Published in Clin Transl Sci on September 01, 2008
β2-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study. BMC Med Genet (2015) 0.76
Beta2 adrenergic receptor (ADRβ2) haplotype pair (2/4) is associated with severe asthma. PLoS One (2014) 0.76
Sample size in pilot genetic studies. Clin Transl Sci (2008) 0.75
The structure of haplotype blocks in the human genome. Science (2002) 50.88
A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics (1995) 11.58
Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci U S A (2000) 10.27
Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered (2002) 8.64
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry (1994) 4.33
Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol (1993) 3.50
Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol (1995) 3.27
The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med (2000) 3.08
Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest (1997) 2.85
Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics. Lancet (1997) 2.80
Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes (2004) 2.52
Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma. J Allergy Clin Immunol (2006) 2.49
beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med (2005) 2.45
Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet (2007) 2.41
Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. J Clin Invest (1995) 2.17
Polymorphisms in the beta2-adrenoreceptor gene are associated with decreased airway responsiveness. Clin Exp Allergy (1999) 1.73
Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med (2006) 1.59
Beta 2-adrenergic receptor polymorphisms: pharmacogenetic response to bronchodilator among African American asthmatics. Hum Genet (2006) 1.43
beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. Am J Respir Crit Care Med (1998) 1.40
Beta2-adrenoceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population. Clin Exp Allergy (1998) 1.39
Association of persistent bronchial hyperresponsiveness with beta2-adrenoceptor (ADRB2) haplotypes. A population study. Am J Respir Crit Care Med (1998) 1.16
Association of beta2-adrenergic receptor polymorphisms with severe asthma. Clin Exp Allergy (2000) 1.07
Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling. J Allergy Clin Immunol (2002) 1.05
Beta2-adrenoceptor polymorphisms: relation between in vitro and in vivo phenotypes. Life Sci (2004) 0.99
Beta-adrenergic receptor polymorphisms and drug responses in asthma. Pharmacogenomics (2002) 0.84
Pharmacogenetics of the response to beta 2 agonist drugs: a systematic overview of the field. Pharmacogenomics (2007) 0.82
Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA (2004) 11.27
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
The genetic structure and history of Africans and African Americans. Science (2009) 10.65
Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA (2003) 6.24
Association of numeracy and diabetes control. Ann Intern Med (2008) 5.08
Bioinformatics challenges for genome-wide association studies. Bioinformatics (2010) 4.45
Genetic analysis of African populations: human evolution and complex disease. Nat Rev Genet (2002) 4.23
New strategies for identifying gene-gene interactions in hypertension. Ann Med (2002) 4.19
Influence of patient literacy on the effectiveness of a primary care-based diabetes disease management program. JAMA (2004) 4.16
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet Epidemiol (2007) 4.15
Patient understanding of food labels: the role of literacy and numeracy. Am J Prev Med (2006) 4.13
Asthma as a risk factor for invasive pneumococcal disease. N Engl J Med (2005) 4.04
Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology (2006) 4.03
Effect of a pharmacist intervention on clinically important medication errors after hospital discharge: a randomized trial. Ann Intern Med (2012) 3.85
Evidence of a causal role of winter virus infection during infancy in early childhood asthma. Am J Respir Crit Care Med (2008) 3.84
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A (2011) 3.80
Epistasis and its implications for personal genetics. Am J Hum Genet (2009) 3.52
Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis. Bioessays (2005) 3.47
Rhinovirus-associated hospitalizations in young children. J Infect Dis (2007) 3.35
Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Crit Care Med (2010) 3.32
Increased coronary-artery atherosclerosis in rheumatoid arthritis: relationship to disease duration and cardiovascular risk factors. Arthritis Rheum (2005) 3.17
Increased concentration of proatherogenic inflammatory cytokines in systemic lupus erythematosus: relationship to cardiovascular risk factors. J Rheumatol (2006) 3.10
Six-month neuropsychological outcome of medical intensive care unit patients. Crit Care Med (2003) 2.83
Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J Am Soc Nephrol (2009) 2.77
Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS One (2009) 2.72
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68
Early intervention improves mortality and hospitalization rates in incident hemodialysis patients: RightStart program. Clin J Am Soc Nephrol (2007) 2.60
Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit Care Med (2011) 2.59
Genetic epidemiologic studies of preterm birth: guidelines for research. Am J Obstet Gynecol (2007) 2.56
Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care (2005) 2.53
Data simulation software for whole-genome association and other studies in human genetics. Pac Symp Biocomput (2006) 2.49
