Published in Crit Care on April 30, 2010
Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future. Crit Care (2012) 1.08
Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care (2010) 1.04
Post return of spontaneous circulation factors associated with mortality in pediatric in-hospital cardiac arrest: a prospective multicenter multinational observational study. Crit Care (2014) 0.96
Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.92
Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling. J Biol Chem (2012) 0.92
Systemic inflammation impairs respiratory chemoreflexes and plasticity. Respir Physiol Neurobiol (2011) 0.91
Regulation of gene expression by carbon dioxide. J Physiol (2011) 0.91
Community-acquired pneumonia and survival of critically ill acute exacerbation of COPD patients in respiratory intensive care units. Int J Chron Obstruct Pulmon Dis (2016) 0.85
Hypocapnia and hypercapnia are predictors for ICU admission and mortality in hospitalized patients with community-acquired pneumonia. Chest (2012) 0.84
Monitoring in the intensive care. Crit Care Res Pract (2012) 0.79
Dietary methanol regulates human gene activity. PLoS One (2014) 0.78
Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps. Rev Bras Ter Intensiva (2015) 0.78
Hypercapnia accelerates wound healing in endothelial cell monolayers exposed to hypoxia. Open Respir Med J (2013) 0.78
Rebuttal from Jeremy R. Beitler, Rolf D. Hubmayr and Atul Malhotra. J Physiol (2013) 0.76
Cardiac index and oxygen delivery during low and high tidal volume ventilation strategies in patients with acute respiratory distress syndrome: a crossover randomized clinical trial. Crit Care (2013) 0.76
Hypercapnia attenuates ventilator-induced lung injury via a disintegrin and metalloprotease-17. J Physiol (2014) 0.76
Adherence to oxygenation and ventilation targets in mechanically ventilated premature and sick newborns: a retrospective study. BMC Pediatr (2013) 0.75
Advances in the support of respiratory failure: putting all the evidence together. Crit Care (2015) 0.75
Global cerebral edema from hypercapnic respiratory acidosis and response to hyperosmolar therapy. Neurology (2016) 0.75
Carbon dioxide: Global warning for nephrologists. World J Nephrol (2016) 0.75
A pilot feasibility, safety and biological efficacy multicentre trial of therapeutic hypercapnia after cardiac arrest: study protocol for a randomized controlled trial. Trials (2015) 0.75
Yogic breathing when compared to attention control reduces the levels of pro-inflammatory biomarkers in saliva: a pilot randomized controlled trial. BMC Complement Altern Med (2016) 0.75
Partial pressure of arterial carbon dioxide and survival to hospital discharge among patients requiring acute mechanical ventilation: A cohort study. J Crit Care (2017) 0.75
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med (2000) 48.03
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science (2000) 5.36
Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med (2001) 5.06
The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time. Stroke (1974) 4.89
Hypocapnia. N Engl J Med (2002) 2.67
Cellular mechanisms involved in CO(2) and acid signaling in chemosensitive neurons. Am J Physiol Cell Physiol (2004) 2.41
Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism. Crit Care Med (2007) 2.32
Carbon dioxide attenuates pulmonary impairment resulting from hyperventilation. Crit Care Med (2003) 2.31
Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial. J Neurosurg (1991) 2.09
Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: a prospective study. Crit Care Med (1994) 2.01
Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury. Crit Care Med (2008) 1.93
Hypercapnic acidosis and mortality in acute lung injury. Crit Care Med (2006) 1.93
Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome. Intensive Care Med (2009) 1.89
Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia. Anesthesiology (2008) 1.70
Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism. Crit Care Med (2008) 1.69
Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury. Am J Respir Crit Care Med (2002) 1.61
