| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.
|
J Am Chem Soc
|
2002
|
1.82
|
|
2
|
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.
|
J Biol Chem
|
2006
|
1.74
|
|
3
|
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.
|
Cancer Res
|
2009
|
1.53
|
|
4
|
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.
|
J Am Chem Soc
|
2005
|
1.40
|
|
5
|
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action.
|
Proc Natl Acad Sci U S A
|
2007
|
1.29
|
|
6
|
Interaction of telomestatin with the telomeric single-strand overhang.
|
J Biol Chem
|
2004
|
1.27
|
|
7
|
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways.
|
Oncogene
|
2003
|
1.26
|
|
8
|
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
|
EMBO J
|
2013
|
1.25
|
|
9
|
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands.
|
J Am Chem Soc
|
2007
|
1.10
|
|
10
|
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.
|
Blood
|
2010
|
1.02
|
|
11
|
Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format.
|
J Biomol Screen
|
2009
|
0.94
|
|
12
|
Nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78.
|
Neurosci Res
|
2009
|
0.92
|
|
13
|
Streptomyces tateyamensis sp. nov., Streptomyces marinus sp. nov. and Streptomyces haliclonae sp. nov., isolated from the marine sponge Haliclona sp.
|
Int J Syst Evol Microbiol
|
2010
|
0.90
|
|
14
|
Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria.
|
FEMS Microbiol Lett
|
2009
|
0.89
|
|
15
|
Glucose-deprived HT-29 human colon carcinoma cells are sensitive to verrucosidin as a GRP78 down-regulator.
|
Toxicology
|
2006
|
0.89
|
|
16
|
Structure of tyroscherin, an antitumor antibiotic against IGF-1-dependent cells from Pseudallescheria sp.
|
J Antibiot (Tokyo)
|
2004
|
0.89
|
|
17
|
Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. I. Fermentation, isolation and biological activities.
|
J Antibiot (Tokyo)
|
2007
|
0.88
|
|
18
|
JBIR-83 and JBIR-84, new promothiocin derivatives, isolated from Streptomyces sp. RI19.
|
J Antibiot (Tokyo)
|
2010
|
0.88
|
|
19
|
Relative and absolute configuration of versipelostatin, a down-regulator of molecular chaperone GRP78 expression.
|
Org Lett
|
2007
|
0.87
|
|
20
|
Tetracenoquinocin and 5-iminoaranciamycin from a sponge-derived Streptomyces sp. Sp080513GE-26.
|
J Nat Prod
|
2010
|
0.86
|
|
21
|
JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp. NBRC 105896 isolated from a marine sponge.
|
J Antibiot (Tokyo)
|
2009
|
0.86
|
|
22
|
Structure of aspochalasin H, a new member of the aspochalasin family.
|
J Antibiot (Tokyo)
|
2002
|
0.85
|
|
23
|
Three new depsipeptides, JBIR-113, JBIR-114 and JBIR-115, isolated from a marine sponge-derived Penicillium sp. fS36.
|
J Antibiot (Tokyo)
|
2011
|
0.85
|
|
24
|
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78.
|
Biol Pharm Bull
|
2006
|
0.84
|
|
25
|
Oximidines I and II: Novel Antitumor Macrolides from Pseudomonas sp.
|
J Org Chem
|
1999
|
0.84
|
|
26
|
Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph.
|
FEMS Yeast Res
|
2012
|
0.83
|
|
27
|
Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571.
|
J Antibiot (Tokyo)
|
2009
|
0.83
|
|
28
|
JBIR-22, an inhibitor for protein-protein interaction of the homodimer of proteasome assembly factor 3.
|
J Nat Prod
|
2010
|
0.83
|
|
29
|
Identification and biosynthesis of new acyloins from the thermophilic bacterium Thermosporothrix hazakensis SK20-1(T).
|
Chembiochem
|
2014
|
0.83
|
|
30
|
New tensidols, JBIR-86 and JBIR-87, isolated from Aspergillus sp. fJ80.
|
J Antibiot (Tokyo)
|
2010
|
0.82
|
|
31
|
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator.
|
J Cell Physiol
|
2008
|
0.81
|
|
32
|
Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase.
|
Cancer Res
|
2003
|
0.81
|
|
33
|
JBIR-52, a new antimycin-like compound, from Streptomyces sp. ML55.
|
J Antibiot (Tokyo)
|
2009
|
0.81
|
|
34
|
Isolation of a novel macrocyclic dilactone-JBIR-101-from Promicromonospora sp. RL26.
|
J Antibiot (Tokyo)
|
2011
|
0.80
|
|
35
|
A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6.
