Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue.

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🔗 View Article (PMC 3982882)

Published in Nat Commun on February 27, 2014

Authors

Jianxin Shi1, Crystal N Marconett2, Jubao Duan3, Paula L Hyland1, Peng Li1, Zhaoming Wang1, William Wheeler4, Beiyun Zhou5, Mihaela Campan2, Diane S Lee2, Jing Huang6, Weiyin Zhou1, Tim Triche7, Laufey Amundadottir1, Andrew Warner8, Amy Hutchinson1, Po-Han Chen2, Brian S I Chung2, Angela C Pesatori9, Dario Consonni9, Pier Alberto Bertazzi9, Andrew W Bergen10, Mathew Freedman11, Kimberly D Siegmund7, Benjamin P Berman12, Zea Borok13, Nilanjan Chatterjee1, Margaret A Tucker1, Neil E Caporaso1, Stephen J Chanock1, Ite A Laird-Offringa2, Maria Teresa Landi1

Author Affiliations

1: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA.
2: 1] Department of Surgery, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California 90089, USA [2] Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California 90089, USA.
3: Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, North Shore University Health System Research Institute, University of Chicago Pritzker School of Medicine, Evanston, Illinois 60201, USA.
4: Information Management Services Inc., Rockville, Maryland 20852, USA.
5: Will Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, USC Keck School of Medicine, Los Angeles, California 90089, USA.
6: Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA.
7: Bioinformatics Division, Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089, USA.
8: Pathology/Histotechnology Laboratory, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.
9: Unit of Epidemiology, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan 20122, Italy.
10: Molecular Genetics Program, Center for Health Sciences, SRI, Menlo Park, California 94025, USA.
11: 1] Program in Medical and Population Genetics, The Broad Institute, Cambridge, Massachusetts 02142, USA [2] Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
12: 1] Bioinformatics Division, Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089, USA [2] USC Epigenome Center and USC/Norris Comprehensive Cancer Center, Los Angeles, California 90089, USA.
13: 1] Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California 90089, USA [2] Will Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, USC Keck School of Medicine, Los Angeles, California 90089, USA.

Associated clinical trials:

Genetic Epidemiology of Lung Cancer and Smoking | NCT00340340

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