Published in Proc Natl Acad Sci U S A on December 23, 2009
Development and applications of photo-triggered theranostic agents. Adv Drug Deliv Rev (2010) 1.29
Phthalocyanine-peptide conjugates for epidermal growth factor receptor targeting. J Med Chem (2012) 0.86
Synthesis and characterization of new porphyrazine-Gd(III) conjugates as multimodal MR contrast agents. Bioconjug Chem (2010) 0.81
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Conjugation of 2-(1'-hexyloxyethyl)-2-devinylpyropheophorbide-a (HPPH) to carbohydrates changes its subcellular distribution and enhances photodynamic activity in vivo. J Med Chem (2009) 1.07
Intracellular localization of the radiation enhancer motexafin gadolinium using interferometric Fourier fluorescence microscopy. J Pharmacol Exp Ther (2001) 0.97
Cellular uptake and photosensitizing properties of anticancer porphyrins in cell membranes and low and high density lipoproteins. J Photochem Photobiol B (1990) 0.95
Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores. Bioconjug Chem (2005) 0.95
In vitro and in vivo photosensitization by protoporphyrins possessing different lipophilicities and vertical localization in the membrane. Photochem Photobiol (2007) 0.88
Chiral bis-acetal porphyrazines as near-infrared optical agents for detection and treatment of cancer. Photochem Photobiol (2010) 0.85
Circumvention of multidrug resistance and reduction of cardiotoxicity of doxorubicin in vivo by coupling it with low density lipoprotein. Life Sci (2002) 0.85
Tetrapyrrole-photosensitizers vectorization and plasma LDL: a physico-chemical approach. Int J Pharm (2007) 0.85
Synthesis of near-IR absorbing/emitting porphyrazine derivatives with tunable solubility. J Org Chem (2001) 0.85
The role of low-density lipoprotein receptors in sensitivity to killing by Photofrin-mediated photodynamic therapy in cultured human tumor cell lines. J Dermatol Sci (2005) 0.84
Tuning the singlet oxygen quantum yield of near-IR-absorbing porphyrazines. Photochem Photobiol (2003) 0.83
Boronated protoporphyrin (BOPP): localization in lysosomes of the human glioma cell line SF-767 with uptake modulated by lipoprotein levels. Int J Radiat Oncol Biol Phys (1999) 0.82
Dynamics of interactions of photosensitizers with lipoproteins and membrane-models: correlation with cellular incorporation and subcellular distribution. Biochem Pharmacol (2004) 0.82
Spectroscopy, binding to liposomes and production of singlet oxygen by porphyrazines with modularly variable water solubility. Photochem Photobiol (2008) 0.82
Drug delivery in cancer using liposomes. Methods Mol Biol (2008) 0.81
Synthesis and Biological Analysis of Thiotetra(ethylene glycol) monomethyl Ether-Functionalized Porphyrazines: Cellular Uptake and Toxicity Studies. Met Based Drugs (2008) 0.79
Porphyrazinediols: Synthesis, Characterization, and Complexation to Group IVB Metallocenes. J Org Chem (2000) 0.77
The effect of heparin on structural and functional properties of low density lipoproteins. Biophys Chem (2005) 0.77
Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer (2006) 5.06
Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res (2009) 3.40
Mechanism of Mo-dependent nitrogenase. Annu Rev Biochem (2009) 3.00
Dynamic imaging of protease activity with fluorescently quenched activity-based probes. Nat Chem Biol (2005) 2.90
Acidity generated by the tumor microenvironment drives local invasion. Cancer Res (2013) 2.63
Substrate interactions with the nitrogenase active site. Acc Chem Res (2005) 2.27
An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme. J Am Chem Soc (2002) 2.16
Testing if the interstitial atom, X, of the nitrogenase molybdenum-iron cofactor is N or C: ENDOR, ESEEM, and DFT studies of the S = 3/2 resting state in multiple environments. Inorg Chem (2007) 2.12
Electron-nuclear double resonance spectroscopic evidence that S-adenosylmethionine binds in contact with the catalytically active [4Fe-4S](+) cluster of pyruvate formate-lyase activating enzyme. J Am Chem Soc (2002) 1.99
Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma. Sci Transl Med (2013) 1.99
Bioresponsive, cell-penetrating, and multimeric MR contrast agents. Acc Chem Res (2009) 1.94
Trapping H- bound to the nitrogenase FeMo-cofactor active site during H2 evolution: characterization by ENDOR spectroscopy. J Am Chem Soc (2005) 1.93