Management of infants with severe respiratory failure and persistence of the fetal circulation, without hyperventilation. Pediatrics (1985) 1.58
Permissive range of hypercapnia for improved peripheral microcirculation and cardiac output in rabbits. Crit Care Med (2007) 1.52
Incidence of hypo- and hypercarbia in severe traumatic brain injury before and after 2003 pediatric guidelines. Pediatr Crit Care Med (2008) 1.51
Effect of carbon dioxide on systemic oxygenation, oxygen consumption, and blood lactate levels after bidirectional superior cavopulmonary anastomosis. Crit Care Med (2005) 1.50
Changes in the management of severe traumatic brain injury: 1991-1997. Crit Care Med (2000) 1.48
Mechanical controlled hypoventilation in status asthmaticus. Am Rev Respir Dis (1984) 1.48
Heart and brain circulation and CO2 in healthy men. Acta Physiol (Oxf) (2008) 1.46
Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants. J Thorac Cardiovasc Surg (1997) 1.41
High CO2 levels impair alveolar epithelial function independently of pH. PLoS One (2007) 1.33
Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-[kappa]B activation. Am J Respir Cell Mol Biol (2003) 1.21
Hypercapnia improves tissue oxygenation. Anesthesiology (2002) 1.20
Buffering hypercapnic acidosis worsens acute lung injury. Am J Respir Crit Care Med (2000) 1.20
Cardiovascular effects of carbon dioxide in man. Anesthesiology (1974) 1.17
Carbon dioxide protects the perinatal brain from hypoxic-ischemic damage: an experimental study in the immature rat. Pediatrics (1995) 1.17
Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappaB dependent mechanism. Thorax (2009) 1.16
Guidelines for the treatment of acidaemia with THAM. Drugs (1998) 1.14
Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat. Am J Physiol Lung Cell Mol Physiol (2006) 1.11
Improved cerebral resuscitation from cardiac arrest in dogs with mild hypothermia plus blood flow promotion. Stroke (1996) 1.11
The independent effects of hyperventilation, tolazoline, and dopamine on infants with persistent pulmonary hypertension. J Pediatr (1981) 1.10
CO(2) and pH independently modulate L-type Ca(2+) current in rabbit carotid body glomus cells. J Neurophysiol (2002) 1.08
Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis. Crit Care Med (2009) 1.04
Injurious effects of hypocapnic alkalosis in the isolated lung. Am J Respir Crit Care Med (2000) 1.03
Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis. Crit Care Med (2009) 0.98
The carotid chemoreceptors are a major determinant of ventilatory CO2 sensitivity and of PaCO2 during eupneic breathing. Adv Exp Med Biol (2008) 0.98
Acute hypercapnia improves indices of tissue oxygenation more than dobutamine in septic shock. Am J Respir Crit Care Med (2007) 0.95
Arterial hydrogen ion versus CO2 on depth and rate of breathing in decerebrate cats. Respir Physiol (1977) 0.93
Influence of in vitro lactic acidosis and hypercapnia on respiratory activity of isolated rat brain mitochondria. J Cereb Blood Flow Metab (1984) 0.93
Differential effects of buffered hypercapnia versus hypercapnic acidosis on shock and lung injury induced by systemic sepsis. Anesthesiology (2009) 0.93
Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling. Am J Physiol Heart Circ Physiol (2000) 0.93
Therapeutic hypercapnia is not protective in the in vivo surfactant-depleted rabbit lung. Pediatr Res (2003) 0.91
Supplemental oxygen and carbon dioxide each increase subcutaneous and intestinal intramural oxygenation. Anesth Analg (2004) 0.91
Cerebrovascular reactivity in comatose patients resuscitated from a cardiac arrest. Stroke (1997) 0.90
Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats. Am J Physiol Lung Cell Mol Physiol (2009) 0.88
Hyperventilation and cold-pressor stress echocardiography for noninvasive diagnosis of coronary artery spasm. J Am Soc Echocardiogr (2001) 0.87
Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption. Am J Respir Crit Care Med (2005) 0.86
The use of hyperventilation therapy after traumatic brain injury in Europe: an analysis of the BrainIT database. Intensive Care Med (2008) 0.86
