Published in CA Cancer J Clin on June 16, 2010
Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med (2011) 10.33
Analysing biological pathways in genome-wide association studies. Nat Rev Genet (2010) 6.63
Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study. Diabetes Care (2011) 5.63
The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer (2012) 4.72
Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila) (2010) 2.60
Survival among patients with pancreatic cancer and long-standing or recent-onset diabetes mellitus. J Clin Oncol (2014) 2.21
Metformin: multi-faceted protection against cancer. Oncotarget (2011) 2.00
Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancer. J Clin Oncol (2010) 1.80
Diabetes and pancreatic cancer. Mol Carcinog (2012) 1.71
Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling. Cell (2013) 1.69
If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. Aging (Albany NY) (2011) 1.61
Diabetes mellitus and the incidence of colorectal cancer: an updated systematic review and meta-analysis. Dig Dis Sci (2012) 1.56
Diabetes and cause-specific mortality in a prospective cohort of one million U.S. adults. Diabetes Care (2012) 1.42
Predictors of Adherence to Multiple Clinical Preventive Recommendations among Adults with Diabetes in Spain. PLoS One (2015) 1.40
Metformin directly acts on mitochondria to alter cellular bioenergetics. Cancer Metab (2014) 1.34
Cancer risk associated with insulin glargine among adult type 2 diabetes patients--a nationwide cohort study. PLoS One (2011) 1.31
Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity. Obstet Gynecol (2012) 1.29
Insulin glargine and risk of cancer: a cohort study in the French National Healthcare Insurance Database. Diabetologia (2012) 1.28
The 8q24 gene desert: an oasis of non-coding transcriptional activity. Front Genet (2012) 1.28
Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr (2013) 1.25
Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality. J Am Med Inform Assoc (2014) 1.25
Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest (2013) 1.11
TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nat Commun (2015) 1.10
The effect of metformin and thiazolidinedione use on lung cancer in diabetics. BMC Cancer (2012) 1.08
Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors. Carcinogenesis (2013) 1.08
Gerosuppressant metformin: less is more. Aging (Albany NY) (2011) 1.08
Trajectory of body shape in early and middle life and all cause and cause specific mortality: results from two prospective US cohort studies. BMJ (2016) 1.07
Diabetes and risk of cancer. ISRN Oncol (2013) 1.06
Metformin inhibits the growth of human pancreatic cancer xenografts. Pancreas (2013) 1.05
AACR Cancer Progress Report 2014. Clin Cancer Res (2014) 1.05
Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies. Blood (2012) 1.04
Diabetes and racial/ethnic differences in hepatocellular carcinoma risk: the multiethnic cohort. J Natl Cancer Inst (2014) 1.04
Survival benefits of metformin for colorectal cancer patients with diabetes: a systematic review and meta-analysis. PLoS One (2014) 1.04
Disease-specific mortality among stage I-III colorectal cancer patients with diabetes: a large population-based analysis. Diabetologia (2012) 1.03
NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell (2013) 1.03
Metabolic roles of AMPK and metformin in cancer cells. Mol Cells (2013) 1.02
Diabetes and cancer: Associations, mechanisms, and implications for medical practice. World J Diabetes (2014) 1.01
Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions. Drug Resist Updat (2011) 1.01
Increased risk of cancer in patients with type 2 diabetes mellitus: a retrospective cohort study in China. BMC Public Health (2012) 1.00
Glycemic index, glycemic load, dietary carbohydrate, and dietary fiber intake and risk of liver and biliary tract cancers in Western Europeans. Ann Oncol (2012) 1.00
Metformin as an energy restriction mimetic agent for breast cancer prevention. J Carcinog (2011) 1.00
The insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer. Cell Cycle (2011) 0.99
Comparing pioglitazone to insulin with respect to cancer, cardiovascular and bone fracture endpoints, using propensity score weights. Clin Drug Investig (2013) 0.98
Pharmacologic Therapy of Diabetes and Overall Cancer Risk and Mortality: A Meta-Analysis of 265 Studies. Sci Rep (2015) 0.98
The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer. PLoS One (2012) 0.98
Association of type 2 diabetes mellitus and the risk of colorectal cancer: A meta-analysis and systematic review. World J Gastroenterol (2015) 0.97
The impact of adherence to screening guidelines and of diabetes clinics referral on morbidity and mortality in diabetes. PLoS One (2012) 0.97
Association between diagnosed diabetes and self-reported cancer among U.S. adults: findings from the 2009 Behavioral Risk Factor Surveillance System. Diabetes Care (2011) 0.97
Prioritization of care in adults with diabetes and comorbidity. Ann N Y Acad Sci (2011) 0.96
