PubRank

W J Gehring

Author PubWeight™ 278.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 1995 7.35
2 Detection in situ of genomic regulatory elements in Drosophila. Proc Natl Acad Sci U S A 1987 7.02
3 A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature 1984 6.62
4 Homeo boxes in the study of development. Science 1987 6.21
5 P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev 1989 5.76
6 Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Science 1994 5.75
7 Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22. Cell 1986 5.00
8 A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell 1984 4.95
9 The white gene as a marker in a new P-element vector for gene transfer in Drosophila. Nucleic Acids Res 1987 4.92
10 Control elements of the Drosophila segmentation gene fushi tarazu. Cell 1985 4.83
11 An improved in situ hybridization method for the detection of cellular RNAs in Drosophila tissue sections and its application for localizing transcripts of the homeotic Antennapedia gene complex. EMBO J 1983 4.77
12 Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins. Nature 1984 4.33
13 The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors. Cell 1989 4.13
14 Regulation and function of the Drosophila segmentation gene fushi tarazu. Cell 1987 3.91
15 Homeotic genes and the homeobox. Annu Rev Genet 1986 3.60
16 Protein--DNA contacts in the structure of a homeodomain--DNA complex determined by nuclear magnetic resonance spectroscopy in solution. EMBO J 1990 3.50
17 Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster. EMBO J 1986 3.49
18 Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila. EMBO J 1983 3.47
19 P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev 1989 3.45
20 The interaction with DNA of wild-type and mutant fushi tarazu homeodomains. EMBO J 1990 2.97
21 Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell 1984 2.89
22 Position effects on eukaryotic gene expression. Annu Rev Cell Biol 1990 2.82
23 Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia. Nature 1987 2.81
24 Spatial distribution of transcripts from the segmentation gene fushi tarazu during Drosophila embryonic development. Cell 1984 2.72
25 PAX-6 in development and evolution. Annu Rev Neurosci 1997 2.68
26 Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts. Nature 1990 2.67
27 DNA binding properties of the purified Antennapedia homeodomain. Proc Natl Acad Sci U S A 1990 2.60
28 Isolation and sequence-specific DNA binding of the Antennapedia homeodomain. EMBO J 1988 2.57
29 Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development 1998 2.56
30 Unequal crossing-over associated with asymmetrical synapsis between nomadic elements in the Drosophila melanogaster genome. Proc Natl Acad Sci U S A 1983 2.52
31 Expression of the caudal gene in the germ line of Drosophila: formation of an RNA and protein gradient during early embryogenesis. Cell 1987 2.50
32 Spatial distribution of Antennapedia transcripts during Drosophila development. EMBO J 1983 2.50
33 Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain. J Mol Biol 1994 2.43
34 Selective translation of heat shock mRNA in Drosophila melanogaster depends on sequence information in the leader. EMBO J 1985 2.30
35 The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes Dev 1992 2.24
36 Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis. Science 1988 2.23
37 Isolation of a hybrid plasmid with homologous sequences to a transposing element of Drosophila melanogaster. Cell 1980 2.23
38 Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila. Nature 1984 2.16
39 Two hybrid plasmids with D. melanogaster DNA sequences complementary to mRNA coding for the major heat shock protein. Cell 1978 2.10
40 Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes. Cell 1984 2.08
41 RNA binding and translational suppression by bicoid. Nature 1996 2.08
42 Molecular cloning of lethal(2)giant larvae, a recessive oncogene of Drosophila melanogaster. EMBO J 1985 2.07
43 Isolation of caudal, a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage. EMBO J 1985 2.06
44 twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development. Mol Cell 1999 2.06
45 Molecular cloning of the white locus region of Drosophila melanogaster using a large transposable element. EMBO J 1982 2.04
46 spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo. EMBO J 1994 1.99
