Published in Dev Cell on December 01, 2009
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet (2010) 6.81
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 3.36
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development (2011) 3.11
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat Biotechnol (2013) 2.06
Beta-cell growth and regeneration: replication is only part of the story. Diabetes (2010) 1.92
Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell (2010) 1.90
Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development (2011) 1.89
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol (2014) 1.87
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
Pancreatic ductal cells in development, regeneration, and neoplasia. J Clin Invest (2011) 1.80
How to make a functional β-cell. Development (2013) 1.58
Cellular plasticity within the pancreas--lessons learned from development. Dev Cell (2010) 1.58
Tracking adult stem cells. EMBO Rep (2011) 1.56
No evidence for β cell neogenesis in murine adult pancreas. J Clin Invest (2013) 1.54
Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. PLoS One (2012) 1.50
Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol (2010) 1.45
Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells. Endocrinology (2015) 1.45
Adenosine signaling promotes regeneration of pancreatic β cells in vivo. Cell Metab (2012) 1.45
Pancreas-specific Cre driver lines and considerations for their prudent use. Cell Metab (2013) 1.45
GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest (2012) 1.41
Ductal origin hypothesis of pancreatic regeneration under attack. Cell Metab (2010) 1.41
Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci (2010) 1.40
A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development (2012) 1.39
Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing β-cells. Development (2011) 1.36
Blood vessels restrain pancreas branching, differentiation and growth. Development (2011) 1.35
M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. Proc Natl Acad Sci U S A (2014) 1.35
Facultative stem cells in liver and pancreas: fact and fancy. Dev Dyn (2011) 1.32
Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development. Diabetes (2011) 1.30
Gene regulatory networks governing pancreas development. Dev Cell (2013) 1.25
Control of cell identity in pancreas development and regeneration. Gastroenterology (2013) 1.24
β-Cells are not generated in pancreatic duct ligation-induced injury in adult mice. Diabetes (2013) 1.22
Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease. Cell Stem Cell (2014) 1.21
Development of the human pancreas from foregut to endocrine commitment. Diabetes (2013) 1.21
TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation. Diabetes (2012) 1.21
Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling. Development (2010) 1.21
Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel. Proc Natl Acad Sci U S A (2013) 1.20
Progenitor cell domains in the developing and adult pancreas. Cell Cycle (2011) 1.20
The biliary epithelium gives rise to liver progenitor cells. Hepatology (2014) 1.19
Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife (2013) 1.19
MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci U S A (2013) 1.14
Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas. Cell Death Dis (2013) 1.11
Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev Biol (2011) 1.11
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol (2011) 1.06
Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Dev Biol (2012) 1.06
Emerging roles for the TGFbeta family in pancreatic beta-cell homeostasis. Trends Endocrinol Metab (2010) 1.05
Artificial three-dimensional niches deconstruct pancreas development in vitro. Development (2013) 1.04
Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease. Histol Histopathol (2010) 1.04
Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Rep (2012) 1.03
Stem cell approaches for diabetes: towards beta cell replacement. Genome Med (2011) 1.02
Lineage fate of ductular reactions in liver injury and carcinogenesis. J Clin Invest (2015) 1.02
Mind bomb 1 is required for pancreatic β-cell formation. Proc Natl Acad Sci U S A (2012) 1.02
Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Stem Cell Reports (2015) 1.01
Vascular instruction of pancreas development. Development (2012) 1.01
Sox9 and programming of liver and pancreatic progenitors. J Clin Invest (2013) 1.00
Ins1(Cre) knock-in mice for beta cell-specific gene recombination. Diabetologia (2014) 0.99
Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes (2012) 0.99
Very small embryonic-like stem cells are involved in pancreatic regeneration and their dysfunction with age may lead to diabetes and cancer. Stem Cell Res Ther (2015) 0.99
Requirement for Pdx1 in specification of latent endocrine progenitors in zebrafish. BMC Biol (2011) 0.98
The versatile functions of Sox9 in development, stem cells, and human diseases. Genes Dis (2014) 0.98
Deconstructing pancreas developmental biology. Cold Spring Harb Perspect Biol (2012) 0.98
