Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMC 2868927)

Published in Am J Med Genet B Neuropsychiatr Genet on April 05, 2010

Authors

P E Adams1, J S Adams, D V Nguyen, D Hessl, J A Brunberg, F Tassone, W Zhang, K Koldewyn, S M Rivera, J Grigsby, L Zhang, C Decarli, P J Hagerman, R J Hagerman

Author Affiliations

1: M.I.N.D. Institute, University of California, Davis Health System, Sacramento, California, USA.

Articles citing this

Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome. Lancet Neurol (2013) 2.41

Advances in understanding the molecular basis of FXTAS. Hum Mol Genet (2010) 1.83

Emerging topics in FXTAS. J Neurodev Disord (2014) 1.47

Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS. Genes Brain Behav (2012) 1.44

Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms. Acta Neuropathol (2013) 1.41

Widespread non-central nervous system organ pathology in fragile X premutation carriers with fragile X-associated tremor/ataxia syndrome and CGG knock-in mice. Acta Neuropathol (2011) 1.39

Fragile X: leading the way for targeted treatments in autism. Neurotherapeutics (2010) 1.31

Fragile X-associated disorders: a clinical overview. J Neurol (2011) 1.13

Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model. J Neurochem (2012) 1.10

A voxel-based morphometry study of grey matter loss in fragile X-associated tremor/ataxia syndrome. Brain (2011) 1.09

Temporal ordering deficits in female CGG KI mice heterozygous for the fragile X premutation. Behav Brain Res (2010) 1.07

Motor deficits on a ladder rung task in male and female adolescent and adult CGG knock-in mice. Behav Brain Res (2011) 1.04

Immune-mediated disorders among women carriers of fragile X premutation alleles. Am J Med Genet A (2012) 1.04

Defining genetically meaningful language and personality traits in relatives of individuals with fragile X syndrome and relatives of individuals with autism. Am J Med Genet B Neuropsychiatr Genet (2012) 0.96

Associated features in females with an FMR1 premutation. J Neurodev Disord (2014) 0.94

Improving fragile X-associated tremor/ataxia syndrome symptoms with memantine and venlafaxine. J Clin Psychopharmacol (2010) 0.93

PSYCHIATRIC DISORDERS ASSOCIATED WITH FXTAS. Curr Psychiatry Rev (2015) 0.87

Spatiotemporal processing deficits in female CGG KI mice modeling the fragile X premutation. Behav Brain Res (2012) 0.87

Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders. Prog Neurobiol (2012) 0.86

The cognitive neuropsychological phenotype of carriers of the FMR1 premutation. J Neurodev Disord (2014) 0.85

Prepulse inhibition in patients with fragile X-associated tremor ataxia syndrome. Neurobiol Aging (2010) 0.84

Unstable mutations in the FMR1 gene and the phenotypes. Adv Exp Med Biol (2012) 0.84

A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers Using CATSYS. Curr Gerontol Geriatr Res (2011) 0.82

Phenotypes of hypofrontality in older female fragile X premutation carriers. Ann Neurol (2013) 0.81

Molecular Advances Leading to Treatment Implications for Fragile X Premutation Carriers. Brain Disord Ther (2014) 0.81

Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding. Front Hum Neurosci (2012) 0.80

COGNITIVE DYSFUNCTION IN FMR1 PREMUTATION CARRIERS. Curr Psychiatry Rev (2013) 0.79

Advances in the Understanding of the Gabaergic Neurobiology of FMR1 Expanded Alleles Leading to Targeted Treatments for Fragile X Spectrum Disorder. Curr Pharm Des (2015) 0.79

Towards an Understanding of Neuropsychiatric Manifestations in Fragile X Premutation Carriers. Future Neurol (2014) 0.78

Investigation of amygdala volume in men with the fragile X premutation. Brain Imaging Behav (2011) 0.77

Fragile X syndrome: a pilot proton magnetic resonance spectroscopy study in premutation carriers. J Neurodev Disord (2012) 0.76

Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety. J Neurodev Disord (2017) 0.75

