Published in Source Code Biol Med on January 14, 2010
Multilevel Parallelization of AutoDock 4.2. J Cheminform (2011) 1.06
Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One (2011) 0.85
New small molecule agonists to the thyrotropin receptor. Thyroid (2015) 0.82
Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. Mol Cancer Ther (2015) 0.80
Monte Carlo loop refinement and virtual screening of the thyroid-stimulating hormone receptor transmembrane domain. J Biomol Struct Dyn (2014) 0.78
Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis. J Biol Chem (2015) 0.75
TSH Receptor Signaling Abrogation by a Novel Small Molecule. Front Endocrinol (Lausanne) (2016) 0.75
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Virtual ligand screening: strategies, perspectives and limitations. Drug Discov Today (2006) 2.59
Virtual screening and fast automated docking methods. Drug Discov Today (2002) 2.48
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Role of binding entropy in the refinement of protein-ligand docking predictions: analysis based on the use of 11 scoring functions. J Comput Chem (2007) 1.35
Computer aided identification of small molecules disrupting uPAR/alpha5beta1--integrin interaction: a new paradigm for metastasis prevention. PLoS One (2009) 0.93
Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J Med Chem (2008) 0.90
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell (2010) 6.94
Structure and conserved RNA binding of the PAZ domain. Nature (2003) 5.28
Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol (2006) 4.55
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol (2008) 3.74
Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell (2007) 3.51
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev (2009) 2.98
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing. Mol Cell (2007) 2.77
The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood (2007) 2.58
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol Cell (2004) 2.43
Structure and regulation of MAPK phosphatases. Cell Signal (2004) 2.42
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell (2002) 2.20
Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature (2010) 2.02
The role of human bromodomains in chromatin biology and gene transcription. Curr Opin Drug Discov Devel (2009) 1.99
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (2012) 1.88
Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (2008) 1.86
The PHD finger: a versatile epigenome reader. Trends Biochem Sci (2011) 1.81
A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3. Nat Struct Biol (2003) 1.67
Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem (2012) 1.66
Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP. Structure (2003) 1.54
Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J (2002) 1.49
BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy. Cancer Res (2013) 1.43
Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem (2011) 1.43
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol (2011) 1.35
Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator. Structure (2009) 1.35
Epigenetic transcriptional repression of cellular genes by a viral SET protein. Nat Cell Biol (2008) 1.34
Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing. Nat Struct Mol Biol (2008) 1.32
Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression. Cancer Res (2011) 1.31
Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase. J Mol Biol (2006) 1.30
Keeping it in the family: diverse histone recognition by conserved structural folds. Crit Rev Biochem Mol Biol (2010) 1.29
Structure and hemimethylated CpG binding of the SRA domain from human UHRF1. J Biol Chem (2008) 1.26
Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol (2006) 1.25
Selective small molecules blocking HIV-1 Tat and coactivator PCAF association. J Am Chem Soc (2005) 1.18
p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS One (2010) 1.18
Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription. Biochemistry (2011) 1.10
Structure and chromosomal DNA binding of the SWIRM domain. Nat Struct Mol Biol (2005) 1.06
T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation. J Exp Med (2013) 1.03
Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2. Cell Res (2010) 1.02
Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found Symp (2004) 1.01
A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporter. J Biol Chem (2002) 1.01
Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics. Structure (2004) 1.01
The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in Arabidopsis. PLoS Genet (2011) 0.95
Biochemical profiling of histone binding selectivity of the yeast bromodomain family. PLoS One (2010) 0.93
Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem (2013) 0.93
Computer aided identification of small molecules disrupting uPAR/alpha5beta1--integrin interaction: a new paradigm for metastasis prevention. PLoS One (2009) 0.93
Viral-encoded enzymes that target host chromatin functions. Biochim Biophys Acta (2009) 0.93
Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor. J Med Chem (2007) 0.92
Molecular basis of distinct interactions between Dok1 PTB domain and tyrosine-phosphorylated EGF receptor. J Mol Biol (2004) 0.91
Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J Med Chem (2008) 0.90
An archaeal SET domain protein exhibits distinct lysine methyltransferase activity towards DNA-associated protein MC1-alpha. FEBS Lett (2005) 0.90
Dimerization of a viral SET protein endows its function. Proc Natl Acad Sci U S A (2010) 0.89
Coupling of folding and binding in the PTB domain of the signaling protein Shc. Structure (2003) 0.88
Human uroporphyrinogen III synthase: NMR-based mapping of the active site. Proteins (2008) 0.88
Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1. Proc Natl Acad Sci U S A (2012) 0.88
Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors. J Am Chem Soc (2011) 0.87
Structure and function of protein modules in chromatin biology. Results Probl Cell Differ (2006) 0.85
Prevalence of plasmid-mediated quinolone resistance in Escherichia coli isolates in Wenzhou, Southern China, 2002-2008. Jpn J Infect Dis (2011) 0.85
Structure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activity. J Med Chem (2011) 0.85
New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding. J Mol Biol (2005) 0.85
γ-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers. PLoS One (2012) 0.83
Integration of small-molecule discovery in academic biomedical research. Mt Sinai J Med (2010) 0.83
PTB or not to be: promiscuous, tolerant and Bizarro domains come of age. IUBMB Life (2004) 0.83
Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype. Cancer Res (2006) 0.82
Modulating molecular functions of p53 with small molecules. Cell Cycle (2006) 0.81
Structure of the adaptor protein p14 reveals a profilin-like fold with distinct function. J Mol Biol (2005) 0.81
Scaling the druggability landscape of human bromodomains, a new class of drug targets. J Med Chem (2012) 0.80
Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain. Proteins (2011) 0.80
ChEpiMod: a knowledgebase for chemical modulators of epigenome reader domains. Bioinformatics (2014) 0.80
FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors. J Biol Chem (2002) 0.80
Optimization of ultrasonic-assisted enzymatic hydrolysis for the extraction of luteolin and apigenin from celery. J Food Sci (2011) 0.80
Anti-viral opportunities during transcriptional activation of latent HIV in the host chromatin. Methods (2010) 0.79
Catalysis and regioselectivity of the aqueous Heck reaction by Pd(0) nanoparticles under ultrasonic irradiation. J Org Chem (2006) 0.79
Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors. J Mol Neurosci (2002) 0.78
Use of nuclear magnetic resonance spectroscopy to study structure-function of bromodomains. Methods Enzymol (2004) 0.77
The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure. Biochemistry (2014) 0.76
TAGging the target for damage control. Nat Struct Biol (2002) 0.75
Examining both sides of a Janus PTB domain. Structure (2003) 0.75
Paramecium bursaria chlorella virus 1 encodes a polyamine acetyltransferase. J Biol Chem (2012) 0.75
Structural insights into FRS2α PTB domain recognition by neurotrophin receptor TrkB. Proteins (2014) 0.75
Pspace: a program that assesses protein space. Source Code Biol Med (2007) 0.75
Structure-based rational design of chemical ligands for AMPA-subtype glutamate receptors. J Mol Neurosci (2003) 0.75
1H, 13C and 15N resonance assignments for the N-cadherin prodomain. J Biomol NMR (2004) 0.75
Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors. J Mol Neurosci (2004) 0.75
1H, 15N and 13C resonance assignments for the PTB domain of the signaling protein Shc. J Biomol NMR (2003) 0.75
Bromodomains as targets for therapeutic intervention. Drug Discov Today Technol (2016) 0.75
1H, 13C and 15N resonance assignments of the catalytic domain of human MAPK phosphatase, PAC-1. J Biomol NMR (2003) 0.75
Resonance assignments for the endosomal adaptor protein p14. J Biomol NMR (2004) 0.75
1H, 13C and 15N resonance assignments of a viral SET domain histone lysine methyltransferase. J Biomol NMR (2003) 0.75
[Molecular evidence for origin of plastid-like organelle apicoplast: a review]. Yi Chuan (2005) 0.75
Regulation of Raf activity by dimerization. Pigment Cell Melanoma Res (2010) 0.75