β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice. Dis Model Mech (2012) 0.98
Exocrine ontogenies: on the development of pancreatic acinar, ductal and centroacinar cells. Semin Cell Dev Biol (2012) 0.97
Pancreatic beta-cells: from generation to regeneration. Semin Cell Dev Biol (2010) 0.97
Isolation, culture and genetic manipulation of mouse pancreatic ductal cells. Nat Protoc (2013) 0.97
Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming. PLoS One (2012) 0.97
Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS One (2011) 0.97
The use of stem cells for pancreatic regeneration in diabetes mellitus. Nat Rev Endocrinol (2013) 0.97
Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis. Development (2015) 0.97
Metabolic regulation of cellular plasticity in the pancreas. Curr Biol (2013) 0.96
Severely fibrotic pancreases from young patients with chronic pancreatitis: evidence for a ductal origin of islet neogenesis. Acta Diabetol (2011) 0.95
Regeneration and repair of the exocrine pancreas. Annu Rev Physiol (2014) 0.94
Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas. J Biol Chem (2013) 0.94
Differential effects of prenatal and postnatal nutritional environment on ß-cell mass development and turnover in male and female rats. Endocrinology (2010) 0.94
Beta cell count instead of beta cell mass to assess and localize growth in beta cell population following pancreatic duct ligation in mice. PLoS One (2012) 0.94
The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation. Development (2012) 0.93
Smad signaling pathways regulate pancreatic endocrine development. Dev Biol (2013) 0.93
Lineage determinants in early endocrine development. Semin Cell Dev Biol (2012) 0.92
Stem cells versus plasticity in liver and pancreas regeneration. Nat Cell Biol (2016) 0.92
Feedback control of growth, differentiation, and morphogenesis of pancreatic endocrine progenitors in an epithelial plexus niche. Genes Dev (2015) 0.92
Concise Review: New Insights Into the Role of Macrophages in β-Cell Proliferation. Stem Cells Transl Med (2015) 0.91
The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development (2014) 0.90
Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development. Dev Biol (2011) 0.90
Pancreatic stem cells remain unresolved. Stem Cells Dev (2014) 0.89
De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data. Cell Stem Cell (2016) 0.89
Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas. PLoS Biol (2015) 0.89
Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration. Endocrinology (2013) 0.88
Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into β cells in mice with reversal of diabetes. Proc Natl Acad Sci U S A (2016) 0.88
Sox9 marks adult organ progenitors. Nat Genet (2011) 0.88
Generating β cells from stem cells-the story so far. Cold Spring Harb Perspect Med (2012) 0.88
Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells. Genes Dev (2016) 0.87
Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology (2011) 0.87
ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol (2012) 0.87
Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration. Rev Diabet Stud (2010) 0.86
Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development (2015) 0.86
Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation. Cell Rep (2016) 0.85
TNF-like weak inducer of apoptosis (TWEAK) promotes beta cell neogenesis from pancreatic ductal epithelium in adult mice. PLoS One (2013) 0.85
In vitro multilineage differentiation and self-renewal of single pancreatic colony-forming cells from adult C57BL/6 mice. Stem Cells Dev (2014) 0.85
β-Cell Generation: Can Rodent Studies Be Translated to Humans? J Transplant (2011) 0.85
Islet cell plasticity and regeneration. Mol Metab (2014) 0.85
Sox9: a master regulator of the pancreatic program. Rev Diabet Stud (2014) 0.84
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell (2008) 8.57
A map of open chromatin in human pancreatic islets. Nat Genet (2010) 6.75
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell (2009) 4.47
Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene. PLoS Med (2007) 3.17
Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1. Hepatology (2013) 2.34
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab (2012) 2.22
The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology (2006) 2.10
Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells. Gastroenterology (2010) 2.03
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J (2006) 2.02
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet (2012) 1.88
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol (2002) 1.79
Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program. Genome Res (2010) 1.68
Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver. Mol Cell Biol (2009) 1.58
Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes (2002) 1.54
The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun (2013) 1.50
Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas. Hum Mol Genet (2003) 1.50
Notes on the scorpions (Arachnida, Scorpiones) from Xizang with the redescription of Scorpiops jendeki Kovařík, 2000 (Scorpiones, Euscorpiidae) from Yunnan (China). Zookeys (2013) 1.46
