The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008.

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🔗 View Article (PMID 19631008)

Published in Parasitology on July 27, 2009

Authors

A Fenwick1, J P Webster, E Bosque-Oliva, L Blair, F M Fleming, Y Zhang, A Garba, J R Stothard, A F Gabrielli, A C A Clements, N B Kabatereine, S Toure, R Dembele, U Nyandindi, J Mwansa, A Koukounari

Author Affiliations

1: Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College, St. Mary's Campus, Norfolk Place, London W2 1PG, UK. a.fenwick@imperial.ac.uk

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Refrigerated Skin Grafts. Ann Surg (1944) 2.78

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Transformation of mycobacterial species using hygromycin resistance as selectable marker. Microbiology (1994) 2.55

Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol Ther (2001) 2.53

Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med (2001) 2.53

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