High intakes of choline and betaine reduce breast cancer mortality in a population-based study.

PubWeight™: 0.99‹?› | Rank: Top 15%

🔗 View Article (PMC 2775010)

Published in FASEB J on July 27, 2009

Authors

Xinran Xu1, Marilie D Gammon, Steven H Zeisel, Patrick T Bradshaw, James G Wetmur, Susan L Teitelbaum, Alfred I Neugut, Regina M Santella, Jia Chen

Author Affiliations

1: Department of Community and Preventive Medicine, Box 1057, Mt. Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

Articles citing this

The Emerging Hallmarks of Cancer Metabolism. Cell Metab (2016) 2.32

Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology (2010) 2.30

Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40

DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study. FASEB J (2012) 1.21

Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J (2010) 1.18

Marine omega-3 phospholipids: metabolism and biological activities. Int J Mol Sci (2012) 1.12

Epigenetic repression of phosphatidylethanolamine N-methyltransferase (PEMT) in BRCA1-mutated breast cancer. Oncotarget (2014) 1.05

Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones. Mutat Res (2011) 0.95

The supply of choline is important for fetal progenitor cells. Semin Cell Dev Biol (2011) 0.87

Associations between dietary intake of choline and betaine and lung cancer risk. PLoS One (2013) 0.86

The Fifty Year Rehabilitation of the Egg. Nutrients (2015) 0.84

Choline and betaine intakes are associated with reduced risk of nasopharyngeal carcinoma in adults: a case-control study. Br J Cancer (2013) 0.84

Choline. Adv Nutr (2010) 0.78

Choline and betaine consumption lowers cancer risk: a meta-analysis of epidemiologic studies. Sci Rep (2016) 0.75

Articles cited by this

The fundamental role of epigenetic events in cancer. Nat Rev Genet (2002) 30.05

Concentrations of choline-containing compounds and betaine in common foods. J Nutr (2003) 4.12

Choline and human nutrition. Annu Rev Nutr (1994) 3.09

DNA methylation and breast carcinogenesis. Oncogene (2002) 3.03

Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts. Cancer Epidemiol Biomarkers Prev (2002) 2.83

The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Res Treat (2002) 2.71

Dissecting complex epigenetic alterations in breast cancer using CpG island microarrays. Cancer Res (2001) 2.60

Choline phospholipid metabolism: a target in cancer cells? J Cell Biochem (2003) 2.12

Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst (2007) 2.07

Dietary Reference Intakes: the new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc (1998) 1.79

Weight gain prior to diagnosis and survival from breast cancer. Cancer Epidemiol Biomarkers Prev (2007) 1.73

DNA methylation in breast cancer. Endocr Relat Cancer (2001) 1.68

Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. FASEB J (2003) 1.59

Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. Cancer Epidemiol Biomarkers Prev (2004) 1.52

Choline metabolism and risk of breast cancer in a population-based study. FASEB J (2008) 1.51

Betaine: a key modulator of one-carbon metabolism and homocysteine status. Clin Chem Lab Med (2005) 1.38

Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism. Pharmacogenomics (2006) 1.38

Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal women. Cancer Epidemiol Biomarkers Prev (2007) 1.31

Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up. Int J Cancer (2008) 1.19

Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis (2003) 1.17

The association between betaine and choline intakes and the plasma concentrations of homocysteine in women. Am J Clin Nutr (2007) 1.16

Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women. Eur J Clin Nutr (2007) 1.15

The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. Int J Cancer (2009) 1.14

Hypomethylation of CpG sites and c-myc gene overexpression in hepatocellular carcinomas, but not hyperplastic nodules, induced by a choline-deficient L-amino acid-defined diet in rats. Jpn J Cancer Res (1999) 1.13

The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. Carcinogenesis (1984) 1.08

Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. Am J Med Genet A (2003) 1.06

Coffee consumption and risk of breast cancer: a metaanalysis. Am J Obstet Gynecol (2008) 1.04

Labile methyl groups and the promotion of cancer. Annu Rev Nutr (1986) 1.01

Consumption of coffee, but not black tea, is associated with decreased risk of premenopausal breast cancer. J Nutr (2006) 0.98

Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. Carcinogenesis (1995) 0.87

Procarbazine carcinogenicity in methotrexate-treated or lipotrope-deficient male rats. Carcinogenesis (1990) 0.81

Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. FASEB J (2008) 0.80

Prolonged survival of female AKR mice fed diets supplemented with methionine and choline. Carcinogenesis (1990) 0.77

Articles by these authors

Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2008) 13.35

Epidemiology of gastric cancer. World J Gastroenterol (2006) 7.67

Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. J Natl Cancer Inst (2007) 4.97

A cis-regulatory map of the Drosophila genome. Nature (2011) 4.80

Robotically assisted vs laparoscopic hysterectomy among women with benign gynecologic disease. JAMA (2013) 4.67

The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer. Breast Cancer Res (2004) 4.54

Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. J Clin Oncol (2010) 4.43

Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk. JAMA (2004) 4.31

Risk of perforation after colonoscopy and sigmoidoscopy: a population-based study. J Natl Cancer Inst (2003) 3.71

Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology (2003) 3.58

Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer. Breast Cancer Res Treat (2010) 3.35

Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst (2003) 3.07

Racial disparities in treatment and survival among women with early-stage breast cancer. J Clin Oncol (2005) 3.02

Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Natl Cancer Inst (2005) 2.99

In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ Health Perspect (2004) 2.85

Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts. Cancer Epidemiol Biomarkers Prev (2002) 2.83

The impact of suboptimal bowel preparation on adenoma miss rates and the factors associated with early repeat colonoscopy. Gastrointest Endosc (2011) 2.73