Implications of the FMR1 Premutation for Children, Adolescents, Adults, and Their Families. Pediatrics (2017) 0.75

Clinical and molecular correlates in fragile X premutation females. eNeurologicalSci (2017) 0.75

Articles cited by this

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (2003) 16.14

Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome. Am J Hum Genet (2000) 6.73

Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X. Neurology (2001) 6.55

Fragile X premutation tremor/ataxia syndrome: molecular, clinical, and neuroimaging correlates. Am J Hum Genet (2003) 5.51

Hippocampal volume reduction in major depression. Am J Psychiatry (2000) 5.04

Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry (2000) 4.99

Regional dissociations within the hippocampus--memory and anxiety. Neurosci Biobehav Rev (2004) 4.44

Neuronal intranuclear inclusions in a new cerebellar tremor/ataxia syndrome among fragile X carriers. Brain (2002) 4.05

Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS). Brain (2005) 3.99

The fragile-X premutation: a maturing perspective. Am J Hum Genet (2004) 3.89

Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data. Am J Med Genet (1999) 3.82

A rapid polymerase chain reaction-based screening method for identification of all expanded alleles of the fragile X (FMR1) gene in newborn and high-risk populations. J Mol Diagn (2007) 3.80

Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J Neurosci (1993) 3.11

The fragile X prevalence paradox. J Med Genet (2008) 3.05

Association of FMR1 repeat size with ovarian dysfunction. Hum Reprod (2004) 3.01

Expanded clinical phenotype of women with the FMR1 premutation. Am J Med Genet A (2008) 2.91

Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry (2000) 2.87

Fragile X-associated tremor/ataxia syndrome: clinical features, genetics, and testing guidelines. Mov Disord (2007) 2.68

Fragile X premutation carriers: characteristic MR imaging findings of adult male patients with progressive cerebellar and cognitive dysfunction. AJNR Am J Neuroradiol (2002) 2.58

Mood and anxiety disorders in females with the FMR1 premutation. Am J Med Genet B Neuropsychiatr Genet (2009) 2.37

Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation. Am J Med Genet B Neuropsychiatr Genet (2005) 2.35

Fragile-X-associated tremor/ataxia syndrome (FXTAS) in females with the FMR1 premutation. Am J Hum Genet (2004) 2.33

FMRP expression as a potential prognostic indicator in fragile X syndrome. Am J Med Genet (1999) 2.23

Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells. Hum Mol Genet (2005) 2.17

Penetrance of FMR1 premutation associated pathologies in fragile X syndrome families. Eur J Hum Genet (2009) 2.16

Ventral hippocampal lesions affect anxiety but not spatial learning. Behav Brain Res (2003) 2.12

Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1. Lancet Neurol (2007) 2.00

A review of fragile X premutation disorders: expanding the psychiatric perspective. J Clin Psychiatry (2009) 1.98

Genotype-phenotype relationship in female carriers of the premutation and full mutation of FMR-1. Psychiatry Res (1998) 1.95

Elevated FMR1 mRNA in premutation carriers is due to increased transcription. RNA (2007) 1.87

Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety. J Affect Disord (2000) 1.83

Psychiatric phenotype of the fragile X-associated tremor/ataxia syndrome (FXTAS) in males: newly described fronto-subcortical dementia. J Clin Psychiatry (2006) 1.80

FMR1 CGG repeat length predicts motor dysfunction in premutation carriers. Neurology (2007) 1.80

Progression of tremor and ataxia in male carriers of the FMR1 premutation. Mov Disord (2007) 1.77

Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS). Neurology (2007) 1.77

Intranuclear inclusions in neural cells with premutation alleles in fragile X associated tremor/ataxia syndrome. J Med Genet (2004) 1.77

Quantitative MRI of the hippocampus and amygdala in severe depression. Psychol Med (2000) 1.77

Impairment in the cognitive functioning of men with fragile X-associated tremor/ataxia syndrome (FXTAS). J Neurol Sci (2006) 1.75

CGG repeat length correlates with age of onset of motor signs of the fragile X-associated tremor/ataxia syndrome (FXTAS). Am J Med Genet B Neuropsychiatr Genet (2007) 1.66

