Published in Mol Cell on September 02, 2011
Cell biology. Metabolic control of cell death. Science (2014) 1.98
Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice. Cell Death Differ (2012) 1.19
The tangled circuitry of metabolism and apoptosis. Mol Cell (2013) 0.99
Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice. Cell Death Dis (2015) 0.94
Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. PLoS One (2013) 0.92
Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis. J Biol Chem (2013) 0.91
System-wide identification of wild-type SUMO-2 conjugation sites. Nat Commun (2015) 0.90
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. Genes Cancer (2013) 0.89
Sirtuins in epigenetic regulation. Chem Rev (2015) 0.88
Engineered bromodomains to explore the acetylproteome. Proteomics (2015) 0.84
Macromolecular crowding effect is critical for maintaining SIRT1's nuclear localization in cancer cells. Cell Cycle (2016) 0.84
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. Oncogene (2014) 0.80
Solid-phase capture for the detection and relative quantification of S-nitrosoproteins by mass spectrometry. Methods (2012) 0.79
Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket. J Biol Chem (2015) 0.78
Nucleus or cytoplasm? The mysterious case of SIRT1's subcellular localization. Cell Cycle (2016) 0.75
Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A). J Biol Chem (2014) 0.75
Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-mediated Inhibition of Mitochondrial Respiration. Mol Cell Biol (2017) 0.75
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (2009) 20.49
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell (2006) 11.38
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer (2006) 8.50
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE (2001) 6.09
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell (2000) 4.05
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol (2010) 3.38
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell (2005) 3.32
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem (2006) 3.18
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05
SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res (2007) 2.98
SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A (2006) 2.89
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture. Nat Biotechnol (2009) 2.69
DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proc Natl Acad Sci U S A (2002) 2.58
The critical role of the class III histone deacetylase SIRT1 in cancer. Cancer Res (2009) 2.29
HDAC6 expression is correlated with better survival in breast cancer. Clin Cancer Res (2004) 1.74
14-3-3s regulate global cleavage of their diverse binding partners in sugar-starved Arabidopsis cells. EMBO J (2000) 1.50
Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1. Cancer Res (2005) 1.50
Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. EMBO J (2009) 1.42
Acetylation goes global: the emergence of acetylation biology. Sci Signal (2009) 1.41
Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2. Dev Cell (2009) 1.41
Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. Int J Biol Sci (2010) 1.24
Negative modulation of Escherichia coli NAD kinase by NADPH and NADH. J Bacteriol (1987) 0.98
Interactions between DBC1 and SIRT 1 are deregulated in breast cancer cells. Cell Cycle (2009) 0.97
Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase. Cell Death Differ (2010) 0.87
NADP(H) phosphatase activities of archaeal inositol monophosphatase and eubacterial 3'-phosphoadenosine 5'-phosphate phosphatase. Appl Environ Microbiol (2007) 0.83
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell (2005) 3.32
Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture. Nat Biotechnol (2009) 2.69
Caspases and kinases in a death grip. Cell (2009) 2.47
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes Dev (2007) 2.32
An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med (2013) 2.23
PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat Cell Biol (2009) 2.20
Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. Genes Dev (2007) 2.17
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15
Simultaneous stretching and contraction of stress fibers in vivo. Mol Biol Cell (2004) 2.12
The apoptosome: physiological, developmental, and pathological modes of regulation. Dev Cell (2006) 1.94
Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition. Nat Cell Biol (2002) 1.94
Site-specific analysis of protein S-acylation by resin-assisted capture. J Lipid Res (2010) 1.77
Direct ribosomal binding by a cellular inhibitor of translation. Nat Struct Mol Biol (2006) 1.64
High predictive accuracy of an unbiased proteomic profile for sustained virologic response in chronic hepatitis C patients. Hepatology (2011) 1.59
Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. Sci Signal (2012) 1.57
Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export. Cell Cycle (2010) 1.54
Cdc25 and Wee1: analogous opposites? Cell Div (2007) 1.54
Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. PLoS One (2011) 1.52
The engine driving the ship: metabolic steering of cell proliferation and death. Nat Rev Mol Cell Biol (2010) 1.51
Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms. Mol Microbiol (2011) 1.51
PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. EMBO J (2003) 1.50
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. Mol Cell (2004) 1.48
Cellular mechanisms controlling caspase activation and function. Cold Spring Harb Perspect Biol (2013) 1.47
Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. EMBO J (2009) 1.42
Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2. Dev Cell (2009) 1.41
Exploiting the complementary nature of LC/MALDI/MS/MS and LC/ESI/MS/MS for increased proteome coverage. J Am Soc Mass Spectrom (2003) 1.37
The protein expression landscape of the Arabidopsis root. Proc Natl Acad Sci U S A (2012) 1.36
Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol Biol Cell (2003) 1.32
Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. Mol Cell Biol (2008) 1.32
A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25. Mol Biol Cell (2006) 1.31
A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. Curr Biol (2007) 1.27
Identification of S-nitrosylated targets of thioredoxin using a quantitative proteomic approach. Biochemistry (2010) 1.23
Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis. Infect Immun (2010) 1.22
An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. Biochem J (2009) 1.19
Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. Drug Metab Dispos (2007) 1.14
Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation. Curr Biol (2007) 1.14
Cataract formation in a strain of rats selected for high oxidative stress. Exp Eye Res (2004) 1.13
Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. Proc Natl Acad Sci U S A (2007) 1.13
A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. J Biol Chem (2003) 1.12
Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. J Cell Biol (2005) 1.09
Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A. Proc Natl Acad Sci U S A (2007) 1.09
Aven-dependent activation of ATM following DNA damage. Curr Biol (2008) 1.08
Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Mol Biol Cell (2011) 1.07
Post-cytochrome C protection from apoptosis conferred by a MAPK pathway in Xenopus egg extracts. Mol Biol Cell (2002) 1.06
A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Sci Signal (2013) 1.04
Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. Mol Biol Cell (2002) 1.04
Quantitative label-free phosphoproteomics strategy for multifaceted experimental designs. Anal Chem (2011) 1.04
Reaper is regulated by IAP-mediated ubiquitination. J Biol Chem (2002) 1.03
Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation. Free Radic Biol Med (2012) 1.02
Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx. Mol Cancer Res (2003) 1.02
Ion mobility-derived collision cross section as an additional measure for lipid fingerprinting and identification. Anal Chem (2014) 1.02
Kinetic characterization of Salmonella FliK-FlhB interactions demonstrates complexity of the Type III secretion substrate-specificity switch. Biochemistry (2010) 1.01
Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells. Mol Cell Proteomics (2010) 1.01
Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era. J Cell Sci (2008) 1.01
Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions. J Biol Chem (2007) 1.01
Ion mobility derived collision cross sections to support metabolomics applications. Anal Chem (2014) 1.00
Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. Blood (2011) 1.00
Caspase cleavage is not for everyone. Cell (2008) 1.00
Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells. Cancer Res (2006) 0.99
The tangled circuitry of metabolism and apoptosis. Mol Cell (2013) 0.99
Distribution, spherical structure and predicted Mie scattering of multilamellar bodies in human age-related nuclear cataracts. Exp Eye Res (2004) 0.98
Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C. PLoS One (2011) 0.98
Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. Mol Cell Biol (2004) 0.98
Resistance to ErbB2 tyrosine kinase inhibitors in breast cancer is mediated by calcium-dependent activation of RelA. Mol Cancer Ther (2010) 0.98
Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. J Proteome Res (2011) 0.98
DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7. J Cell Biol (2004) 0.95
Predicted light scattering from particles observed in human age-related nuclear cataracts using mie scattering theory. Invest Ophthalmol Vis Sci (2007) 0.95
Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun (2013) 0.94
Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress. Mol Cell Biol (2009) 0.94