Published in J Biol Chem on February 18, 2010
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A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. J Biol Chem (2014) 0.93
Mitochondrial sirtuins and metabolic homeostasis. Best Pract Res Clin Endocrinol Metab (2012) 0.92
Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs. PLoS One (2013) 0.91
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Structures, substrates, and regulators of Mammalian sirtuins - opportunities and challenges for drug development. Front Pharmacol (2012) 0.90
Catalysis and mechanistic insights into sirtuin activation. Chembiochem (2010) 0.89
Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorg Med Chem Lett (2011) 0.89
Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity. J Biol Chem (2010) 0.88
Genealogy of an ancient protein family: the Sirtuins, a family of disordered members. BMC Evol Biol (2013) 0.88
Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome. PLoS One (2014) 0.87
Ten new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A. Eur J Hum Genet (2015) 0.87
Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α. Arthritis Rheumatol (2015) 0.85
SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation. Mol Cell (2014) 0.84
SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. Am J Cancer Res (2014) 0.84
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett (2013) 0.82
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism. Genome Integr (2013) 0.82
Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J Biol Chem (2010) 0.81
CCN2 exerts direct cytoprotective actions in adult cardiac myocytes by activation of the PI3-kinase/Akt/GSK-3β signaling pathway. J Cell Commun Signal (2012) 0.81
Potential Modulation of Sirtuins by Oxidative Stress. Oxid Med Cell Longev (2015) 0.81
DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome. Front Behav Neurosci (2016) 0.79
Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer. PLoS One (2016) 0.79
Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium. Antioxid Redox Signal (2013) 0.79
Resveratrol activates SIRT1 in a Lamin A-dependent manner. Cell Cycle (2013) 0.79
DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis. Mol Cell Oncol (2015) 0.79
Discovery of single nucleotide polymorphisms in candidate genes associated with fertility and production traits in Holstein cattle. BMC Genet (2013) 0.78
Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A). J Biol Chem (2014) 0.78
New targets to treat obesity and the metabolic syndrome. Eur J Pharmacol (2015) 0.77
Defining genome maintenance pathways using functional genomic approaches. Crit Rev Biochem Mol Biol (2011) 0.77
Metabolic syndrome: genetic insights into disease pathogenesis. Curr Opin Lipidol (2016) 0.76
DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med (2015) 0.76
DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner. PLoS One (2015) 0.75
Senescence (ageing) @ 2011. Indian J Dermatol (2011) 0.75
Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development. Curr Biol (2017) 0.75
Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders. Neural Plast (2016) 0.75
The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice. EMBO Rep (2017) 0.75
Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability. Nucleic Acids Res (2017) 0.75
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
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Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
The Sir2 family of protein deacetylases. Annu Rev Biochem (2004) 9.28
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun (2000) 9.09
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol (2004) 7.69
Sir2 links chromatin silencing, metabolism, and aging. Genes Dev (2000) 5.95
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell (2007) 5.01
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science (2009) 4.80
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol Cell (2007) 3.67
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science (2009) 3.64
Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet (2007) 3.59
How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17
Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol (2002) 3.00
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Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. Mol Cell Biol (2002) 2.51
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol (2007) 2.47
Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30
Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem (1998) 2.29
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell (2007) 2.18
Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. Biochemistry (2004) 2.11
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One (2009) 2.07
Specificity determinants of substrate recognition by the protein kinase DYRK1A. J Biol Chem (2000) 2.05
Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity. Prog Nucleic Acid Res Mol Biol (1999) 1.97
The ups and downs of SIRT1. Trends Biochem Sci (2008) 1.97
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol (2009) 1.73
Structure and autoregulation of the yeast Hst2 homolog of Sir2. Nat Struct Biol (2003) 1.59
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide. Structure (2003) 1.55
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CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One (2009) 1.43
Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases. FEBS Lett (2002) 1.40
