Published in Gastroenterology on June 01, 2013
Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation. Genes Dev (2015) 1.58
Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis. Cell Stem Cell (2016) 0.93
MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice. Gastroenterology (2013) 0.91
Mst1 and Mst2 kinases: regulations and diseases. Cell Biosci (2013) 0.85
Activation of vitamin D receptor signaling downregulates the expression of nuclear FOXM1 protein and suppresses pancreatic cancer cell stemness. Clin Cancer Res (2014) 0.84
Impaired autophagy triggers chronic pancreatitis: lessons from pancreas-specific atg5 knockout mice. Gastroenterology (2015) 0.84
Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells. Endocrinology (2015) 0.81
The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. PLoS One (2016) 0.81
Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style. Nat Rev Mol Cell Biol (2016) 0.81
Inflammatory macrophages in pancreatic acinar cell metaplasia and initiation of pancreatic cancer. Oncoscience (2015) 0.80
Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development (2014) 0.80
A non-invasive method of quantifying pancreatic volume in mice using micro-MRI. PLoS One (2014) 0.80
The secret origins and surprising fates of pancreas tumors. Carcinogenesis (2014) 0.80
A computer-based automated algorithm for assessing acinar cell loss after experimental pancreatitis. PLoS One (2014) 0.79
Progenitor Epithelium: Sorting Out Pancreatic Lineages. J Histochem Cytochem (2015) 0.79
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Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis. PLoS One (2015) 0.78
The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos. PLoS One (2015) 0.78
Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol (2015) 0.77
The crosstalk between acinar cells with Kras mutations and M1-polarized macrophages leads to initiation of pancreatic precancerous lesions. Oncoimmunology (2015) 0.77
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Cells of origin of pancreatic neoplasms. Surg Today (2017) 0.77
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Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A. Mol Cell Biol (2016) 0.76
The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis. Cell Rep (2017) 0.75
Four and a Half LIM Domains 1b (Fhl1b) Is Essential for Regulating the Liver versus Pancreas Fate Decision and for β-Cell Regeneration. PLoS Genet (2016) 0.75
Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation. Neoplasia (2016) 0.75
Closing in on pancreatic beta cells. Nat Biotechnol (2014) 0.75
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma. Nat Rev Gastroenterol Hepatol (2017) 0.75
Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity. PLoS One (2016) 0.75
Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRAS(G12D)-driven Pancreatic Tumorigenesis. Cell Mol Gastroenterol Hepatol (2017) 0.75
Light-emitting diode modulates carbohydrate metabolism by pancreatic duct regeneration. Lasers Med Sci (2017) 0.75
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EMT and dissemination precede pancreatic tumor formation. Cell (2012) 9.27
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell (2008) 8.57
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell (2007) 8.47
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CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science (2011) 7.95
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Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell (2009) 3.63
Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology (2005) 3.56
Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes (2009) 3.45
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A (2008) 3.40
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 3.36
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer (2010) 3.27
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development (2011) 3.11
Mutations in PTF1A cause pancreatic and cerebellar agenesis. Nat Genet (2004) 3.09
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest (2010) 2.90
Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet (2012) 2.75
Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology (2008) 2.71
Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev (1998) 2.66
Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. Diabetes (2009) 2.62
Cholangiocarcinomas can originate from hepatocytes in mice. J Clin Invest (2012) 2.56
Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell (2011) 2.49
Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development (2000) 2.49
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest (2007) 2.46
Stabilization of beta-catenin impacts pancreas growth. Development (2006) 2.44
Beta-catenin is essential for pancreatic acinar but not islet development. Development (2005) 2.38
Molecular basis of transdifferentiation of pancreas to liver. Nat Cell Biol (2000) 2.29
Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology (2007) 2.26
Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development (2004) 2.21
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Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell (2009) 2.00
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Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development (2004) 1.80
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev (2007) 1.79
Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. Genes Dev (2011) 1.69
Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes (2007) 1.67
Epithelial dynamics of pancreatic branching morphogenesis. Development (2010) 1.65
Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev Biol (2003) 1.61
Cellular plasticity within the pancreas--lessons learned from development. Dev Cell (2010) 1.58
Glucose-dependent insulin release from genetically engineered K cells. Science (2000) 1.52
Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells. Development (2006) 1.50
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev (2011) 1.48
