Published in Epigenetics on November 06, 2009
Quantitative comparison of genome-wide DNA methylation mapping technologies. Nat Biotechnol (2010) 5.96
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci (2015) 2.43
Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. Gene (2011) 2.03
Environmental chemical exposures and human epigenetics. Int J Epidemiol (2011) 1.97
Commentary: The seven plagues of epigenetic epidemiology. Int J Epidemiol (2012) 1.88
Prenatal famine and adult health. Annu Rev Public Health (2011) 1.67
Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics. Biol Sex Differ (2013) 1.60
Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy. Epigenetics (2011) 1.60
Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues. PLoS One (2012) 1.36
Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. PLoS One (2012) 1.32
Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight. Cancer Causes Control (2012) 1.27
Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects. Proc Nutr Soc (2011) 1.25
Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics (2012) 1.25
Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19. PLoS One (2012) 1.24
Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics. Gastroenterology (2013) 1.24
Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children. J Pediatr (2012) 1.23
Childhood exposure to violence and lifelong health: clinical intervention science and stress-biology research join forces. Dev Psychopathol (2013) 1.14
Neonatal genome-wide methylation patterns in relation to birth weight in the Norwegian Mother and Child Cohort. Am J Epidemiol (2014) 1.11
In utero life and epigenetic predisposition for disease. Adv Genet (2010) 1.06
Basic concepts of epigenetics: impact of environmental signals on gene expression. Epigenetics (2012) 1.02
The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring. Clin Epigenetics (2011) 1.00
Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction. Int J Epidemiol (2011) 0.96
Epigenetic mechanisms involved in developmental nutritional programming. World J Diabetes (2011) 0.95
Micronutrients in pregnancy in low- and middle-income countries. Nutrients (2015) 0.94
Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort. Epigenetics (2014) 0.93
High folate gestational and post-weaning diets alter hypothalamic feeding pathways by DNA methylation in Wistar rat offspring. Epigenetics (2013) 0.92
The epigenetic lorax: gene-environment interactions in human health. Epigenomics (2012) 0.92
Epigenetics and phenotypic variability: some interesting insights from birds. Genet Sel Evol (2013) 0.91
Association of maternal and nutrient supply line factors with DNA methylation at the imprinted IGF2/H19 locus in multiple tissues of newborn twins. Epigenetics (2013) 0.89
Space/population and time/age in DNA methylation variability in humans: a study on IGF2/H19 locus in different Italian populations and in mono- and di-zygotic twins of different age. Aging (Albany NY) (2012) 0.88
Brain activation during cognitive planning in twins discordant or concordant for obsessive-compulsive symptoms. Brain (2010) 0.87
Metabolic programming of obesity by energy restriction during the perinatal period: different outcomes depending on gender and period, type and severity of restriction. Front Physiol (2012) 0.86
Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome. Int J Epidemiol (2015) 0.86
In the womb's shadow. The theory of prenatal programming as the fetal origin of various adult diseases is increasingly supported by a wealth of evidence. EMBO Rep (2011) 0.85
Cross-tissue comparisons of leptin and adiponectin: DNA methylation profiles. Adipocyte (2014) 0.84
Dietary intake, plasma homocysteine, and repetitive element DNA methylation in the Multi-Ethnic Study of Atherosclerosis (MESA). Nutr Metab Cardiovasc Dis (2013) 0.83
Do epigenetic marks govern bone mass and homeostasis? Curr Genomics (2012) 0.83
Epidemiologic evidence for association between adverse environmental exposures in early life and epigenetic variation: a potential link to disease susceptibility? Clin Epigenetics (2015) 0.82
Fetal lung and placental methylation is associated with in utero nicotine exposure. Epigenetics (2014) 0.82
A prospective study of LINE-1DNA methylation and development of adiposity in school-age children. PLoS One (2013) 0.82
Stress-related programming of autonomic imbalance: role in allergy and asthma. Chem Immunol Allergy (2012) 0.81
Environmental Impact on DNA Methylation in the Germline: State of the Art and Gaps of Knowledge. Biomed Res Int (2015) 0.80
Cancer control and prevention by nutrition and epigenetic approaches. Antioxid Redox Signal (2012) 0.79