Metformin and its clinical use: new insights for an old drug in clinical practice. Arch Med Sci (2012) 0.96
Obesity and economic environments. CA Cancer J Clin (2014) 0.96
AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell. Cancer Biol Ther (2015) 0.96
HbA1C and cancer risk in patients with type 2 diabetes--a nationwide population-based prospective cohort study in Sweden. PLoS One (2012) 0.95
Medical risk factors associated with cholangiocarcinoma in Taiwan: a population-based case-control study. PLoS One (2013) 0.95
Cancer risks among patients with type 2 diabetes: a 10-year follow-up study of a nationwide population-based cohort in Taiwan. BMC Cancer (2014) 0.93
Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells. Front Physiol (2014) 0.93
A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors. Int J Endocrinol (2013) 0.93
Opportunities for cancer prevention during midlife: highlights from a meeting of experts. Am J Prev Med (2014) 0.92
Does chronic obstructive pulmonary disease with or without type 2 diabetes mellitus influence the risk of lung cancer? Result from a population-based cohort study. PLoS One (2014) 0.91
Gene expression profile analysis of type 2 diabetic mouse liver. PLoS One (2013) 0.91
Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci (2014) 0.91
Pretreatment Insulin Levels as a Prognostic Factor for Breast Cancer Progression. Oncologist (2016) 0.90
A prospective study of intakes of zinc and heme iron and colorectal cancer risk in men and women. Cancer Causes Control (2011) 0.90
Quantitative analysis of energy metabolic pathways in MCF-7 breast cancer cells by selected reaction monitoring assay. Mol Cell Proteomics (2012) 0.89
Warburg Effect - a Consequence or the Cause of Carcinogenesis? J Cancer (2016) 0.89
A dietary pattern that is associated with C-peptide and risk of colorectal cancer in women. Cancer Causes Control (2012) 0.88
Cancer incidence and mortality in patients with type 2 diabetes treated with human insulin: a cohort study in Shanghai. PLoS One (2013) 0.88
History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium. Cancer Epidemiol Biomarkers Prev (2011) 0.87
Impact of glycemia on survival of glioblastoma patients treated with radiation and temozolomide. J Neurooncol (2015) 0.86
The association of diabetes and anti-diabetic medications with clinical outcomes in multiple myeloma. Br J Cancer (2014) 0.86
The metabolic and mitogenic properties of basal insulin analogues. Arch Physiol Biochem (2013) 0.86
Diabetes mellitus and ovarian cancer: more complex than just increasing risk. Gynecol Oncol (2014) 0.85
The association between type 2 diabetes mellitus and women cancer: the epidemiological evidences and putative mechanisms. Biomed Res Int (2015) 0.85
Diabetes mellitus and poorer prognosis in hepatocellular carcinoma: a systematic review and meta-analysis. PLoS One (2014) 0.85
Serum glucose and fructosamine in relation to risk of cancer. PLoS One (2013) 0.85
Risk of cancer in patients using glucose-lowering agents: a nationwide cohort study of 3.6 million people. BMJ Open (2012) 0.84
The elevated preoperative fasting blood glucose predicts a poor prognosis in patients with esophageal squamous cell carcinoma: The Fujian prospective investigation of cancer (FIESTA) study. Oncotarget (2016) 0.84
Targeting Intracellular Cholesterol is a Novel Therapeutic Strategy for Cancer Treatment. J Cancer Sci Ther (2014) 0.84
Diabetes protects from prostate cancer by downregulating androgen receptor: new insights from LNCaP cells and PAC120 mouse model. PLoS One (2013) 0.84
Exploring opportunities for colorectal cancer screening and prevention in the context of diabetes self-management: an analysis of the 2010 National Health Interview Survey. Transl Behav Med (2013) 0.84
The impact of type 2 diabetes on the outcome of localized renal cell carcinoma. World J Urol (2013) 0.84
Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai. BMC Cancer (2015) 0.84
Diabetes and risk of bladder cancer among postmenopausal women in the Iowa Women's Health Study. Cancer Causes Control (2013) 0.84
Metformin therapy associated with survival benefit in lung cancer patients with diabetes. Oncotarget (2016) 0.84
Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study. Br J Cancer (2012) 0.83
Pancreatic cancer: translational research aspects and clinical implications. World J Gastroenterol (2012) 0.83
Insulin priming effect on estradiol-induced breast cancer metabolism and growth. Cancer Biol Ther (2015) 0.82
Diabetes and risk of subsequent gastric cancer: a population-based cohort study in Taiwan. Gastric Cancer (2012) 0.82
Diabetes mellitus and metformin in hepatocellular carcinoma. World J Gastroenterol (2016) 0.82
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. Cancer Causes Control (2016) 0.81
Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cells. Oncogene (2016) 0.81
Long-term status and change of body fat distribution, and risk of colorectal cancer: a prospective cohort study. Int J Epidemiol (2015) 0.81
