Hypercapnic acidosis in ventilator-induced lung injury.

Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus 'conventional' protective ventilation (6 ml/kg) in severe ARDS: the prospective randomized Xtravent-study. Intensive Care Med (2013) 1.49

Bench-to-bedside review: hypercapnic acidosis in lung injury--from 'permissive' to 'therapeutic'. Crit Care (2010) 1.01

Ventilation with "clinically relevant" high tidal volumes does not promote stretch-induced injury in the lungs of healthy mice. Crit Care Med (2012) 0.99

Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling. J Biol Chem (2012) 0.92

Effect of spontaneous breathing on ventilator-induced lung injury in mechanically ventilated healthy rabbits: a randomized, controlled, experimental study. Crit Care (2011) 0.89

The preconditioning pulmonary protective effect of volatile isoflurane in acute lung injury is mediated by activation of endogenous iNOS. J Anesth (2012) 0.84

Year in review in Intensive Care Medicine 2010: I. Acute renal failure, outcome, risk assessment and ICU performance, sepsis, neuro intensive care and experimentals. Intensive Care Med (2011) 0.78

Effects of different tidal volume ventilation on paraquat-induced acute lung injury in piglets. Med Sci Monit (2015) 0.77

Hypercapnia attenuates ventilator-induced lung injury via a disintegrin and metalloprotease-17. J Physiol (2014) 0.76

Comparison of the effects of moderate and severe hypercapnic acidosis on ventilation-induced lung injury. BMC Anesthesiol (2015) 0.75

Incidence, risk factors and consequences of ICU delirium. Intensive Care Med (2006) 4.82

Hypocapnia. N Engl J Med (2002) 2.67

Atelectasis causes alveolar injury in nonatelectatic lung regions. Am J Respir Crit Care Med (2006) 2.56

Hypocapnia and the injured brain: more harm than benefit. Crit Care Med (2010) 2.35

Carbon dioxide attenuates pulmonary impairment resulting from hyperventilation. Crit Care Med (2003) 2.31

Lung-protective ventilation in the operating room: time to implement? Anesthesiology (2014) 2.15

Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium rates. Anesth Analg (2010) 2.09

Early changes in lung gene expression due to high tidal volume. Am J Respir Crit Care Med (2003) 2.03

Molecular evidence of placental hypoxia in preeclampsia. J Clin Endocrinol Metab (2005) 1.98

Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia? Circ Res (2004) 1.83

Insulin-like growth factor-I receptor-mediated vasculogenesis/angiogenesis in human lung development. Am J Respir Cell Mol Biol (2003) 1.80

Negative-pressure ventilation: better oxygenation and less lung injury. Am J Respir Crit Care Med (2007) 1.71

Effect of chemical stabilizers of hypoxia-inducible factors on early lung development. Am J Physiol Lung Cell Mol Physiol (2007) 1.68

Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery. Reg Anesth Pain Med (2010) 1.67

Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition. Crit Care Med (2012) 1.63

Lung development and susceptibility to ventilator-induced lung injury. Am J Respir Crit Care Med (2005) 1.62

Pulmonary atelectasis: a pathogenic perioperative entity. Anesthesiology (2005) 1.57

The role of alpha-, beta-, and gamma-ENaC subunits in distal lung epithelial fluid absorption induced by pulmonary edema fluid. Am J Physiol Lung Cell Mol Physiol (2007) 1.55

Airway pressure release ventilation improves pulmonary blood flow in infants after cardiac surgery. Crit Care Med (2011) 1.52

Glucose in the ICU--evidence, guidelines, and outcomes. N Engl J Med (2012) 1.52

Emergency airway management: competence versus expertise? Anesthesiology (2008) 1.49

Imaging the interaction of atelectasis and overdistension in surfactant-depleted lungs. Crit Care Med (2013) 1.48

Dissociation of inflammatory mediators and function: experimental lung injury in nonpulmonary sepsis. Crit Care Med (2013) 1.48

Continuous negative abdominal distension augments recruitment of atelectatic lung. Crit Care Med (2012) 1.46

Mechanical ventilation induces neutrophil extracellular trap formation. Anesthesiology (2015) 1.44

Airway management in the lateral position: a randomized controlled trial. Anesth Analg (2005) 1.37

Amiloride-insensitive Na+ and fluid absorption in the mammalian distal lung. Am J Physiol Lung Cell Mol Physiol (2007) 1.32

Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat. Am J Respir Crit Care Med (2004) 1.31