In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST. Toxicol In Vitro (2015) 0.78
Epigenetic mechanisms in the actions of endocrine-disrupting chemicals: gonadal effects and role in female reproduction. Reprod Domest Anim (2012) 0.78
3D Cohort Study: The Integrated Research Network in Perinatology of Quebec and Eastern Ontario. Paediatr Perinat Epidemiol (2016) 0.76
Epigenetic analysis of neurocognitive development at 1 year of age in a community-based pregnancy cohort. Behav Genet (2014) 0.76
9th International Conference on Conservative Management of Spinal Deformities - SOSORT 2012 Annual Meeting Milan, Italy. 10-12 May 2012. Abstracts. Scoliosis (2013) 0.75
Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive-compulsive disorder. BMC Neurosci (2016) 0.75
Frontal Cortex Transcriptome Analysis of Mice Exposed to Electronic Cigarettes During Early Life Stages. Int J Environ Res Public Health (2016) 0.75
Early-Life Nutritional Programming of Type 2 Diabetes: Experimental and Quasi-Experimental Evidence. Nutrients (2017) 0.75
Long-range autocorrelations of CpG islands in the human genome. PLoS One (2012) 0.75
On chromatin remodeling in mammary gland differentiation and breast tumorigenesis. Cold Spring Harb Perspect Biol (2012) 0.75
Epigenetics, obesity and early-life cadmium or lead exposure. Epigenomics (2016) 0.75
Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A (2008) 8.39
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet (2009) 4.25
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48
Effect of soy protein isolate supplementation on biochemical recurrence of prostate cancer after radical prostatectomy: a randomized trial. JAMA (2013) 3.40
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet (2007) 3.06
Telomere length predicts survival independent of genetic influences. Aging Cell (2007) 3.01
Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet (2006) 2.89
Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol (2005) 2.81
Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. FASEB J (2010) 2.74
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47
Screening for syphilis among homosexual men in bars and saunas in Amsterdam. Br J Vener Dis (1982) 2.42
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell (2011) 2.37
Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip. Arthritis Rheum (2004) 2.33
Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. J Am Geriatr Soc (2009) 2.30
Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One (2009) 2.23
Reduced insulin/IGF-1 signalling and human longevity. Aging Cell (2005) 2.13
Intrauterine famine exposure and body proportions at birth: the Dutch Hunger Winter. Int J Epidemiol (2004) 2.09
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. Arthritis Rheum (2006) 2.00
PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data. Bioinformatics (2012) 1.95
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet (2008) 1.91
The continuing value of twin studies in the omics era. Nat Rev Genet (2012) 1.88
Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet (2009) 1.87
Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. Eur J Hum Genet (2007) 1.85
The American, British and Dutch responses to unlinked anonymous HIV seroprevalence studies: an international comparison. AIDS (1990) 1.76
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (2010) 1.75
Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet (2013) 1.72
Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study. J Gerontol A Biol Sci Med Sci (2009) 1.70
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Ann Rheum Dis (2012) 1.66
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. J Gerontol A Biol Sci Med Sci (2010) 1.65
The Netherlands Twin Register biobank: a resource for genetic epidemiological studies. Twin Res Hum Genet (2010) 1.65
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array. Epigenetics Chromatin (2013) 1.62
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity. Proc Natl Acad Sci U S A (2010) 1.60
Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet (2008) 1.60
Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell (2012) 1.55
Genes encoding longevity: from model organisms to humans. Aging Cell (2008) 1.53
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. PLoS Genet (2013) 1.52
Heritabilities of apolipoprotein and lipid levels in three countries. Twin Res (2002) 1.50
Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine. Am J Clin Nutr (2007) 1.50
Famine, third-trimester pregnancy weight gain, and intrauterine growth: the Dutch Famine Birth Cohort Study. Hum Biol (1995) 1.50
The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection. Twin Res Hum Genet (2013) 1.49