47 The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell 1990 1.99
48 The 5S genes of Drosophila melanogaster. Cell 1977 1.94
49 Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene. Nature 1992 1.84
50 Physical map of two D. melanogaster DNA segments containing sequences coding for the 70,000 dalton heat shock protein. Cell 1979 1.80
51 Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts. EMBO J 1985 1.77
52 Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated. Genes Dev 1990 1.75
53 Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex. EMBO J 1988 1.72
54 Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster. EMBO J 1991 1.72
55 Germ line dependence of the deep orange maternal effect in Drosophila. Dev Biol 1977 1.69
56 Homeodomain proteins and the regulation of gene expression. Curr Opin Cell Biol 1990 1.65
57 Spatial and temporal targeting of gene expression in Drosophila by means of a tetracycline-dependent transactivator system. Development 1998 1.62
58 Expression, modification, and localization of the fushi tarazu protein in Drosophila embryos. Genes Dev 1988 1.57
59 The homeo box: a key to the understanding of development? Cell 1985 1.55
60 Cloning and transcriptional analysis of the segmentation gene fushi tarazu of Drosophila. Cell 1984 1.55
61 Deletions of two heat-activated loci in Drosophila melanogaster and their effects on heat-induced protein synthesis. Cell 1977 1.54
62 Developmentally regulated Drosophila gene family encoding the fork head domain. Proc Natl Acad Sci U S A 1992 1.54
63 Molecular analysis of the dominant homeotic Antennapedia phenotype. EMBO J 1987 1.53
64 Direct regulatory interaction of the eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila. Development 1999 1.49
65 Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear magnetic resonance spectroscopy. J Mol Biol 1990 1.47
66 The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered. Development 1996 1.46
67 Fruit flies with additional expression of the elongation factor EF-1 alpha live longer. Proc Natl Acad Sci U S A 1989 1.44
68 Sequence requirement for expression of the Drosophila melanogaster heat shock protein hsp22 gene during heat shock and normal development. Mol Cell Biol 1986 1.43
69 New perspectives on eye evolution. Curr Opin Genet Dev 1995 1.42
70 The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism. Development 2000 1.40
71 Protein component from Drosophila larval nuclei showing sequence specificity for a short region near a major heat-shock protein gene. Cell 1981 1.39
72 Functional specificity of the Antennapedia homeodomain. Proc Natl Acad Sci U S A 1993 1.39
73 Excision of copia element in a revertant of the white-apricot mutation of Drosophila melanogaster leaves behind one long-terminal repeat. Mol Gen Genet 1985 1.39
74 The Drosophila homologue of vertebrate myogenic-determination genes encodes a transiently expressed nuclear protein marking primary myogenic cells. Proc Natl Acad Sci U S A 1991 1.38
75 Are cross-regulatory interactions between homoeotic genes functionally significant? Nature 1990 1.38
76 Developmental expression of the white locus of Drosophila melanogaster. EMBO J 1984 1.38
77 Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila. Proc Natl Acad Sci U S A 1999 1.37
78 Localization of the Antennapedia protein in Drosophila embryos and imaginal discs. EMBO J 1986 1.35
79 P-element-mediated enhancer detection applied to the study of oogenesis in Drosophila. Development 1989 1.34
80 Empty spiracles, a gap gene containing a homeobox involved in Drosophila head development. EMBO J 1992 1.33
81 Germline transformation with Drosophila mutant actin genes induces constitutive expression of heat shock genes. Cell 1986 1.33
82 Developmental genetics of Drosophila. Annu Rev Genet 1976 1.29
83 NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein. Proc Natl Acad Sci U S A 1992 1.27
84 The homeotic gene Sex Combs Reduced of Drosophila: gene structure and embryonic expression. EMBO J 1989 1.27
85 Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments. Genes Dev 1994 1.26
86 Transfer RNA genes of Drosophila melanogaster. Nucleic Acids Res 1980 1.25
87 In vivo analysis of scaffold-associated regions in Drosophila: a synthetic high-affinity SAR binding protein suppresses position effect variegation. EMBO J 1998 1.23