Hedgehog signaling in pancreas development. Mech Dev (2003) 1.45
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Dynamics of embryonic pancreas development using real-time imaging. Dev Biol (2007) 1.38
Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice. Gastroenterology (2011) 1.35
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Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. Cell Metab (2006) 1.28
Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol (2011) 1.27
Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA. Biochem J (2012) 1.23
Novel SOX9 expression during human pancreas development correlates to abnormalities in Campomelic dysplasia. Mech Dev (2002) 1.20
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Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development (2007) 1.13
Mutant neurogenin-3 in congenital malabsorptive diarrhea. N Engl J Med (2007) 1.10
Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. Gastroenterology (2010) 1.09
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol (2011) 1.06
Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. PLoS One (2009) 1.05
β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice. Dis Model Mech (2012) 0.98
How neural mediation of anticipatory and compensatory insulin release helps us tolerate food. Physiol Behav (2011) 0.97
Primary cilia regulate Gli/Hedgehog activation in pancreas. Proc Natl Acad Sci U S A (2010) 0.96
Suppression of Ptf1a activity induces acinar-to-endocrine conversion. Curr Biol (2011) 0.92
Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C R Biol (2007) 0.87
The comparative anatomy of islets. Adv Exp Med Biol (2010) 0.87
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 10.33
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Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol (2011) 4.77
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev (2009) 4.21
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell (2011) 3.47
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 3.36
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer (2010) 3.27
Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev (2006) 3.09
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest (2010) 2.90
Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A (2007) 2.61
Stabilization of beta-catenin impacts pancreas growth. Development (2006) 2.44
Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PLoS One (2007) 2.26
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest (2007) 2.20
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A (2007) 2.17
Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One (2007) 2.08
Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology (2009) 1.86
Stabilization of beta-catenin induces pancreas tumor formation. Gastroenterology (2008) 1.81
Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology (2006) 1.77
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes (2011) 1.74
Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development (2004) 1.73
Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. Hepatology (2006) 1.69
Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes (2007) 1.67
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Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut (2013) 1.58
Cellular plasticity within the pancreas--lessons learned from development. Dev Cell (2010) 1.58
Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res (2013) 1.49
Wnt5a is essential for intestinal elongation in mice. Dev Biol (2008) 1.41
Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy. Hepatology (2007) 1.40
Dynamics of embryonic pancreas development using real-time imaging. Dev Biol (2007) 1.38
Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. Cell Stem Cell (2013) 1.34
A role for von Hippel-Lindau protein in pancreatic beta-cell function. Diabetes (2008) 1.33
Hedgehog signaling regulates expansion of pancreatic epithelial cells. Dev Biol (2005) 1.31
Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol (2011) 1.27
Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development (2003) 1.26
Stem cells to pancreatic beta-cells: new sources for diabetes cell therapy. Endocr Rev (2009) 1.22
Dicer is required for proper liver zonation. J Pathol (2009) 1.11
Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs. Diabetes (2013) 1.08
Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming. Hum Mol Genet (2012) 1.07
Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. PLoS Genet (2010) 1.04
Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function. Diabetes (2010) 1.00
Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc Natl Acad Sci U S A (2011) 0.99
Primary cilia regulate Gli/Hedgehog activation in pancreas. Proc Natl Acad Sci U S A (2010) 0.96
DNA methylation directs functional maturation of pancreatic β cells. J Clin Invest (2015) 0.96
Development and cancer: lessons learned in the pancreas. Cell Cycle (2004) 0.94
Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer. Cancer Res (2013) 0.92
VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus. Genes Dev (2013) 0.91
Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes (2005) 0.88
Bmi1 is required for regeneration of the exocrine pancreas in mice. Gastroenterology (2012) 0.88
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Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia. Gastroenterology (2013) 0.81
Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice. PLoS One (2013) 0.79
It's a free for all--insulin-positive cells join the group of potential progenitors for pancreatic ductal adenocarcinoma. Cancer Cell (2009) 0.78
Advances in acute and chronic pancreatitis: from development to inflammation and repair. Gastroenterology (2012) 0.78
Safer, longer-lasting regulatory T cells with beta-catenin. Nat Med (2008) 0.78
Hedgehog spikes pancreas regeneration. Gastroenterology (2008) 0.76
Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy. ACS Nano (2017) 0.75