PubRank

C Ronald Kahn

Author PubWeight™ 428.41‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009 20.57
2 Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A 2003 17.10
3 Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006 10.67
4 Developmental origin of fat: tracking obesity to its source. Cell 2007 8.80
5 Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003 8.53
6 Suppression of aging in mice by the hormone Klotho. Science 2005 8.11
7 Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 2008 7.97
8 New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008 6.82
9 SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 2010 6.48
10 Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A 2009 5.19
11 Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 2008 5.07
12 Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 2002 5.01
13 Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci U S A 2006 4.81
14 From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol 2006 4.58
15 Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 2002 4.35
16 Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 2010 4.23
17 Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell 2007 3.82
18 A guide to analysis of mouse energy metabolism. Nat Methods 2011 3.82
19 Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 2004 3.79
20 Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 2007 3.69
21 Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 2008 3.66
22 Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 2005 3.52
23 Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci U S A 2007 3.40
24 Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab 2006 3.34
25 SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell 2011 3.33
26 Endocrine regulation of ageing. Nat Rev Mol Cell Biol 2007 3.28
27 Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci U S A 2010 3.16
28 Retracted Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J Biol Chem 2003 3.06
29 Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab 2010 3.05
30 Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest 2003 2.87
31 Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med 2012 2.86
32 Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab 2006 2.82
33 The emerging genetic architecture of type 2 diabetes. Cell Metab 2008 2.77
34 Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes 2005 2.72
35 Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol 2005 2.68
36 Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics 2012 2.66
37 Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest 2002 2.65
38 PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest 2004 2.56
39 Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 2004 2.54
40 Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A 2004 2.54
41 Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 2004 2.54
42 Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest 2002 2.53
43 Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 2001 2.49
44 Phlorizin: a review. Diabetes Metab Res Rev 2005 2.48
45 Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab 2012 2.43
46 Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol 2002 2.42
47 SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab 2007 2.42
48 Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A 2011 2.41
49 Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates. Proc Natl Acad Sci U S A 2006 2.32
50 Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science 2002 2.28
51 Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet 2006 2.21
52 Mir193b-365 is essential for brown fat differentiation. Nat Cell Biol 2011 2.20
53 Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest 2007 2.17
54 Mouse models of insulin resistance. Physiol Rev 2004 2.16
55 Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol 2004 2.14
56 The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest 2003 2.11
57 Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J 2003 2.11
58 Dissection of the insulin signaling pathway via quantitative phosphoproteomics. Proc Natl Acad Sci U S A 2008 2.11
59 Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab 2010 2.09
60 Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol 2006 2.09
61 Lessons on conditional gene targeting in mouse adipose tissue. Diabetes 2013 2.04
62 Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest 2005 2.01
63 Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A 2013 2.01
64 Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest 2008 2.00
65 The cellular fate of glucose and its relevance in type 2 diabetes. Endocr Rev 2004 1.98
66 Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochem J 2011 1.96
67 A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med 2010 1.93
68 Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol 2005 1.93
69 Brown fat as a therapy for obesity and diabetes. Curr Opin Endocrinol Diabetes Obes 2010 1.93
70 Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes 2012 1.91
71 Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice. Proc Natl Acad Sci U S A 2002 1.86
72 Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem 2002 1.86
73 Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A 2004 1.80
74 Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. Proc Natl Acad Sci U S A 2006 1.79
75 Glypican-4 enhances insulin signaling via interaction with the insulin receptor and serves as a novel adipokine. Diabetes 2012 1.76
76 Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism. Diabetes 2009 1.76
77 Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One 2011 1.74
78 Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes 2003 1.73
79 Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production. J Clin Invest 2003 1.73
80 Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. J Biol Chem 2003 1.72
81 Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J Clin Invest 2004 1.71
