Published in Mol Cell on April 25, 2008
Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol (2010) 7.95
A small molecule inhibitor of inducible heat shock protein 70. Mol Cell (2009) 2.63
Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci (2010) 1.91
The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J (2009) 1.57
Cellular mechanisms controlling caspase activation and function. Cold Spring Harb Perspect Biol (2013) 1.47
Apoptosome structure, assembly, and procaspase activation. Structure (2013) 1.33
The mitochondrial death pathway: a promising therapeutic target in diseases. J Cell Mol Med (2009) 1.30
Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxid Redox Signal (2012) 1.27
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Proc Natl Acad Sci U S A (2013) 1.24
Mitochondria-mediated apoptosis in mammals. Protein Cell (2014) 1.19
Mitochondrial regulation of cell death. Cold Spring Harb Perspect Biol (2013) 1.19
Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Proc Natl Acad Sci U S A (2011) 1.16
The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3. Structure (2011) 1.15
PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis. J Biol Chem (2009) 1.05
A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Sci Signal (2013) 1.04
Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR). J Biol Chem (2010) 1.04
2-phenylethynesulfonamide Prevents Induction of Pro-inflammatory Factors and Attenuates LPS-induced Liver Injury by Targeting NHE1-Hsp70 Complex in Mice. PLoS One (2013) 0.92
HLJ1 is a novel caspase-3 substrate and its expression enhances UV-induced apoptosis in non-small cell lung carcinoma. Nucleic Acids Res (2010) 0.91
Mitochondrial and postmitochondrial survival signaling in cancer. Mitochondrion (2013) 0.90
Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis. EMBO J (2012) 0.90
Molecular evidence of the toxic effects of diatom diets on gene expression patterns in copepods. PLoS One (2011) 0.89
Cracking the ANP32 whips: important functions, unequal requirement, and hints at disease implications. Bioessays (2014) 0.88
Apoptotic regulation and tRNA. Protein Cell (2010) 0.86
Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway. Cell Death Dis (2011) 0.86
tRNA and cytochrome c in cell death and beyond. Cell Cycle (2010) 0.85
Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation. PLoS One (2011) 0.84
Dysfunction of the stress-responsive FOXC1 transcription factor contributes to the earlier-onset glaucoma observed in Axenfeld-Rieger syndrome patients. Cell Death Dis (2014) 0.83
Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity. Cancers (Basel) (2011) 0.83
Intracellular death platform steps-in: targeting prostate tumors via endoplasmic reticulum (ER) apoptosis. Prostate (2008) 0.82
Novel small molecules relieve prothymosin alpha-mediated inhibition of apoptosome formation by blocking its interaction with Apaf-1. Biochemistry (2010) 0.80
Regulation of cell death by transfer RNA. Antioxid Redox Signal (2013) 0.80
Silibinin-Induced Apoptosis and Downregulation of MicroRNA-21 and MicroRNA-155 in MCF-7 Human Breast Cancer Cells. J Breast Cancer (2016) 0.80
Understanding the role of heat shock protein isoforms in male fertility, aging and apoptosis. World J Mens Health (2014) 0.78
A systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation. J Biol Chem (2014) 0.78
The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation. J Biol Chem (2015) 0.76
Differential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lung. Int J Oncol (2014) 0.75
ANP32B deficiency impairs proliferation and suppresses tumor progression by regulating AKT phosphorylation. Cell Death Dis (2016) 0.75
Morphine Protects Spinal Cord Astrocytes from Glutamate-Induced Apoptosis via Reducing Endoplasmic Reticulum Stress. Int J Mol Sci (2016) 0.75
Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction. J Biol Chem (2016) 0.75
DARK apoptosome secrets come to light. Structure (2011) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell (2009) 11.36
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (2012) 10.47
R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (2003) 9.53
The BioGRID Interaction Database: 2011 update. Nucleic Acids Res (2010) 8.46
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell (2005) 6.86
TNF-alpha induces two distinct caspase-8 activation pathways. Cell (2008) 6.81
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell (2005) 6.47
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev (2003) 6.17
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
Cytochrome C-mediated apoptosis. Annu Rev Biochem (2004) 5.38
Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell (2005) 5.37
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20
WormBase: a comprehensive resource for nematode research. Nucleic Acids Res (2009) 5.20
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell (2007) 5.09
Jaundice Constrain or Indication? Response. Radiology (2017) 5.07
A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science (2004) 4.95
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell (2012) 4.37
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell (2006) 4.36
Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci U S A (2004) 4.20
WormBase: new content and better access. Nucleic Acids Res (2006) 4.01
WormBase 2012: more genomes, more data, new website. Nucleic Acids Res (2011) 3.87
WormBase 2007. Nucleic Acids Res (2007) 3.69
Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc Natl Acad Sci U S A (2004) 3.63
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science (2013) 3.61
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science (2003) 3.59
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med (2007) 3.58
Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array. Physiol Genomics (2003) 3.39
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol (2007) 3.23
Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity (2012) 3.07
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell (2002) 3.06
SNARE proteins are required for macroautophagy. Cell (2011) 2.99
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell (2010) 2.97
Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling. Cancer Discov (2014) 2.79
Indirect emissions from biofuels: how important? Science (2009) 2.71
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A (2011) 2.64
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro (2005) 2.60
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nat Chem Biol (2007) 2.57
WormBase 2014: new views of curated biology. Nucleic Acids Res (2013) 2.39
Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell (2011) 2.32
The role of oxygen during fracture healing. Bone (2012) 2.21
Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1. Proc Natl Acad Sci U S A (2005) 2.18
Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell (2011) 2.09
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci U S A (2011) 2.06
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology (2008) 1.90
HIV/STD prevalence among men who have sex with men in Chengdu, China and associated risk factors for HIV infection. J Acquir Immune Defic Syndr (2010) 1.76
Cytokines in alcoholic liver disease. Arch Toxicol (2012) 1.74
The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy (2013) 1.71
Silica encapsulation of n-octadecane via sol-gel process: a novel microencapsulated phase-change material with enhanced thermal conductivity and performance. J Colloid Interface Sci (2009) 1.67
Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol (2002) 1.61
Autophagy is involved in influenza A virus replication. Autophagy (2009) 1.60
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal (2010) 1.60
A Bayesian connectivity-based approach to constructing probabilistic gene regulatory networks. Bioinformatics (2004) 1.57
A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure (2005) 1.53
Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death. Development (2006) 1.50
Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma. Cell Res (2009) 1.48
Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free Radic Biol Med (2010) 1.47
Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine. Mol Cell (2006) 1.46
Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer. J Mol Biol (2005) 1.43
Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression. Proc Natl Acad Sci U S A (2010) 1.42
Structure of an apoptosome-procaspase-9 CARD complex. Structure (2010) 1.42
Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci U S A (2012) 1.41
Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases. Mol Biol Cell (2003) 1.41
Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling. Hepatology (2012) 1.40
The difference in superior adjacent segment pathology after lumbar posterolateral fusion by using 2 different pedicle screw insertion techniques in 9-year minimum follow-up. Spine (Phila Pa 1976) (2014) 1.40
MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest (2013) 1.34
Gene clustering based on clusterwide mutual information. J Comput Biol (2004) 1.30
Gene regulatory network reconstruction using conditional mutual information. EURASIP J Bioinform Syst Biol (2008) 1.30
MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination. J Biol Chem (2011) 1.27
Missing-value estimation using linear and non-linear regression with Bayesian gene selection. Bioinformatics (2003) 1.27
Automatic categorization of diverse experimental information in the bioscience literature. BMC Bioinformatics (2012) 1.27
PTEN at a glance. J Cell Sci (2012) 1.26
Multiple roles for CCR2 during fracture healing. Dis Model Mech (2010) 1.26
Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy. Nat Struct Mol Biol (2012) 1.26
Autophagy protects LNCaP cells under androgen deprivation conditions. Autophagy (2007) 1.25
Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation. Biochem J (2008) 1.24
Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis. J Biol Chem (2005) 1.23
Mdm2 and MdmX partner to regulate p53. FEBS Lett (2012) 1.22
Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett (2012) 1.22
Biochemical mechanisms of the RNA-induced silencing complex. Cell Res (2007) 1.22
Histone deacetylase inhibitors in programmed cell death and cancer therapy. Cell Cycle (2005) 1.22
Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol (2004) 1.21
Mitochondria-mediated apoptosis in mammals. Protein Cell (2014) 1.19
Wnt/beta-Catenin pathway in human glioma: expression pattern and clinical/prognostic correlations. Clin Exp Med (2010) 1.19
Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division. Proc Natl Acad Sci U S A (2007) 1.19
Quantitative modeling of coupled piezo-elastodynamic behavior of piezoelectric actuators bonded to an elastic medium for structural health monitoring: a review. Sensors (Basel) (2010) 1.18