Cysteine cathepsins in human cancer. Biol Chem (2004) 1.91
An organometallic intermediate during alkyne reduction by nitrogenase. J Am Chem Soc (2004) 1.89
Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res (2012) 1.89
Multimodal MRI contrast agents. J Biol Inorg Chem (2007) 1.86
Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study. Neuroimage (2004) 1.86
Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging. Neuroimage (2002) 1.82
Connecting nitrogenase intermediates with the kinetic scheme for N2 reduction by a relaxation protocol and identification of the N2 binding state. Proc Natl Acad Sci U S A (2007) 1.79
The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation. Biochemistry (2009) 1.75
Facile one-pot synthesis of aromatic and heteroaromatic sulfonamides. J Org Chem (2003) 1.72
Pericellular cathepsin B and malignant progression. Cancer Metastasis Rev (2003) 1.68
Intermediates trapped during nitrogenase reduction of N triple bond N, CH3-N=NH, and H2N-NH2. J Am Chem Soc (2005) 1.68
The synthesis and in vitro testing of a zinc-activated MRI contrast agent. Proc Natl Acad Sci U S A (2007) 1.65
Mechanistic studies of a calcium-dependent MRI contrast agent. Inorg Chem (2002) 1.64
Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents. Nano Lett (2005) 1.59
Electron inventory, kinetic assignment (E(n)), structure, and bonding of nitrogenase turnover intermediates with C2H2 and CO. J Am Chem Soc (2005) 1.57
ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S] cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications. J Am Chem Soc (2009) 1.54
Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster. Proc Natl Acad Sci U S A (2003) 1.54
Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol (2004) 1.52
Characterization of the particulate methane monooxygenase metal centers in multiple redox states by X-ray absorption spectroscopy. Inorg Chem (2006) 1.50
Gd(III)-nanodiamond conjugates for MRI contrast enhancement. Nano Lett (2010) 1.50
Spectroscopic approaches to elucidating novel iron-sulfur chemistry in the "radical-Sam" protein superfamily. Inorg Chem (2005) 1.49
Synthesis of multimeric MR contrast agents for cellular imaging. J Am Chem Soc (2008) 1.49
Catalytic mechanism of heme oxygenase through EPR and ENDOR of cryoreduced oxy-heme oxygenase and its Asp 140 mutants. J Am Chem Soc (2002) 1.48
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia (2008) 1.48
Multimodal gadolinium-enriched DNA-gold nanoparticle conjugates for cellular imaging. Angew Chem Int Ed Engl (2009) 1.47
Trapping a hydrazine reduction intermediate on the nitrogenase active site. Biochemistry (2005) 1.44
Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. J Cell Sci (2005) 1.43
PSA enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness. Prostate (2013) 1.43
Coordination and mechanism of reversible cleavage of S-adenosylmethionine by the [4Fe-4S] center in lysine 2,3-aminomutase. J Am Chem Soc (2003) 1.42
Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ. Cancer Res (2009) 1.41
A modular system for the synthesis of multiplexed magnetic resonance probes. J Am Chem Soc (2011) 1.40
The metal centers of particulate methane monooxygenase from Methylosinus trichosporium OB3b. Biochemistry (2008) 1.38
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res (2012) 1.38
Localization of a substrate binding site on the FeMo-cofactor in nitrogenase: trapping propargyl alcohol with an alpha-70-substituted MoFe protein. Biochemistry (2003) 1.37
Dynamic docking and electron-transfer between cytochrome b5 and a suite of myoglobin surface-charge mutants. Introduction of a functional-docking algorithm for protein-protein complexes. J Am Chem Soc (2004) 1.37
Cathepsin B and its role(s) in cancer progression. Biochem Soc Symp (2003) 1.36
Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. Exp Cell Res (2009) 1.35
Lanthanide probes for bioresponsive imaging. Chem Rev (2013) 1.34
Is Mo involved in hydride binding by the four-electron reduced (E4) intermediate of the nitrogenase MoFe protein? J Am Chem Soc (2010) 1.33
Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment. Semin Cancer Biol (2004) 1.33
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue. Am J Pathol (2005) 1.32
