PubRank

Philippe Froguel

Author PubWeight™ 573.21‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007 35.08
2 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010 23.08
3 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
4 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010 16.96
5 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008 15.94
6 Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007 13.62
7 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012 11.09
8 Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003 9.79
9 Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010 7.94
10 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010 6.66
11 Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 2009 6.39
12 FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet 2007 5.93
13 Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 2007 5.89
14 Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 2008 5.55
15 A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 2008 5.49
16 Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 2009 5.43
17 Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA 2009 5.32
18 Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N Engl J Med 2006 4.88
19 Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 2002 4.79
20 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet 2012 4.73
21 Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 2005 4.44
22 A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science 2008 4.38
23 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012 4.37
24 Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 2002 4.16
25 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 2014 4.13
26 Genome-wide association study identifies five loci associated with lung function. Nat Genet 2009 4.10
27 Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem 2003 4.08
28 Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes 2010 4.07
29 Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. Hum Mol Genet 2007 4.07
30 Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med 2011 3.94
31 Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet 2011 3.46
32 Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 2012 3.41
33 Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. Am J Hum Genet 2007 3.31
34 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 2013 3.25
35 Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum Mol Genet 2008 3.24
36 Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet 2008 3.24
37 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
38 Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet 2010 3.21
39 Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 2011 3.18
40 TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med (Berl) 2007 3.17
41 New gene functions in megakaryopoiesis and platelet formation. Nature 2011 3.14
42 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet 2012 3.04
43 Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002 3.04
44 Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes 2009 2.92
45 Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 2006 2.85
46 The genetics of human obesity. Nat Rev Genet 2005 2.83
47 Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet 2013 2.83
48 A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet 2010 2.81
49 Seventy-five genetic loci influencing the human red blood cell. Nature 2012 2.77
50 Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 2002 2.72
51 The genetic contribution to non-syndromic human obesity. Nat Rev Genet 2009 2.70
52 Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study. Diabetes 2007 2.69
53 The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. Diabetes 2008 2.65
54 A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet 2012 2.60
55 Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature 2011 2.59
56 Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). J Infect Dis 2009 2.53
57 Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Hum Mol Genet 2007 2.50
58 Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet 2012 2.34
59 Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care 2008 2.32
60 Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet 2010 2.30
61 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011 2.21
62 Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat Genet 2012 2.15
63 Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem 2004 2.15
64 Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet 2009 2.09
65 Comment on "A common genetic variant is associated with adult and childhood obesity". Science 2007 2.04
66 Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome. Am J Hum Genet 2003 2.04
67 Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome. PLoS One 2010 1.99
68 A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. Hum Mol Genet 2009 1.95
69 Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. PLoS One 2008 1.94
70 KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nat Genet 2012 1.93
71 New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet 2012 1.90
72 Inflammation is associated with a decrease of lipogenic factors in omental fat in women. Am J Physiol Regul Integr Comp Physiol 2008 1.88
73 Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet 2013 1.86
74 GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLoS Biol 2003 1.83
75 Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med 2011 1.78
76 Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 2013 1.72
77 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
78 Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group. Diabetes 2008 1.71
79 The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC Med Genet 2008 1.68
80 Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians. Diabetes 2009 1.65
81 Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes. Endocr Rev 2008 1.63
82 Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. Diabetes 2002 1.63
83 Genetic approaches to the molecular understanding of type 2 diabetes. Am J Physiol Endocrinol Metab 2002 1.63
84 ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes 2006 1.62
85 Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. J Mol Med (Berl) 2009 1.62
86 The FTO gene is associated with adulthood obesity in the Mexican population. Obesity (Silver Spring) 2008 1.62
87 A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab 2006 1.59
88 Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proc Natl Acad Sci U S A 2005 1.59