88 Identification of target genes of the homeotic gene Antennapedia by enhancer detection. Genes Dev 1991 1.22
89 Comparison of homeobox-containing genes of the honeybee and Drosophila. Proc Natl Acad Sci U S A 1989 1.21
90 Functional specificity of the homeodomain protein fushi tarazu: the role of DNA-binding specificity in vivo. Proc Natl Acad Sci U S A 1993 1.20
91 The use of 'normal' and 'transformed' gynandromorphs in mapping the primordial germ cells and the gonadal mesoderm in Drosophila. J Embryol Exp Morphol 1976 1.20
92 The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development. Development 1994 1.20
93 Transgenic planarian lines obtained by electroporation using transposon-derived vectors and an eye-specific GFP marker. Proc Natl Acad Sci U S A 2003 1.20
94 Three maternal coordinate systems cooperate in the patterning of the Drosophila head. Development 1994 1.19
95 Searching for the prototypic eye genetic network: Sine oculis is essential for eye regeneration in planarians. Proc Natl Acad Sci U S A 2000 1.19
96 Functional redundancy: the respective roles of the two sloppy paired genes in Drosophila segmentation. Proc Natl Acad Sci U S A 1994 1.19
97 Event-related brain potentials and error-related processing: an analysis of incorrect responses to go and no-go stimuli. Psychophysiology 1996 1.18
98 Distamycin-induced inhibition of homeodomain-DNA complexes. EMBO J 1992 1.18
99 Molecular analysis of large transposable elements carrying the white locus of Drosophila melanogaster. EMBO J 1983 1.16
100 Isolation of a Pax-6 homolog from the ribbonworm Lineus sanguineus. Proc Natl Acad Sci U S A 1996 1.15
101 In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster. Genes Dev 1992 1.14
102 Homeotic genes, the homeo box, and the genetic control of development. Cold Spring Harb Symp Quant Biol 1985 1.13
103 Notch signaling and the determination of appendage identity. Proc Natl Acad Sci U S A 2000 1.12
104 Genetic control of development of the mushroom bodies, the associative learning centers in the Drosophila brain, by the eyeless, twin of eyeless, and Dachshund genes. Proc Natl Acad Sci U S A 2000 1.12
105 Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila. Neuron 1995 1.11
106 Effects of ectopic expression of caudal during Drosophila development. Development 1990 1.11
107 Ultrastructural studies of oocytes and embryos derived from females flies carrying the grandchildless mutation in Drosophila subobscura. Dev Biol 1979 1.09
108 The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen. Development 1997 1.07
109 Isolation and developmental expression of the amphioxus Pax-6 gene (AmphiPax-6): insights into eye and photoreceptor evolution. Development 1998 1.06
110 In situ hybridization at the electron microscope level: localization of transcripts on ultrathin sections of Lowicryl K4M-embedded tissue using biotinylated probes and protein A-gold complexes. J Cell Biol 1986 1.04
111 Isolation and characterization of drosocrystallin, a lens crystallin gene of Drosophila melanogaster. Dev Biol 1999 1.04
112 Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila. Proc Natl Acad Sci U S A 1996 1.03
113 The eyeless homeodomain is dispensable for eye development in Drosophila. Genes Dev 2001 1.03
114 Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina. Proc Natl Acad Sci U S A 1999 1.02
115 Occurrence of sialic acids in Drosophila melanogaster. Science 1992 1.01
116 Conservation of Pax-6 in a lower chordate, the ascidian Phallusia mammillata. Development 1997 0.98
117 Pax gene diversity in the basal cnidarian Acropora millepora (Cnidaria, Anthozoa): implications for the evolution of the Pax gene family. Proc Natl Acad Sci U S A 2000 0.97
118 A new method for the purification of DNA-binding proteins with sequence specificity. Eur J Biochem 1980 0.96
119 Homeobox genes in the ribbonworm Lineus sanguineus: evolutionary implications. Proc Natl Acad Sci U S A 1998 0.95
120 Molecular basis for the inhibition of Drosophila eye development by Antennapedia. EMBO J 2001 0.95
121 Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development. Mech Dev 2001 0.95
122 Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development. Proc Natl Acad Sci U S A 1998 0.94
123 A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax. Dev Biol 1997 0.94
124 Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila. Development 1998 0.94