Relationship between Metabolic Syndrome and History of Cervical Cancer among a US National Population. ISRN Oncol (2013) 0.81
Prevalence of diagnosed cancer according to duration of diagnosed diabetes and current insulin use among U.S. adults with diagnosed diabetes: findings from the 2009 Behavioral Risk Factor Surveillance System. Diabetes Care (2013) 0.80
Risk of cancer following primary total hip replacement or primary resurfacing arthroplasty of the hip: a retrospective cohort study in Scotland. Br J Cancer (2013) 0.80
Diabetes, insulin and cancer risk. World J Diabetes (2012) 0.80
Therapeutic implications of targeting energy metabolism in breast cancer. PPAR Res (2013) 0.80
Genetic polymorphisms potentially associated with response to metformin in postmenopausal diabetics suffering and not suffering with cancer. Cell Cycle (2013) 0.79
Associations between Diabetes and Quality of Life among Breast Cancer Survivors. PLoS One (2016) 0.79
Television watching and risk of colorectal adenoma. Br J Cancer (2015) 0.79
Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care (2012) 21.62
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med (2013) 15.58
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med (2002) 8.84
Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med (2013) 8.74
50-year trends in smoking-related mortality in the United States. N Engl J Med (2013) 7.80
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res (2006) 6.99
Diabetes and cancer: a consensus report. Diabetes Care (2010) 6.71
Achieving weight and activity goals among diabetes prevention program lifestyle participants. Obes Res (2004) 5.74
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res (2007) 5.45
APOBEC3B is an enzymatic source of mutation in breast cancer. Nature (2013) 5.18
A new look at screening and diagnosing diabetes mellitus. J Clin Endocrinol Metab (2008) 4.97
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest (2008) 4.95
Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem (2005) 4.40
Use of twice-daily exenatide in Basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial. Ann Intern Med (2010) 4.03
Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care (2010) 3.98
Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology (2003) 3.93
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet (2010) 3.93
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet (2010) 3.91
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
An integrated risk function for estimating the global burden of disease attributable to ambient fine particulate matter exposure. Environ Health Perspect (2014) 3.69
Leisure time spent sitting in relation to total mortality in a prospective cohort of US adults. Am J Epidemiol (2010) 3.64
Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncol (2008) 3.62
The T1D Exchange clinic registry. J Clin Endocrinol Metab (2012) 3.45
Lung cancer and cardiovascular disease mortality associated with ambient air pollution and cigarette smoke: shape of the exposure-response relationships. Environ Health Perspect (2011) 3.36
Survival after pancreas transplantation in patients with diabetes and preserved kidney function. JAMA (2003) 3.33
Surveillance and survival in Barrett's adenocarcinomas: a population-based study. Gastroenterology (2002) 3.28
A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet (2012) 3.20
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci U S A (2010) 3.13
ADHD drugs and serious cardiovascular events in children and young adults. N Engl J Med (2011) 3.12
Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer. J Natl Cancer Inst (2002) 3.03
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat Genet (2010) 2.96
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell (2004) 2.91
Waist circumference and all-cause mortality in a large US cohort. Arch Intern Med (2010) 2.88
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell (2013) 2.74
The type 1 insulin-like growth factor receptor pathway. Clin Cancer Res (2008) 2.70
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers. Am J Respir Crit Care Med (2011) 2.64
Insulin secretion in type 1 diabetes. Diabetes (2004) 2.59
Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mol Cancer Ther (2007) 2.50
Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H). Transplantation (2003) 2.48
Leisure time physical activity of moderate to vigorous intensity and mortality: a large pooled cohort analysis. PLoS Med (2012) 2.45
Exercise and type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: joint position statement. Exercise and type 2 diabetes. Med Sci Sports Exerc (2010) 2.44
Screening statins for possible carcinogenic risk: up to 9 years of follow-up of 361,859 recipients. Pharmacoepidemiol Drug Saf (2008) 2.43
Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res (2008) 2.37
Impact of body mass index on survival after colorectal cancer diagnosis: the Cancer Prevention Study-II Nutrition Cohort. J Clin Oncol (2011) 2.35
