Published in Circulation on March 15, 2010
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol (2011) 3.26
The Rotterdam Study: 2014 objectives and design update. Eur J Epidemiol (2013) 2.56
Cohort Profile: TwinsUK and healthy ageing twin study. Int J Epidemiol (2012) 2.37
Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients. Blood (2012) 2.17
The UK Adult Twin Registry (TwinsUK Resource). Twin Res Hum Genet (2012) 1.81
MaCH-admix: genotype imputation for admixed populations. Genet Epidemiol (2012) 1.77
Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project. Blood (2013) 1.69
The Rotterdam Study: 2016 objectives and design update. Eur J Epidemiol (2015) 1.61
Functional architecture of Weibel-Palade bodies. Blood (2011) 1.55
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol (2014) 1.45
Genetics of venous thrombosis: insights from a new genome wide association study. PLoS One (2011) 1.43
Estimation and partition of heritability in human populations using whole-genome analysis methods. Annu Rev Genet (2013) 1.41
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains. PLoS Genet (2011) 1.35
Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol (2013) 1.30
A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q. J Thromb Haemost (2012) 1.23
Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. Am J Hum Genet (2015) 1.23
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet (2016) 1.22
Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism. J Thromb Haemost (2011) 1.19
Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis. Blood (2010) 1.17
von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy. Blood (2013) 1.17
Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses. PLoS One (2013) 1.16
Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Proc Natl Acad Sci U S A (2012) 1.16
Dominance genetic variation contributes little to the missing heritability for human complex traits. Am J Hum Genet (2015) 1.14
Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study. Blood (2010) 1.13
Genetic determinants of plasma von Willebrand factor antigen levels: a target gene SNP and haplotype analysis of ARIC cohort. Blood (2011) 1.10
Epidemiology of venous thromboembolism. Nat Rev Cardiol (2015) 1.07
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. Am J Hum Genet (2012) 1.05
Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation (2011) 1.05
Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PLoS One (2013) 1.02
Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. BMC Med Genet (2011) 1.02
Effect of genetic variations in syntaxin-binding protein-5 and syntaxin-2 on von Willebrand factor concentration and cardiovascular risk. Circ Cardiovasc Genet (2010) 1.01
Characterizing polymorphisms and allelic diversity of von Willebrand factor gene in the 1000 Genomes. J Thromb Haemost (2013) 0.99
von Willebrand disease: clinical and laboratory lessons learned from the large von Willebrand disease studies. Am J Hematol (2012) 0.97
The molecular characterization of von Willebrand disease: good in parts. Br J Haematol (2013) 0.94
Prioritizing genetic variants for causality on the basis of preferential linkage disequilibrium. Am J Hum Genet (2012) 0.94
Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. Hum Mol Genet (2016) 0.94
Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum Mol Genet (2013) 0.93
Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion. J Clin Invest (2014) 0.93
Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children. Haematologica (2011) 0.93
The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels. Blood (2013) 0.92
Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC Study. Blood (2012) 0.91
ABO Blood Groups and Cardiovascular Diseases. Int J Vasc Med (2012) 0.91
Platelet secretion and hemostasis require syntaxin-binding protein STXBP5. J Clin Invest (2014) 0.89
von Willebrand factor: at the crossroads of bleeding and thrombosis. Int J Hematol (2012) 0.88
A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations. PLoS One (2012) 0.87
Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study. Biomed Rep (2015) 0.87
Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. Blood (2015) 0.85
Effect of genetic variation in STXBP5 and STX2 on von Willebrand factor and bleeding phenotype in type 1 von Willebrand disease patients. PLoS One (2012) 0.85
Possible race and gender divergence in association of genetic variations with plasma von Willebrand factor: a study of ARIC and 1000 genome cohorts. PLoS One (2014) 0.84
Molecular testing for disorders of hemostasis. Int J Lab Hematol (2013) 0.84
Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects. PLoS One (2015) 0.82
Association between variations in coagulation system genes and carotid plaque. J Neurol Sci (2012) 0.81
Endothelial protein C receptor gene variants not associated with severe malaria in ghanaian children. PLoS One (2014) 0.81