82 Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest 2010 1.70
83 Insulin receptor knockout mice. Annu Rev Physiol 2002 1.70
84 Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology 2004 1.69
85 Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 2003 1.68
86 Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. Cancer Res 2003 1.66
87 Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι. Metabolism 2012 1.63
88 Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 2003 1.60
89 Role of Foxa-2 in adipocyte metabolism and differentiation. J Clin Invest 2003 1.60
90 Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat Med 2012 1.57
91 Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat Rev Endocrinol 2010 1.56
92 Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci U S A 2012 1.56
93 Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. J Clin Invest 2013 1.55
94 Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev 2002 1.52
95 Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab 2012 1.52
96 Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell 2007 1.52
97 Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J Biol Chem 2008 1.52
98 Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab 2006 1.50
99 Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nat Commun 2012 1.43
100 Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest 2003 1.43
101 TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity. Mol Cell Biol 2007 1.43
102 Interplay between FGF21 and insulin action in the liver regulates metabolism. J Clin Invest 2014 1.42
103 A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease. Diabetes 2010 1.41
104 The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Res 2010 1.41
105 p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol 2004 1.39
106 Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. J Biol Chem 2002 1.38
107 Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol 2014 1.38
108 Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc Natl Acad Sci U S A 2008 1.37
109 Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol 2004 1.36
110 The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Mol Cell Biol 2007 1.35
111 Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma. FASEB J 2010 1.35
112 Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease. Proc Natl Acad Sci U S A 2003 1.35
113 Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest 2010 1.34
114 Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol Cell Biol 2006 1.34
115 Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I. J Biol Chem 2004 1.33
116 Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf) 2002 1.32
117 Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metab 2010 1.32
118 Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell Metab 2012 1.32
119 Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action. Bioessays 2002 1.30
120 Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler Thromb Vasc Biol 2012 1.28
121 Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. Diabetes 2005 1.27
122 Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. J Biol Chem 2010 1.27
123 Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab 2009 1.26
124 Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci U S A 2010 1.25
125 Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 2006 1.25
126 Altered insulin signaling in retinal tissue in diabetic states. J Biol Chem 2004 1.23
127 Measurement of human brown adipose tissue volume and activity using anatomic MR imaging and functional MR imaging. J Nucl Med 2013 1.23
128 Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes 2013 1.22
129 Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance. PLoS Genet 2010 1.22
130 Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess. J Biol Chem 2005 1.22
131 Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol 2006 1.21
132 Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metab 2010 1.20
133 Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab 2010 1.19
134 Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging. Obesity (Silver Spring) 2012 1.18
135 Role of insulin action and cell size on protein expression patterns in adipocytes. J Biol Chem 2004 1.17
136 Berson, Yalow, and the JCI: the agony and the ecstasy. J Clin Invest 2004 1.16
137 PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest 2011 1.15
138 Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). J Biol Chem 2012 1.14
139 Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration. Proc Natl Acad Sci U S A 2011 1.14
140 Divergent roles of growth factors in the GnRH regulation of puberty in mice. J Clin Invest 2010 1.13
141 A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis. Sci Signal 2010 1.12
142 Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem 2007 1.12
143 Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J Clin Invest 2014 1.12
144 Retracted Bi-directional regulation of brown fat adipogenesis by the insulin receptor. J Biol Chem 2003 1.12
145 Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha. Proc Natl Acad Sci U S A 2002 1.11
146 Prevalence of mutations in AGPAT2 among human lipodystrophies. Diabetes 2003 1.11
147 Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes 2003 1.10
148 Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor. Proc Natl Acad Sci U S A 2008 1.09
149 Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem 2003 1.09
150 High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem 2007 1.09
151 Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro. Hum Mol Genet 2002 1.07
152 Adiponectin: linking the fat cell to insulin sensitivity. Lancet 2003 1.07
153 Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. J Biol Chem 2004 1.07
154 Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration. Circulation 2005 1.06