Effect of acute exposure to CO 2 on lung mechanics in normal man. Respir Physiol (1973) 0.84
Temporary acidosis during reperfusion limits myocardial infarct size in dogs. Am J Physiol (1997) 0.84
Cerebral carbohydrate metabolism of man during respiratory and etabolic alkalosis. J Appl Physiol (1968) 0.84
Tissue oxygenation response to mild hypercapnia during cardiopulmonary bypass with constant pump output. Br J Anaesth (2006) 0.83
Ventilation heterogeneity is increased in hypocapnic dogs but not pigs. Respir Physiol (1998) 0.83
Effects of hypercarbic acidotic reperfusion on recovery of myocardial function after cardioplegic ischemia in neonatal lambs. Circulation (1994) 0.83
Effects of voluntary hyperventilation on cortical sensory responses. Electroencephalographic and magnetoencephalographic studies. Exp Brain Res (1999) 0.82
Carbon dioxide--a major determinant of collateral ventilation. J Appl Physiol Respir Environ Exerc Physiol (1978) 0.81
Effect of CDP-choline on hypocapnic neurons in culture. J Neurochem (1986) 0.79
Activation of tyrosine hydroxylase in striatum of newborn piglets in response to hypocapnic ischemia and recovery. Adv Exp Med Biol (1997) 0.79
Effect of inspired CO2 on ventilation and perfusion heterogeneity in hyperventilated dogs. J Appl Physiol (1985) (1993) 0.79
Pathophysiologic role of hypocarbia in post-traumatic pulmonary insufficiency. Am J Surg (1971) 0.79
CO2 relaxes parenchyma in the liquid-filled rat lung. J Appl Physiol (1985) (2007) 0.78
Nutrition and lung function in the critically ill patient. Clin Nutr (1998) 0.77
Effect of inhaled CO2 on hemorrhagic consolidation due to unilateral pulmonary arterial ligation. J Appl Physiol (1969) 0.76
The analgesic efficacy of transversus abdominis plane block after abdominal surgery: a prospective randomized controlled trial. Anesth Analg (2007) 8.66
Incidence, risk factors and consequences of ICU delirium. Intensive Care Med (2006) 4.82
The analgesic efficacy of transversus abdominis plane block after cesarean delivery: a randomized controlled trial. Anesth Analg (2008) 3.04
Transversus abdominis plane block. Anesth Analg (2007) 2.73
Hypocapnia. N Engl J Med (2002) 2.67
Atelectasis causes alveolar injury in nonatelectatic lung regions. Am J Respir Crit Care Med (2006) 2.56
The transversus abdominis plane block provides effective postoperative analgesia in patients undergoing total abdominal hysterectomy. Anesth Analg (2008) 2.42
Hypocapnia and the injured brain: more harm than benefit. Crit Care Med (2010) 2.35
Carbon dioxide attenuates pulmonary impairment resulting from hyperventilation. Crit Care Med (2003) 2.31
Lung-protective ventilation in the operating room: time to implement? Anesthesiology (2014) 2.15
Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax (2011) 2.10
Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium rates. Anesth Analg (2010) 2.09
Early changes in lung gene expression due to high tidal volume. Am J Respir Crit Care Med (2003) 2.03
Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury. Crit Care Med (2008) 1.93
Transversus abdominis plane block: a cadaveric and radiological evaluation. Reg Anesth Pain Med (2007) 1.89
Negative-pressure ventilation: better oxygenation and less lung injury. Am J Respir Crit Care Med (2007) 1.71
Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia. Anesthesiology (2008) 1.70
Hypercapnia and acidosis in sepsis: a double-edged sword? Anesthesiology (2010) 1.70
Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism. Crit Care Med (2008) 1.69
Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery. Reg Anesth Pain Med (2010) 1.67
Endotracheal intubation in patients with cervical spine immobilization: a comparison of macintosh and airtraq laryngoscopes. Anesthesiology (2007) 1.66
Lung development and susceptibility to ventilator-induced lung injury. Am J Respir Crit Care Med (2005) 1.62
Pulmonary atelectasis: a pathogenic perioperative entity. Anesthesiology (2005) 1.57
Evolution of the inflammatory and fibroproliferative responses during resolution and repair after ventilator-induced lung injury in the rat. Anesthesiology (2011) 1.53