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes. Dev Cell (2013) 1.46
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. Cancer Res (2013) 1.46
Specific and combined effects of insulin and glucose on functional pancreatic beta-cell mass in vivo in adult rats. Endocrinology (2003) 1.43
Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro. Gastroenterology (2009) 1.42
Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. Proc Natl Acad Sci U S A (2010) 1.36
Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas. Virchows Arch (2003) 1.33
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. PLoS Genet (2013) 1.28
Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth. Endocr Dev (2007) 1.27
The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis. PLoS One (2013) 1.25
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. Free Radic Biol Med (2006) 1.24
Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. Biochem Pharmacol (2004) 1.23
Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice. Mol Endocrinol (2004) 1.23
PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression. Cell Metab (2009) 1.21
Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages. Cancer Res (2012) 1.20
Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology (2011) 1.20
The biliary epithelium gives rise to liver progenitor cells. Hepatology (2014) 1.19
Stem cell marker prominin-1/AC133 is expressed in duct cells of the adult human pancreas. Pancreas (2008) 1.19
Functional targets of the monogenic diabetes transcription factors HNF-1alpha and HNF-4alpha are highly conserved between mice and humans. Diabetes (2009) 1.19
Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function. J Clin Invest (2002) 1.16
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut (2012) 1.14
Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Am J Pathol (2006) 1.12
Nestin expression in pancreatic stellate cells and angiogenic endothelial cells. Histochem Cell Biol (2002) 1.11
Ampakines promote spine actin polymerization, long-term potentiation, and learning in a mouse model of Angelman syndrome. Neurobiol Dis (2012) 1.08
Beta cells within single human islets originate from multiple progenitors. PLoS One (2008) 1.05
Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells. Diabetes (2010) 1.05
Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas. Gene Expr (2003) 1.05
Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer. Cancer Res (2013) 1.04
Lineage fate of ductular reactions in liver injury and carcinogenesis. J Clin Invest (2015) 1.02
Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development. Stem Cells (2007) 1.01
Nestin is expressed in vascular endothelial cells in the adult human pancreas. J Histochem Cytochem (2003) 1.01
Clusters of conserved beta cell marker genes for assessment of beta cell phenotype. PLoS One (2011) 1.01
Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture. Hepatology (2004) 1.00
Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha. PLoS Genet (2010) 0.99
Ins1(Cre) knock-in mice for beta cell-specific gene recombination. Diabetologia (2014) 0.99
Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets. PLoS Genet (2008) 0.99
Pancreatic beta-cells: from generation to regeneration. Semin Cell Dev Biol (2010) 0.97
Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming. PLoS One (2012) 0.97
The use of stem cells for pancreatic regeneration in diabetes mellitus. Nat Rev Endocrinol (2013) 0.97
Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters). J Gene Med (2008) 0.97
Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. Biochem Biophys Res Commun (2003) 0.95
Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing β-like cells. Diabetes (2013) 0.95
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. Cell Metab (2012) 0.95
Purification of rat pancreatic B-cells by fluorescence-activated cell sorting. Methods Mol Med (2003) 0.94
Metaplasia in the pancreas. Differentiation (2005) 0.93
Hyperopic laser in situ keratomileusis for refractive accommodative esotropia. J Cataract Refract Surg (2002) 0.93
Signaling pathways during maintenance and definitive endoderm differentiation of embryonic stem cells. Int J Dev Biol (2013) 0.92
Downwelling and upwelling radiance distributions sampled under cloudless conditions in Antarctica. Appl Opt (2013) 0.92
Molecular diversity of Chaerilidae venom peptides reveals the dynamic evolution of scorpion venom components from Buthidae to non-Buthidae. J Proteomics (2013) 0.92
Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1α in acinar cell homeostasis. Gut (2011) 0.91
GATA believe it: new essential regulators of pancreas development. J Clin Invest (2012) 0.91
Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells. Genes Dev (2012) 0.91
Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochem Pharmacol (2008) 0.90
Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development. Dev Biol (2011) 0.90
EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade. Lab Invest (2005) 0.89