155 Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metab 2010 1.05
156 SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling. Am J Hum Genet 2013 1.05
157 Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans. Diabetes 2012 1.04
158 Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome. Hepatol Res 2005 1.02
159 The differential role of Hif1β/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation. Cell Metab 2011 1.02
160 The role and importance of brown adipose tissue in energy homeostasis. Curr Opin Pediatr 2010 1.01
161 Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol Cell Biol 2008 1.01
162 GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization. J Clin Invest 2003 1.01
163 Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. J Mol Cell Cardiol 2009 1.01
164 Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation. J Biol Chem 2004 1.01
165 Mitochondrial proton leak in obesity-resistant and obesity-prone mice. Am J Physiol Regul Integr Comp Physiol 2007 0.97
166 Vascular endothelial growth factor is important for brown adipose tissue development and maintenance. FASEB J 2013 0.97
167 Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner. Endocrinology 2011 0.96
168 Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform. Diabetes 2009 0.96
169 Mosaic analysis of insulin receptor function. J Clin Invest 2004 0.95
170 Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice. Endocrinology 2003 0.95
171 Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Mol Cell Biol 2011 0.95
172 Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation. Biochim Biophys Acta 2007 0.95
173 Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Mol Cell Biol 2005 0.95
174 Pancreatic function in carboxyl-ester lipase knockout mice. Pancreatology 2010 0.94
175 Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes. J Biol Chem 2003 0.94
176 Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes. Diabetes 2002 0.93
177 New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it. J Clin Invest 2012 0.92
178 Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem 2011 0.91
179 Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes. Science 2004 0.91
180 A patient with type B insulin resistance syndrome, responsive to immune therapy. Nat Clin Pract Endocrinol Metab 2007 0.89
181 Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice. J Biol Chem 2013 0.89
182 IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance. Biochem Biophys Res Commun 2007 0.88
183 Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha. J Biol Chem 2002 0.87
184 Metabolic syndrome: is Nlrp3 inflammasome a trigger or a target of insulin resistance? Circ Res 2011 0.86
185 Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function. PLoS Biol 2013 0.86
186 Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level. Proc Natl Acad Sci U S A 2006 0.84
187 Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation. Age (Dordr) 2010 0.84
188 Shox2 is a molecular determinant of depot-specific adipocyte function. Proc Natl Acad Sci U S A 2013 0.83
189 Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms. Endocrinology 2013 0.83
190 Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier. Biochem Biophys Res Commun 2004 0.83
191 Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle. Endocrinology 2008 0.83
192 PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest 2016 0.82
193 Receptor antibodies as novel therapeutics for diabetes. Sci Transl Med 2011 0.82
194 Mitochondria, obesity and aging. Aging (Albany NY) 2012 0.82
195 p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A 2014 0.82
196 Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young). PLoS One 2013 0.81
197 Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes. Am J Physiol Endocrinol Metab 2002 0.81
198 PI 3-kinase regulatory subunits as regulators of the unfolded protein response. Methods Enzymol 2011 0.81
199 Interplay between FGF21 and insulin action in the liver regulates metabolism. J Clin Invest 2015 0.80
200 Ephs and ephrins keep pancreatic Beta cells connected. Cell 2007 0.80
201 Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. J Clin Invest 2016 0.79
202 Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes. Biochemistry 2004 0.79
203 Severe insulin resistance alters metabolism in mesenchymal progenitor cells. Endocrinology 2015 0.78
204 Insulin's discovery: new insights on its ninetieth birthday. Diabetes Metab Res Rev 2012 0.77
205 High baseline vitamin C levels do not prevent a positive outcome of a lifestyle intervention: response to Thamer et al. Diabetes Care 2010 0.76
206 Turning on brown fat and muscle metabolism: hedging your bets. Cell 2012 0.76
207 Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells. Diabetes 2002 0.76
208 Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55α and p50α regulate autophagy in vivo. FEBS J 2014 0.76
209 Corrigendum: Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature 2017 0.75
210 CDK4 is an essential insulin effector in adipocytes. J Clin Invest 2015 0.75
211 Antibiotic effects on gut microbiota and metabolism are host dependent. J Clin Invest 2016 0.75
212 Leptin therapy for type 1 diabetes gains traction. Nat Med 2010 0.75
213 Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J Biol Chem 2017 0.75
214 Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I. J Biol Chem 2016 0.75
215 Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. J Clin Invest 2016 0.75
216 Effect of cholesterol reduction on receptor signaling in neurons. J Biol Chem 2016 0.75
217 Interview: C. Ronald Kahn. Interview by Misia Landau. Clin Chem 2010 0.75
218 Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5). J Biol Chem 2016 0.75
219 Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Nat Med 2017 0.75
220 People to know 2014. Diabetes Forecast 2014 0.75
221 Erratum: FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nat Commun 2015 0.75