Published in Proc Natl Acad Sci U S A on October 27, 2009
The neuronal organization of the retina. Neuron (2012) 3.13
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology (2010) 2.31
Transient receptor potential channelopathies. Pflugers Arch (2010) 1.40
TRPM1: the endpoint of the mGluR6 signal transduction cascade in retinal ON-bipolar cells. Bioessays (2010) 1.37
TRPM1 mutations are associated with the complete form of congenital stationary night blindness. Mol Vis (2010) 1.37
GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet (2012) 1.33
Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons. Proc Natl Acad Sci U S A (2012) 1.26
Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet (2012) 1.25
A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites. J Neurosci (2011) 1.24
Multiple pathways of inhibition shape bipolar cell responses in the retina. Vis Neurosci (2010) 1.21
Whole-exome sequencing identifies LRIT3 mutations as a cause of autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet (2012) 1.18
TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner. J Neurosci (2011) 1.17
Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction. PLoS One (2011) 1.12
Kainate receptors mediate signaling in both transient and sustained OFF bipolar cell pathways in mouse retina. J Neurosci (2014) 1.10
RGS7 and -11 complexes accelerate the ON-bipolar cell light response. Invest Ophthalmol Vis Sci (2009) 1.10
Teleost polarization vision: how it might work and what it might be good for. Philos Trans R Soc Lond B Biol Sci (2011) 1.06
Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation. J Neurophysiol (2012) 1.05
Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool. PLoS Biol (2015) 1.04
Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions. J Biol Chem (2011) 1.04
Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter. EMBO Mol Med (2014) 1.04
Roles of ON cone bipolar cell subtypes in temporal coding in the mouse retina. J Neurosci (2014) 1.03
The Role of TRP Proteins in Mast Cells. Front Immunol (2012) 1.02
Autoantibodies in melanoma-associated retinopathy target TRPM1 cation channels of retinal ON bipolar cells. J Neurosci (2011) 1.02
Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice. J Biol Chem (2012) 1.01
G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer. Proc Natl Acad Sci U S A (2012) 1.00
mGluR6 deletion renders the TRPM1 channel in retina inactive. J Neurophysiol (2011) 1.00
TRPM channels modulate epileptic-like convulsions via systemic ion homeostasis. Curr Biol (2011) 0.99
Mouse b-wave mutants. Doc Ophthalmol (2014) 0.97
TRP channel gene expression in the mouse retina. Vision Res (2011) 0.96
Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception. Eur J Neurosci (2012) 0.95
Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer. J Clin Invest (2015) 0.95
R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells. Vis Neurosci (2010) 0.95
Evidence for a retroviral insertion in TRPM1 as the cause of congenital stationary night blindness and leopard complex spotting in the horse. PLoS One (2013) 0.95
Coordinated control of sensitivity by two splice variants of Gα(o) in retinal ON bipolar cells. J Gen Physiol (2010) 0.94
Differential function of Gγ13 in rod bipolar and ON cone bipolar cells. J Physiol (2015) 0.93
Neuronal remodeling in retinal circuit assembly, disassembly, and reassembly. Trends Neurosci (2014) 0.92
Light-evoked responses of the retinal pigment epithelium: changes accompanying photoreceptor loss in the mouse. J Neurophysiol (2010) 0.92
Intersecting circuits generate precisely patterned retinal waves. Neuron (2013) 0.92
Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB). PLoS One (2014) 0.89
GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells. J Neurosci (2014) 0.88
Visual threshold is set by linear and nonlinear mechanisms in the retina that mitigate noise: how neural circuits in the retina improve the signal-to-noise ratio of the single-photon response. Bioessays (2011) 0.87
PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform. Front Mol Neurosci (2014) 0.87
Synaptic remodeling generates synchronous oscillations in the degenerated outer mouse retina. Front Neural Circuits (2014) 0.86
Presence of the Gpr179(nob5) allele in a C3H-derived transgenic mouse. Mol Vis (2013) 0.86
Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina. PLoS One (2012) 0.86
Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons. Invest Ophthalmol Vis Sci (2013) 0.85
Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina. Vision Res (2010) 0.85
Illuminating the multifaceted roles of neurotransmission in shaping neuronal circuitry. Neuron (2014) 0.84
Relief of Mg²⁺-dependent inhibition of TRPM1 by PKCα at the rod bipolar cell synapse. J Neurosci (2011) 0.84
Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness. Hum Mol Genet (2015) 0.84
Complexity of retinal cone bipolar cells. Prog Retin Eye Res (2010) 0.84
Serum TRPM1 autoantibodies from melanoma associated retinopathy patients enter retinal on-bipolar cells and attenuate the electroretinogram in mice. PLoS One (2013) 0.83
Biallelic Mutations in GNB3 Cause a Unique Form of Autosomal-Recessive Congenital Stationary Night Blindness. Am J Hum Genet (2016) 0.83
A novel role for the immunoproteasome in retinal function. Invest Ophthalmol Vis Sci (2011) 0.83
Astrocytes in the optic nerve head express putative mechanosensitive channels. Mol Vis (2015) 0.83
Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes. Pigment Cell Melanoma Res (2013) 0.82
TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision. Cells (2014) 0.82
Voriconazole, an antifungal triazol that causes visual side effects, is an inhibitor of TRPM1 and TRPM3 channels. Invest Ophthalmol Vis Sci (2015) 0.82
Retinal cell death induced by TRPV1 activation involves NMDA signaling and upregulation of nitric oxide synthases. Cell Mol Neurobiol (2013) 0.82
Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. PLoS One (2012) 0.81
Functional and structural studies of TRP channels heterologously expressed in budding yeast. Adv Exp Med Biol (2011) 0.81
"mGlu Receptors in the Retina" - WIREs Membrane Transport and Signaling. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.81
Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy. BMC Ophthalmol (2012) 0.81
Ion transport in pigmentation. Arch Biochem Biophys (2014) 0.81
Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication. Cell Res (2016) 0.80
Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy. PLoS One (2013) 0.80
TRPM channels: same ballpark, different players, and different rules in immunogenetics. Immunogenetics (2011) 0.79
LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation. Eur J Neurosci (2015) 0.79
Diagnosis of occult melanoma using transient receptor potential melastatin 1 (TRPM1) autoantibody testing: a novel approach. Ophthalmology (2013) 0.78
mGluR6 transcripts in non-neuronal tissues. J Histochem Cytochem (2011) 0.78
Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements. Invest Ophthalmol Vis Sci (2014) 0.78
Vertebrate vision: TRP channels in the spotlight. Curr Biol (2010) 0.78
Characterization of Trpm1 desensitization in ON bipolar cells and its role in downstream signalling. J Physiol (2011) 0.78
Transient receptor potential melastatin 1: a hair cell transduction channel candidate. PLoS One (2013) 0.77
Ocular transient receptor potential channel function in health and disease. BMC Ophthalmol (2015) 0.77
Behavioural and physiological limits to vision in mammals. Philos Trans R Soc Lond B Biol Sci (2017) 0.76
Response properties of slow PIII in the Large (vls) mutant. Doc Ophthalmol (2012) 0.76
Topological analysis of small leucine-rich repeat proteoglycan nyctalopin. PLoS One (2012) 0.76
Autoantibodies to transient receptor potential cation channel, subfamily M, member 1 in a Japanese patient with melanoma-associated retinopathy. Jpn J Ophthalmol (2014) 0.76
TRPM3 expression in mouse retina. PLoS One (2015) 0.76
Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. Mol Brain (2016) 0.76
A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness. PLoS One (2015) 0.76
Identification of a new mutant allele, Grm6(nob7), for complete congenital stationary night blindness. Vis Neurosci (2015) 0.76
Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior. Elife (2015) 0.76
Oligomeric state of purified transient receptor potential melastatin-1 (TRPM1), a protein essential for dim light vision. J Biol Chem (2014) 0.76
Secondary glaucoma as initial manifestation of ring melanoma: a case report and review of literature. Int J Clin Exp Pathol (2014) 0.75
15q13.3 homozygous knockout mouse model display epilepsy-, autism- and schizophrenia-related phenotypes. Transl Psychiatry (2016) 0.75
The Effect of PKCα on the Light Response of Rod Bipolar Cells in the Mouse Retina. Invest Ophthalmol Vis Sci (2015) 0.75
LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells. Invest Ophthalmol Vis Sci (2017) 0.75
G protein signaling in the retina and beyond: the Cogan lecture. Invest Ophthalmol Vis Sci (2014) 0.75
Alterations in Kainate Receptor and TRPM1 Localization in Bipolar Cells after Retinal Photoreceptor Degeneration. Front Cell Neurosci (2015) 0.75
Physical aspects of sensory transduction on seeing, hearing and smelling. Biophysics (Nagoya-shi) (2013) 0.75
Ultrastructural localization of GPR179 and the impact of mutant forms on retinal function in CSNB1 patients and a mouse model. Invest Ophthalmol Vis Sci (2013) 0.75
ON-OFF Interactions in the Retina: Role of Glycine and GABA. Curr Neuropharmacol (2014) 0.75
