Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.

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Published in Am J Hum Genet on March 12, 2015

Authors

Marine Germain1, Daniel I Chasman2, Hugoline de Haan3, Weihong Tang4, Sara Lindström5, Lu-Chen Weng4, Mariza de Andrade6, Marieke C H de Visser7, Kerri L Wiggins8, Pierre Suchon9, Noémie Saut9, David M Smadja10, Grégoire Le Gal11, Astrid van Hylckama Vlieg3, Antonio Di Narzo12, Ke Hao12, Christopher P Nelson13, Ares Rocanin-Arjo1, Lasse Folkersen14, Ramin Monajemi15, Lynda M Rose16, Jennifer A Brody17, Eline Slagboom18, Dylan Aïssi1, France Gagnon19, Jean-Francois Deleuze20, Panos Deloukas21, Christophe Tzourio22, Jean-Francois Dartigues22, Claudine Berr23, Kent D Taylor24, Mete Civelek25, Per Eriksson26, Cardiogenics Consortium, Bruce M Psaty27, Jeanine Houwing-Duitermaat15, Alison H Goodall13, François Cambien1, Peter Kraft5, Philippe Amouyel28, Nilesh J Samani13, Saonli Basu29, Paul M Ridker2, Frits R Rosendaal3, Christopher Kabrhel30, Aaron R Folsom4, John Heit31, Pieter H Reitsma7, David-Alexandre Trégouët1, Nicholas L Smith32, Pierre-Emmanuel Morange33

Author Affiliations

1: Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, 75013 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, 75013 Paris, France; Institute for Cardiometabolism and Nutrition (ICAN), 75013 Paris, France.
2: Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.
3: Department of Thrombosis and Hemostasis, Department of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
4: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA.
5: Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
6: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN 55905, USA.
7: Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
8: Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.
9: Laboratory of Haematology, La Timone Hospital, 13385 Marseille, France; INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, 13385 Marseille, France; Nutrition Obesity and Risk of Thrombosis, Aix-Marseille University, UMR_S 1062, 13385 Marseille, France.
10: Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; AP-HP, Hopital Européen Georges Pompidou, Service d'Hématologie Biologique, 75015 Paris, France; Faculté de Pharmacie, INSERM, UMR_S 1140, 75006 Paris, France.
11: Université de Brest, EA3878 and CIC1412, 29238 Brest, France; Ottawa Hospital Research Institute at the University of Ottawa, Ottawa, ON K1Y 4E9, Canada.
12: Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.
13: Department of Cardiovascular Sciences, University of Leicester, LE1 7RH Leicester, UK; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Leicester LE3 9QP, UK.
14: Department of PharmacoGenetics, Novo Nordisk Park 9.1.21, 2400 Copenhagen, Denmark.
15: Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
16: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
17: Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA 98195-5852, USA.
18: Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
19: Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.
20: Commissariat à l'Energie Atomique/Direction des Sciences du Vivant/Institut de Génomique, Centre National de Génotypage, 91057 Evry, France.
21: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia.
22: Inserm Research Center U897, University of Bordeaux, 33000 Bordeaux, France.
23: Inserm Research Unit U1061, University of Montpellier I, 34000 Montpellier, France.
24: Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrence, CA 90502, USA.
25: Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
26: Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
27: Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA 98195-5852, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA.
28: Institut Pasteur de Lille, Université de Lille Nord de France, INSERM UMR_S 744, 59000 Lille, France; Centre Hospitalier Régional Universitaire de Lille, 59000 Lille, France.
29: Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA.
30: Department of Emergency Medicine, Massachusetts General Hospital, Channing Network Medicine, Harvard Medical School, Boston, MA 2114, USA.
31: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
32: Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA; Seattle Epidemiologic Research and Information Center, VA Office of Research and Development, Seattle, WA 98108, USA. Electronic address: nlsmith@u.washington.edu.
33: Laboratory of Haematology, La Timone Hospital, 13385 Marseille, France; INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, 13385 Marseille, France; Nutrition Obesity and Risk of Thrombosis, Aix-Marseille University, UMR_S 1062, 13385 Marseille, France. Electronic address: pierre.morange@ap-hm.fr.

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