Published in J Biol Chem on March 16, 2010
Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol (2017) 2.03
Conformational motions regulate phosphoryl transfer in related protein tyrosine phosphatases. Science (2013) 1.14
Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase β activity. J Biol Chem (2012) 1.12
The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch Biochem Biophys (2012) 0.86
Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry (2014) 0.84
New aspects of the phosphatase VHZ revealed by a high-resolution structure with vanadate and substrate screening. Biochemistry (2012) 0.83
Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research. Front Pharmacol (2015) 0.80
Inhibition of ecto-phosphatase activity in conidia reduces adhesion and virulence of Metarhizium anisopliae on the host insect Dysdercus peruvianus. Curr Microbiol (2013) 0.80
Metavanadate at the active site of the phosphatase VHZ. J Am Chem Soc (2012) 0.79
The metal face of protein tyrosine phosphatase 1B. Coord Chem Rev (2016) 0.78
A HaloTag-based small molecule microarray screening methodology with increased sensitivity and multiplex capabilities. ACS Chem Biol (2012) 0.78
New functional aspects of the atypical protein tyrosine phosphatase VHZ. Biochemistry (2013) 0.77
A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation. Nat Commun (2016) 0.77
SHP family protein tyrosine phosphatases adopt canonical active-site conformations in the apo and phosphate-bound states. Protein Pept Lett (2013) 0.77
Structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease. Mol Biochem Parasitol (2012) 0.77
Kinetic isotope effects in the characterization of catalysis by protein tyrosine phosphatases. Biochim Biophys Acta (2015) 0.77
Using NMR spectroscopy to elucidate the role of molecular motions in enzyme function. Prog Nucl Magn Reson Spectrosc (2015) 0.76
Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry (2015) 0.76
Catalytic scaffolds for phosphoryl group transfer. Curr Opin Struct Biol (2016) 0.75
Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides. Nat Commun (2016) 0.75
Characterization of PTP1B Inhibition by Chlorogenic Acid and Cichoric Acid. Biochemistry (2016) 0.75
Leveraging reciprocity to identify and characterize unknown allosteric sites in protein tyrosine phosphatases. J Mol Biol (2017) 0.75
The interactions of metal cations and oxyanions with protein tyrosine phosphatase 1B. Biometals (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr (2002) 53.61
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. Nucleic Acids Res (2007) 37.31
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr D Biol Crystallogr (2006) 14.21
A graphical user interface to the CCP4 program suite. Acta Crystallogr D Biol Crystallogr (2003) 13.43
Signaling--2000 and beyond. Cell (2000) 11.78
Protein tyrosine phosphatases in the human genome. Cell (2004) 8.09
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (1999) 7.84
Crystal structure of human protein tyrosine phosphatase 1B. Science (1994) 4.95
Protein-tyrosine phosphatases and cancer. Nat Rev Cancer (2006) 3.65
The structure and mechanism of protein phosphatases: insights into catalysis and regulation. Annu Rev Biophys Biomol Struct (1998) 3.64
Structural and evolutionary relationships among protein tyrosine phosphatase domains. Mol Cell Biol (2001) 3.37
Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate. J Biol Chem (1997) 3.20
Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate. Nature (1994) 3.10
Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. Science (1995) 3.02
The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases. Proc Natl Acad Sci U S A (2003) 2.76
Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate. J Biol Chem (1991) 2.72
The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds. Chem Rev (2004) 2.69
Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development. Annu Rev Pharmacol Toxicol (2002) 2.63
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell (2000) 2.32
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B. J Biol Chem (2002) 2.17
PTP1B as a drug target: recent developments in PTP1B inhibitor discovery. Drug Discov Today (2007) 2.09
Protein tyrosine phosphatase 1B inhibitors for diabetes. Nat Rev Drug Discov (2002) 2.04
Inhibitors of protein tyrosine phosphatases: next-generation drugs? Angew Chem Int Ed Engl (2005) 1.73
Molecular reactions of protein phosphatases--insights from structure and chemistry. Chem Rev (2001) 1.73
Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis. Proc Natl Acad Sci U S A (1996) 1.57
Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402. Biochemistry (1993) 1.53
Isotope effects in the study of phosphoryl and sulfuryl transfer reactions. Acc Chem Res (2002) 1.38
Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis. Crit Rev Biochem Mol Biol (1998) 1.36
Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure. J Biol Chem (2001) 1.36
Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography. J Biol Chem (1998) 1.33