The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Res Treat (2002) 2.71

Short telomere length and breast cancer risk: a study in sister sets. Cancer Res (2007) 2.70

Racial disparities in utilization of liver transplantation for hepatocellular carcinoma in the United States, 1998-2002. Am J Gastroenterol (2007) 2.69

Comparative effectiveness of robotic versus laparoscopic hysterectomy for endometrial cancer. J Clin Oncol (2012) 2.59

Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environ Health Perspect (2011) 2.56

Genomic DNA methylation among women in a multiethnic New York City birth cohort. Cancer Epidemiol Biomarkers Prev (2008) 2.52

DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics (2011) 2.51

Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am J Epidemiol (2007) 2.51

Use of the Internet by women with breast cancer. J Med Internet Res (2003) 2.46

Timing of adjuvant chemotherapy initiation after surgery for stage III colon cancer. Cancer (2006) 2.36

Increased influence of genetic variation on PON1 activity in neonates. Environ Health Perspect (2003) 2.36

Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry. Anal Chem (2002) 2.35

Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). FASEB J (2005) 2.34

Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. J Nutr (2002) 2.33

Dopaminergic differentiation of human embryonic stem cells. Stem Cells (2004) 2.30

Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology (2010) 2.30

Delay of adjuvant chemotherapy initiation following breast cancer surgery among elderly women. Breast Cancer Res Treat (2006) 2.26

Prostate cancer in fathers with fewer male offspring: the Jerusalem Perinatal Study cohort. J Natl Cancer Inst (2007) 2.24

Persistence of multiple illnesses in World Trade Center rescue and recovery workers: a cohort study. Lancet (2011) 2.24

Trends in relative survival for ovarian cancer from 1975 to 2011. Obstet Gynecol (2015) 2.22

Uptake and economic impact of first-cycle colony-stimulating factor use during adjuvant treatment of breast cancer. J Clin Oncol (2012) 2.21

DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer. J Natl Cancer Inst (2005) 2.20

Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics (2011) 2.12

Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study. J Clin Oncol (2005) 2.11

Epidemiology of upper gastrointestinal malignancies. Semin Oncol (2004) 2.10

Elevated preoperative neutrophil:lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Ann Surg Oncol (2011) 2.10

Carbonated soft drink consumption and risk of esophageal adenocarcinoma. J Natl Cancer Inst (2006) 2.08

Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J (2006) 2.07

Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst (2007) 2.07

Electric blanket use and breast cancer on Long Island. Epidemiology (2003) 2.06

Nationwide trends in the performance of inpatient hysterectomy in the United States. Obstet Gynecol (2013) 2.05

Socioeconomic and other predictors of colonoscopy preparation quality. Dig Dis Sci (2010) 2.04

Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environ Health Perspect (2007) 2.04

Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study. Breast Cancer Res (2004) 2.03

Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement use. Am J Epidemiol (2005) 2.03

Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. Clin Cancer Res (2007) 2.02

The role for adjuvant radiotherapy in the treatment of hemangiopericytoma: a Surveillance, Epidemiology, and End Results analysis. J Neurosurg (2013) 2.01

An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic acid and drought stress responses. Plant Cell (2006) 2.01

Prognostic significance of adenocarcinoma histology in women with cervical cancer. Gynecol Oncol (2012) 1.98

A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology (2006) 1.98

Fear, anxiety, worry, and breast cancer screening behavior: a critical review. Cancer Epidemiol Biomarkers Prev (2004) 1.96

Global methylation profiles in DNA from different blood cell types. Epigenetics (2011) 1.94

Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer. Ann Intern Med (2002) 1.89

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. Am J Clin Nutr (2013) 1.88

Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J (2006) 1.88

Lifetime alcohol intake and breast cancer risk. Ann Epidemiol (2005) 1.85

Risk of malignancy in patients with celiac disease. Am J Med (2003) 1.85

Effect of breast cancer radiotherapy and cigarette smoking on risk of second primary lung cancer. J Clin Oncol (2008) 1.83

Acid suppression therapy may not alter malignant progression in Barrett's metaplasia showing p53 protein accumulation. Am J Gastroenterol (2002) 1.81

Genome-wide DNA methylation profiles in hepatocellular carcinoma. Hepatology (2012) 1.81

Breast cancers among very young premenopausal women (United States). Cancer Causes Control (2003) 1.80

Hormone receptor status and survival in a population-based cohort of patients with breast carcinoma. Cancer (2005) 1.78

Delay in initiating adjuvant radiotherapy following breast conservation surgery and its impact on survival. Int J Radiat Oncol Biol Phys (2006) 1.77

Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr (2007) 1.76

High radical prostatectomy surgical volume is related to lower radical prostatectomy total hospital charges. Eur Urol (2006) 1.76

Adherence to biopsy guidelines for Barrett's esophagus surveillance in the community setting in the United States. Clin Gastroenterol Hepatol (2009) 1.76

Indium-111-capromab pendetide radioimmunoscintigraphy and prognosis for durable biochemical response to salvage radiation therapy in men after failed prostatectomy. J Clin Oncol (2003) 1.74

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J (2007) 1.74

Weight gain prior to diagnosis and survival from breast cancer. Cancer Epidemiol Biomarkers Prev (2007) 1.73

Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A (2005) 1.73

Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus. J Nutr (2003) 1.73

Trends in hospital volume and patterns of referral for women with gynecologic cancers. Obstet Gynecol (2013) 1.72

Colonoscopic screening in average-risk individuals ages 40 to 49 vs 50 to 59 years. Gastroenterology (2008) 1.71

Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr (2006) 1.71

Telomere length, oxidative damage, antioxidants and breast cancer risk. Int J Cancer (2009) 1.70