|
J Antibiot (Tokyo)
|
2008
|
0.79
|
|
36
|
New species of actinomycetes do not always produce new compounds with high frequency.
|
J Antibiot (Tokyo)
|
2011
|
0.78
|
|
37
|
JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.
|
J Antibiot (Tokyo)
|
2009
|
0.78
|
|
38
|
Tetrapeptides possessing a unique skeleton, JBIR-34 and JBIR-35, isolated from a sponge-derived actinomycete, Streptomyces sp. Sp080513GE-23.
|
J Nat Prod
|
2010
|
0.78
|
|
39
|
Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole.
|
Org Biomol Chem
|
2010
|
0.78
|
|
40
|
Antioxidant activity of propofol and related monomeric and dimeric compounds.
|
Chem Pharm Bull (Tokyo)
|
2005
|
0.77
|
|
41
|
A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55.
|
J Antibiot (Tokyo)
|
2007
|
0.77
|
|
42
|
Cation involvement in telomestatin binding to g-quadruplex DNA.
|
J Nucleic Acids
|
2010
|
0.77
|
|
43
|
Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis.
|
Angew Chem Int Ed Engl
|
2015
|
0.77
|
|
44
|
Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A.
|
Eur J Med Chem
|
2013
|
0.77
|
|
45
|
Construction of a natural product library containing secondary metabolites produced by actinomycetes.
|
J Antibiot (Tokyo)
|
2012
|
0.76
|
|
46
|
JBIR-65, a new diterpene, isolated from a sponge-derived Actinomadura sp. SpB081030SC-15.
|
J Antibiot (Tokyo)
|
2010
|
0.76
|
|
47
|
JBIR-12, a novel antioxidative agent from Penicillium sp. NBRC 103941.
|
J Antibiot (Tokyo)
|
2009
|
0.75
|
|
48
|
Trapping effect of eugenol on hydroxyl radicals induced by L-DOPA in vitro.
|
Chem Pharm Bull (Tokyo)
|
2005
|
0.75
|
|
49
|
Stereochemical Assignment of the Protein-Protein Interaction Inhibitor JBIR-22 by Total Synthesis.
|
Angew Chem Weinheim Bergstr Ger
|
2015
|
0.75
|
|
50
|
Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties.
|
J Nucleic Acids
|
2010
|
0.75
|
|
51
|
Two novel decanedienamide derivatives, JBIR-07 and -08, from Streptomyces versipellis 4083-SVS6.
|
Nat Prod Res
|
2009
|
0.75
|
|
52
|
G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer.
|
Nucleic Acids Symp Ser (Oxf)
|
2009
|
0.75
|
|
53
|
JBIR-120: a new growth inhibitor of hormone-refractory prostate cancer cells.
|
J Antibiot (Tokyo)
|
2012
|
0.75
|
|
54
|
JBIR-78 and JBIR-95: phenylacetylated peptides isolated from Kibdelosporangium sp. AK-AA56.
|
J Nat Prod
|
2012
|
0.75
|
|
55
|
Burkholone, a new cytotoxic antibiotic against IGF-I dependent cells from Burkholderia sp.
|
J Antibiot (Tokyo)
|
2007
|
0.75
|
|
56
|
JBIR-66, a new metabolite isolated from tunicate-derived Saccharopolyspora sp. SS081219JE-28.
|
Biosci Biotechnol Biochem
|
2010
|
0.75
|
|
57
|
A novel neuronal cell protecting substance, halxazone, produced by Streptomyces halstedii.
|
J Antibiot (Tokyo)
|
2002
|
0.75
|
|
58
|
Flaviogeranin, a new neuroprotective compound from Streptomyces sp.
|
J Antibiot (Tokyo)
|
2010
|
0.75
|
|
59
|
JBIR-37 and -38, novel glycosyl benzenediols, isolated from the sponge-derived fungus, Acremonium sp. SpF080624G1f01.
|
Biosci Biotechnol Biochem
|
2009
|
0.75
|
|
60
|
JBIR-26, a novel natural compound from Streptomyces sp. AK-AH76, regulates mammalian circadian clock.
|
J Antibiot (Tokyo)
|
2008
|
0.75
|
|
61
|
New acylated anthocyanins from purple yam and their antioxidant activity.
|
Biosci Biotechnol Biochem
|
2015
|
0.75
|
|
62
|
Total synthesis and structure elucidation of JBIR-39: a linear hexapeptide possessing piperazic acid and γ-hydroxypiperazic acid residues.
|
Chemistry
|
2014
|
0.75
|