The power of vanadate in crystallographic investigations of phosphoryl transfer enzymes. FEBS Lett (2004) 1.32
Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition. Biochemistry (2000) 1.23
The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications. J Biol Chem (1996) 1.20
The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state. Proc Natl Acad Sci U S A (2008) 1.19
Purification and crystallization of the catalytic domain of human protein tyrosine phosphatase 1B expressed in Escherichia coli. J Mol Biol (1994) 1.16
Crystal structure of bovine low molecular weight phosphotyrosyl phosphatase complexed with the transition state analog vanadate. Biochemistry (1997) 1.15
High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide. Biochemistry (2003) 1.14
A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase. Protein Sci (1995) 1.13
Nature of the transition state of the protein-tyrosine phosphatase-catalyzed reaction. Biochemistry (1995) 1.13
Phosphatases and kinases delivered to the host cell by bacterial pathogens. Trends Microbiol (2000) 1.08
Leishmania donovani engages in regulatory interference by targeting macrophage protein tyrosine phosphatase SHP-1. Clin Immunol (2005) 1.05
Impaired transition state complementarity in the hydrolysis of O-arylphosphorothioates by protein-tyrosine phosphatases. Biochemistry (1999) 1.04
Kinetic isotope effects for alkaline phosphatase reactions: implications for the role of active-site metal ions in catalysis. J Am Chem Soc (2007) 1.03
Energetics of nucleophile activation in a protein tyrosine phosphatase. J Mol Biol (1997) 1.02
Phosphate isosteres in medicinal chemistry. Curr Med Chem (2005) 1.02
2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J Biol Chem (2000) 1.02
Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J Am Chem Soc (2009) 1.01
A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site. Proc Natl Acad Sci U S A (2006) 1.00
Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition. J Biol Chem (2002) 0.99
Density functional study of the mechanism of a tyrosine phosphatase: I. Intermediate formation. J Am Chem Soc (2002) 0.98
Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B. Acta Crystallogr D Biol Crystallogr (2004) 0.97
Effects on general acid catalysis from mutations of the invariant tryptophan and arginine residues in the protein tyrosine phosphatase from Yersinia. Biochemistry (2000) 0.97
Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure (2005) 0.96
Probing the function of the conserved tryptophan in the flexible loop of the Yersinia protein-tyrosine phosphatase. Eur J Biochem (1999) 0.96
Reactivity of alcohols toward the phosphoenzyme intermediate in the protein-tyrosine phosphatase-catalyzed reaction: probing the transition state of the dephosphorylation step. Biochemistry (1996) 0.96
Transition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects. Biochemistry (2009) 0.94
Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics. J Biol Chem (2006) 0.94
Altered mechanisms of reactions of phosphate esters bridging a dinuclear metal center. J Am Chem Soc (2004) 0.93
Interaction of inorganic vanadate with glucose-6-phosphate dehydrogenase. Nonenzymic formation of glucose 6-vanadate. J Biol Chem (1985) 0.93
Examination of the transition state of the low-molecular mass small tyrosine phosphatase 1. Comparisons with other protein phosphatases. Biochemistry (1997) 0.91
Altered transition state for the reaction of an RNA model catalyzed by a dinuclear zinc(II) catalyst. J Am Chem Soc (2008) 0.90
Secondary 18O isotope effects for hexokinase-catalyzed phosphoryl transfer from ATP. Biochemistry (1991) 0.90
Intramolecular general acid catalysis of the hydrolysis of 2-(2'-imidazolium)phenyl phosphate, and bond length-reactivity correlations for reactions of phosphate monoester monoanions. J Org Chem (2007) 0.89
Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis. Biochem J (2004) 0.86
Is the PTPase-vanadate complex a true transition state analogue? Biochemistry (2002) 0.84
Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery. Acta Crystallogr D Biol Crystallogr (2006) 0.83
Intramolecular general acid catalysis of phosphate transfer. nucleophilic attack by oxyanions on the PO3 2- group. J Am Chem Soc (2005) 0.79
Intramolecular acid-base catalysis of a phosphate diester: modeling the ribonuclease mechanism. J Am Chem Soc (2008) 0.77
Computational modeling of the rate limiting step in low molecular weight protein tyrosine phosphatase. FEBS Lett (1999) 0.77
The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing. EMBO J (2010) 2.25
Enzymatic mechanisms of phosphate and sulfate transfer. Chem Rev (2006) 1.88
Conformational motions regulate phosphoryl transfer in related protein tyrosine phosphatases. Science (2013) 1.14
Generality of solvation effects on the hydrolysis rates of phosphate monoesters and their possible relevance to enzymatic catalysis. J Org Chem (2002) 1.09
