Published in Aging (Albany NY) on July 24, 2009
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell (2011) 2.37
Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis (2015) 1.22
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Lipid metabolism in long-lived families: the Leiden Longevity Study. Age (Dordr) (2010) 1.14
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Lipidomics of familial longevity. Aging Cell (2013) 1.05
Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring. Aging (Albany NY) (2012) 1.01
Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R. PLoS One (2012) 0.97
C-reactive protein and glucose regulation in familial longevity. Age (Dordr) (2011) 0.93
Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice. Aging Cell (2011) 0.92
Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5). Aging (Albany NY) (2015) 0.86
High serum glucose levels are associated with a higher perceived age. Age (Dordr) (2011) 0.84
Metabolic syndrome in the offspring of centenarians: focus on prevalence, components, and adipokines. Age (Dordr) (2012) 0.82
Targeted biomarker discovery by high throughput glycosylation profiling of human plasma alpha1-antitrypsin and immunoglobulin A. PLoS One (2013) 0.82
Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study. Aging (Albany NY) (2015) 0.80
Insulin, aging, and the brain: mechanisms and implications. Front Endocrinol (Lausanne) (2015) 0.79
Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study. PLoS One (2012) 0.79
Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging? Aging (Albany NY) (2010) 0.79
Integrating metabolism and longevity through insulin and IGF1 signaling. Endocrinol Metab Clin North Am (2012) 0.78
Osteosarcopenic Obesity Syndrome: What Is It and How Can It Be Identified and Diagnosed? Curr Gerontol Geriatr Res (2016) 0.76
Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer's disease. Mol Neurodegener (2016) 0.76
Association of dietary vitamin D, serum 25-hydroxyvitamin D, insulin-like growth factor-1 concentrations and components of metabolic syndrome among Iranian women. Adv Biomed Res (2014) 0.75
Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age. Aging (Albany NY) (2016) 0.75
Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health. Sci Rep (2017) 0.75
Demography. Broken limits to life expectancy. Science (2002) 10.65
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature (2002) 10.52
Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science (2001) 8.06
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Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A (2008) 5.14
Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science (2007) 4.80
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A (2001) 4.30
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Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet (2006) 2.89
Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab (2003) 2.40
Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. J Am Geriatr Soc (2009) 2.30
Serum insulin-like growth factor-1 in centenarians: implications of IGF-1 as a rapid turnover protein. J Gerontol A Biol Sci Med Sci (2001) 2.27
Reduced insulin/IGF-1 signalling and human longevity. Aging Cell (2005) 2.13
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Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab (2003) 2.09
Clinical phenotype of families with longevity. J Am Geriatr Soc (2004) 2.03
Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings. Aging Cell (2008) 1.88
Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab (1991) 1.84
Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Horm IGF Res (2003) 1.79
Cardiovascular advantages among the offspring of centenarians. J Gerontol A Biol Sci Med Sci (2003) 1.62
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Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet (2002) 17.19
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet (2010) 14.24
Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A (2008) 8.39
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Thyroid status, disability and cognitive function, and survival in old age. JAMA (2004) 5.39
Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA (2010) 5.20
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet (2009) 4.25
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48
Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis. J Am Coll Cardiol (2008) 3.43
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Measuring cognitive function with age: the influence of selection by health and survival. Epidemiology (2008) 3.19
Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet (2007) 3.06
Telomere length predicts survival independent of genetic influences. Aging Cell (2007) 3.01
Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study. Arch Intern Med (2008) 2.90
Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet (2006) 2.89
Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell (2005) 2.83
Predicting survival in oldest old people. Am J Med (2012) 2.81
Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol (2005) 2.81
No effect of preoperative selective gut decontamination on endotoxemia and cytokine activation during cardiopulmonary bypass: a randomized, placebo-controlled study. Crit Care Med (2002) 2.79
Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. FASEB J (2010) 2.74
Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol (2002) 2.57
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell (2011) 2.37
Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip. Arthritis Rheum (2004) 2.33
Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation. Gastroenterology (2005) 2.30
Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. J Am Geriatr Soc (2009) 2.30
External validity of a trial comprised of elderly patients with hormone receptor-positive breast cancer. J Natl Cancer Inst (2014) 2.26
Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med (2012) 2.24
Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One (2009) 2.23
Setting and registry characteristics affect the prevalence and nature of multimorbidity in the elderly. J Clin Epidemiol (2008) 2.20
Microalbuminuria and lower glomerular filtration rate at young adult age in subjects born very premature and after intrauterine growth retardation. J Am Soc Nephrol (2005) 2.16
Reduced insulin/IGF-1 signalling and human longevity. Aging Cell (2005) 2.13
Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study. CMAJ (2009) 2.11
Framingham stroke risk score and cognitive impairment for predicting first-time stroke in the oldest old. Stroke (2013) 2.10
In a population-based prospective study, no association between high blood pressure and mortality after age 85 years. J Hypertens (2006) 2.04
Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study. CMAJ (2010) 2.03
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. Arthritis Rheum (2006) 2.00
Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer. JAMA (2012) 2.00
PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data. Bioinformatics (2012) 1.95
Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients. Gynecol Oncol (2005) 1.93
Systemic markers of inflammation and cognitive decline in old age. J Am Geriatr Soc (2007) 1.91
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet (2008) 1.91
The continuing value of twin studies in the omics era. Nat Rev Genet (2012) 1.88
Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet (2009) 1.87
Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. Eur J Hum Genet (2007) 1.85
The epigenome: archive of the prenatal environment. Epigenetics (2009) 1.82
From promises to practical strategies in epigenetic epidemiology. Nat Rev Genet (2013) 1.82
Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old. Age Ageing (2010) 1.79
Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Circulation (2012) 1.79