Published in PLoS One on January 21, 2010
Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biol Psychiatry (2011) 2.45
Addiction science: Uncovering neurobiological complexity. Neuropharmacology (2013) 1.50
Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity. J Neurosci (2012) 1.11
Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence. Addiction (2015) 1.01
Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. PLoS One (2011) 1.00
Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances. Mol Psychiatry (2012) 0.96
Individual differences in the effects of environmental stimuli on cocaine choice in socially housed male cynomolgus monkeys. Psychopharmacology (Berl) (2011) 0.95
Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? Pharmacol Ther (2013) 0.93
Cytoskeletal determinants of stimulus-response habits. J Neurosci (2013) 0.93
Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction. BMC Genomics (2011) 0.91
"Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs. Am J Med Genet B Neuropsychiatr Genet (2010) 0.89
Genetics of dopamine receptors and drug addiction. Hum Genet (2012) 0.89
Synaptic Cytoskeletal Plasticity in the Prefrontal Cortex Following Psychostimulant Exposure. Traffic (2015) 0.81
Menthol preference among smokers: association with TRPA1 variants. Nicotine Tob Res (2011) 0.80
Addiction as a systems failure: focus on adolescence and smoking. J Am Acad Child Adolesc Psychiatry (2011) 0.79
Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia. Transl Psychiatry (2016) 0.78
Mouse model for PTPRD associations with WED/RLS and addiction: reduced expression alters locomotion, sleep behaviors and cocaine-conditioned place preference. Mol Med (2015) 0.76
Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence. Transl Psychiatry (2015) 0.75
Re-defininG AddiC(CH3)Tion: genomics and epigenomics on substance use disorders. Mol Genet Genomic Med (2014) 0.75
Altered CSMD1 Expression Alters Cocaine-Conditioned Place Preference: Mutual Support for a Complex Locus from Human and Mouse Models. PLoS One (2015) 0.75
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genetic dissection of complex traits. Science (1994) 29.54
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature (2008) 18.21
Complement factor H variant increases the risk of age-related macular degeneration. Science (2005) 17.95
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet (2006) 13.16
Power and sample size calculations. A review and computer program. Control Clin Trials (1990) 9.58
Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet (2006) 7.90
Mapping complex disease loci in whole-genome association studies. Nature (2004) 7.31
Whole-genome association study of bipolar disorder. Mol Psychiatry (2008) 6.80
Power and sample size calculations for studies involving linear regression. Control Clin Trials (1998) 5.84
DNA Pooling: a tool for large-scale association studies. Nat Rev Genet (2002) 5.66
Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry (1998) 4.69
An open access database of genome-wide association results. BMC Med Genet (2009) 4.61
Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls. Hum Genet (2007) 3.92
Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Arch Gen Psychiatry (2000) 3.33
Molecular genetics of successful smoking cessation: convergent genome-wide association study results. Arch Gen Psychiatry (2008) 3.12
Non-replication and inconsistency in the genome-wide association setting. Hum Hered (2007) 2.99
On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies. Int J Epidemiol (2006) 2.66
Spurious genetic associations. Biol Psychiatry (2007) 2.62
Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans. Nucleic Acids Res (2006) 2.33
Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am J Hum Genet (2001) 2.26
Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs. BMC Genet (2007) 2.24
Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am J Hum Genet (2005) 2.18
Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. Am J Med Genet B Neuropsychiatr Genet (2006) 2.09
Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. Proc Natl Acad Sci U S A (2005) 2.00
Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes. Am J Med Genet B Neuropsychiatr Genet (2006) 1.95
SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children. Hum Mol Genet (2005) 1.91
Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates. Nucleic Acids Res (2006) 1.88
Identification of disease causing loci using an array-based genotyping approach on pooled DNA. BMC Genomics (2005) 1.83
Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs. Am J Med Genet (2000) 1.74
Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry (2008) 1.72
Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. Am J Med Genet (1999) 1.72
Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels. Hum Genomics (2004) 1.71
Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. Ann N Y Acad Sci (2008) 1.69
Non-replication of association studies: "pseudo-failures" to replicate? Genet Med (2007) 1.62
Genes and (common) pathways underlying drug addiction. PLoS Comput Biol (2007) 1.57
Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. Hum Mol Genet (2007) 1.56
Genomewide suggestive linkage of opioid dependence to chromosome 14q. Hum Mol Genet (2007) 1.54
Genetic heterogeneity of Alzheimer's disease: complexity and advances. Psychoneuroendocrinology (2007) 1.54
Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms. Mol Psychiatry (2005) 1.46
D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers. Biol Psychiatry (1996) 1.38
Genetic risk for alcoholism relates to level of response to alcohol in Asian-American men and women. J Stud Alcohol (2002) 1.25
"Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. Biochem Pharmacol (2007) 1.22
Making memories stick: cell-adhesion molecules in synaptic plasticity. Trends Cell Biol (2000) 1.22
Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers. Arch Gen Psychiatry (1992) 1.16
Multiple sclerosis genetics. Curr Top Microbiol Immunol (2008) 1.04
A fresh look at an ancient receptor family: emerging roles for low density lipoprotein receptors in synaptic plasticity and memory formation. Neurobiol Learn Mem (2005) 1.03
Convergent genome wide association results for bipolar disorder and substance dependence. Am J Med Genet B Neuropsychiatr Genet (2009) 0.99
Estimation of relative allele frequencies of single-nucleotide polymorphisms in different populations by microarray hybridization of pooled DNA. Anal Biochem (2004) 0.97
Cell adhesion molecules: key players in memory consolidation? News Physiol Sci (2003) 0.86
Genome-wide association in bipolar. Mol Psychiatry (2008) 0.85