Airway pressure release ventilation improves pulmonary blood flow in infants after cardiac surgery. Crit Care Med (2011) 1.52
Glucose in the ICU--evidence, guidelines, and outcomes. N Engl J Med (2012) 1.52
Emergency airway management: competence versus expertise? Anesthesiology (2008) 1.49
Imaging the interaction of atelectasis and overdistension in surfactant-depleted lungs. Crit Care Med (2013) 1.48
Dissociation of inflammatory mediators and function: experimental lung injury in nonpulmonary sepsis. Crit Care Med (2013) 1.48
Continuous negative abdominal distension augments recruitment of atelectatic lung. Crit Care Med (2012) 1.46
Mechanical ventilation induces neutrophil extracellular trap formation. Anesthesiology (2015) 1.44
Airway management in the lateral position: a randomized controlled trial. Anesth Analg (2005) 1.37
Simvastatin in the acute respiratory distress syndrome. N Engl J Med (2014) 1.29
Bench-to-bedside review: Permissive hypercapnia. Crit Care (2004) 1.22
Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs. Am J Respir Crit Care Med (2003) 1.20
Clinical review: Special populations--critical illness and pregnancy. Crit Care (2011) 1.20
Have changes in ventilation practice improved outcome in children with acute lung injury? Pediatr Crit Care Med (2007) 1.20
Tracheal intubation by inexperienced medical residents using the Airtraq and Macintosh laryngoscopes--a manikin study. Am J Emerg Med (2006) 1.19
Determination Of The Efficacy And Side-effect Profile Of Lower Doses Of Intrathecal Morphine In Patients Undergoing Total Knee Arthroplasty. BMC Anesthesiol (2008) 1.13
Comparison of the Airtraq and Truview laryngoscopes to the Macintosh laryngoscope for use by Advanced Paramedics in easy and simulated difficult intubation in manikins. BMC Emerg Med (2009) 1.12
Oxygenation response to positive end-expiratory pressure predicts mortality in acute respiratory distress syndrome. A secondary analysis of the LOVS and ExPress trials. Am J Respir Crit Care Med (2014) 1.11
Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat. Am J Physiol Lung Cell Mol Physiol (2006) 1.11
Comparison of the Glidescope and Pentax AWS laryngoscopes to the Macintosh laryngoscope for use by advanced paramedics in easy and simulated difficult intubation. BMC Emerg Med (2009) 1.11
Permissive hypercapnia--role in protective lung ventilatory strategies. Intensive Care Med (2004) 1.10
Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide. Am J Physiol Lung Cell Mol Physiol (2007) 1.06
Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κB-dependent mechanism. Crit Care Med (2012) 1.05
A comparison of the Glidescope, Pentax AWS, and Macintosh laryngoscopes when used by novice personnel: a manikin study. Can J Anaesth (2009) 1.05
Clinical review: Stem cell therapies for acute lung injury/acute respiratory distress syndrome - hope or hype? Crit Care (2012) 1.04
Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis. Crit Care Med (2009) 1.04
High tidal volume ventilation causes different inflammatory responses in newborn versus adult lung. Am J Respir Crit Care Med (2004) 1.04
Effects of ventilation strategy on distribution of lung inflammatory cell activity. Crit Care (2013) 1.03
Lung-derived soluble mediators are pathogenic in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2011) 1.03
Permissive hypercapnia: role in protective lung ventilatory strategies. Curr Opin Crit Care (2005) 1.03
Spontaneous effort causes occult pendelluft during mechanical ventilation. Am J Respir Crit Care Med (2013) 1.02
Mesenchymal stem cell trials for pulmonary diseases. J Cell Biochem (2014) 1.01
Effects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury. Am J Respir Crit Care Med (2003) 0.99
Registration and design alterations of clinical trials in critical care: a cross-sectional observational study. Intensive Care Med (2014) 0.99
Effects of intratracheal mesenchymal stromal cell therapy during recovery and resolution after ventilator-induced lung injury. Anesthesiology (2013) 0.99