New insights into genotype and phenotype of VWD. Hematology Am Soc Hematol Educ Program (2014) 0.81
Markers of vascular perturbation correlate with airway structural change in asthma. Am J Respir Crit Care Med (2013) 0.81
Identification and characterisation of mutations associated with von Willebrand disease in a Turkish patient cohort. Thromb Haemost (2013) 0.81
A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium. Hum Mol Genet (2011) 0.81
Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A. Blood (2016) 0.81
Classification of exon 18 linked variants of VWF gene in von Willebrand disease. Int J Mol Epidemiol Genet (2012) 0.79
Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip. Thromb Haemost (2013) 0.79
Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans. Am J Hematol (2015) 0.79
Syntaxin-binding protein 5 exocytosis regulation: differential role in endothelial cells and platelets. J Clin Invest (2014) 0.78
Environmental and Genetic Risk Factors Associated with Venous Thromboembolism. Semin Thromb Hemost (2016) 0.78
Genetic sequence analysis of inherited bleeding diseases. Blood (2013) 0.77
A genetic risk score comprising known venous thromboembolism loci is associated with chronic venous disease in a multi-ethnic cohort. Thromb Res (2015) 0.77
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nat Genet (2017) 0.77
Association between polymorphisms in the coagulation factor VII gene and coronary heart disease risk in different ethnicities: a meta-analysis. BMC Med Genet (2011) 0.76
ABO Blood Group as a Model for Platelet Glycan Modification in Arterial Thrombosis. Arterioscler Thromb Vasc Biol (2015) 0.76
Genome-wide association studies identify genetic loci for low von Willebrand factor levels. Eur J Hum Genet (2015) 0.76
Canalization effect in the coagulation cascade and the interindividual variability of oral anticoagulant response. A simulation study. Theor Biol Med Model (2011) 0.75
Dissecting the genetic determinants of hemostasis and thrombosis. Curr Opin Hematol (2015) 0.75
Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice. Arterioscler Thromb Vasc Biol (2016) 0.75
FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes. PLoS One (2015) 0.75
Performance related factors are the main determinants of the von Willebrand factor response to exhaustive physical exercise. PLoS One (2014) 0.75
Third Åland islands conference on von Willebrand disease, 26-28 September 2012: meeting report. Haemophilia (2013) 0.75
Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. PLoS One (2017) 0.75
Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease. PLoS One (2015) 0.75
Thrombosis Related ABO, F5, MTHFR, and FGG Gene Polymorphisms in Morbidly Obese Patients. Dis Markers (2016) 0.75
Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age (Dordr) (2015) 0.75
Replication and Characterization of Association between ABO SNPs and Red Blood Cell Traits by Meta-Analysis in Europeans. PLoS One (2016) 0.75
Genome-wide association study for endothelial growth factors. Circ Cardiovasc Genet (2014) 0.75
Genome-wide studies of von Willebrand factor propeptide identify loci contributing to variation in propeptide levels and von Willebrand factor clearance. J Thromb Haemost (2016) 0.75
Current and Emerging Options for the Management of Inherited von Willebrand Disease. Drugs (2017) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol (1989) 37.83
The Cardiovascular Health Study: design and rationale. Ann Epidemiol (1991) 27.24
Epidemiological approaches to heart disease: the Framingham Study. Am J Public Health Nations Health (1951) 20.27
Imputation-based analysis of association studies: candidate regions and quantitative traits. PLoS Genet (2007) 15.55
The Framingham Offspring Study. Design and preliminary data. Prev Med (1975) 10.53
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42
The genetics of haemostasis: a twin study. Lancet (2001) 8.08
Determinants of disease and disability in the elderly: the Rotterdam Elderly Study. Eur J Epidemiol (1991) 7.67
Genomic control, a new approach to genetic-based association studies. Theor Popul Biol (2001) 6.90
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet (2008) 5.93
The Rotterdam Study: objectives and design update. Eur J Epidemiol (2007) 5.78
Runs of homozygosity in European populations. Am J Hum Genet (2008) 5.34
Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res (2001) 4.50
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet (2008) 4.31
Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet (2007) 4.09
Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet (1995) 4.01
Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation (1997) 3.27
Lifecourse influences on health among British adults: effects of region of residence in childhood and adulthood. Int J Epidemiol (2007) 3.15
Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Thromb Haemost (1993) 3.12
The effect of ABO blood group on the diagnosis of von Willebrand disease. Blood (1987) 2.84
Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. Lancet (2006) 2.72
Testing for association on the X chromosome. Biostatistics (2008) 2.55
Association analysis in a variance components framework. Genet Epidemiol (2001) 2.38
Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity. J Thromb Haemost (2007) 2.28
von Willebrand factor in cardiovascular disease: focus on acute coronary syndromes. Circulation (2008) 2.20
Regulation of Weibel-Palade body exocytosis. Trends Cardiovasc Med (2005) 2.16
The mutational spectrum of type 1 von Willebrand disease: Results from a Canadian cohort study. Blood (2007) 2.07
Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem (2007) 2.01
Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. N Engl J Med (2000) 1.94
Which hemostatic markers add to the predictive value of conventional risk factors for coronary heart disease and ischemic stroke? The Caerphilly Study. Circulation (2005) 1.89
Rare Bleeding Disorder Registry: deficiencies of factors II, V, VII, X, XIII, fibrinogen and dysfibrinogenemias. J Thromb Haemost (2004) 1.69
Genetic determinants of hemostasis phenotypes in Spanish families. Circulation (2000) 1.63
Diurnal, seasonal, and blood-processing patterns in levels of circulating fibrinogen, fibrin D-dimer, C-reactive protein, tissue plasminogen activator, and von Willebrand factor in a 45-year-old population. Circulation (2007) 1.47
Effect of alteration in triglyceride levels on factor VII-phospholipid complexes in plasma. Arteriosclerosis (1990) 1.46
Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors. Atherosclerosis (1991) 1.40
Structural organization of the human MS4A gene cluster on Chromosome 11q12. Immunogenetics (2001) 1.38
Molecular genetics of hemophilia A in man (factor VIII deficiency). Mol Biol Med (1987) 1.37
Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. Arterioscler Thromb Vasc Biol (2006) 1.36
Hemostatic risk factors for atherothrombotic disease: an epidemiologic view. Thromb Haemost (2001) 1.36
Short-term intraindividual variability in hemostasis factors. The ARIC Study. Atherosclerosis Risk in Communities Intraindividual Variability Study. Ann Epidemiol (1992) 1.30
Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. N Engl J Med (2001) 1.30
von Willebrand disease. Medicine (Baltimore) (1997) 1.27
Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. J Biol Chem (2004) 1.25
ABO genotype and risk of thrombotic events and hemorrhagic stroke. J Thromb Haemost (2008) 1.18
The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E. Glycobiology (2008) 1.12
ABO blood group genotypes and the risk of venous thrombosis: effect of factor V Leiden. J Thromb Haemost (2005) 1.08
Inherited factor VII deficiency: molecular genetics and pathophysiology. Thromb Haemost (1997) 1.08
Polymorphism and recombination events at the ABO locus: a major challenge for genomic ABO blood grouping strategies. Transfus Med (2001) 1.06
Relation of the prothrombotic state to increasing age (from the Framingham Offspring Study). Am J Cardiol (2005) 1.03
Association of fibrinogen and coagulation factors VII and VIII with cardiovascular risk factors in the elderly: the Cardiovascular Health Study. Cardiovascular Health Study Investigators. Am J Epidemiol (1996) 1.00
Type 2N von Willebrand disease: clinical manifestations, pathophysiology, laboratory diagnosis and molecular biology. Best Pract Res Clin Haematol (2001) 0.95
Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study. Atherosclerosis (2005) 0.93
Factor VII gene polymorphism, factor VII levels, and prevalent cardiovascular disease: the Framingham Heart Study. Arterioscler Thromb Vasc Biol (2000) 0.90
Factor VII coagulant activity, factor VII -670A/C and -402G/A polymorphisms, and risk of venous thromboembolism. J Thromb Haemost (2007) 0.88
Low plasma levels of factor VIIc and antigen are more strongly associated with the 10 base pair promoter (-323) insertion than the glutamine 353 variant. Thromb Haemost (1996) 0.87
Linkage analysis for three coagulation factors clustering on chromosome 13q34: factor VII, factor X and protein Z. J Thromb Haemost (2007) 0.79
The association of dietary fat and fiber with coagulation factor VII in the elderly: the Rotterdam Study. Am J Clin Nutr (1997) 0.79
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med (2008) 43.36
Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol (2002) 35.63
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation (2010) 30.07
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet (2010) 26.48
Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet (2012) 25.96
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation (2014) 22.74
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2006) 19.43
Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation (2010) 19.30
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med (2008) 18.34
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12