89 Direct estimates of natural selection in Iberia indicate calcium absorption was not the only driver of lactase persistence in Europe. Mol Biol Evol 2014 1.57
90 Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). J Infect Dis 2009 1.57
91 Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes 2009 1.54
92 Effects of TCF7L2 polymorphisms on obesity in European populations. Obesity (Silver Spring) 2008 1.49
93 Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers. Nucleic Acids Res 2012 1.46
94 TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Diabetes 2006 1.45
95 R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population. Hum Mol Genet 2008 1.44
96 A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. Diabetes 2004 1.44
97 Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. Diabetes 2004 1.44
98 Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients. Diabetes 2004 1.43
99 Impact of common variation in bone-related genes on type 2 diabetes and related traits. Diabetes 2012 1.42
100 cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs. Nat Methods 2010 1.41
101 The emerging genetics of type 2 diabetes. Trends Mol Med 2010 1.38
102 Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. Nat Genet 2012 1.37
103 Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts. PLoS One 2012 1.35
104 Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees. Diabetes 2008 1.35
105 Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity (Silver Spring) 2007 1.32
106 Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes 2011 1.31
107 Small deletion variants have stable breakpoints commonly associated with alu elements. PLoS One 2008 1.30
108 From obesity genetics to the future of personalized obesity therapy. Nat Rev Endocrinol 2013 1.29
109 Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits. Diabetes 2009 1.29
110 Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. Hum Mol Genet 2003 1.28
111 G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes 2009 1.27
112 Childhood obesity is associated with shorter leukocyte telomere length. J Clin Endocrinol Metab 2011 1.27
113 Integration of clinical data with a genome-scale metabolic model of the human adipocyte. Mol Syst Biol 2013 1.26
114 Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population. BMC Med Genet 2005 1.26
115 Genetic basis of maturity-onset diabetes of the young. Endocrinol Metab Clin North Am 2006 1.24
116 Whole-exome sequencing and high throughput genotyping identified KCNJ11 as the thirteenth MODY gene. PLoS One 2012 1.24
117 New ABCC8 mutations in relapsing neonatal diabetes and clinical features. Diabetes 2007 1.22
118 Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians. Diabetes 2005 1.21
119 TCF7L2 genetic defect and type 2 diabetes. Curr Diab Rep 2008 1.21
120 Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans. Hum Genet 2009 1.20
121 TCF7L2 splice variants have distinct effects on beta-cell turnover and function. Hum Mol Genet 2011 1.20
122 Molecular genetics of human obesity-associated MC4R mutations. Ann N Y Acad Sci 2003 1.19
123 ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. Biochem Biophys Res Commun 2009 1.19
124 Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet 2009 1.18
125 Highly sensitive diagnosis of 43 monogenic forms of diabetes or obesity through one-step PCR-based enrichment in combination with next-generation sequencing. Diabetes Care 2013 1.18
126 Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proc Natl Acad Sci U S A 2007 1.17
127 A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity. Diabetes 2003 1.17
128 Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS. J Infect Dis 2010 1.16
129 MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. J Biol Chem 2009 1.15
130 Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention. Diabetes 2009 1.14
131 Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Mol Genet Metab 2006 1.14
132 Genetics of obesity and the prediction of risk for health. Hum Mol Genet 2006 1.14
133 Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes 2011 1.12
134 Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2). Diabetes Care 2008 1.12
135 A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes. Hum Mol Genet 2003 1.11
136 Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians. Diabetes 2006 1.11
137 Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q. Diabetes 2004 1.10
138 Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets. Mol Genet Metab 2010 1.10
139 Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. Curr Drug Targets Immune Endocr Metabol Disord 2003 1.10
140 A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults. Diabetes 2008 1.10
141 Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine. Ann N Y Acad Sci 2010 1.10
142 The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects. Hum Mol Genet 2009 1.09
143 Regulation of carboxylesterase 1 (CES1) in human adipose tissue. Biochem Biophys Res Commun 2009 1.09
144 Genomic insights into the origin of farming in the ancient Near East. Nature 2016 1.07
145 Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. J Biol Chem 2011 1.06
146 A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians. Diabetes 2005 1.06
147 Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes 2011 1.05
148 SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. Diabetes 2004 1.05
149 Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications. Nat Genet 2013 1.04
150 Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. Diabetes 2006 1.04
151 Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population. Acta Diabetol 2007 1.04
152 Common variation in SIM1 is reproducibly associated with BMI in Pima Indians. Diabetes 2009 1.04
153 Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in men. J Clin Endocrinol Metab 2012 1.03
154 GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm. PLoS Genet 2013 1.03
155 Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women. J Bone Miner Res 2007 1.02
156 Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. Diabetes 2006 1.02
157 High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. Mol Genet Metab 2012 1.01
158 Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. J Mol Med (Berl) 2008 1.01
159 Inflammatory role of Toll-like receptors in human and murine adipose tissue. Mediators Inflamm 2010 1.01
160 A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity. Obesity (Silver Spring) 2009 1.01
161 Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone. Am J Physiol Regul Integr Comp Physiol 2012 1.01
