TP53 mutations in human cancers: origins, consequences, and clinical use.

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Published in Cold Spring Harb Perspect Biol on January 01, 2010

Authors

Magali Olivier1, Monica Hollstein, Pierre Hainaut

Author Affiliations

1: Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France.

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Human papillomavirus type 16 and TP53 mutation in oral cancer: matched analysis of the IARC multicenter study. Cancer Res (2004) 1.25

Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73. EMBO Rep (2006) 1.24

Worldwide genetic diversity of HBV genotypes and risk of hepatocellular carcinoma. Cancer Lett (2009) 1.22

Aflatoxin exposure and viral hepatitis in the etiology of liver cirrhosis in the Gambia, West Africa. Environ Health Perspect (2008) 1.22

Amount of DNA in plasma and cancer risk: a prospective study. Int J Cancer (2004) 1.21

The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation. Mol Cell Biol (2011) 1.20

Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome. Curr Opin Oncol (2010) 1.17

TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study. Cancer Res (2006) 1.16

Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene. Proc Natl Acad Sci U S A (2004) 1.16

Evaluating the arrayed primer extension resequencing assay of TP53 tumor suppressor gene. Proc Natl Acad Sci U S A (2002) 1.16

Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell Cycle (2006) 1.15

How to become immortal: let MEFs count the ways. Aging (Albany NY) (2010) 1.14

DNA adducts and lung cancer risk: a prospective study. Cancer Res (2005) 1.14

Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity. Oncogene (2005) 1.13

Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer. Cancer Res (2010) 1.13

Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy. Curr Opin Oncol (2013) 1.12

Biospecimen Reporting for Improved Study Quality. Biopreserv Biobank (2011) 1.12

Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity. Cancer Epidemiol Biomarkers Prev (2005) 1.12

Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells. PLoS One (2011) 1.11

TP53 mutations in squamous-cell carcinomas of the conjunctiva: evidence for UV-induced mutagenesis. Mutagenesis (2004) 1.11

Cross-validation study for epidermal growth factor receptor and KRAS mutation detection in 74 blinded non-small cell lung carcinoma samples: a total of 5550 exons sequenced by 15 molecular French laboratories (evaluation of the EGFR mutation status for the administration of EGFR-TKIs in non-small cell lung carcinoma [ERMETIC] project--part 1). J Thorac Oncol (2011) 1.09

The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy. Cancer Lett (2009) 1.09

Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis. Int J Cancer (2007) 1.06

Biobanking in a fast moving world: an international perspective. J Natl Cancer Inst Monogr (2011) 1.06

Aetiological differences in demographical, clinical and pathological characteristics of hepatocellular carcinoma in The Gambia. Liver Int (2010) 1.05

Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization. Nucleic Acids Res (2012) 1.05

MEF immortalization to investigate the ins and outs of mutagenesis. Carcinogenesis (2006) 1.04

p53 protein variants: structural and functional similarities with p63 and p73 isoforms. Oncogene (2004) 1.04

Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium. Cancer Genet (2012) 1.04

Human tissue biobanks as instruments for drug discovery and development: impact on personalized medicine. Biomark Med (2010) 1.02

Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: the EPIC study. Int J Cancer (2011) 1.01

Increase in female liver cancer in the Gambia, West Africa: evidence from 19 years of population-based cancer registration (1988-2006). PLoS One (2011) 1.01

Prognostic value of TP53, KRAS and EGFR mutations in nonsmall cell lung cancer: the EUELC cohort. Eur Respir J (2012) 1.01

Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis. PLoS One (2012) 1.01

Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiol Biomarkers Prev (2010) 1.00

p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations. Cancer Lett (2005) 1.00

Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids. Epigenetics (2009) 1.00

DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy. Am J Kidney Dis (2004) 0.99

Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53. Oncogene (2005) 0.99

Ser-249TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West Africa. Int J Cancer (2004) 0.98

Control of hepatocellular carcinoma through hepatitis B vaccination in areas of high endemicity: perspectives for global liver cancer prevention. Cancer Lett (2009) 0.98

TP53 and mutations in human cancer. Acta Biochim Pol (2003) 0.98

Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence. Antioxid Redox Signal (2011) 0.98

KRAS mutation status in primary nonsmall cell lung cancer and matched metastases. Cancer (2010) 0.98

Mutant p53 targeting by the low molecular weight compound STIMA-1. Mol Oncol (2008) 0.98