The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Dev Cell (2008) 1.31
DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine. FEBS J (2008) 1.26
Mirk/Dyrk1B in cancer. J Cell Biochem (2007) 1.25
SIRT1 shows no substrate specificity in vitro. J Biol Chem (2005) 1.20
SIRTUIN 1: regulating the regulator. Biochem Biophys Res Commun (2008) 1.06
Developmental defects in trisomy 21 and mouse models. ScientificWorldJournal (2006) 1.03
mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development. Blood (2001) 0.92
REDK, a novel human regulatory erythroid kinase. Blood (2000) 0.89
Increased expression of Dyrk1a in HPV16 immortalized keratinocytes enable evasion of apoptosis. Int J Cancer (2007) 0.84
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab (2009) 5.02
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev (2010) 2.55
Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol Cell Biol (2010) 1.94
Sirtuin 1 in lipid metabolism and obesity. Ann Med (2011) 1.65
microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis (2010) 1.59
Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers: an immunohistochemical and fluorescent in situ hybridization study. Mod Pathol (2004) 1.59
A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo. Endocrinology (2014) 1.56
Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis. Nat Cell Biol (2009) 1.51
miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma. J Cell Sci (2011) 1.41
Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. EMBO J (2013) 1.40
Circulating miR-17, miR-20a, miR-29c, and miR-223 combined as non-invasive biomarkers in nasopharyngeal carcinoma. PLoS One (2012) 1.37
Population structure and genetic diversity in a rice core collection (Oryza sativa L.) investigated with SSR markers. PLoS One (2011) 1.34
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci U S A (2010) 1.30
NMR characterization of full-length farnesylated and non-farnesylated H-Ras and its implications for Raf activation. J Mol Biol (2004) 1.25
Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling. J Biol Chem (2008) 1.21
Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth. Brain Res (2011) 1.16
Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos). J Neurochem (2009) 1.16
miR-18a promotes malignant progression by impairing microRNA biogenesis in nasopharyngeal carcinoma. Carcinogenesis (2012) 1.15
p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci (2007) 1.14
Inhibition of IL-18 reduces myeloperoxidase activity and prevents edema in intestine following alcohol and burn injury. J Leukoc Biol (2005) 1.10
The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma. J Cancer Res Clin Oncol (2011) 1.10
LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1 alpha/CXCR4-mediated ERK1/2 and Akt signaling pathways. J Cell Biochem (2008) 1.09
Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis. Acta Biochim Biophys Sin (Shanghai) (2009) 1.08
The ways and means that fine tune Sirt1 activity. Trends Biochem Sci (2013) 1.07
Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. Carcinogenesis (2004) 1.07
Lactotransferrin: a candidate tumor suppressor-Deficient expression in human nasopharyngeal carcinoma and inhibition of NPC cell proliferation by modulating the mitogen-activated protein kinase pathway. Int J Cancer (2008) 1.07
Selenium nanoparticles as a carrier of 5-fluorouracil to achieve anticancer synergism. ACS Nano (2012) 1.06
MiR-185 targets the DNA methyltransferases 1 and regulates global DNA methylation in human glioma. Mol Cancer (2011) 1.05
Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. J Mol Histol (2013) 1.05
Transcriptional regulation of BRD7 expression by Sp1 and c-Myc. BMC Mol Biol (2008) 1.04
Family-based association analysis validates chromosome 3p21 as a putative nasopharyngeal carcinoma susceptibility locus. Genet Med (2006) 1.03
Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC. Curr Genomics (2009) 1.03
Immunoassay using probe-labelling immunogold nanoparticles with silver staining enhancement via surface-enhanced Raman scattering. Analyst (2003) 1.03
Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3. Mol Cell Proteomics (2011) 1.02
miR-214 promotes tumorigenesis by targeting lactotransferrin in nasopharyngeal carcinoma. Tumour Biol (2013) 1.02
Consortium-based science: the NIEHS's multipronged, collaborative approach to assessing the health effects of bisphenol A. Environ Health Perspect (2012) 1.02
Characterization of heparin-binding site of tissue transglutaminase: its importance in cell surface targeting, matrix deposition, and cell signaling. J Biol Chem (2012) 1.00
Analysis of gene expression identifies candidate molecular markers in nasopharyngeal carcinoma using microdissection and cDNA microarray. J Cancer Res Clin Oncol (2006) 0.99
Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray. Genes Chromosomes Cancer (2003) 0.99
The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status. Sci Rep (2012) 0.98
NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells. J Cell Biochem (2005) 0.98
Strategy to enhance the therapeutic effect of doxorubicin in human hepatocellular carcinoma by selenocystine, a synergistic agent that regulates the ROS-mediated signaling. Oncotarget (2014) 0.98
Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation. J Mol Biol (2008) 0.98
PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction. Int J Nanomedicine (2012) 0.98
Protein-protein interaction analysis by nuclear magnetic resonance spectroscopy. Methods Mol Biol (2004) 0.97
