Published in Proc Natl Acad Sci U S A on November 12, 2009
A gene ontology inferred from molecular networks. Nat Biotechnol (2013) 2.95
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? Genes Dev (2010) 2.88
ATPase-dependent quality control of DNA replication origin licensing. Nature (2013) 2.72
Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell (2011) 2.54
Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell (2011) 2.40
Regulated eukaryotic DNA replication origin firing with purified proteins. Nature (2015) 2.07
Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast. EMBO J (2011) 1.94
Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading. Cell (2015) 1.75
Uncoupling of sister replisomes during eukaryotic DNA replication. Mol Cell (2010) 1.73
Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication. Science (2014) 1.69
Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA. Nat Struct Mol Biol (2013) 1.66
How dormant origins promote complete genome replication. Trends Biochem Sci (2011) 1.60
Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork. Nat Struct Mol Biol (2014) 1.59
MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. J Biol Chem (2011) 1.55
Regulating DNA replication in eukarya. Cold Spring Harb Perspect Biol (2013) 1.52
Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA. Mol Cell (2015) 1.50
Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis. Proc Natl Acad Sci U S A (2012) 1.44
Quality control in the initiation of eukaryotic DNA replication. Philos Trans R Soc Lond B Biol Sci (2011) 1.40
A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA. Genes Dev (2014) 1.40
DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome. Elife (2014) 1.40
Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. EMBO J (2012) 1.37
Structure of the eukaryotic MCM complex at 3.8 Å. Nature (2015) 1.35
The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks. Mol Cell (2013) 1.32
Helicase activation and establishment of replication forks at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.32
Mechanisms for initiating cellular DNA replication. Annu Rev Biochem (2013) 1.28
Helicase loading at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.26
Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases. EMBO J (2011) 1.25
Sister acts: coordinating DNA replication and cohesion establishment. Genes Dev (2010) 1.24
Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase. Mol Cell (2014) 1.23
Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function. Genes Dev (2014) 1.22
ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote. Proc Natl Acad Sci U S A (2012) 1.21
CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6. Genes Dev (2011) 1.16
Cdc45 is a critical effector of myc-dependent DNA replication stress. Cell Rep (2013) 1.16
A conserved MCM single-stranded DNA binding element is essential for replication initiation. Elife (2014) 1.15
Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. EMBO J (2012) 1.15
Crystal structure of the eukaryotic origin recognition complex. Nature (2015) 1.14
Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication. EMBO J (2014) 1.14
The bacterial DnaC helicase loader is a DnaB ring breaker. Cell (2013) 1.14
Replication timing and its emergence from stochastic processes. Trends Genet (2012) 1.12
The dynamics of replication licensing in live Caenorhabditis elegans embryos. J Cell Biol (2012) 1.11
Chromosome Duplication in Saccharomyces cerevisiae. Genetics (2016) 1.11
Multiple functions for Mcm2-7 ATPase motifs during replication initiation. Mol Cell (2014) 1.09
Origin plasticity during budding yeast DNA replication in vitro. EMBO J (2014) 1.08
Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat Struct Mol Biol (2016) 1.08
A structural framework for replication origin opening by AAA+ initiation factors. Curr Opin Struct Biol (2012) 1.06
Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy. Structure (2012) 1.06
The origin recognition complex: a biochemical and structural view. Subcell Biochem (2012) 1.05
MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. Genes Dev (2010) 1.04
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate. Nat Commun (2016) 1.04
Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase. Cell Rep (2015) 1.03
In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization. Nucleic Acids Res (2013) 1.03
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated. Chromosoma (2014) 1.03
Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation. Mol Cell Biol (2012) 1.02
Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation. J Cell Sci (2012) 1.02
The contribution of dormant origins to genome stability: from cell biology to human genetics. DNA Repair (Amst) (2014) 1.01
Origin DNA melting and unwinding in DNA replication. Curr Opin Struct Biol (2010) 1.01
Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload. J Cell Biol (2011) 1.00
Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement. Proc Natl Acad Sci U S A (2015) 0.99
Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts. Nucleic Acids Res (2013) 0.99
The replication initiation protein Sld2 regulates helicase assembly. J Biol Chem (2013) 0.99
Specificity and function of archaeal DNA replication initiator proteins. Cell Rep (2013) 0.99
Analysis of the crystal structure of an active MCM hexamer. Elife (2014) 0.98
Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication. Genes Cells (2013) 0.98
New insights into replisome fluidity during chromosome replication. Trends Biochem Sci (2012) 0.98
Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation. EMBO J (2016) 0.97
The replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplication. Genes (Basel) (2013) 0.97
Retracted The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly. J Biol Chem (2014) 0.96
Structure and evolutionary origins of the CMG complex. Chromosoma (2013) 0.96
Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex. J Biol Chem (2011) 0.95
Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem (2011) 0.95
The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level. Mol Cell (2015) 0.95
Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex. Proc Natl Acad Sci U S A (2012) 0.93
Mechanistic analysis of local ori melting and helicase assembly by the papillomavirus E1 protein. Mol Cell (2011) 0.93
Assembly of the transcription machinery: ordered and stable, random and dynamic, or both? Chromosoma (2011) 0.93
Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex. J Biol Chem (2015) 0.93
How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication. Mol Cell (2016) 0.92
Helicobacter pylori oriC--the first bipartite origin of chromosome replication in Gram-negative bacteria. Nucleic Acids Res (2012) 0.92
Activation of a human chromosomal replication origin by protein tethering. Nucleic Acids Res (2013) 0.92
Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos. Development (2011) 0.92
Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture. PLoS One (2012) 0.92
CRL2(Lrr1) promotes unloading of the vertebrate replisome from chromatin during replication termination. Genes Dev (2017) 0.91
Insights into bacteriophage T5 structure from analysis of its morphogenesis genes and protein components. J Virol (2013) 0.91
Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase. Proc Natl Acad Sci U S A (2015) 0.91
Molecular architecture of a multifunctional MCM complex. Nucleic Acids Res (2011) 0.90
Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits. J Biol Chem (2013) 0.89
Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle. EMBO J (2015) 0.89
RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans. G3 (Bethesda) (2016) 0.89
Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly. Genes Dev (2015) 0.89
Mcm10 coordinates the timely assembly and activation of the replication fork helicase. Nucleic Acids Res (2015) 0.88
Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology. Nucleic Acids Res (2013) 0.88
Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell (2013) 0.87
Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates. Mol Cell (2016) 0.87
Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase. J Biol Chem (2015) 0.86
Termination of DNA replication forks: "Breaking up is hard to do". Nucleus (2015) 0.86
Crystal structure of pb9, the distal tail protein of bacteriophage T5: a conserved structural motif among all siphophages. J Virol (2013) 0.86
Structural insights into the Cdt1-mediated MCM2-7 chromatin loading. Nucleic Acids Res (2011) 0.86
Phosphorylation of ORC2 protein dissociates origin recognition complex from chromatin and replication origins. J Biol Chem (2012) 0.86
Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome. J Biol Chem (2010) 0.85
Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition. J Biol Chem (2011) 0.85
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature (1992) 11.06
Two steps in the assembly of complexes at yeast replication origins in vivo. Cell (1994) 6.42
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol (2006) 6.36
Uninterrupted MCM2-7 function required for DNA replication fork progression. Science (2000) 6.27
Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc Natl Acad Sci U S A (2006) 5.66
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A (1997) 5.51
ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication. Nature (1989) 4.64
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev (2007) 4.60
The structure and function of MCM from archaeal M. Thermoautotrophicum. Nat Struct Biol (2003) 4.27
ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell (1995) 4.23
Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev (2004) 4.19
Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature (2001) 3.98
An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature (1996) 3.89
Cell cycle regulation of DNA replication. Annu Rev Genet (2007) 3.80
Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. Science (1998) 3.63
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Natl Acad Sci U S A (2008) 3.29
Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol (2002) 3.12
Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase. Mol Cell (2006) 3.08
The Mcm2-7 complex has in vitro helicase activity. Mol Cell (2008) 3.08
ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication. Mol Cell (2004) 2.66
Molecular substructure of a viral receptor-recognition protein. The gp17 tail-fiber of bacteriophage T7. J Mol Biol (1988) 2.59
Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase. Trends Biochem Sci (2005) 2.53
Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. Mol Cell (1998) 2.49
