Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels.

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Published in Br J Pharmacol on July 08, 2009

Authors

C E Riera1, C Menozzi-Smarrito, M Affolter, S Michlig, C Munari, F Robert, H Vogel, S A Simon, J le Coutre

Author Affiliations

1: Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland.

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Homeodomain-DNA recognition. Cell (1994) 4.68

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Multiple defects and perinatal death in mice deficient in follistatin. Nature (1995) 2.96

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Steric repulsion between phosphatidylcholine bilayers. Biochemistry (1987) 2.76

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Repulsive interactions between uncharged bilayers. Hydration and fluctuation pressures for monoglycerides. Biophys J (1989) 1.30

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Study of ligand-receptor interactions by fluorescence correlation spectroscopy with different fluorophores: evidence that the homopentameric 5-hydroxytryptamine type 3As receptor binds only one ligand. Biochemistry (1999) 1.29

Progressive polyradiculopathy in acquired immune deficiency syndrome. Neurology (1986) 1.27

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The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development. Development (1998) 1.27

The noneffect of a large linear hydrocarbon, squalene, on the phosphatidylcholine packing structure. Biophys J (1977) 1.26

Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brain. Learn Mem (2000) 1.26