Grg1 acts as a lung-specific oncogene in a transgenic mouse model. Cancer Res (2006) 1.31

Bench-to-bedside review: carbon dioxide. Crit Care (2010) 1.29

Role of oxygen and vascular development in epithelial branching morphogenesis of the developing mouse lung. Am J Physiol Lung Cell Mol Physiol (2004) 1.29

Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs. Am J Respir Crit Care Med (2003) 1.20

Have changes in ventilation practice improved outcome in children with acute lung injury? Pediatr Crit Care Med (2007) 1.20

Stretch-activated signaling pathways responsible for early response gene expression in fetal lung epithelial cells. J Cell Physiol (2007) 1.18

Mouse snail is a target gene for HIF. Mol Cancer Res (2011) 1.18

Congenital diaphragmatic hernia: comparison of animal models and relevance to the human situation. Neonatology (2009) 1.16

Conversion of mechanical force into biochemical signaling. J Biol Chem (2004) 1.15

Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation. Cell Res (2008) 1.13

Oxygenation response to positive end-expiratory pressure predicts mortality in acute respiratory distress syndrome. A secondary analysis of the LOVS and ExPress trials. Am J Respir Crit Care Med (2014) 1.11

Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat. Am J Physiol Lung Cell Mol Physiol (2006) 1.11

Human placental hypoxia-inducible factor-1alpha expression correlates with clinical outcomes in chronic hypoxia in vivo. Am J Pathol (2007) 1.11

Similarities and dissimilarities of branching and septation during lung development. Pediatr Pulmonol (2005) 1.11

Permissive hypercapnia--role in protective lung ventilatory strategies. Intensive Care Med (2004) 1.10

Dynamic HIF1A regulation during human placental development. Biol Reprod (2006) 1.08

Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide. Am J Physiol Lung Cell Mol Physiol (2007) 1.06

Surfactant lipid synthesis and lamellar body formation in glycogen-laden type II cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.05

Placental expression of soluble fms-like tyrosine kinase 1 is increased in singletons and twin pregnancies with intrauterine growth restriction. J Clin Endocrinol Metab (2007) 1.05

High tidal volume ventilation causes different inflammatory responses in newborn versus adult lung. Am J Respir Crit Care Med (2004) 1.04

Effects of ventilation strategy on distribution of lung inflammatory cell activity. Crit Care (2013) 1.03

Lung-derived soluble mediators are pathogenic in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2011) 1.03

Spontaneous effort causes occult pendelluft during mechanical ventilation. Am J Respir Crit Care Med (2013) 1.02

Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3. Am J Pathol (2007) 1.00

Effects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury. Am J Respir Crit Care Med (2003) 0.99

Down-regulation of sonic hedgehog expression in pulmonary hypoplasia is associated with congenital diaphragmatic hernia. Am J Pathol (2003) 0.99

Registration and design alterations of clinical trials in critical care: a cross-sectional observational study. Intensive Care Med (2014) 0.99

Continuous positive airway pressure causes lung injury in a model of sepsis. Am J Physiol Lung Cell Mol Physiol (2005) 0.98

An official multi-society statement: the role of clinical research results in the practice of critical care medicine. Am J Respir Crit Care Med (2012) 0.97

Iroquois genes influence proximo-distal morphogenesis during rat lung development. Am J Physiol Lung Cell Mol Physiol (2005) 0.97

Hypoxia-inducible factors in the first trimester human lung. J Histochem Cytochem (2006) 0.96

Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies. PLoS One (2010) 0.96

Mechanical stretch-induced serotonin release from pulmonary neuroendocrine cells: implications for lung development. Am J Physiol Lung Cell Mol Physiol (2005) 0.96

Atelectasis in the perioperative patient. Curr Opin Anaesthesiol (2007) 0.96

Reduced viability of mice with lung epithelial-specific knockout of glucocorticoid receptor. Am J Respir Cell Mol Biol (2009) 0.95

The molecular basis for abnormal human lung development. Biol Neonate (2004) 0.95

Early growth response-1 worsens ventilator-induced lung injury by up-regulating prostanoid synthesis. Am J Respir Crit Care Med (2010) 0.95

Measuring diaphragm thickness with ultrasound in mechanically ventilated patients: feasibility, reproducibility and validity. Intensive Care Med (2015) 0.95

Early growth response factor-1 in acute lung injury. Am J Physiol Lung Cell Mol Physiol (2007) 0.95