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1. Cancer Res (2005) 1.32
Magnetic resonance imaging of self-assembled biomaterial scaffolds. Bioconjug Chem (2005) 1.29
Diazene (HN=NH) is a substrate for nitrogenase: insights into the pathway of N2 reduction. Biochemistry (2007) 1.29
Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis. Mol Imaging (2003) 1.29
A methyldiazene (HN=N-CH3)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism. Proc Natl Acad Sci U S A (2006) 1.28
Visualizing protease activity in living cells: from two dimensions to four dimensions. Curr Protoc Cell Biol (2008) 1.26
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res (2006) 1.26
Functional imaging of tumor proteolysis. Annu Rev Pharmacol Toxicol (2006) 1.26
Molecular regulation of human cathepsin B: implication in pathologies. Biol Chem (2003) 1.26
Formation of {[HIPTN(3)N]Mo(III)H}(-) by heterolytic cleavage of H(2) as established by EPR and ENDOR spectroscopy. Inorg Chem (2010) 1.25
Probing in vivo Mn2+ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopy. Proc Natl Acad Sci U S A (2010) 1.25
Mechanistic investigation of beta-galactosidase-activated MR contrast agents. Inorg Chem (2007) 1.24
The copper chelator methanobactin from Methylosinus trichosporium OB3b binds copper(I). J Am Chem Soc (2005) 1.23
The in vitro effects of a bimodal contrast agent on cellular functions and relaxometry. NMR Biomed (2007) 1.23
Substrate binding to NO-ferro-naphthalene 1,2-dioxygenase studied by high-resolution Q-band pulsed 2H-ENDOR spectroscopy. J Am Chem Soc (2003) 1.22
Dynamic docking and electron transfer between Zn-myoglobin and cytochrome b(5). J Am Chem Soc (2002) 1.22
Breaking the N2 triple bond: insights into the nitrogenase mechanism. Dalton Trans (2006) 1.20
57Fe ENDOR spectroscopy and 'electron inventory' analysis of the nitrogenase E4 intermediate suggest the metal-ion core of FeMo-cofactor cycles through only one redox couple. J Am Chem Soc (2011) 1.20
Cellular delivery of MRI contrast agents. Chem Biol (2004) 1.20
Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts. Cancer Res (2008) 1.20
Trapping an intermediate of dinitrogen (N2) reduction on nitrogenase. Biochemistry (2009) 1.20
DNA-TiO2 nanoconjugates labeled with magnetic resonance contrast agents. J Am Chem Soc (2007) 1.19
ENDOR/HYSCORE studies of the common intermediate trapped during nitrogenase reduction of N2H2, CH3N2H, and N2H4 support an alternating reaction pathway for N2 reduction. J Am Chem Soc (2011) 1.19
Reporter protein-targeted probes for magnetic resonance imaging. J Am Chem Soc (2011) 1.18
Identification of protonated oxygenic ligands of ribonucleotide reductase intermediate X. J Am Chem Soc (2009) 1.18
Synthesis and structural characterization of integrally oxidized, metal-free phthalocyanine compounds: [H(2)(pc)][IBr(2)] and [H(2)(pc)](2)[IBr(2)]Br.C(10)H(7)Br. Inorg Chem (2002) 1.18
EPR and ENDOR characterization of the reactive intermediates in the generation of NO by cryoreduced oxy-nitric oxide synthase from Geobacillus stearothermophilus. J Am Chem Soc (2009) 1.17
Experimental and theoretical EPR study of Jahn-Teller-active [HIPTN(3)N]MoL complexes (L = N(2), CO, NH(3)). J Am Chem Soc (2010) 1.17
A gadolinium chelate for detection of beta-glucuronidase: a self-immolative approach. J Am Chem Soc (2005) 1.16
Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate. Proc Natl Acad Sci U S A (2009) 1.15
Substrate modulation of the properties and reactivity of the oxy-ferrous and hydroperoxo-ferric intermediates of cytochrome P450cam as shown by cryoreduction-EPR/ENDOR spectroscopy. J Am Chem Soc (2005) 1.15
Cathepsin B: a potential prognostic marker for inflammatory breast cancer. J Transl Med (2011) 1.15
Mechanisms of ZnII-activated magnetic resonance imaging agents. Inorg Chem (2008) 1.14
EPR and ENDOR characterization of intermediates in the cryoreduced oxy-nitric oxide synthase heme domain with bound L-arginine or N(G)-hydroxyarginine. Biochemistry (2002) 1.14
Kinetic isotope effects on the rate-limiting step of heme oxygenase catalysis indicate concerted proton transfer/heme hydroxylation. J Am Chem Soc (2003) 1.13
Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer. Neoplasia (2005) 1.11
Cystatin m: a novel candidate tumor suppressor gene for breast cancer. Cancer Res (2004) 1.10