Published in J Biol Chem on December 07, 2009
ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17. PLoS One (2013) 0.98
P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y₂ receptor interactions in neuroinflammation. Mol Neurobiol (2012) 0.94
Neuroprotective roles of the P2Y(2) receptor. Purinergic Signal (2012) 0.84
Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol (2011) 0.82
Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function. Purinergic Signal (2011) 0.79
P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential. CNS Neurol Disord Drug Targets (2012) 0.77
P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway. PLoS One (2015) 0.77
Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells. J Biol Chem (2016) 0.75
Lipid rafts and signal transduction. Nat Rev Mol Cell Biol (2000) 25.87
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88
Molecular physiology of P2X receptors. Physiol Rev (2002) 13.61
Endocytic recycling. Nat Rev Mol Cell Biol (2004) 10.87
Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J Biol Chem (2000) 9.96
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev (2003) 9.32
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature (2000) 7.03
Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res (2003) 6.43
Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev (2007) 6.05
Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol (2003) 5.55
The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer (2004) 5.47
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature (1996) 5.40
Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A (2005) 5.37
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev (2006) 5.28
Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J Biol Chem (1996) 4.50
Myristylation and palmitylation of Src family members: the fats of the matter. Cell (1994) 4.21
Lipid rafts: bringing order to chaos. J Lipid Res (2003) 4.20
Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts. Nat Cell Biol (1999) 4.08
A detergent-free method for purifying caveolae membrane from tissue culture cells. Proc Natl Acad Sci U S A (1995) 3.84
Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol Rev (2006) 3.82
Roles of lipid rafts in membrane transport. Curr Opin Cell Biol (2001) 3.70
Lipid raft microdomains and neurotransmitter signalling. Nat Rev Neurosci (2006) 3.69
Lipid rafts: heterogeneity on the high seas. Biochem J (2004) 3.46
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem (1997) 3.12
Epidermal growth factor receptors: critical mediators of multiple receptor pathways. Curr Opin Cell Biol (1999) 2.75
The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharmacol (2004) 2.70
Historical review: ATP as a neurotransmitter. Trends Pharmacol Sci (2006) 2.32
Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling. J Med Chem (2004) 2.15
Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods. Methods Enzymol (2002) 1.99
G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there? J Mol Endocrinol (2004) 1.97
Regulation of caveolin and caveolae by cholesterol in MDCK cells. J Lipid Res (1998) 1.96
Identification of filamin as a novel ligand for caveolin-1: evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton. Mol Biol Cell (2000) 1.90
Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle. Proc Natl Acad Sci U S A (1996) 1.87
Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton. J Cell Sci (2002) 1.87
Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. Mol Cell Biol (2000) 1.83
Transforming growth factor-alpha mediates nuclear factor kappaB activation in strained arteries. Circ Res (2006) 1.58
Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res (1999) 1.52
P2 receptors: intracellular signaling. Pflugers Arch (2006) 1.48
Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors. J Biol Chem (2003) 1.44
The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1). J Biol Chem (2004) 1.39
EGF induces coalescence of different lipid rafts. J Cell Sci (2008) 1.38
Retracted cAbl tyrosine kinase mediates reactive oxygen species- and caveolin-dependent AT1 receptor signaling in vascular smooth muscle: role in vascular hypertrophy. Circ Res (2005) 1.29
Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway. Circ Res (2003) 1.26
P2Y(1), P2Y(2), P2Y(4), and P2Y(6) receptors are coupled to Rho and Rho kinase activation in vascular myocytes. Am J Physiol Heart Circ Physiol (2000) 1.24
P2Y(1) and P2Y(2) receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed. Br J Pharmacol (2002) 1.22
Epidermal growth factor, a vascular smooth muscle mitogen, induces rat aortic contraction. J Clin Invest (1985) 1.19
The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells. J Biol Chem (2003) 1.18
The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration. J Biol Chem (2005) 1.14
Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. J Biol Chem (2008) 1.14
The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase. Cell Signal (2007) 1.09
Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Circ Res (2004) 1.09
Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. J Biol Chem (1998) 1.08
ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.08
Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor. Circ Res (2002) 1.08
The P2Y2 nucleotide receptor requires interaction with alpha v integrins to access and activate G12. J Cell Sci (2007) 1.06
Extracellular ATP activates multiple signalling pathways and potentiates growth factor-induced c-fos gene expression in MCF-7 breast cancer cells. Carcinogenesis (2000) 1.04
Prostacyclin and thromboxane in gynecology and obstetrics. Am J Obstet Gynecol (1985) 1.04
Binding of the P2Y2 nucleotide receptor to filamin A regulates migration of vascular smooth muscle cells. Circ Res (2008) 1.03
Regulation of vascular reactivity by established and emerging GPCRs. Trends Pharmacol Sci (2005) 1.02
Transactivation: a novel signaling pathway from angiotensin II to tyrosine kinase receptors. J Mol Cell Cardiol (2001) 1.01
EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation. Mol Biol Cell (2008) 1.01
Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor. Biochem J (2008) 1.00
Vascular actions of epidermal growth factor-urogastrone: possible relationship to prostaglandin production. Can J Physiol Pharmacol (1985) 0.96
Agonist-induced internalization of the P2Y2 receptor. Mol Pharmacol (1998) 0.96
Belt-like localisation of caveolin in deep caveolae and its re-distribution after cholesterol depletion. Histochem Cell Biol (2005) 0.94
The Rho-related protein Rnd1 inhibits Ca2+ sensitization of rat smooth muscle. J Physiol (1999) 0.93
A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade. Am J Physiol Heart Circ Physiol (2005) 0.90
Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells. J Cell Sci (2007) 0.90
Constitutive and agonist-induced dimerizations of the P2Y1 receptor: relationship to internalization and scaffolding. J Biol Chem (2008) 0.89
P2Y1 and P2Y2 receptor distribution varies along the human placental vascular tree: role of nucleotides in vascular tone regulation. J Physiol (2006) 0.88
Pharmacological identification of P2X1, P2X4 and P2X7 nucleotide receptors in the smooth muscles of human umbilical cord and chorionic blood vessels. Placenta (2003) 0.88
Endocytosis mechanism of P2Y2 nucleotide receptor tagged with green fluorescent protein: clathrin and actin cytoskeleton dependence. Cell Mol Life Sci (2005) 0.87
Internalization and desensitization of a green fluorescent protein-tagged P2Y nucleotide receptor are differently controlled by inhibition of calmodulin-dependent protein kinase II. J Neurochem (2006) 0.87
Role of calcium-sensitive tyrosine kinase Pyk2/CAKbeta/RAFTK in angiotensin II induced Ras/ERK signaling. Hypertension (1998) 0.83
Tyrosine kinase-mediated signal transduction pathways and the actions of polypeptide growth factors and G-protein-coupled agonists in smooth muscle. Mol Cell Biochem (1996) 0.82
UTP transactivates epidermal growth factor receptors and promotes cardiomyocyte hypertrophy despite inhibiting transcription of the hypertrophic marker gene, atrial natriuretic peptide. J Biol Chem (2003) 0.82
Regulation of fetal vascular tone in the human placenta. Reprod Fertil Dev (1991) 0.77
Effects of extracellular nucleotides in the thyroid: P2Y2 receptor-mediated ERK1/2 activation and c-Fos induction in PC Cl3 cells. Cell Signal (2004) 0.77
P2Y1 receptor activation elicits its partition out of membrane rafts and its rapid internalization from human blood vessels: implications for receptor signaling. Mol Pharmacol (2008) 0.76
Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev (2011) 2.14
Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Mol Biol Cell (2007) 1.35
P2Y(1) and P2Y(2) receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed. Br J Pharmacol (2002) 1.22
Allosteric modulation of ATP-gated P2X receptor channels. Rev Neurosci (2011) 1.16
Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis. J Exp Med (2007) 1.10
Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. J Physiol (2005) 1.07
The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites. Virology (2009) 1.05
Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition. J Biol Chem (2007) 1.04
Novel mechanism for regulation of epidermal growth factor receptor endocytosis revealed by protein kinase A inhibition. Mol Biol Cell (2002) 1.03
Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor. J Neurochem (2007) 0.99
Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT(2A) and 5-HT(2C) receptors. Br J Pharmacol (2002) 0.99
EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases. Exp Cell Res (2004) 0.98
The adaptor protein-1 μ1B subunit expands the repertoire of basolateral sorting signal recognition in epithelial cells. Dev Cell (2013) 0.98
Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells. Exp Cell Res (2006) 0.97
Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc. J Biol Chem (2003) 0.96
Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells. Proc Natl Acad Sci U S A (2004) 0.95
NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors. Am J Physiol Heart Circ Physiol (2009) 0.94
A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade. Am J Physiol Heart Circ Physiol (2005) 0.90
Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1/2 activation supported by protein kinase A down-regulation. J Biol Chem (2009) 0.90
Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells. J Cell Sci (2007) 0.90
Galectin-8 promotes cytoskeletal rearrangement in trabecular meshwork cells through activation of Rho signaling. PLoS One (2012) 0.90
Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation. J Neurochem (2005) 0.89
P2Y1 and P2Y2 receptor distribution varies along the human placental vascular tree: role of nucleotides in vascular tone regulation. J Physiol (2006) 0.88
The 5'-untranslated region of the mouse mammary tumor virus mRNA exhibits cap-independent translation initiation. Nucleic Acids Res (2009) 0.88
Reactive oxygen species potentiate the P2X2 receptor activity through intracellular Cys430. J Neurosci (2009) 0.87
Phosphatidic acid induces ligand-independent epidermal growth factor receptor endocytic traffic through PDE4 activation. Mol Biol Cell (2010) 0.87
Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer's and Huntington's disease therapy. Neurotoxicology (2007) 0.86
Selective plasma membrane permeabilization by freeze-thawing and immunofluorescence epitope access to determine the topology of intracellular membrane proteins. J Immunol Methods (2003) 0.85
Effects of deep cervical flexor training on pressure pain thresholds over myofascial trigger points in patients with chronic neck pain. J Manipulative Physiol Ther (2013) 0.85
Chronic intermittent hypoxia augments sympatho-excitatory response to ATP but not to L-glutamate in the RVLM of rats. Auton Neurosci (2011) 0.85
Inhibition of the catalase activity from Phaseolus vulgaris and Medicago sativa by sodium chloride. Plant Physiol Biochem (2007) 0.84
Heavy metals modulate the activity of the purinergic P2X4 receptor. Toxicol Appl Pharmacol (2005) 0.84
Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice. Arthritis Rheumatol (2015) 0.83
Epidermal growth factor receptor endocytic traffic perturbation by phosphatidate phosphohydrolase inhibition: new strategy against cancer. FEBS J (2014) 0.82
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes. Br J Pharmacol (2004) 0.82
Sorting competition with membrane-permeable peptides in intact epithelial cells revealed discrimination of transmembrane proteins not only at the trans-Golgi network but also at pre-Golgi stages. J Biol Chem (2004) 0.82
The role of adenosine A2A and A3 receptors on the differential modulation of norepinephrine and neuropeptide Y release from peripheral sympathetic nerve terminals. J Neurochem (2006) 0.82
The hypolipidemic drug metabolites nafenopin-CoA and ciprofibroyl-CoA are competitive P2Y1 receptor antagonists. FEBS Lett (2003) 0.82
Sodium flux ratio in Na/K pump-channels opened by palytoxin. J Gen Physiol (2007) 0.81
A cis-acting element present within the Gag open reading frame negatively impacts on the activity of the HIV-1 IRES. PLoS One (2013) 0.80
Role of copper in prion diseases: deleterious or beneficial? Curr Pharm Des (2006) 0.79
Neuromodulator role of zinc and copper during prolonged ATP applications to P2X4 purinoceptors. Eur J Pharmacol (2003) 0.78
alpha2-Adrenoceptors control the release of noradrenaline but not neuropeptide Y from perivascular nerve terminals. Peptides (2002) 0.78
Neuropeptide Y is released from human mammary and radial vascular biopsies and is a functional modulator of sympathetic cotransmission. J Vasc Res (2004) 0.78
[Antibodies against galectin-8 in patients with systemic lupus erythematosus]. Rev Med Chil (2006) 0.77
Lipopolysaccharide inhibits the channel activity of the P2X7 receptor. Mediators Inflamm (2011) 0.77
Formation of carnosine-Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X4 and P2X7 receptors. J Neurochem (2002) 0.76
P2Y1 receptor activation elicits its partition out of membrane rafts and its rapid internalization from human blood vessels: implications for receptor signaling. Mol Pharmacol (2008) 0.76
Release and functional role of neuropeptide Y as a sympathetic modulator in human saphenous vein biopsies. Peptides (2004) 0.76
The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X4 receptor without modifying the zinc action. J Neurochem (2003) 0.76
Modulator role of neuropeptide Y in human vascular sympathetic neuroeffector junctions. EXS (2006) 0.75
The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors. Int J Alzheimers Dis (2011) 0.75
[Validation of the PRIME-MD for the detection of generalized anxiety disorder]. Invest Clin (2008) 0.75
Physiological and biochemical responses of common vetch to the imazamox accumulation. Plant Physiol Biochem (2013) 0.75
Lymphoid B cells induce NF-kappaB activation in high endothelial cells from human tonsils. Int Immunol (2005) 0.75