Kinetic isotope effects for alkaline phosphatase reactions: implications for the role of active-site metal ions in catalysis. J Am Chem Soc (2007) 1.03
Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J Am Chem Soc (2009) 1.01
An altered mechanism of hydrolysis for a metal-complexed phosphate diester. J Am Chem Soc (2002) 1.01
Probing the origin of the compromised catalysis of E. coli alkaline phosphatase in its promiscuous sulfatase reaction. J Am Chem Soc (2007) 0.98
Diesterase activity and substrate binding in purple acid phosphatases. J Am Chem Soc (2007) 0.96
Probing potential medium effects on phosphate ester bonds using 18O isotope shifts on 31P NMR. J Org Chem (2005) 0.94
Transition state differences in hydrolysis reactions of alkyl versus aryl phosphate monoester monoanions. J Am Chem Soc (2003) 0.94
Altered mechanisms of reactions of phosphate esters bridging a dinuclear metal center. J Am Chem Soc (2004) 0.93
The CR3 motif of Rrp44p is important for interaction with the core exosome and exosome function. Nucleic Acids Res (2012) 0.93
Mechanistic study of protein phosphatase-1 (PP1), a catalytically promiscuous enzyme. J Am Chem Soc (2008) 0.93
Comparisons of phosphorothioate with phosphate transfer reactions for a monoester, diester, and triester: isotope effect studies. J Am Chem Soc (2003) 0.92
The effects of sulfur substitution for the nucleophile and bridging oxygen atoms in reactions of hydroxyalkyl phosphate esters. J Org Chem (2008) 0.91
Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J Mol Biol (2011) 0.91
Altered transition state for the reaction of an RNA model catalyzed by a dinuclear zinc(II) catalyst. J Am Chem Soc (2008) 0.90
Thermodynamic origin of the increased rate of hydrolysis of phosphate and phosphorothioate esters in DMSO/water mixtures. J Org Chem (2006) 0.90
The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch Biochem Biophys (2012) 0.86
A concerted mechanism for the transfer of the thiophosphinoyl group from aryl dimethylphosphinothioate esters to oxyanionic nucleophiles in aqueous solution. J Am Chem Soc (2005) 0.86
The catalytic mechanism of Cdc25A phosphatase. J Biol Chem (2002) 0.85
Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. J Am Chem Soc (2008) 0.84
Investigation of the molecular origins of protein-arginine methyltransferase I (PRMT1) product specificity reveals a role for two conserved methionine residues. J Biol Chem (2011) 0.84
Mechanistic studies of protein tyrosine phosphatases YopH and Cdc25A with m-nitrobenzyl phosphate. Biochemistry (2004) 0.83
Active-site dynamics of SpvC virulence factor from Salmonella typhimurium and density functional theory study of phosphothreonine lyase catalysis. J Phys Chem B (2009) 0.83
New aspects of the phosphatase VHZ revealed by a high-resolution structure with vanadate and substrate screening. Biochemistry (2012) 0.83
Transition state of the sulfuryl transfer reaction of estrogen sulfotransferase. J Biol Chem (2006) 0.82
Interaction between the RNA-dependent ATPase and poly(A) polymerase subunits of the TRAMP complex is mediated by short peptides and important for snoRNA processing. Nucleic Acids Res (2015) 0.82
Metal-catalyzed phosphodiester cleavage: secondary 18O isotope effects as an indicator of mechanism. J Am Chem Soc (2006) 0.81
Probing the transition-state structure of dual-specificity protein phosphatases using a physiological substrate mimic. Biochemistry (2004) 0.81
A mechanistic study of the alkaline hydrolysis of diaryl sulfate diesters. J Org Chem (2004) 0.81
The thermodynamics of phosphate versus phosphorothioate ester hydrolysis. J Org Chem (2005) 0.80
A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors. J Med Chem (2003) 0.80
Mechanism of rhodium-catalyzed carbene formation from diazo compounds. Org Lett (2007) 0.79
Metavanadate at the active site of the phosphatase VHZ. J Am Chem Soc (2012) 0.79
Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase. Bioorg Med Chem Lett (2012) 0.79
Insights into the phosphoryl transfer mechanism of cyclin-dependent protein kinases from ab initio QM/MM free-energy studies. J Phys Chem B (2011) 0.78
Examination of P-OR bridging bond orders in phosphate monoesters using (18)O isotope shifts in 31P NMR. J Org Chem (2005) 0.78
New functional aspects of the atypical protein tyrosine phosphatase VHZ. Biochemistry (2013) 0.77
Mechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center. J Am Chem Soc (2009) 0.77
A nonhydrolyzable analogue of phosphotyrosine, and related aryloxymethano- and aryloxyethano-phosphonic acids as motifs for inhibition of phosphatases. Bioorg Med Chem Lett (2004) 0.76
NMR data do not implicate a phosphorane in the T4 DNA ligase reaction. Proc Natl Acad Sci U S A (2008) 0.75
The divalent metal ion in the active site of uteroferrin modulates substrate binding and catalysis. J Am Chem Soc (2010) 0.75
Crystal structures of S-HPCDH reveal determinants of stereospecificity for R- and S-hydroxypropyl-coenzyme M dehydrogenases. Arch Biochem Biophys (2013) 0.75