Alcohol-related flushing and the risk for alcoholism in sons of alcoholics. J Clin Psychiatry (1982) 0.79
A comparison of association statistics between pooled and individual genotypes. Hum Hered (2009) 0.77
Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature (2012) 4.95
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron (2013) 3.25
Molecular genetics of successful smoking cessation: convergent genome-wide association study results. Arch Gen Psychiatry (2008) 3.12
Brain-derived neurotrophic factor and obesity in the WAGR syndrome. N Engl J Med (2008) 2.91
Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res (2006) 2.62
Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res (2005) 2.34
Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs. BMC Genet (2007) 2.24
Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. Am J Med Genet B Neuropsychiatr Genet (2006) 2.09
Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann N Y Acad Sci (2006) 2.07
Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. Proc Natl Acad Sci U S A (2005) 2.00
Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes. Am J Med Genet B Neuropsychiatr Genet (2006) 1.95
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol Med (2010) 1.83
Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. J Natl Cancer Inst (2012) 1.83
Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry (2008) 1.72
Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. Ann N Y Acad Sci (2008) 1.69
Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Am J Med Genet B Neuropsychiatr Genet (2005) 1.60
Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. Hum Mol Genet (2007) 1.56
Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. Am J Med Genet B Neuropsychiatr Genet (2006) 1.51
Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice. Neuropsychopharmacology (2003) 1.48
Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities. Pharmacogenomics J (2003) 1.42
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology (2004) 1.41
Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. J Neurosci (2009) 1.33
A human-specific de novo protein-coding gene associated with human brain functions. PLoS Comput Biol (2010) 1.31
CHRNA3 rs1051730 genotype and short-term smoking cessation. Nicotine Tob Res (2011) 1.31
Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers. Mol Med (2008) 1.27
Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. PLoS One (2008) 1.26
NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. Neuropsychopharmacology (2006) 1.24
Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. Behav Pharmacol (2008) 1.23
"Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. Biochem Pharmacol (2007) 1.22
How individual sensitivity to opiates can be predicted by gene analyses. Trends Pharmacol Sci (2005) 1.22
Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Alcohol Clin Exp Res (2012) 1.19
Buprenorphine antinociception is abolished, but naloxone-sensitive reward is retained, in mu-opioid receptor knockout mice. Neuropsychopharmacology (2004) 1.15
Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement. Mol Med (2010) 1.14
Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci (2012) 1.12
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Circ Cardiovasc Genet (2013) 1.12
Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. Ann N Y Acad Sci (2008) 1.12
Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples. BMC Med Genet (2008) 1.12
Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. Pharmacogenomics (2010) 1.10
Mu opioid receptor-dependent and independent components in effects of tramadol. Neuropharmacology (2006) 1.09
SLC18A2 promoter haplotypes and identification of a novel protective factor against alcoholism. Hum Mol Genet (2005) 1.08
Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates. Open Biol (2012) 1.07
Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain (2013) 1.06
Common human 5' dopamine transporter (SLC6A3) haplotypes yield varying expression levels in vivo. Cell Mol Neurobiol (2006) 1.05
Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. Neuropharmacology (2010) 1.04
Genome-wide association for smoking cessation success: participants in a trial with adjunctive denicotinized cigarettes. Mol Med (2009) 1.02
A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell (2013) 1.01
OKCAM: an ontology-based, human-centered knowledgebase for cell adhesion molecules. Nucleic Acids Res (2008) 1.01
Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice. Neuropsychopharmacology (2006) 1.01
Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. PLoS One (2011) 1.00
Molecular mechanisms underlying the rewarding effects of cocaine. Ann N Y Acad Sci (2004) 1.00
Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Eur J Pharmacol (2007) 1.00
mu-Opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine-induced locomotion. Brain Res Mol Brain Res (2004) 1.00
Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. J Biol Chem (2003) 1.00
Active behaviours produced by antidepressants and opioids in the mouse tail suspension test. Int J Neuropsychopharmacol (2012) 0.99
Convergent genome wide association results for bipolar disorder and substance dependence. Am J Med Genet B Neuropsychiatr Genet (2009) 0.99
Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Mol Pharmacol (2002) 0.98
Methods to study the behavioral effects and expression of CB2 cannabinoid receptor and its gene transcripts in the chronic mild stress model of depression. Methods Mol Med (2006) 0.97
KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. J Biol Chem (2002) 0.96
Endocannabinoids and cannabinoid receptor genetics. Prog Neurobiol (2002) 0.95
Treatment-seeking inpatient cocaine abusers show hypothalamic dysregulation of both basal prolactin and cortisol secretion. Neuroendocrinology (2003) 0.94
The interaction of methylphenidate and benztropine with the dopamine transporter is different than other substrates and ligands. Biochem Pharmacol (2005) 0.94
Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm. PLoS One (2009) 0.94
Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? Pharmacol Ther (2013) 0.93
dextro- and levo-morphine attenuate opioid delta and kappa receptor agonist produced analgesia in mu-opioid receptor knockout mice. Eur J Pharmacol (2006) 0.93
Competency Guidelines for Public Health Laboratory Professionals: CDC and the Association of Public Health Laboratories. MMWR Surveill Summ (2015) 0.92
Reduced emotional and corticosterone responses to stress in mu-opioid receptor knockout mice. Neuropharmacology (2009) 0.92
Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction. BMC Genomics (2011) 0.91
Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis. Biol Psychiatry (2007) 0.91