Fragile X-associated tremor/ataxia syndrome presenting in a woman after chemotherapy. Neurology (2005) 1.63

Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus (2005) 1.58

Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems. Clin Interv Aging (2008) 1.57

Molecular and imaging correlates of the fragile X-associated tremor/ataxia syndrome. Neurology (2006) 1.55

Reproductive and menstrual history of females with fragile X expansions. Eur J Hum Genet (2000) 1.55

Fragile X-associated tremor/ataxia syndrome in sisters related to X-inactivation. Ann Neurol (2005) 1.48

Amygdala dysfunction in men with the fragile X premutation. Brain (2006) 1.46

Screening for fragile X syndrome in women of reproductive age. Prenat Diagn (2000) 1.46

A neuropsychological investigation of male premutation carriers of fragile X syndrome. Neuropsychologia (2004) 1.38

The emerging fragile X premutation phenotype: evidence from the domain of social cognition. Brain Cogn (2005) 1.38

Evidence for, and a spectrum of, neurological involvement in carriers of the fragile X pre-mutation: FXTAS and beyond. Clin Genet (2005) 1.37

Altered hypothalamus-pituitary-adrenal gland axis regulation in the expanded CGG-repeat mouse model for fragile X-associated tremor/ataxia syndrome. Psychoneuroendocrinology (2008) 1.31

Neurobehavioral phenotype in carriers of the fragile X premutation. Am J Med Genet (2001) 1.28

Effect of the fragile X status categories and the fragile X mental retardation protein levels on executive functioning in males and females with fragile X. Neuropsychology (2003) 1.25

Magnetic resonance imaging study in older fragile X premutation male carriers. Ann Neurol (2005) 1.16

FMR1 premutation as a rare cause of late onset ataxia--evidence for FXTAS in female carriers. J Neurol (2004) 1.15

Reduced Hippocampal Activation During Recall is Associated with Elevated FMR1 mRNA and Psychiatric Symptoms in Men with the Fragile X Premutation. Brain Imaging Behav (2008) 1.14

Neuropathy as a presenting feature in fragile X-associated tremor/ataxia syndrome. Am J Med Genet A (2007) 1.13

Volumetric brain imaging findings in mood disorders. Bipolar Disord (2002) 1.13

Factors associated with parenting stress in mothers of children with fragile X syndrome. J Dev Behav Pediatr (2003) 1.08

Dementia with mood symptoms in a fragile X premutation carrier with the fragile X-associated tremor/ataxia syndrome: clinical intervention with donepezil and venlafaxine. J Neuropsychiatry Clin Neurosci (2006) 1.08

Genetic influences on the neural basis of social cognition. Philos Trans R Soc Lond B Biol Sci (2006) 1.06

Cognitive impairment in a 65-year-old male with the fragile X-associated tremor-ataxia syndrome (FXTAS). Cogn Behav Neurol (2006) 1.01

Spastic paraparesis, cerebellar ataxia, and intention tremor: a severe variant of FXTAS? J Med Genet (2005) 0.98

Molecular/clinical correlations in females with fragile X. Am J Med Genet (1996) 0.93

Articles by these authors

The sequence of the human genome. Science (2001) 101.55

Serial analysis of gene expression. Science (1995) 60.15

Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med (1999) 14.30

Characterization of the yeast transcriptome. Cell (1997) 11.33

The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med (1996) 10.62

A public database for gene expression in human cancers. Cancer Res (1999) 8.81

Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med (1995) 8.23

PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95

14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20

Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome. Am J Hum Genet (2000) 6.73

Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X. Neurology (2001) 6.55

Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet (1982) 6.40

Analysis of human transcriptomes. Nat Genet (1999) 6.14

The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87

Evolution and phylogeny of Wolbachia: reproductive parasites of arthropods. Proc Biol Sci (1995) 5.70

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol (2001) 5.36

Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation (2000) 5.09

Ligand binding to integrins. J Biol Chem (2000) 4.94

American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) (2012) 4.82

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68

Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo. Radiology (1990) 4.42

Microarrays: handling the deluge of data and extracting reliable information. Trends Biotechnol (2001) 4.38

VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest (2000) 4.36

Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet (1999) 4.36

Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement. J Clin Virol (2004) 4.28

Delay or probability discounting in a model of impulsive behavior: effect of alcohol. J Exp Anal Behav (1999) 4.23

Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet (2000) 4.17

The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med (2000) 4.08

Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A (1994) 4.07

Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science (1997) 4.07

Neuronal intranuclear inclusions in a new cerebellar tremor/ataxia syndrome among fragile X carriers. Brain (2002) 4.05

Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS). Brain (2005) 3.99

A quantum dot single-photon turnstile device. Science (2000) 3.89

DNA supercoiling promotes formation of a bent repression loop in lac DNA. J Mol Biol (1987) 3.81

The genome reconstruction manager: a software environment for supporting high-throughput DNA sequencing. Genomics (1994) 3.69

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc (1997) 3.69

The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med (1992) 3.63

Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60

TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J (1998) 3.49

HIV-1 drug resistance in newly infected individuals. JAMA (1999) 3.49

An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene (2006) 3.48

Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest (1983) 3.41

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38

Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee--the MOVE consensus. Rheumatology (Oxford) (2004) 3.38

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity (1998) 3.36

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34

Analysis of effects of salts and uncharged solutes on protein and nucleic acid equilibria and processes: a practical guide to recognizing and interpreting polyelectrolyte effects, Hofmeister effects, and osmotic effects of salts. Adv Protein Chem (1998) 3.30

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity (2001) 3.29

Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene-b-poly(acrylic acid) Block Copolymers. Science (1995) 3.16

Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy. J Virol (1999) 3.15

A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med (1998) 3.15

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A (2000) 3.12

High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc (1992) 3.12

PUMA, a potent killer with or without p53. Oncogene (2008) 3.09

TraI, a LuxI homologue, is responsible for production of conjugation factor, the Ti plasmid N-acylhomoserine lactone autoinducer. Proc Natl Acad Sci U S A (1994) 3.08

Identification and classification of p53-regulated genes. Proc Natl Acad Sci U S A (1999) 3.07

Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00

Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res (2001) 2.98

Rickettsial relative associated with male killing in the ladybird beetle (Adalia bipunctata). J Bacteriol (1994) 2.97

Protein composition of the intranuclear inclusions of FXTAS. Brain (2005) 2.95

Isolation of an efficient actin promoter for use in rice transformation. Plant Cell (1990) 2.94

Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5. J Biol Chem (1995) 2.93

Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann Oncol (2013) 2.92

Sustained photobiological hydrogen gas production upon reversible inactivation of oxygen evolution in the green alga Chlamydomonas reinhardtii. Plant Physiol (2000) 2.92

Hydrogen peroxide is involved in abscisic acid-induced stomatal closure in Vicia faba. Plant Physiol (2001) 2.91

Sequence-directed curvature of DNA. Nature (1986) 2.89

Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. Proc Natl Acad Sci U S A (1999) 2.88

Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review. Ann Rheum Dis (2005) 2.88

Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience (2001) 2.84

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol (2001) 2.78

Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop. J Virol (1996) 2.77

A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet (2009) 2.76

Visualizing the kinetics of tumor-cell clearance in living animals. Proc Natl Acad Sci U S A (1999) 2.76

Investigation of the flexibility of DNA using transient electric birefringence. Biopolymers (1981) 2.74

NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature (2005) 2.74

Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res (2000) 2.71

Evidence for the existence of stable curvature of DNA in solution. Proc Natl Acad Sci U S A (1984) 2.67

Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66

Site-directed alkylation and the alternating access model for LacY. Proc Natl Acad Sci U S A (2006) 2.65

The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell (2001) 2.64

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol (1995) 2.62

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature (1994) 2.61

Sequence dependence of the curvature of DNA: a test of the phasing hypothesis. Biochemistry (1985) 2.60

Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. Br J Cancer (2009) 2.58

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci U S A (2001) 2.58

Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J Biol Chem (2001) 2.57