Published in Proc Natl Acad Sci U S A on April 01, 1981
A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site. Proc Natl Acad Sci U S A (1982) 11.42
Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG. Mol Cell Biol (1984) 7.83
A small segment of polyoma virus DNA enhances the expression of a cloned beta-globin gene over a distance of 1400 base pairs. Nucleic Acids Res (1981) 7.57
Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae. Mol Cell Biol (1984) 6.23
Shuttle mutagenesis: a method of transposon mutagenesis for Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1986) 5.75
A comparison of yeast ribosomal protein gene DNA sequences. Nucleic Acids Res (1984) 4.92
Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. Proc Natl Acad Sci U S A (1984) 4.90
Specific protein binding to far upstream activating sequences in polymerase II promoters. Proc Natl Acad Sci U S A (1985) 4.85
Yeast genes fused to beta-galactosidase in Escherichia coli can be expressed normally in yeast. Proc Natl Acad Sci U S A (1981) 4.79
Uses of lac fusions for the study of biological problems. Microbiol Rev (1985) 4.38
Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae. Mol Cell Biol (1991) 4.23
A synthetic HIS4 regulatory element confers general amino acid control on the cytochrome c gene (CYC1) of yeast. Proc Natl Acad Sci U S A (1985) 4.13
Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor. Proc Natl Acad Sci U S A (1986) 4.07
An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast. Proc Natl Acad Sci U S A (1983) 3.95
MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J (1999) 3.89
Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast. Genes Dev (1997) 3.31
Regulation of HIS4-lacZ fusions in Saccharomyces cerevisiae. Mol Cell Biol (1982) 3.07
Intracellular targeting and import of an F1-ATPase beta-subunit-beta-galactosidase hybrid protein into yeast mitochondria. Proc Natl Acad Sci U S A (1984) 3.02
Tripartite upstream promoter element essential for expression of Saccharomyces cerevisiae ribosomal protein genes. Mol Cell Biol (1986) 3.00
Context affects nuclear protein localization in Saccharomyces cerevisiae. Mol Cell Biol (1989) 2.96
Delimitation of far upstream sequences required for maximal in vitro transcription of an H2A histone gene. Proc Natl Acad Sci U S A (1982) 2.90
Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron. Proc Natl Acad Sci U S A (1992) 2.87
Identification of a DNA segment that is necessary and sufficient for alpha-specific gene control in Saccharomyces cerevisiae: implications for regulation of alpha-specific and a-specific genes. Mol Cell Biol (1988) 2.79
Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Proc Natl Acad Sci U S A (1989) 2.71
Met31p and Met32p, two related zinc finger proteins, are involved in transcriptional regulation of yeast sulfur amino acid metabolism. Mol Cell Biol (1997) 2.68
Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Mol Cell Biol (1985) 2.63
Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. EMBO J (1996) 2.62
Ubiquitous upstream repression sequences control activation of the inducible arginase gene in yeast. Proc Natl Acad Sci U S A (1987) 2.61
Nutrient availability and the RAS/cyclic AMP pathway both induce expression of ribosomal protein genes in Saccharomyces cerevisiae but by different mechanisms. Mol Cell Biol (1995) 2.56
A presumptive helicase (MOT1 gene product) affects gene expression and is required for viability in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.56
From DNA sequence to transcriptional behaviour: a quantitative approach. Nat Rev Genet (2009) 2.54
Transcriptional regulation of an hsp70 heat shock gene in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.52
MET4, a leucine zipper protein, and centromere-binding factor 1 are both required for transcriptional activation of sulfur metabolism in Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.51
The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proc Natl Acad Sci U S A (1995) 2.50
mRNA structures influencing translation in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1988) 2.50
Open reading frame cloning: identification, cloning, and expression of open reading frame DNA. Proc Natl Acad Sci U S A (1982) 2.39
Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region. Mol Cell Biol (1986) 2.36
Negative regulation of STE6 gene expression by the alpha 2 product of Saccharomyces cerevisiae. Mol Cell Biol (1984) 2.34
GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae. J Bacteriol (1986) 2.30
Modulator sequences mediate oxygen regulation of CYC1 and a neighboring gene in yeast. Proc Natl Acad Sci U S A (1983) 2.27
Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML. Mol Cell Biol (1998) 2.21
Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae. Mol Biol Cell (2003) 2.18
Accurate initiation at RNA polymerase II promoters in extracts from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1987) 2.10
FLO11, a yeast gene related to the STA genes, encodes a novel cell surface flocculin. J Bacteriol (1996) 2.08
Mammalian p53 can function as a transcription factor in yeast. Nucleic Acids Res (1992) 2.07
Identification of a sequence responsible for periodic synthesis of yeast histone 2A mRNA. Proc Natl Acad Sci U S A (1982) 2.07
Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila. EMBO J (1991) 2.04
Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases. Mol Cell Biol (1993) 2.03
Expression of a human placental alkaline phosphatase gene in transfected cells: use as a reporter for studies of gene expression. Proc Natl Acad Sci U S A (1988) 2.02
Constitutive transcription of yeast ribosomal protein gene TCM1 is promoted by uncommon cis- and trans-acting elements. Mol Cell Biol (1988) 1.98
Histone H3 transcription in Saccharomyces cerevisiae is controlled by multiple cell cycle activation sites and a constitutive negative regulatory element. Mol Cell Biol (1992) 1.94
Invertase beta-galactosidase hybrid proteins fail to be transported from the endoplasmic reticulum in Saccharomyces cerevisiae. Mol Cell Biol (1984) 1.91
The NAM2 proteins from S. cerevisiae and S. douglasii are mitochondrial leucyl-tRNA synthetases, and are involved in mRNA splicing. EMBO J (1988) 1.91
Regulation of RAD54- and RAD52-lacZ gene fusions in Saccharomyces cerevisiae in response to DNA damage. Mol Cell Biol (1987) 1.90
The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p. EMBO J (1998) 1.90
A positive regulatory site and a negative regulatory site control the expression of the Saccharomyces cerevisiae CYC7 gene. Mol Cell Biol (1984) 1.88
Transcriptional slippage occurs during elongation at runs of adenine or thymine in Escherichia coli. Nucleic Acids Res (1990) 1.87
Isolation of the catalase T structural gene of Saccharomyces cerevisiae by functional complementation. Mol Cell Biol (1983) 1.81
Identification of two factors which bind to the upstream sequences of a number of nuclear genes coding for mitochondrial proteins and to genetic elements important for cell division in yeast. Nucleic Acids Res (1988) 1.80
Transcriptional regulation of SSA3, an HSP70 gene from Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.77
Identification of a Ty1 regulatory sequence responsive to STE7 and STE12. Mol Cell Biol (1988) 1.76
Elements involved in oxygen regulation of the Saccharomyces cerevisiae CYC7 gene. Mol Cell Biol (1987) 1.75
Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. Proc Natl Acad Sci U S A (1998) 1.73
Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression. Mol Cell Biol (1997) 1.73
Analysis of sequences in the INO1 promoter that are involved in its regulation by phospholipid precursors. Nucleic Acids Res (1991) 1.71
Saccharomyces cerevisiae CYC1 mRNA 5'-end positioning: analysis by in vitro mutagenesis, using synthetic duplexes with random mismatch base pairs. Mol Cell Biol (1985) 1.71
Positive and negative regulation of basal expression of a yeast HSP70 gene. Mol Cell Biol (1989) 1.68
Role of transcriptional and posttranscriptional regulation in expression of histone genes in Saccharomyces cerevisiae. Mol Cell Biol (1987) 1.67
Recruiting TATA-binding protein to a promoter: transcriptional activation without an upstream activator. Mol Cell Biol (1995) 1.67
Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.66
Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Eukaryot Cell (2002) 1.66
Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol Cell Biol (1999) 1.63
Differential regulation of the duplicated isocytochrome c genes in yeast. Proc Natl Acad Sci U S A (1984) 1.61
Evidence for a heat shock transcription factor-independent mechanism for heat shock induction of transcription in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1990) 1.58
Expression of the lacZ gene from two methanol-regulated promoters in Pichia pastoris. Nucleic Acids Res (1987) 1.57
Cooperative Pho2-Pho4 interactions at the PHO5 promoter are critical for binding of Pho4 to UASp1 and for efficient transactivation by Pho4 at UASp2. Mol Cell Biol (1998) 1.57
Identification of the DNA sequences controlling the expression of the MAT alpha locus of yeast. Proc Natl Acad Sci U S A (1986) 1.55
Kar4p, a karyogamy-specific component of the yeast pheromone response pathway. Mol Cell Biol (1996) 1.53
Opposing regulatory functions of positive and negative elements in UASG control transcription of the yeast GAL genes. Mol Cell Biol (1990) 1.53