The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors. Neuron (2017) 0.75
The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go. Sci Rep (2016) 0.75
Photopharmacological control of bipolar cells restores visual function in blind mice. J Clin Invest (2017) 0.75
Autoantibodies in Melanoma-Associated Retinopathy Recognize an Epitope Conserved Between TRPM1 and TRPM3. Invest Ophthalmol Vis Sci (2017) 0.75
Mouse retinal ganglion cell signalling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways. J Physiol (2017) 0.75
TRP channels. Annu Rev Biochem (2007) 8.09
2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research. Science (1981) 4.63
Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron (1989) 3.79
The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors. Neuron (1992) 3.19
Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness. Nat Genet (2000) 2.70
Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene. Neuron (1992) 2.58
Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res (1998) 2.43
The Drosophila light-activated conductance is composed of the two channels TRP and TRPL. Cell (1996) 2.41
Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. Proc Natl Acad Sci U S A (2005) 2.36
A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells. J Neurosci (2009) 2.35
Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells. Nature (1990) 2.31
Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell (1994) 2.20
Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus). Genetics (2008) 2.15
Functions of the ON and OFF channels of the visual system. Nature (1986) 2.14
The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein. Nat Genet (2000) 2.08
Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein. Proc Biol Sci (1990) 1.95
Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nat Rev Neurosci (2007) 1.89
TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal (2009) 1.75
Identification of molecular markers of bipolar cells in the murine retina. J Comp Neurol (2008) 1.68
Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram. Invest Ophthalmol Vis Sci (2005) 1.57
Abnormal activation and inactivation mechanisms of rod transduction in patients with autosomal dominant retinitis pigmentosa and the pro-23-his mutation. Invest Ophthalmol Vis Sci (1995) 1.56
The light-activated signaling pathway in SCN-projecting rat retinal ganglion cells. Eur J Neurosci (2006) 1.52
Response characteristics and receptive field widths of on-bipolar cells in the mouse retina. J Physiol (2000) 1.49
Localization of nyctalopin in the mammalian retina. Eur J Neurosci (2006) 1.44
Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice. Proc Natl Acad Sci U S A (2003) 1.31
Human melanoma-associated retinopathy (MAR) antibodies alter the retinal ON-response of the monkey ERG in vivo. Invest Ophthalmol Vis Sci (2000) 1.29
Expression and Up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells. Biochem Biophys Res Commun (2000) 1.26
Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1). Genomics (1998) 1.26
The developmental sequence of gene expression within the rod photoreceptor lineage in embryonic zebrafish. Dev Dyn (2008) 1.06
Syngeneic Schwann cell transplantation preserves vision in RCS rat without immunosuppression. Invest Ophthalmol Vis Sci (2007) 1.05
Isolation of ON bipolar cell genes via hrGFP-coupled cell enrichment using the mGluR6 promoter. J Biochem (2009) 0.97
Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17. Curr Biol (2006) 2.36
Intrinsic light responses of retinal ganglion cells projecting to the circadian system. Eur J Neurosci (2003) 1.58
The light-activated signaling pathway in SCN-projecting rat retinal ganglion cells. Eur J Neurosci (2006) 1.52
Melanopsin forms a functional short-wavelength photopigment. Biochemistry (2003) 1.39
TRPM1: the endpoint of the mGluR6 signal transduction cascade in retinal ON-bipolar cells. Bioessays (2010) 1.37
Gbeta5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar cells. Eur J Neurosci (2007) 1.32
Synaptic inputs to retinal ganglion cells that set the circadian clock. Eur J Neurosci (2006) 1.28
Differential loss and preservation of glutamate receptor function in bipolar cells in the rd10 mouse model of retinitis pigmentosa. Eur J Neurosci (2009) 1.23
Functional role of lipid raft microdomains in cyclic nucleotide-gated channel activation. Mol Pharmacol (2004) 1.21
Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A (2006) 1.19
Photochemistry of retinal chromophore in mouse melanopsin. Proc Natl Acad Sci U S A (2008) 1.16
Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse. J Neurosci (2004) 1.15
RGS7 and -11 complexes accelerate the ON-bipolar cell light response. Invest Ophthalmol Vis Sci (2009) 1.10