Continuous positive airway pressure causes lung injury in a model of sepsis. Am J Physiol Lung Cell Mol Physiol (2005) 0.98
Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis. Crit Care Med (2009) 0.98
An official multi-society statement: the role of clinical research results in the practice of critical care medicine. Am J Respir Crit Care Med (2012) 0.97
Ipsilateral transversus abdominis plane block provides effective analgesia after appendectomy in children: a randomized controlled trial. Anesth Analg (2010) 0.97
Atelectasis in the perioperative patient. Curr Opin Anaesthesiol (2007) 0.96
Early growth response-1 worsens ventilator-induced lung injury by up-regulating prostanoid synthesis. Am J Respir Crit Care Med (2010) 0.95
Measuring diaphragm thickness with ultrasound in mechanically ventilated patients: feasibility, reproducibility and validity. Intensive Care Med (2015) 0.95
Early growth response factor-1 in acute lung injury. Am J Physiol Lung Cell Mol Physiol (2007) 0.95
CrossTalk proposal: there is added benefit to providing permissive hypercapnia in the treatment of ARDS. J Physiol (2013) 0.93
Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury. Crit Care Med (2005) 0.93
Differential effects of buffered hypercapnia versus hypercapnic acidosis on shock and lung injury induced by systemic sepsis. Anesthesiology (2009) 0.93
Effects and mechanisms of action of sildenafil citrate in human chorionic arteries. Reprod Biol Endocrinol (2009) 0.93
Mesenchymal stem cells - a promising therapy for Acute Respiratory Distress Syndrome. F1000 Med Rep (2012) 0.93
Hypercapnic acidosis in ventilator-induced lung injury. Intensive Care Med (2010) 0.92
Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling. J Biol Chem (2012) 0.92
New strategies to control the inflammatory response in cardiac surgery. Curr Opin Anaesthesiol (2004) 0.91
Therapeutic hypercapnia is not protective in the in vivo surfactant-depleted rabbit lung. Pediatr Res (2003) 0.91
Cell-based therapies for the acute respiratory distress syndrome. Curr Opin Crit Care (2014) 0.90
Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia. Crit Care (2013) 0.90
Oxygen attenuates atelectasis-induced injury in the in vivo rat lung. Anesthesiology (2005) 0.89
Mechanical ventilation: taking its toll on the lung. Anesthesiology (2009) 0.88
Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats. Am J Physiol Lung Cell Mol Physiol (2009) 0.88
Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat model. Anesth Analg (2006) 0.87
Can 'permissive' hypercapnia modulate the severity of sepsis-induced ALI/ARDS? Crit Care (2011) 0.87
Hypercapnia increases cerebral tissue oxygen tension in anesthetized rats. Can J Anaesth (2003) 0.86
Do soluble mediators cause ventilator-induced lung injury and multi-organ failure? Intensive Care Med (2010) 0.86
Prolonged mechanical ventilation induces cell cycle arrest in newborn rat lung. PLoS One (2011) 0.85
Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome. Anesthesiology (2014) 0.85
Relative effects of negative versus positive pressure ventilation depend on applied conditions. Intensive Care Med (2012) 0.84
Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury. BMC Pulm Med (2008) 0.84
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension. Am J Physiol Heart Circ Physiol (2010) 0.84
Mechanical ventilation-induced apoptosis in newborn rat lung is mediated via FasL/Fas pathway. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
Therapeutic efficacy of human mesenchymal stromal cells in the repair of established ventilator-induced lung injury in the rat. Anesthesiology (2015) 0.84
Clinical review: gene-based therapies for ALI/ARDS: where are we now? Crit Care (2011) 0.83
Hydrogen sulfide in lung injury: therapeutic hope from a toxic gas? Anesthesiology (2010) 0.83
Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury. Intensive Care Med (2011) 0.83
12-hour versus 24-hour creatinine clearance in critically ill pediatric patients. Pediatr Res (2005) 0.82
Scoring systems for the critically ill: use, misuse and abuse. Can J Anaesth (2006) 0.82