Interaction between polyketide synthase and transporter suggests coupled synthesis and export of virulence lipid in M. tuberculosis. PLoS Pathog (2005) 1.52
Vaccinia virus 4c (A26L) protein on intracellular mature virus binds to the extracellular cellular matrix laminin. J Virol (2006) 1.52
HAP1 and ROX1 form a regulatory pathway in the repression of HEM13 transcription in Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.51
Isolation and DNA-binding characteristics of a protein involved in transcription activation of two divergently transcribed, essential yeast genes. EMBO J (1989) 1.50
The role of RAP1 in the regulation of the MAT alpha locus. Mol Cell Biol (1991) 1.49
Characterization of the DNA target site for the yeast ARGR regulatory complex, a sequence able to mediate repression or induction by arginine. Mol Cell Biol (1992) 1.48
Coordinate genetic control of yeast fatty acid synthase genes FAS1 and FAS2 by an upstream activation site common to genes involved in membrane lipid biosynthesis. EMBO J (1992) 1.47
Upstream regulatory sequences of the yeast RNR2 gene include a repression sequence and an activation site that binds the RAP1 protein. Mol Cell Biol (1989) 1.45
The sequential activation of the yeast HOG and SLT2 pathways is required for cell survival to cell wall stress. Mol Biol Cell (2008) 1.45
The nine amino-terminal residues of delta-aminolevulinate synthase direct beta-galactosidase into the mitochondrial matrix. Mol Cell Biol (1986) 1.45
Role of the Saccharomyces cerevisiae general regulatory factor CP1 in methionine biosynthetic gene transcription. Mol Cell Biol (1995) 1.42
Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it. Mol Cell Biol (1989) 1.41
SWI-SNF complex participation in transcriptional activation at a step subsequent to activator binding. Mol Cell Biol (1998) 1.40
MEI4, a meiosis-specific yeast gene required for chromosome synapsis. Mol Cell Biol (1992) 1.37
Sequences required for delivery and localization of the ADP/ATP translocator to the mitochondrial inner membrane. Mol Cell Biol (1986) 1.36
Residues in the WD repeats of Tup1 required for interaction with alpha2. Mol Cell Biol (1997) 1.36
Multiple control elements in the TRP1 promoter of Saccharomyces cerevisiae. Mol Cell Biol (1986) 1.34
Transcriptional regulation of ribosomal proteins during a nutritional upshift in Saccharomyces cerevisiae. Mol Cell Biol (1986) 1.34
Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction. Proc Natl Acad Sci U S A (1996) 1.32
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
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Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene (1979) 19.39
Construction of plasmids carrying the cI gene of bacteriophage lambda. Proc Natl Acad Sci U S A (1976) 13.10
Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae. Cell (1979) 10.86
How the lambda repressor and cro work. Cell (1980) 6.65
Deletion mapping of sequences essential for in vivo transcription of the iso-1-cytochrome c gene. Proc Natl Acad Sci U S A (1981) 6.26
Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit beta-globin. Cell (1980) 6.20
The DNA sequence of sea urchin (S. purpuratus) H2A, H2B and H3 histone coding and spacer regions. Cell (1978) 5.05
Chemical synthesis of restriction enzyme recognition sites useful for cloning. Science (1977) 4.81
Yeast genes fused to beta-galactosidase in Escherichia coli can be expressed normally in yeast. Proc Natl Acad Sci U S A (1981) 4.79
Transcriptional regulation of the yeast cytochrome c gene. Proc Natl Acad Sci U S A (1979) 3.85
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Mutants of yeast initiating translation of iso-1-cytochrome c within a region spanning 37 nucleotides. Cell (1980) 3.37
Genetic mapping of the regulator and operator genes of the lac operon. J Mol Biol (1968) 3.19
Use of gene fusions to isolate promoter mutants in the transfer RNA gene tyrT of Escherichia coli. J Mol Biol (1979) 1.68
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
GAL4-VP16 is an unusually potent transcriptional activator. Nature (1988) 16.53
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
Deletion analysis of GAL4 defines two transcriptional activating segments. Cell (1987) 14.13
Construction of plasmids carrying the cI gene of bacteriophage lambda. Proc Natl Acad Sci U S A (1976) 13.10
Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast. Methods Enzymol (1983) 12.99
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98
A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site. Proc Natl Acad Sci U S A (1982) 11.42
Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site. Cell (1983) 10.52