On helicases and other motor proteins. Curr Opin Struct Biol (2008) 2.43
Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BMC Biochem (2001) 2.36
Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication. Mol Cell (2001) 2.28
Origin recognition and the chromosome cycle. FEBS Lett (2005) 2.22
Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture. J Biol Chem (2002) 2.01
Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading. Genes Dev (2007) 1.97
ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA. Nat Struct Mol Biol (2005) 1.92
A rotary pumping model for helicase function of MCM proteins at a distance from replication forks. EMBO Rep (2003) 1.86
Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol (2006) 1.80
Stepwise assembly of initiation proteins at budding yeast replication origins in vitro. Proc Natl Acad Sci U S A (2000) 1.69
Assembly of a double hexameric helicase. Mol Cell (2005) 1.59
The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation. Proc Natl Acad Sci U S A (2001) 1.54
Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication. J Biol Chem (2007) 1.36
Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication. EMBO J (2003) 1.30
Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro. Genes Cells (2006) 1.21
Overexpression of multisubunit replication factors in yeast. Methods (1999) 1.18
Unwinding the structure and function of the archaeal MCM helicase. Mol Microbiol (2009) 1.17
Stoichiometry of DnaA and DnaB protein in initiation at the Escherichia coli chromosomal origin. J Biol Chem (2001) 1.14
Double hexamer disruption and biochemical activities of Methanobacterium thermoautotrophicum MCM. J Biol Chem (2005) 1.13
The knockout mouse project. Nat Genet (2004) 7.80
Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature (2012) 6.37
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol (2008) 5.32
Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA. PLoS Biol (2003) 3.29
The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells (2010) 3.17
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression. Mol Cell (2006) 3.00
Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal (2010) 2.95
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. EMBO J (2004) 2.87
Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Mol Cell (2002) 2.81
Fiber formation across the bacterial outer membrane by the chaperone/usher pathway. Cell (2008) 2.69
The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature (2010) 2.50
Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins. Bioessays (2003) 2.50
Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J Cell Biol (2004) 2.48
Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo. Proc Natl Acad Sci U S A (2003) 2.36
Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Cell (2002) 2.34
The postsynaptic density proteins Homer and Shank form a polymeric network structure. Cell (2009) 2.27
VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion. EMBO J (2003) 2.23
The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. Science (2004) 2.18
Structure of a viral DNA gatekeeper at 10 A resolution by cryo-electron microscopy. EMBO J (2003) 2.16
Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization. J Biol Chem (2002) 2.12
Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature (2005) 2.08
Orc6 involved in DNA replication, chromosome segregation, and cytokinesis. Science (2002) 2.07
TraG-like proteins of DNA transfer systems and of the Helicobacter pylori type IV secretion system: inner membrane gate for exported substrates? J Bacteriol (2002) 2.04
Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue. Mol Microbiol (2005) 2.00
Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes Dev (2008) 1.96
Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles. J Physiol (2004) 1.96
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure (2009) 1.96
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol. Mol Microbiol (2005) 1.94
An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly. Mol Cell (2013) 1.94
ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA. Nat Struct Mol Biol (2005) 1.92
Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate. Mol Microbiol (2006) 1.92
Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing. EMBO J (2002) 1.89
Inhibitors selective for mycobacterial versus human proteasomes. Nature (2009) 1.89
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. Biochemistry (2006) 1.88
Principles and concepts of DNA replication in bacteria, archaea, and eukarya. Cold Spring Harb Perspect Biol (2013) 1.79
Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity. Mol Microbiol (2006) 1.79
Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. Proc Natl Acad Sci U S A (2006) 1.77
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. J Mol Biol (2008) 1.75
Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell (2010) 1.73
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev (2010) 1.71
Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol (2006) 1.71
Role of heteromultimers in the generation of myocardial transient outward K+ currents. Circ Res (2002) 1.68
Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature (2011) 1.67
Meier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplication. Genes Dev (2012) 1.66
Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA. Nat Struct Mol Biol (2013) 1.66