Dihydrotestosterone inhibits granulosa cell proliferation by decreasing the cyclin D2 mRNA expression and cell cycle arrest at G1 phase. Endocrinology (2002) 0.97
Camptothecin induces the ubiquitin-like protein, ISG15, and enhances ISG15 conjugation in response to interferon. J Interferon Cytokine Res (2004) 0.96
Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury. Am J Physiol Gastrointest Liver Physiol (2009) 0.96
Buccal permeation of buspirone: mechanistic studies on transport pathways. J Pharm Sci (2005) 0.96
Nasopharyngeal carcinoma: advances in genomics and molecular genetics. Sci China Life Sci (2011) 0.95
Epstein-Barr virus integrates frequently into chromosome 4q, 2q, 1q and 7q of Burkitt's lymphoma cell line (Raji). J Virol Methods (2006) 0.95
Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice. Mol Cell Biol (2012) 0.94
Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE1 nasopharyngeal carcinoma cell line. J Cancer Res Clin Oncol (2003) 0.94
Enhancement of cell permeabilization apoptosis-inducing activity of selenium nanoparticles by ATP surface decoration. Nanomedicine (2012) 0.94
Pol β associated complex and base excision repair factors in mouse fibroblasts. Nucleic Acids Res (2012) 0.94
Transbuccal delivery of 2',3'-dideoxycytidine: in vitro permeation study and histological investigation. Int J Pharm (2002) 0.94
Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression. J Cell Biochem (2006) 0.94
SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation. Mol Cell Biol (2013) 0.93
Thin films of Ag nanoparticles prepared from the reduction of AgI nanoparticles in self-assembled films. J Colloid Interface Sci (2002) 0.93
The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis. Biomaterials (2011) 0.93
Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation. Dalton Trans (2014) 0.93
Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase. PLoS One (2013) 0.93
Thalamus segmentation from diffusion tensor magnetic resonance imaging. Int J Biomed Imaging (2007) 0.92
The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor. Cancer Sci (2007) 0.92
Evaluation of the prognostic value of TGF-β superfamily type I receptor and TGF-β type II receptor expression in nasopharyngeal carcinoma using high-throughput tissue microarrays. J Mol Histol (2012) 0.92
Long non-coding RNAs in cancer. Sci China Life Sci (2012) 0.92
Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily. FEBS Lett (2005) 0.92
Early appearance of functional deficits after neonatal excitotoxic and hypoxic-ischemic injury: fragile recovery after development and role of the NMDA receptor. Dev Neurosci (2002) 0.91
Promoter hypermethylation-mediated inactivation of LRRC4 in gliomas. BMC Mol Biol (2008) 0.91
Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding. FASEB J (2011) 0.91
Identification of candidate molecular markers of nasopharyngeal carcinoma by microarray analysis of subtracted cDNA libraries constructed by suppression subtractive hybridization. Eur J Cancer Prev (2008) 0.91
Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury. Shock (2013) 0.90
New prognosis biomarkers identified by dynamic proteomic analysis of colorectal cancer. Mol Biosyst (2012) 0.90
Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. PLoS One (2010) 0.90
Effect of osmotherapy with hypertonic saline on regional cerebral edema following experimental stroke: a study utilizing magnetic resonance imaging. Neurocrit Care (2007) 0.90
HSV-2 induces TLRs and NF-kappaB-dependent cytokines in cervical epithelial cells. Biochem Biophys Res Commun (2009) 0.90
Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets. J Cereb Blood Flow Metab (2007) 0.89
NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma. Carcinogenesis (2011) 0.89
Evaluation of polyethylene oxide compacts as gastroretentive delivery systems. AAPS PharmSciTech (2009) 0.88
LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression. J Neurooncol (2006) 0.88
LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses. J Cell Physiol (2008) 0.88
Cloning and characterization of the BRD7 gene promoter. DNA Cell Biol (2006) 0.87
Novel in vitro model barriers for evaluation of the permeability of antitumor compounds, thioxanthones. Invest New Drugs (2006) 0.86
Effect of fixed aqueous layer thickness of polymeric stabilizers on zeta potential and stability of aripiprazole nanosuspensions. Pharm Dev Technol (2012) 0.86
LPLUNC1 inhibits nasopharyngeal carcinoma cell growth via down-regulation of the MAP kinase and cyclin D1/E2F pathways. PLoS One (2013) 0.86
Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA Repair (Amst) (2013) 0.86
Diversity in penaeidin antimicrobial peptide form and function. Dev Comp Immunol (2007) 0.86
Leucine-rich repeat C4 protein is involved in nervous tissue development and neurite outgrowth, and induction of glioma cell differentiation. Acta Biochim Biophys Sin (Shanghai) (2007) 0.85
SIRT1 performs a balancing act on the tight-rope toward longevity. Aging (Albany NY) (2009) 0.85
SPLUNC1 regulates cell progression and apoptosis through the miR-141-PTEN/p27 pathway, but is hindered by LMP1. PLoS One (2013) 0.84
Breast reconstruction and radiation therapy: A Canadian perspective. Can J Plast Surg (2012) 0.84
Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study. PLoS One (2013) 0.84
Analysis of the contribution of nasopharyngeal epithelial cancer cells to the induction of a local inflammatory response. J Cancer Res Clin Oncol (2011) 0.83