Alternative splicing unmasks dendritic and axonal targeting signals in metabotropic glutamate receptor 1. J Neurosci (2002) 1.08
Subretinal transplantation of forebrain progenitor cells in nonhuman primates: survival and intact retinal function. Invest Ophthalmol Vis Sci (2009) 1.04
Anti-recoverin antibodies induce an increase in intracellular calcium, leading to apoptosis in retinal cells. J Autoimmun (2006) 1.03
Purification and cloning of toxins from elapid venoms that target cyclic nucleotide-gated ion channels. Biochemistry (2002) 0.99
High-level expression of rabbit 15-lipoxygenase induces collapse of the mitochondrial pH gradient in cell culture. Biochemistry (2004) 0.96
R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells. Vis Neurosci (2010) 0.95
Measures of anxiety, sensorimotor function, and memory in male and female mGluR4⁻/⁻ mice. Behav Brain Res (2012) 0.94
Structures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domain. Acta Crystallogr D Biol Crystallogr (2008) 0.93
TonB interacts with nonreceptor proteins in the outer membrane of Escherichia coli. J Bacteriol (2002) 0.91
Divalent cations modulate the activity of metabotropic glutamate receptors. J Neurosci Res (2004) 0.90
Defective trafficking of cone photoreceptor CNG channels induces the unfolded protein response and ER-stress-associated cell death. Biochem J (2012) 0.89
Distribution of group-III metabotropic glutamate receptors in the retina. J Comp Neurol (2007) 0.88
Retinal sensitivity loss in third-generation n-3 PUFA-deficient rats. Lipids (2002) 0.87
Phosphorylation of mouse melanopsin by protein kinase A. PLoS One (2012) 0.86
Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies. J Med Chem (2005) 0.86
The development of melanopsin-containing retinal ganglion cells in mice with early retinal degeneration. Eur J Neurosci (2009) 0.85
Effects of site-directed mutagenesis of mglA on motility and swarming of Myxococcus xanthus. BMC Microbiol (2010) 0.84
Role of mGluR4 in acquisition of fear learning and memory. Neuropharmacology (2012) 0.84
Serum TRPM1 autoantibodies from melanoma associated retinopathy patients enter retinal on-bipolar cells and attenuate the electroretinogram in mice. PLoS One (2013) 0.83
mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. Neuropsychopharmacology (2011) 0.83
Preschool Worth 4-Shape test: testability, reliability, and validity. J AAPOS (2002) 0.82
Visual development: Neural basis and new assessment methods. J Pediatr (2003) 0.82
Measurement of stereoacuity outcomes at ages 1 to 24 months: Randot Stereocards. J AAPOS (2005) 0.81
Sorting out co-occurrence of rare monogenic retinopathies: Stargardt disease co-existing with congenital stationary night blindness. Ophthalmic Genet (2014) 0.81
Matrix metalloproteinase-9 and -2 enhance the ligand sensitivity of photoreceptor cyclic nucleotide-gated channels. Channels (Austin) (2012) 0.81
Anatomy of the posterior caudal lobe of the cerebellum and the eminentia granularis posterior in a mormyrid fish. J Comp Neurol (2007) 0.81
Diagnosis of occult melanoma using transient receptor potential melastatin 1 (TRPM1) autoantibody testing: a novel approach. Ophthalmology (2013) 0.78
Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating. Biochemistry (2013) 0.78
Related functions of mGlu4 and mGlu8. Pharmacol Biochem Behav (2013) 0.77
Mice with early retinal degeneration show differences in neuropeptide expression in the suprachiasmatic nucleus. Behav Brain Funct (2010) 0.76
[Endoscopic intrasellar tumor surgery]. Zhonghua Er Bi Yan Hou Ke Za Zhi (2002) 0.76
Novel metabotropic glutamate receptor 4 and glutamate receptor 8 therapeutics for the treatment of anxiety. Expert Opin Investig Drugs (2014) 0.76
γ-glutamyl Spermine Synthetase PauA2 as a potential target of antibiotic development against Pseudomonas aeruginosa. Antimicrob Agents Chemother (2012) 0.76
Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds. Neuropharmacology (2012) 0.75
Tyrosine kinase inhibitors enhance ciprofloxacin-induced phototoxicity by inhibiting ABCG2. Oncology (2014) 0.75
Evaluation of the effect of TM208 on the activity of five cytochrome P450 enzymes using on-line solid-phase extraction HPLC-DAD: a cocktail approach. J Chromatogr B Analyt Technol Biomed Life Sci (2013) 0.75
Metabolic profiling study on potential toxicity and immunotoxicity-biomarker discovery in rats treated with cyclophosphamide using HPLC-ESI-IT-TOF-MS. Biomed Chromatogr (2014) 0.75
Pioglitazone lowers serum retinol binding protein 4 by suppressing its expression in adipose tissue of obese rats. Cell Physiol Biochem (2015) 0.75
Enhancement of nitrate removal in synthetic groundwater using wheat rice stone. Water Sci Technol (2012) 0.75
[Some bio-chemical indice change of rats striatum poisoned by rotenone]. Wei Sheng Yan Jiu (2010) 0.75