Dynamics of pre-replication complex proteins during the cell division cycle. Philos Trans R Soc Lond B Biol Sci (2004) 1.65
Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2007) 1.65
Orc1 controls centriole and centrosome copy number in human cells. Science (2009) 1.65
Streptococcus pyogenes pSM19035 requires dynamic assembly of ATP-bound ParA and ParB on parS DNA during plasmid segregation. Nucleic Acids Res (2008) 1.62
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nat Chem Biol (2011) 1.54
Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug. Nat Biotechnol (2009) 1.53
Projecting individualized absolute invasive breast cancer risk in Asian and Pacific Islander American women. J Natl Cancer Inst (2011) 1.51
Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells. J Biol Chem (2007) 1.49
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J (2006) 1.45
The ectodomain of the viral receptor YueB forms a fiber that triggers ejection of bacteriophage SPP1 DNA. J Biol Chem (2006) 1.45
The terminally redundant, nonpermuted genome of Listeria bacteriophage A511: a model for the SPO1-like myoviruses of gram-positive bacteria. J Bacteriol (2008) 1.44
The VirB4 family of proposed traffic nucleoside triphosphatases: common motifs in plasmid RP4 TrbE are essential for conjugation and phage adsorption. J Bacteriol (2003) 1.44
Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation. Nat Struct Mol Biol (2010) 1.40
NMR structure of the KaiC-interacting C-terminal domain of KaiA, a circadian clock protein: implications for KaiA-KaiC interaction. Proc Natl Acad Sci U S A (2004) 1.40
Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization. Proc Natl Acad Sci U S A (2010) 1.38
"Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substrates. Mol Cell (2010) 1.37
Bacterially derived 400 nm particles for encapsulation and cancer cell targeting of chemotherapeutics. Cancer Cell (2007) 1.36
Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication. J Biol Chem (2007) 1.36
Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle. J Physiol (2003) 1.36
Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. J Clin Invest (2012) 1.35
Bacillus subtilis bacteriophage SPP1 DNA packaging motor requires terminase and portal proteins. J Biol Chem (2003) 1.32
The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents. PLoS Genet (2009) 1.32
ATP-dependent assembly of the human origin recognition complex. J Biol Chem (2007) 1.32
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay. Proc Natl Acad Sci U S A (2002) 1.30
A molecular pathogenesis for transcription factor associated poly-alanine tract expansions. Hum Mol Genet (2004) 1.29
Novel virulent and broad-host-range Erwinia amylovora bacteriophages reveal a high degree of mosaicism and a relationship to Enterobacteriaceae phages. Appl Environ Microbiol (2011) 1.26
Formation of higher-order nuclear Rad51 structures is functionally linked to p21 expression and protection from DNA damage-induced apoptosis. J Cell Sci (2002) 1.26
The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2008) 1.25
Reversible suppression of an essential gene in adult mice using transgenic RNA interference. Proc Natl Acad Sci U S A (2011) 1.23
Replication-coupled chromatin assembly generates a neuronal bilateral asymmetry in C. elegans. Cell (2011) 1.22
Analysis of protein-DNA interactions using surface plasmon resonance. Adv Biochem Eng Biotechnol (2007) 1.20
Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome. J Biol Chem (2002) 1.18
RNA recognition and cleavage by the SARS coronavirus endoribonuclease. J Mol Biol (2006) 1.18
Protein secretion in the absence of ATP: the autotransporter, two-partner secretion and chaperone/usher pathways of gram-negative bacteria (review). Mol Membr Biol (2005) 1.17
PY54, a linear plasmid prophage of Yersinia enterocolitica with covalently closed ends. Mol Microbiol (2003) 1.16
Mutational analysis of the SARS virus Nsp15 endoribonuclease: identification of residues affecting hexamer formation. J Mol Biol (2005) 1.15
Quaternary organization of a phytochrome dimer as revealed by cryoelectron microscopy. Proc Natl Acad Sci U S A (2010) 1.14
Evidence for conservation of architecture and physical properties of Omp85-like proteins throughout evolution. Proc Natl Acad Sci U S A (2004) 1.14
Oligomeric state of the Escherichia coli metal transporter YiiP. J Biol Chem (2004) 1.14
Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2013) 1.13
Bacillus subtilis RecU protein cleaves Holliday junctions and anneals single-stranded DNA. Proc Natl Acad Sci U S A (2003) 1.13
Chinese herbal medicine Tianqi reduces progression from impaired glucose tolerance to diabetes: a double-blind, randomized, placebo-controlled, multicenter trial. J Clin Endocrinol Metab (2014) 1.13
Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease. J Biol Chem (2003) 1.13
Homologous-pairing activity of the Bacillus subtilis bacteriophage SPP1 replication protein G35P. J Biol Chem (2002) 1.13
A common telomeric gene silencing assay is affected by nucleotide metabolism. Mol Cell (2011) 1.13
Archaeal histone tetramerization determines DNA affinity and the direction of DNA supercoiling. J Biol Chem (2002) 1.10
Rhabdomyosarcoma: current challenges and their implications for developing therapies. Cold Spring Harb Perspect Med (2014) 1.10