Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMC 2876963)

Published in EMBO J on April 27, 2010

Authors

Liyong Zhang1, Chi-Hoon Park, Jing Wu, Hyun Kim, Weijun Liu, Takeo Fujita, Manimalha Balasubramani, Emanuel M Schreiber, Xiao-Fan Wang, Yong Wan

Author Affiliations

1: Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.

Articles citing this

APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity. Cell Cycle (2010) 1.06

APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage. J Cell Biol (2011) 1.06

The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis. Front Oncol (2012) 1.01

Early-onset aging and defective DNA damage response in Cdc14b-deficient mice. Mol Cell Biol (2011) 1.00

Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis. Biochim Biophys Acta (2014) 1.00

APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage. EMBO J (2014) 0.97

Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle. Cell Cycle (2011) 0.86

CAPNS1 regulates USP1 stability and maintenance of genome integrity. Mol Cell Biol (2013) 0.85

Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination. J Biol Chem (2014) 0.84

Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit. PLoS One (2013) 0.83

REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1. Cell Cycle (2012) 0.82

Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem (2014) 0.80

Identification of anaphase promoting complex substrates in S. cerevisiae. PLoS One (2012) 0.79

Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Mol Cell Biol (2015) 0.78

Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment. J Biol Chem (2013) 0.78

Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun (2015) 0.78

Controlling the response to DNA damage by the APC/C-Cdh1. Cell Mol Life Sci (2015) 0.76

Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis. EBioMedicine (2016) 0.75

Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein. J Biol Chem (2016) 0.75

Erratum to: Controlling the response to DNA damage by the APC/C-Cdh1. Cell Mol Life Sci (2016) 0.75

Insights into APC/C: from cellular function to diseases and therapeutics. Cell Div (2016) 0.75

Articles cited by this

The DNA damage response: putting checkpoints in perspective. Nature (2000) 19.07

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem (2004) 14.93

Cell-cycle checkpoints and cancer. Nature (2004) 13.19

Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev (2001) 12.46

ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86

The DNA damage response: ten years after. Mol Cell (2007) 11.80

An oncogene-induced DNA damage model for cancer development. Science (2008) 11.60

Defining the human deubiquitinating enzyme interaction landscape. Cell (2009) 11.39

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol Cell Biol (2000) 9.21

DNA repair pathways as targets for cancer therapy. Nat Rev Cancer (2008) 6.69

Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science (1999) 6.07

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev (2002) 4.58

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell (2008) 4.04

Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol (2008) 3.31

Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes. Nucleic Acids Res (2000) 3.16

Human DNA repair genes, 2005. Mutat Res (2005) 3.09

RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage. Genetics (1997) 2.84

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell (2006) 2.75

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell (2005) 2.75

Regulation of DNA repair by ubiquitylation. Nat Rev Mol Cell Biol (2006) 2.73

Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol Cell (2004) 2.64

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature (2001) 2.50

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell (2006) 2.45

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol (2006) 2.09

Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci U S A (2003) 1.77

The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Mol Cell (2001) 1.76

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell (2006) 1.65

Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev (2003) 1.64

Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system. Mol Cell Proteomics (2003) 1.49

The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells. Oncogene (2007) 1.41

Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. EMBO J (2004) 1.38

Biomechanical properties of native basement membranes. FEBS J (2007) 1.31

Cloning and characterization of RAD17, a gene controlling cell cycle responses to DNA damage in Saccharomyces cerevisiae. Nucleic Acids Res (1996) 1.30

Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D. Cell Cycle (2005) 1.26

Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination. EMBO J (2004) 1.22

Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell (2009) 1.18

Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair (Amst) (2004) 1.13

Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Proc Natl Acad Sci U S A (2001) 1.08

Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition. Mol Cell Biol (2007) 1.07

Critical role for chicken Rad17 and Rad9 in the cellular response to DNA damage and stalled DNA replication. Genes Cells (2004) 1.06

Nucleotide excision repair and neurological diseases. DNA Repair (Amst) (2008) 1.03

Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases. DNA Repair (Amst) (2009) 0.99

Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complex. Curr Biol (2006) 0.97

Proteolysis of CDH1 enhances susceptibility to UV radiation-induced apoptosis. Carcinogenesis (2008) 0.95

Turning off the G2 DNA damage checkpoint. DNA Repair (Amst) (2007) 0.91

cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. Genomics (1998) 0.85

hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation. Oncogene (1999) 0.81

Articles by these authors

(truncated to the top 100)

Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52

Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66

HDAC6 is a microtubule-associated deacetylase. Nature (2002) 12.76

Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature (2005) 7.72

Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron (2006) 5.48

Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65

Molecular code for transmembrane-helix recognition by the Sec61 translocon. Nature (2007) 4.60

Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res (2009) 3.66

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet (2009) 3.65

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell (2004) 3.63

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature (2004) 3.63

Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science (2013) 3.54

GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A (2003) 3.32

Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation (2007) 3.07

Notch promotes radioresistance of glioma stem cells. Stem Cells (2010) 3.07

NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation. Nat Neurosci (2006) 2.91

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol (2002) 2.83

Human gut microbiome and risk for colorectal cancer. J Natl Cancer Inst (2013) 2.76

TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell (2012) 2.60

The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. Cell (2004) 2.59

Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol (2004) 2.49

China's health system performance. Lancet (2008) 2.36

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science (2003) 2.31

Persistence of multiple illnesses in World Trade Center rescue and recovery workers: a cohort study. Lancet (2011) 2.24

Phase studies of model biomembranes: complex behavior of DSPC/DOPC/cholesterol. Biochim Biophys Acta (2007) 2.22

Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets. Am J Hum Genet (2011) 2.22

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17

Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15

High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2007) 2.15

Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Genes Dev (2006) 2.15

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis. Proc Natl Acad Sci U S A (2010) 2.12

Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents. Biol Psychiatry (2013) 2.07

GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae. Nat Protoc (2008) 2.06

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. Nat Genet (2011) 2.05

Geographic information system-based identification of suitable cultivation sites for wood-cultivated ginseng. J Ginseng Res (2013) 2.04

Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Genes Dev (2008) 2.00

The effect of platelet-rich plasma on flap survival in random extension of an axial pattern flap in rabbits. Plast Reconstr Surg (2013) 1.98

Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells (2009) 1.97

Klotho is a target gene of PPAR-gamma. Kidney Int (2008) 1.96

Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res (2010) 1.94

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling. Genes Dev (2008) 1.93

Amygdala depotentiation and fear extinction. Proc Natl Acad Sci U S A (2007) 1.91

Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. J Clin Invest (2015) 1.89

Comparison of three ternary lipid bilayer mixtures: FRET and ESR reveal nanodomains. Biophys J (2010) 1.88

Regulation of the autophagy protein LC3 by phosphorylation. J Cell Biol (2010) 1.86

Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation. Methods Mol Biol (2004) 1.85

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79

Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system. J Biol Chem (2002) 1.79

Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans. Nat Commun (2012) 1.78

Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol Cell Biol (2004) 1.77

TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. EMBO J (2008) 1.74

Adolescents with major depression demonstrate increased amygdala activation. J Am Acad Child Adolesc Psychiatry (2010) 1.69

Haptics in minimally invasive surgical simulation and training. IEEE Comput Graph Appl (2004) 1.67

Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther (2005) 1.66

Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax. J Neurosci (2004) 1.66

SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses. Neuron (2006) 1.66

Neuroprotective effect of topiramate on hypoxic ischemic brain injury in neonatal rats. Exp Neurol (2006) 1.65

Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress Anxiety (2005) 1.64

Effect of limb ischemic preconditioning on myocardial injury in patients undergoing mitral valve replacement surgery. -A randomized controlled trial-. Circ J (2011) 1.62

Phase studies of model biomembranes: macroscopic coexistence of Lalpha+Lbeta, with light-induced coexistence of Lalpha+Lo Phases. Biochim Biophys Acta (2007) 1.61

Effect of celecoxib on E-cadherin, VEGF, Microvessel density and apoptosis in gastric cancer. Cancer Biol Ther (2007) 1.59

DC isoketal-modified proteins activate T cells and promote hypertension. J Clin Invest (2014) 1.59

The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene. Genetics (2004) 1.57

Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol (2004) 1.56

Obesity phenotype and incident hypertension: a prospective community-based cohort study. J Hypertens (2013) 1.56

Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest (2015) 1.55

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase. Mol Cell (2008) 1.54

Decreased plasma BDNF level in depressive patients. J Affect Disord (2006) 1.53

Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis. Mol Microbiol (2008) 1.52

Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. J Biol Chem (2003) 1.52

Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization. J Neurosci (2002) 1.51

Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system. Mol Cell Proteomics (2003) 1.49

Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron (2011) 1.49

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev (2004) 1.47

Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production. Proc Natl Acad Sci U S A (2008) 1.46

O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability. Cell Metab (2012) 1.46

Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting. J Clin Invest (2007) 1.45

Non-clustered protocadherin. Cell Adh Migr (2011) 1.44

Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study. J Neurooncol (2012) 1.42

LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. Proc Natl Acad Sci U S A (2010) 1.40

Targeted Inhibition of Leucine-Rich Repeat and Immunoglobulin Domain-Containing Protein 1 in Transplanted Neural Stem Cells Promotes Neuronal Differentiation and Functional Recovery in Rats Subjected to Spinal Cord Injury. Crit Care Med (2016) 1.40

Association between high nocturnal blood pressure and white matter change and its interaction by obstructive sleep apnoea among normotensive adults. J Hypertens (2014) 1.40

gamma-Cyclodextrin: a review on enzymatic production and applications. Appl Microbiol Biotechnol (2007) 1.39

GUV preparation and imaging: minimizing artifacts. Biochim Biophys Acta (2010) 1.39

The effects of midday nap duration on the risk of hypertension in a middle-aged and older Chinese population: a preliminary evidence from the Tongji-Dongfeng Cohort Study, China. J Hypertens (2014) 1.39

ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J (2004) 1.36

SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Ther (2004) 1.35

Application of multivariate statistical techniques in the assessment of water quality in the Southwest New Territories and Kowloon, Hong Kong. Environ Monit Assess (2010) 1.34

Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition. Mol Cell Biol (2011) 1.34

Atypical CT and MRI manifestations of mature ovarian cystic teratomas. AJR Am J Roentgenol (2004) 1.34

CT and MR imaging features of adnexal torsion. Radiographics (2002) 1.32

Biomechanical properties of native basement membranes. FEBS J (2007) 1.31

Interferon-gamma release assay performance in pulmonary and extrapulmonary tuberculosis. PLoS One (2012) 1.29

PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nat Neurosci (2011) 1.28

Control of a nanoscopic-to-macroscopic transition: modulated phases in four-component DSPC/DOPC/POPC/Chol giant unilamellar vesicles. Biophys J (2011) 1.28

Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. J Biol Chem (2010) 1.28

Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. J Biol Chem (2008) 1.26

Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. Circ Res (2004) 1.26

Amygdala response and functional connectivity during emotion regulation: a study of 14 depressed adolescents. J Affect Disord (2012) 1.24

Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder. J Affect Disord (2007) 1.24