Published in J Cell Physiol on April 01, 2011
Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape. Cell Res (2011) 1.41
Specimen collection for induced pluripotent stem cell research: harmonizing the approach to informed consent. Stem Cells Transl Med (2012) 1.24
Pharmacological activation of p53 in cancer cells. Curr Pharm Des (2011) 0.92
MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitro. PLoS One (2012) 0.88
Senescence impairs direct conversion of human somatic cells to neurons. Nat Commun (2014) 0.88
Non-viral expression of mouse Oct4, Sox2, and Klf4 transcription factors efficiently reprograms tadpole muscle fibers in vivo. J Biol Chem (2012) 0.85
Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs. Mol Biosyst (2012) 0.84
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Molecular mechanisms of induced pluripotency. Acta Naturae (2012) 0.77
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The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1. PLoS One (2012) 0.75
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Cellular Reprogramming toward the Erythroid Lineage. Int J Cell Biol (2011) 0.75
Shift of EMT gradient in 3D spheroid MSCs for activation of mesenchymal niche function. Sci Rep (2017) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol (2007) 21.93
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Human induced pluripotent stem cells free of vector and transgene sequences. Science (2009) 17.16
Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell (2010) 15.58
Generation of mouse induced pluripotent stem cells without viral vectors. Science (2008) 15.25
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature (2007) 13.54
Induced pluripotent stem cells generated without viral integration. Science (2008) 13.38
Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A (2008) 13.09
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell (2008) 12.45
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29
Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature (2007) 11.72
Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell (2009) 11.65
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature (2009) 11.27
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell (2008) 10.68
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol (2008) 10.63
Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science (2008) 10.55
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell (2009) 10.52
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol (2008) 10.29
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature (2009) 9.75
A protein interaction network for pluripotency of embryonic stem cells. Nature (2006) 9.63
Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature (2009) 9.29
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74
Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71
Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature (2009) 8.70
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development (1996) 7.98
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature (2009) 7.96
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell (2010) 7.94
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91
Stepwise reprogramming of B cells into macrophages. Cell (2004) 7.68
Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 7.57
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51
Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46
The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature (2009) 7.39
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Naive and primed pluripotent states. Cell Stem Cell (2009) 7.15
Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature (2008) 7.07
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature (2010) 7.05
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet (2001) 6.92
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat Biotechnol (2009) 6.76
iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51
Oct4-induced pluripotency in adult neural stem cells. Cell (2009) 6.50
Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature (2010) 6.20
A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell (2008) 5.99
A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 5.90
A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell (2008) 5.83
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells (2009) 5.69
Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci (2009) 5.58
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell (2009) 5.49
Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development (2009) 5.49
Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature (2007) 5.39
Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol (2009) 5.14
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00
Generation of induced pluripotent stem cells in the absence of drug selection. Cell Stem Cell (2007) 4.94
Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev (2009) 4.69
Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells (2008) 4.67
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell (2009) 4.64
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell (2008) 4.63
Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43
A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42
Nanog promotes transfer of pluripotency after cell fusion. Nature (2006) 4.38
Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell (2009) 4.38
Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Curr Biol (2008) 4.34
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol (2008) 4.30
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet (2009) 4.28
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods (2009) 4.27
Adult mice generated from induced pluripotent stem cells. Nature (2009) 4.21
Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature (2009) 4.13
iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell (2009) 4.04
Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells. Cell Stem Cell (2010) 4.03
KAP1 controls endogenous retroviruses in embryonic stem cells. Nature (2010) 4.02
Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nat Biotechnol (2010) 3.98
Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell (2009) 3.92
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46
Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell (2010) 7.16
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis (2006) 6.64
Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90
Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature (2009) 4.13
The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. Science (2013) 4.12
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis. Genome Res (2009) 3.36
Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell (2009) 3.03
Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes Dev (2009) 2.70
Female human iPSCs retain an inactive X chromosome. Cell Stem Cell (2010) 2.59
Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells (2009) 2.51
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol Cell (2009) 2.27
Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. BMC Genomics (2009) 2.15
Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells. Stem Cells (2009) 1.94
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem Cells (2008) 1.83
Molecular analyses of human induced pluripotent stem cells and embryonic stem cells. Cell Stem Cell (2010) 1.81
Epigenetics of reprogramming to induced pluripotency. Cell (2013) 1.73
Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape. Cell Res (2011) 1.41
Post-translational regulation of Oct4 transcriptional activity. PLoS One (2009) 1.41
Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry. Mol Cell Proteomics (2005) 1.38
X chromosome inactivation in the absence of Dicer. Proc Natl Acad Sci U S A (2009) 1.38
Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency. Nat Cell Biol (2013) 1.33
Mediator coordinates PIC assembly with recruitment of CHD1. Genes Dev (2011) 1.28
Identification of context-dependent motifs by contrasting ChIP binding data. Bioinformatics (2010) 1.19
Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins. Cell Rep (2013) 1.11
From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols. Stem Cells Transl Med (2011) 1.07
Highly efficient large-scale lentiviral vector concentration by tandem tangential flow filtration. J Virol Methods (2011) 1.06
Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin. Hum Mol Genet (2011) 1.02
The many ways to make an iPS cell. Nat Biotechnol (2008) 1.01
The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation. Genome Biol (2012) 1.00
Epigenetics of human T cells during the G0-->G1 transition. Genome Res (2009) 0.99
Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One (2012) 0.95
Concise review: Pluripotency and the transcriptional inactivation of the female Mammalian X chromosome. Stem Cells (2012) 0.94
Illuminating the black box of reprogramming. Cell Stem Cell (2008) 0.92
The pluripotency factor-bound intron 1 of Xist is dispensable for X chromosome inactivation and reactivation in vitro and in vivo. Cell Rep (2013) 0.92
Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function. Cell Rep (2012) 0.91
Developmental regulation of Suz 12 localization. Chromosoma (2005) 0.89
Pluripotency in 3D: genome organization in pluripotent cells. Curr Opin Cell Biol (2012) 0.89
The histone domain of macroH2A1 contains several dispersed elements that are each sufficient to direct enrichment on the inactive X chromosome. J Mol Biol (2007) 0.89
A functional assay for microRNA target identification and validation. Nucleic Acids Res (2012) 0.88
Small RNAs loom large during reprogramming. Cell Stem Cell (2011) 0.87
Pluripotency re-centered around Esrrb. EMBO J (2012) 0.86
Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry. Mol Syst Biol (2012) 0.82
A new route to human embryonic stem cells. Nat Med (2013) 0.77
Cell reprogramming. Curr Opin Genet Dev (2012) 0.75