162 Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations. Hum Mol Genet 2008 1.00
163 A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. Hum Mutat 2004 1.00
164 Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population. Clin Biochem 2010 1.00
165 Is obesity our genetic legacy? J Clin Endocrinol Metab 2008 1.00
166 Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population. Obesity (Silver Spring) 2011 0.99
167 Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study. BMC Med Genet 2009 0.99
168 Neonatal hyperglycaemia and abnormal development of the pancreas. Best Pract Res Clin Endocrinol Metab 2008 0.98
169 Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS. J Acquir Immune Defic Syndr 2011 0.98
170 ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity. Obes Res 2005 0.98
171 Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. Diabetes 2004 0.97
172 Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies. Expert Rev Mol Med 2006 0.97
173 Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. PLoS Clin Trials 2006 0.97
174 The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Diabetes 2006 0.96
175 Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY). Diabetes Care 2009 0.96
176 Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. Diabetologia 2014 0.96
177 Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. J Clin Invest 2013 0.96
178 Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. BMC Med Genet 2013 0.96
179 Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians. Diabetes 2004 0.96
180 Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. Diabetes 2006 0.95
181 Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q. Diabetes 2009 0.95
182 Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors. Metabolism 2011 0.94
183 Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity. Obesity (Silver Spring) 2009 0.94
184 Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochem Biophys Res Commun 2007 0.94
185 Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. Diabetes 2007 0.93
186 Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children? J Clin Endocrinol Metab 2005 0.93
187 Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. J Clin Endocrinol Metab 2009 0.92
188 The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis. Best Pract Res Clin Endocrinol Metab 2012 0.92
189 Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels. Diabetes 2010 0.92
190 The genetics of adiponectin. Curr Diab Rep 2003 0.91
191 Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans. Eur J Hum Genet 2008 0.91
192 Evaluation of A2BP1 as an obesity gene. Diabetes 2010 0.91
193 A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J Clin Endocrinol Metab 2002 0.91
194 Improved donor/acceptor BRET couples for monitoring beta-arrestin recruitment to G protein-coupled receptors. Biotechnol J 2009 0.91
195 Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PLoS One 2012 0.91
196 What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications? PLoS One 2013 0.90
197 Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes. Pediatr Endocrinol Rev 2009 0.90
198 Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. J Biol Chem 2011 0.90
199 Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity. Obesity (Silver Spring) 2011 0.90
200 Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study. BMC Med Genet 2009 0.89
201 Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition. J Infect Dis 2012 0.89
202 Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population. BMC Med Genet 2006 0.89
203 The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults. J Clin Endocrinol Metab 2006 0.89
204 Improved protocol for laser microdissection of human pancreatic islets from surgical specimens. J Vis Exp 2013 0.88
205 TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet. Am J Clin Nutr 2009 0.88
206 Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. PLoS One 2013 0.88
207 Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level. Diabetologia 2014 0.87
208 Familial early-onset diabetes is not a typical MODY in several Tunisian patients. Tunis Med 2012 0.87
209 Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. Obesity (Silver Spring) 2009 0.87
210 Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study. Diabetologia 2014 0.86
211 Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene. PLoS One 2011 0.86
212 Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population. Diabetes 2006 0.86
213 MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes 2010 0.86
214 Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes. Diabetes 2002 0.86
215 Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population. BMC Genet 2005 0.86
216 No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes 2012 0.86
217 Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Biochem Biophys Res Commun 2006 0.85
218 Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose. Pharmacogenet Genomics 2008 0.85
219 Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C. J Clin Endocrinol Metab 2008 0.85
220 Evidence for leptin receptor isoforms heteromerization at the cell surface. FEBS Lett 2010 0.85
221 famCNV: copy number variant association for quantitative traits in families. Bioinformatics 2011 0.85
222 Peroxisome proliferator-activated receptor γ regulates genes involved in insulin/insulin-like growth factor signaling and lipid metabolism during adipogenesis through functionally distinct enhancer classes. J Biol Chem 2013 0.85
223 A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family. Diabetes 2002 0.85
224 Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians. Diabetes 2008 0.85
225 The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate. Biochem Biophys Res Commun 2013 0.84
226 Clinical and metabolic features of adult-onset diabetes caused by ABCC8 mutations. Diabetes Care 2011 0.84
227 Analysis of the SIM1 contribution to polygenic obesity in the French population. Obesity (Silver Spring) 2010 0.84
228 Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. Diabetes 2007 0.84
229 Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion. J Biol Chem 2011 0.84
230 Early detrimental metabolic outcomes of rs17300539-A allele of ADIPOQ gene despite higher adiponectinemia. Obesity (Silver Spring) 2009 0.84
231 Genotype-by-nutrient interactions assessed in European obese women. A case-only study. Eur J Nutr 2006 0.84