Quality control procedures for genome-wide association studies. Curr Protoc Hum Genet (2011) 2.48
Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma (2008) 2.46
Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Am J Hum Genet (2005) 2.44
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation (2004) 2.35
Toward primary prevention of asthma. Reviewing the evidence for early-life respiratory viral infections as modifiable risk factors to prevent childhood asthma. Am J Respir Crit Care Med (2015) 2.33
Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance plan. Pediatrics (2008) 2.29
Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections. J Allergy Clin Immunol (2012) 2.26
Dysfunctional high-density lipoprotein in patients on chronic hemodialysis. J Am Coll Cardiol (2012) 2.21
Alternation of antiretroviral drug regimens for HIV infection. A randomized, controlled trial. Ann Intern Med (2003) 2.20
Maternal asthma and maternal smoking are associated with increased risk of bronchiolitis during infancy. Pediatrics (2007) 2.20
Fluoroquinolone resistance in Mycobacterium tuberculosis: the effect of duration and timing of fluoroquinolone exposure. Am J Respir Crit Care Med (2009) 2.18
Maternal antidepressant use and adverse outcomes: a cohort study of 228,876 pregnancies. Am J Obstet Gynecol (2012) 2.16
Validity of a Modified Sequential Organ Failure Assessment Score Using the Richmond Agitation-Sedation Scale. Crit Care Med (2016) 2.10
Low health literacy associates with increased mortality in ESRD. J Am Soc Nephrol (2010) 2.03
High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristics and cardiovascular risk factors. Ann Rheum Dis (2006) 2.00
Elevated male European and female African contributions to the genomes of African American individuals. Hum Genet (2006) 1.97
Bronchiolitis to asthma: a review and call for studies of gene-virus interactions in asthma causation. Am J Respir Crit Care Med (2006) 1.96
The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma. J Allergy Clin Immunol (2009) 1.91
Cigarette smoking cessation services in outpatient substance abuse treatment programs in the United States. J Subst Abuse Treat (2007) 1.90
Addressing literacy and numeracy to improve diabetes care: two randomized controlled trials. Diabetes Care (2009) 1.88
G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci U S A (2002) 1.87
Reduction in high rates of antibiotic-nonsusceptible invasive pneumococcal disease in tennessee after introduction of the pneumococcal conjugate vaccine. Clin Infect Dis (2004) 1.84
Shadows of complexity: what biological networks reveal about epistasis and pleiotropy. Bioessays (2009) 1.82
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
Recurrent tissue-specific mtDNA mutations are common in humans. PLoS Genet (2013) 1.77
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Am J Obstet Gynecol (2010) 1.75
Podocyte injury damages other podocytes. J Am Soc Nephrol (2011) 1.75
Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis. Atherosclerosis (2007) 1.73
Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patients. Intensive Care Med (2007) 1.69
Seasonality of invasive pneumococcal disease: temporal relation to documented influenza and respiratory syncytial viral circulation. Am J Med (2005) 1.68
Consciousness monitoring in ventilated patients: bispectral EEG monitors arousal not delirium. Intensive Care Med (2004) 1.68
Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Clin J Am Soc Nephrol (2010) 1.64
Inflammation-associated insulin resistance: differential effects in rheumatoid arthritis and systemic lupus erythematosus define potential mechanisms. Arthritis Rheum (2008) 1.63
Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans. J Infect Dis (2009) 1.63
Distinct injury markers for the early detection and prognosis of incident acute kidney injury in critically ill adults with preserved kidney function. Kidney Int (2013) 1.62
Pilot study of a physician-delivered education tool to increase patient knowledge about CKD. Am J Kidney Dis (2013) 1.59
Ecogeographic genetic epidemiology. Genet Epidemiol (2009) 1.57
Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics. Hum Genet (2008) 1.57
Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis. Arthritis Rheum (2009) 1.56
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet (2013) 1.55
Evaluation of a 12-week home-based walking intervention for breast cancer survivors. Support Care Cancer (2006) 1.53
Delirium in the emergency department: an independent predictor of death within 6 months. Ann Emerg Med (2010) 1.51
Evidence for a causal relationship between respiratory syncytial virus infection and asthma. Expert Rev Anti Infect Ther (2011) 1.51
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin Chem (2006) 1.51
DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination. Mitochondrion (2009) 1.50
Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc Natl Acad Sci U S A (2014) 1.48
Diagnosing delirium in older emergency department patients: validity and reliability of the delirium triage screen and the brief confusion assessment method. Ann Emerg Med (2013) 1.46
Origin and molecular characteristics of a novel 2013 avian influenza A(H6N1) virus causing human infection in Taiwan. Clin Infect Dis (2013) 1.45
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol (2014) 1.45
Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis. Arthritis Rheum (2009) 1.45
Oxidative stress and inflammation are associated with adiposity in moderate to severe CKD. J Am Soc Nephrol (2008) 1.44