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol (2014) 1.45
Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. Diabetes (2009) 1.44
Hallmark features of immunosenescence are absent in familial longevity. J Immunol (2010) 1.43
Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. J Gerontol A Biol Sci Med Sci (2006) 1.39
DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age. Epigenetics (2011) 1.33
Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study. J Am Geriatr Soc (2010) 1.33
Familial longevity is marked by enhanced insulin sensitivity. Aging Cell (2010) 1.32
ApoE plasma levels and risk of cardiovascular mortality in old age. PLoS Med (2006) 1.27
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways. Age (Dordr) (2011) 1.26
Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. Bioessays (2013) 1.26
A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p. Am J Hum Genet (2005) 1.25
The relationship between maternal and offspring birth weights after maternal prenatal famine exposure: the Dutch Famine Birth Cohort Study. Hum Biol (2000) 1.24
Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis. Ann Rheum Dis (2011) 1.24
Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19. PLoS One (2012) 1.24
Exposure to famine during gestation, size at birth, and blood pressure at age 59 y: evidence from the Dutch Famine. Eur J Epidemiol (2006) 1.24
Human insulin/IGF-1 and familial longevity at middle age. Aging (Albany NY) (2009) 1.16
VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiol Aging (2007) 1.16
Lipid metabolism in long-lived families: the Leiden Longevity Study. Age (Dordr) (2010) 1.14
Lipoprotein particle profiles mark familial and sporadic human longevity. PLoS Med (2006) 1.14
Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. Ann Rheum Dis (2012) 1.13
Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression. Behav Genet (2007) 1.13
Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial. J Med Internet Res (2013) 1.13
N-glycomic biomarkers of biological aging and longevity: a link with inflammaging. Ageing Res Rev (2012) 1.10
SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study. J Gerontol A Biol Sci Med Sci (2007) 1.10
New insights into osteoarthritis: early developmental features of an ageing-related disease. Curr Opin Rheumatol (2008) 1.10
Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency. PLoS Genet (2013) 1.10
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. Exp Gerontol (2012) 1.10
Schizoid personality disorder after prenatal exposure to famine. Am J Psychiatry (1996) 1.09
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. Age (Dordr) (2012) 1.09
Glucose tolerance in adults after prenatal exposure to famine. Lancet (2001) 1.07
Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps. Diabetes (2009) 1.07
Genital herpes simplex virus infection and perinatal transmission of human immunodeficiency virus. Obstet Gynecol (2005) 1.06
Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity. PLoS One (2010) 1.05
Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation (2011) 1.05
Prospective risk of fetal death in singleton, twin, and triplet gestations: implications for practice. Obstet Gynecol (2003) 1.05
Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family? Bioessays (2005) 1.05
Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues. Ann Rheum Dis (2012) 1.04
A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer. Cancer Res (2003) 1.04
Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology (2006) 1.04
Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Circ Cardiovasc Genet (2015) 1.03
Butyrylcholinesterase: association with the metabolic syndrome and identification of 2 gene loci affecting activity. Clin Chem (2006) 1.03
The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway. Diabetes (2013) 1.02
Prenatal cocaine exposure and school-age intelligence. Drug Alcohol Depend (1998) 1.02
Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health. J Proteome Res (2011) 1.01
QTLs for height: results of a full genome scan in Dutch sibling pairs. Eur J Hum Genet (2004) 1.01
Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study. Circ Cardiovasc Genet (2012) 1.01
Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis Rheumatol (2014) 1.00
Associations of gestational exposure to famine with energy balance and macronutrient density of the diet at age 58 years differ according to the reference population used. J Nutr (2009) 1.00
Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses. BMC Med Genet (2011) 1.00
High microsatellite and SNP genotyping success rates established in a large number of genomic DNA samples extracted from mouth swabs and genotypes. Twin Res Hum Genet (2006) 0.99