proc Natl Acad Sci U S A (1982) 2.99
Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphism. Proc Natl Acad Sci U S A (1984) 2.99
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ (2009) 2.93
Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res (1996) 2.89
Differences in human alpha-, beta- and delta-globin gene expression in monkey kidney cells. Cell (1982) 2.78
Envelope-binding domain in the cationic amino acid transporter determines the host range of ecotropic murine retroviruses. J Virol (1993) 2.77
Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis. Cell (1992) 2.67
The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A (1993) 2.63
The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci U S A (1987) 2.51
Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease. N Engl J Med (1993) 2.50
Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nat Genet (1999) 2.48
Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest (1990) 2.37
Continuous subcutaenous administration of deferoxamine in patients with iron overload. N Engl J Med (1977) 2.31
The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1. Nat Genet (1995) 2.30
Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell (1985) 2.28
Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1. Nat Genet (1999) 2.28
Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stability. Blood (1984) 2.17
Developmental regulation of human globin genes. Annu Rev Biochem (1985) 2.16
Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis. Blood (1999) 2.14
Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis. J Biol Chem (2001) 2.12
Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. Mol Cell Biol (1993) 2.05
Cloning and characterization of DNA sequences surrounding the human gamma-, delta-, and beta-globin genes. Proc Natl Acad Sci U S A (1980) 2.04
Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex. Neuron (2000) 2.04
Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein. Nucleic Acids Res (1990) 2.01
Beta Thalassemia: mutations which affect processing of the beta-Globin mRNA precursor. Cell (1980) 1.98
Pure red-cell aplasia of 10 years' duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy. N Engl J Med (1989) 1.85
Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells. Proc Natl Acad Sci U S A (1989) 1.84
Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J (1998) 1.83
Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector. Proc Natl Acad Sci U S A (1992) 1.82
Expression of the human c-fms proto-oncogene product (colony-stimulating factor-1 receptor) on peripheral blood mononuclear cells and choriocarcinoma cell lines. J Clin Invest (1986) 1.77
Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease. Gut (2006) 1.77
Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer. Hum Mol Genet (1996) 1.76
Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol (1993) 1.76
Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells. Blood (1994) 1.75
Identification of a receptor-binding pocket on the envelope protein of friend murine leukemia virus. J Virol (1999) 1.75
Translation of rabbit haemoglobin messenger RNA by thalassaemic and non-thalassaemic ribosomes. Nat New Biol (1971) 1.75
Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA. Blood (2001) 1.74
Isolation and translation of hemoglobin messenger RNA from thalassemia, sickle cell anemia, and normal human reticulocytes. J Clin Invest (1971) 1.74
Evidence for a prostate cancer-susceptibility locus on chromosome 20. Am J Hum Genet (2000) 1.69
Intronless human dihydrofolate reductase genes are derived from processed RNA molecules. Proc Natl Acad Sci U S A (1982) 1.69
Mechanism of DNase I hypersensitive site formation within the human globin locus control region. Proc Natl Acad Sci U S A (1992) 1.67
The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis. EMBO J (2001) 1.67
Human cells infected with retrovirus vectors acquire an endogenous murine provirus. J Virol (1990) 1.65
The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q. Proc Natl Acad Sci U S A (1987) 1.64
Targeted and highly efficient gene transfer into CD4+ cells by a recombinant human immunodeficiency virus retroviral vector. J Clin Invest (1991) 1.64
Active conformation of the globin genes in uninduced and induced mouse erythroleukemia cells. Cell (1978) 1.64
Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea. N Engl J Med (1990) 1.63
Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor. Blood (1993) 1.62
5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia. Blood (1983) 1.61
Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells. Proc Natl Acad Sci U S A (1990) 1.59
Selective activation of human beta-but not gamma-globin gene in human fibroblast x mouse erythroleukaemia cell hybrids. Nature (1979) 1.58
Cyclosporine therapy of aplastic anaemia, congenital and acquired red cell aplasia. Br J Haematol (1989) 1.56
Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium. Br J Cancer (2009) 1.54
Isolation and characterization of a 15-kilobase genomic sequence coding for part of the Pro alpha 2 chain of sheep type I collagen. J Biol Chem (1980) 1.53
High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human beta globin cluster. Nucleic Acids Res (1995) 1.52
Allogeneic bone marrow transplantation for infants with acute leukemia or myelodysplastic syndrome. Bone Marrow Transplant (2001) 1.52
Advances in thalassemia research. Blood (1984) 1.52
Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli. Dev Dyn (1998) 1.51
Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate. Exp Hematol (1992) 1.50
Treatment of Diamond-Blackfan anaemia with haematopoietic growth factors, granulocyte-macrophage colony stimulating factor and interleukin 3: sustained remissions following IL-3. Br J Haematol (1991) 1.50
Characterization of the third member of the MCAT family of cationic amino acid transporters. Identification of a domain that determines the transport properties of the MCAT proteins. J Biol Chem (1993) 1.49
Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science (1992) 1.49
Brief report: treatment with azacitidine of patients with end-stage beta-thalassemia. N Engl J Med (1993) 1.48
Promoter sequences required for function of the human gamma globin gene in erythroid cells. EMBO J (1986) 1.47
Contribution of promoter to tissue-specific expression of the mouse immunoglobulin kappa gene. Science (1985) 1.44
Neural basis of endogenous and exogenous spatial orienting. A functional MRI study. J Cogn Neurosci (1999) 1.42
In vitro binding of purified murine ecotropic retrovirus envelope surface protein to its receptor, MCAT-1. J Virol (1997) 1.41
Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector. J Clin Invest (1994) 1.39
An array of murine leukemia virus-related elements is transmitted and expressed in a primate recipient of retroviral gene transfer. J Virol (1996) 1.38
Modular organization of the Friend murine leukemia virus envelope protein underlies the mechanism of infection. Proc Natl Acad Sci U S A (2001) 1.37
Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4. Nat Neurosci (2001) 1.37
Inducible, high-level production of infectious murine leukemia retroviral vector particles pseudotyped with vesicular stomatitis virus G envelope protein. Hum Gene Ther (1995) 1.37
Relative stability of alpha- and beta-globin messenger RNAs in homozygous beta+ thalassemia. Proc Natl Acad Sci U S A (1977) 1.36
Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice. Proc Natl Acad Sci U S A (1988) 1.36
Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells. Mol Cell Biol (1987) 1.35