Specific DNA binding of GAL4, a positive regulatory protein of yeast. Cell (1985) 10.25
Gene regulation by proteins acting nearby and at a distance. Nature (1986) 9.71
A new class of yeast transcriptional activators. Cell (1987) 9.53
Five intermediate complexes in transcription initiation by RNA polymerase II. Cell (1989) 9.22
Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli. Gene (1983) 8.85
Extrachromosomal rDNA circles--a cause of aging in yeast. Cell (1997) 8.68
A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell (1985) 8.30
A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res (1989) 8.06
High-efficiency transformation of yeast by electroporation. Methods Enzymol (1991) 7.99
Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG. Mol Cell Biol (1984) 7.83
Negative effect of the transcriptional activator GAL4. Nature (1988) 7.15
Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae. Cell (1984) 6.86
Autoregulation and function of a repressor in bacteriophage lambda. Science (1976) 6.83
Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein. Science (1986) 6.79
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Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae. Mol Cell Biol (1984) 6.23
Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature (1974) 6.22
Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit beta-globin. Cell (1980) 6.20
Mechanism of action of the lexA gene product. Proc Natl Acad Sci U S A (1981) 6.13
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Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains. Cell (1992) 5.14
Interactions between DNA-bound repressors govern regulation by the lambda phage repressor. Proc Natl Acad Sci U S A (1979) 5.02
Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. Proc Natl Acad Sci U S A (1984) 4.90
Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the "TATA box". Proc Natl Acad Sci U S A (1984) 4.88
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Novel properties of a restriction endonuclease isolated from Haemophilus parahaemolyticus. Proc Natl Acad Sci U S A (1976) 4.74
Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1985) 4.69
Recognition of a DNA operator by the repressor of phage 434: a view at high resolution. Science (1988) 4.60
A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives. Nature (1990) 4.57
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The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80. Cell (1987) 4.49
Mutants of GAL4 protein altered in an activation function. Cell (1987) 4.44
Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes Dev (1989) 4.43
Yeast HAP1 activator binds to two upstream activation sites of different sequence. Cell (1987) 4.37
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Maximizing gene expression on a plasmid using recombination in vitro. Cell (1978) 3.84
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GAL4 derivatives function alone and synergistically with mammalian activators in vitro. Cell (1988) 3.67
An amino-terminal fragment of GAL4 binds DNA as a dimer. J Mol Biol (1989) 3.65
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MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell (1999) 3.62
Functional dissection and sequence of yeast HAP1 activator. Cell (1989) 3.56
Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science (1997) 3.48
Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell (1999) 3.46
Yeast HAP1 activator competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene. Cell (1987) 3.46
Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell (1997) 3.44
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Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors. Cell (1990) 3.31
Generating yeast transcriptional activators containing no yeast protein sequences. Nature (1991) 3.21
Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences. Proc Natl Acad Sci U S A (1989) 3.18
Isolation of the gene encoding the yeast TATA binding protein TFIID: a gene identical to the SPT15 suppressor of Ty element insertions. Cell (1989) 3.18
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A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast. Proc Natl Acad Sci U S A (1991) 2.88
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Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J Cell Biol (1994) 2.71
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Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell (1996) 2.53
DNA loops induced by cooperative binding of lambda repressor. Nature (1986) 2.50
Effect of non-contacted bases on the affinity of 434 operator for 434 repressor and Cro. Nature (1987) 2.49
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