232 Effects of genetic susceptibility for type 2 diabetes on the evolution of glucose homeostasis traits before and after diabetes diagnosis: data from the D.E.S.I.R. Study. Diabetes 2011 0.83
233 Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity. J Clin Endocrinol Metab 2007 0.83
234 Bio-Repository of DNA in stroke (BRAINS): a study protocol. BMC Med Genet 2011 0.83
235 Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1. Hum Genet 2005 0.83
236 ITIH-5 expression in human adipose tissue is increased in obesity. Obesity (Silver Spring) 2011 0.83
237 Characterization of the human SLC30A8 promoter and intronic enhancer. J Mol Endocrinol 2011 0.83
238 TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population. BMC Med Genet 2007 0.83
239 Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity. Hum Mol Genet 2012 0.83
240 Lack of association of CD36 SNPs with early onset obesity: a meta-analysis in 9,973 European subjects. Obesity (Silver Spring) 2010 0.83
241 Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes. Theor Biol Med Model 2013 0.83
242 The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population. Obesity (Silver Spring) 2008 0.82
243 Evaluating the association of FAAH common gene variation with childhood, adult severe obesity and type 2 diabetes in the French population. Obes Facts 2008 0.82
244 Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity. Diabetes 2005 0.82
245 EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families. Diabetes 2006 0.82
246 Genetics of obesity. Am J Pharmacogenomics 2002 0.81
247 Evaluating the association of common APOA2 variants with type 2 diabetes. BMC Med Genet 2009 0.81
248 Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts. Diabetologia 2013 0.81
249 Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects. Obes Res 2003 0.81
250 Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? PLoS One 2013 0.81
251 Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects. Endocrine 2013 0.81
252 The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis. Diabetologia 2015 0.81
253 Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986. PLoS One 2013 0.80
254 Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians. Diabetes 2005 0.80
255 Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients. Pharmacogenetics 2002 0.80
256 Genetic determinants of leucocyte telomere length in children: a neglected and challenging field. Paediatr Perinat Epidemiol 2015 0.80
257 Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations. Pediatr Diabetes 2011 0.80
258 Pluripotent stem cells as a potential tool for disease modelling and cell therapy in diabetes. Stem Cell Rev 2014 0.80
259 Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity. PLoS One 2012 0.79
260 Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children. Diabetes 2007 0.79
261 Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study. Int J Cancer 2013 0.79
262 Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations. J Mol Med (Berl) 2013 0.79
263 Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences. Endocr Dev 2007 0.79
264 Response to comment on: Marquez et al. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes 2012;61:524-530. Diabetes 2012 0.78
265 Chromosome 19p13.3 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems. Am J Med Genet A 2011 0.78
266 A promoter polymorphism in CD36 is associated with an atherogenic lipid profile in a French general population. Atherosclerosis 2004 0.78
267 Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity. BMC Med Genet 2007 0.78
268 [Adipocytokins, obesity and development of type 2 diabetes]. Med Sci (Paris) 2005 0.78
269 Impact of a CART promoter genetic variation on plasma lipid profile in a general population. Mol Genet Metab 2006 0.78
270 [Inputs from the genetics of fasting glucose: lessons for diabetes]. Med Sci (Paris) 2009 0.78
271 Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height. Eur J Endocrinol 2009 0.78
272 Evidence for tuning adipocytes ICER levels for obesity care. Adipocyte 2012 0.78
273 A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents. J Clin Endocrinol Metab 2007 0.78
274 Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants. Ann Hum Genet 2011 0.77
275 Loss-of-function mutations in MC4R are very rare in the Greek severely obese adult population. Obesity (Silver Spring) 2012 0.77
276 VNTR polymorphism of the insulin gene and childhood overweight in a general population. Obes Res 2004 0.77
277 Coexistence in the same family of both focal and diffuse forms of hyperinsulinism. Diabetes Care 2007 0.76
278 Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women. Osteoporos Int 2006 0.76
279 Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population. J Hum Genet 2010 0.76
280 Identification of two novel loss-of-function SIM1 mutations in two overweight children with developmental delay. Obesity (Silver Spring) 2014 0.76
281 Novel LEPR mutations in obese Pakistani children identified by PCR-based enrichment and next generation sequencing. Obesity (Silver Spring) 2013 0.76
282 The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. PLoS One 2012 0.76
283 INS VNTR is not associated with childhood obesity in 1,023 families: a family-based study. Obesity (Silver Spring) 2008 0.76
284 Analysis of KLF transcription factor family gene variants in type 2 diabetes. BMC Med Genet 2007 0.76
285 Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck. Genome Biol 2013 0.76
286 Evaluating the association of common PBX1 variants with type 2 diabetes. BMC Med Genet 2008 0.75
287 Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet 2016 0.75
288 PLCL1 rs7595412 variation is not associated with hip bone size variation in postmenopausal Danish women. BMC Med Genet 2009 0.75
289 Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry. Clin Chem 2011 0.75
290 [ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes]. Med Sci (Paris) 2006 0.75
291 Erratum: Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population. Obesity (Silver Spring) 2017 0.75
292 Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 2017 0.75
293 Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes. J Clin Endocrinol Metab 2007 0.75
294 Reflections on the field of metabolism. Cell Metab 2015 0.75
295 Monogenic forms of diabetes mellitus: an update. Endocrinol Nutr 2009 0.75
296 No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases. Eur J Hum Genet 2006 0.75
297 [Adipocytokins, obesity and development of type 2 diabetes]. Med Sci (Paris) 2003 0.75
298 Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. Biochem J 2014 0.75