125 Analysis of a fushi tarazu autoregulatory element: multiple sequence elements contribute to enhancer activity. EMBO J 1993 0.93
126 Characterization of Drosophila DNA-binding protein DB-2: demonstration of its sequence-specific interaction with DNA. Proc Natl Acad Sci U S A 1980 0.89
127 Purification of a protein from unfertilized eggs of Drosophila with specific affinity for a defined DNA sequence and the cloning of this DNA sequence in bacterial plasmids. Cold Spring Harb Symp Quant Biol 1978 0.88
128 Similarities between the homeodomain and the Hin recombinase DNA-binding domain. Cell 1991 0.88
129 Differentiation markers in the Drosophila ovary. J Embryol Exp Morphol 1984 0.88
130 Dissecting the complexity of the nervous system by enhancer detection. Bioessays 1990 0.88
131 Stage-specific phosphorylation of the fushi tarazu protein during Drosophila development. EMBO J 1989 0.87
132 Characterization and expression analysis of an ancestor-type Pax gene in the hydrozoan jellyfish Podocoryne carnea. Mech Dev 2000 0.87
133 The des(1-6)antennapedia homeodomain: comparison of the NMR solution structure and the DNA-binding affinity with the intact Antennapedia homeodomain. Proc Natl Acad Sci U S A 1994 0.86
134 A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs. Mech Dev 1997 0.85
135 Homeotic genes, the homeobox, and the spatial organization of the embryo. Harvey Lect 1988 0.84
136 Establishment of a Drosophila gene bank in a bacterial plasmids: Elizabeth Goldschmidt Memorial Lecture. Isr J Med Sci 1978 0.84
137 Protein blotting as a means to detect sequence-specific DNA-binding proteins. Cold Spring Harb Symp Quant Biol 1983 0.84
138 The anterior cingulate cortex lends a hand in response selection. Nat Neurosci 1999 0.84
139 Regional repression of a Drosophila POU box gene in the endoderm involves inductive interactions between germ layers. Development 1993 0.83
140 Dominant-negative form of the Pax6 homolog eyeless for tissue-specific loss-of-function studies in the developing eye and brain in drosophila. Genesis 2002 0.81
141 A hybrid plasmid containing Drosophila melanogaster DNA sequences complementary to the large mitochondrial ribosomal RNA. Gene 1981 0.80
142 Homeodomain proteins in development and therapy. Pharmacol Ther 1994 0.80
143 Expression of homeotic mutations in duplicated and regenerated antennae of Drosophila melanogaster. J Embryol Exp Morphol 1975 0.79
144 Morphologic and molecular changes in target cells during in vitro interaction with macrophages. Exp Cell Biol 1976 0.78
145 Response: eye evolution. Science 1996 0.78
146 The molecular basis of development. Sci Am 1985 0.77
147 Gene duplication and recruitment of a specific tropomyosin into striated muscle cells in the jellyfish Podocoryne carnea. J Exp Zool 1999 0.77
148 On the homeobox and its significance. Bioessays 1986 0.76
149 Reverse homeosis in homeotically reconstructed ribbonworms. Proc Natl Acad Sci U S A 1999 0.75
150 Readiness potential. Neurology 1994 0.75
151 Quox-1, a quail homeobox gene expressed in the embryonic central nervous system, including the forebrain. Proc Natl Acad Sci U S A 1991 0.75
152 The location, modification, and function of the fushi tarazu protein during Drosophila embryogenesis. Prog Clin Biol Res 1988 0.75
153 Second Swiss Drosophila workshop 1977 in Berne. Arch Genet (Zur) 1980 0.75
154 Isolation and functional comparison of Dmyd, the Drosophila homologue of the vertebrate myogenic determination genes, with CMD1. Symp Soc Exp Biol 1992 0.75
155 Ernst Hadorn: 1902-1976. Mol Gen Genet 1977 0.75
156 Ernst Hadorn (1902-1976). Dev Biol 1976 0.75
157 Insect molecular biology on Crete. Nature 1978 0.75
158 Functional expression of a locust visual pigment in transgenic Drosophila melanogaster. Eur J Biochem 2000 0.75
159 Purification of two proteins with specific affinity for defined DNA sequences from Drosophila and cloning of these sequences in bacterial plasmids [proceedings]. Ann Microbiol (Paris) 1979 0.75
160 P-element-mediated enhancer detection allows rapid identification of developmentally regulated genes and cell specific markers in Drosophila. J Physiol (Paris) 1990 0.75
161 Genetic control of determination in the Drosophila embryo. Symp Soc Dev Biol 1973 0.75
162 Continuous versus discrete information processing: evidence from movement-related potentials. Electroencephalogr Clin Neurophysiol Suppl 1991 0.75