Following cancer prevention guidelines reduces risk of cancer, cardiovascular disease, and all-cause mortality. Cancer Epidemiol Biomarkers Prev (2011) 2.35
Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies. Ann Intern Med (2008) 2.33
Insulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density. Cancer Epidemiol Biomarkers Prev (2005) 2.28
Human epidermal growth factor receptor 2 assessment in a case-control study: comparison of fluorescence in situ hybridization and quantitative reverse transcription polymerase chain reaction performed by central laboratories. J Clin Oncol (2010) 2.28
Post-diagnosis statin use and breast cancer recurrence in a prospective cohort study of early stage breast cancer survivors. Breast Cancer Res Treat (2007) 2.27
Randomized controlled trial of weight training and lymphedema in breast cancer survivors. J Clin Oncol (2006) 2.27
Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men. Cancer Epidemiol Biomarkers Prev (2003) 2.26
Exercise training for claudication. N Engl J Med (2002) 2.26
A prospective study of plasma C-peptide and colorectal cancer risk in men. J Natl Cancer Inst (2004) 2.22
Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study. J Natl Cancer Inst (2012) 2.21
Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement executive summary. Diabetes Care (2010) 2.17
Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia (2015) 2.13
Impact of diabetes mellitus and insulin use on survival after colorectal cancer diagnosis: the Cancer Prevention Study-II Nutrition Cohort. J Clin Oncol (2011) 2.12
Oophorectomy and hysterectomy and cancer incidence in the Cancer Prevention Study-II Nutrition Cohort. Obstet Gynecol (2014) 2.11
Evidence of a strong association between frequency of self-monitoring of blood glucose and hemoglobin A1c levels in T1D exchange clinic registry participants. Diabetes Care (2013) 2.03
Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes. Diabetes Care (2009) 2.02
Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function. J Clin Endocrinol Metab (2009) 2.01
Weight cycling and cancer incidence in a large prospective US cohort. Am J Epidemiol (2015) 2.00
Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer. Cancer Res (2013) 1.99
Associations of recreational physical activity and leisure time spent sitting with colorectal cancer survival. J Clin Oncol (2013) 1.99
Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth. Endocr Relat Cancer (2008) 1.96
Genome-wide association study of glioma and meta-analysis. Hum Genet (2012) 1.96
Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway. Endocrinology (2002) 1.95
Neoadjuvant chemotherapy of locally advanced breast cancer: predicting response with in vivo (1)H MR spectroscopy--a pilot study at 4 T. Radiology (2004) 1.95
Statin use and risk of prostate cancer in the California Men's Health Study cohort. Cancer Epidemiol Biomarkers Prev (2007) 1.94
Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D Exchange clinic registry. J Clin Endocrinol Metab (2013) 1.92
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab (2013) 1.91
Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits. Diabetes Care (2010) 1.91
Spatial analysis of air pollution and mortality in California. Am J Respir Crit Care Med (2013) 1.91
Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. Oncogene (2005) 1.89
Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience. Diabetes Care (2003) 1.86
Daily aspirin use and cancer mortality in a large US cohort. J Natl Cancer Inst (2012) 1.84
Cohort study of pioglitazone and cancer incidence in patients with diabetes. Diabetes Care (2011) 1.83
Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteins. Cancer Epidemiol Biomarkers Prev (2005) 1.81
Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes. Diabetes (2014) 1.81
Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes. Diabetes Care (2013) 1.81
The effects of a low-fat/high-fiber diet on sex hormone levels and menstrual cycling in premenopausal women: a 12-month randomized trial (the diet and hormone study). Cancer (2003) 1.81
Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am J Clin Nutr (2008) 1.80
Screening pharmaceuticals for possible carcinogenic effects: initial positive results for drugs not previously screened. Cancer Causes Control (2009) 1.79
In vivo quantification of choline compounds in the breast with 1H MR spectroscopy. Magn Reson Med (2003) 1.76
Adiponectin is a negative regulator of bone mineral and bone strength in growing mice. Exp Biol Med (Maywood) (2008) 1.76
Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy. Lancet (2002) 1.76
Long-term use of cholesterol-lowering drugs and cancer incidence in a large United States cohort. Cancer Res (2011) 1.76
Plasma insulin-like growth factors, insulin-like binding protein-3, and outcome in metastatic colorectal cancer: results from intergroup trial N9741. Clin Cancer Res (2008) 1.76